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Serological prevalence of celiac disease in brazilian population of multiple sclerosis, neuromyelitis optica and myelitis
Conclusion Our study do not confirm the relationship between celiac serological antibodies with multiple sclerosis, neuromyelitis optica and inflammatory myelitis of an unknown etiology.
Source: Multiple Sclerosis and Related Disorders - July 28, 2016 Category: Neurology Source Type: research

Evidence Supporting the Use of MRI as a Surrogate for Clinical Endpoints in Randomized Controlled Trials for Pediatric Multiple Sclerosis (P1.342)
Conclusions:Using longitudinal analysis we found significant effects of treatment on risk of relapse and Gd lesion rate, and a statistically significant relationship between the two. These findings suggest that Gd count may serve as appropriate outcome measure in pedMS clinical trials-particularly in trials of therapeutic agents known to reduce both clinical attacks and Gd counts in adult MS.Disclosure: Dr. Brown has received personal compensation for activities with NeuroRx Research as a consultant. Dr. O'Mahony has nothing to disclose. Dr. Yeh has nothing to disclose. Dr. Marrie has received research support from Canadia...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Brown, R., OMahony, J., Yeh, E. A., Marrie, R.-A., Bar-Or, A., Banwell, B., Arnold, D., On behalf of the Canadian Pediatric Demyelinating Disease Network Tags: Pediatric Multiple Sclerosis Source Type: research

Study: Transcranial Direct Current Stimulation (tDCS) can reduce fatigue in patients with Multiple Sclerosis (MS)
Conclusion:  tDCS is a potential treatment for MS-related fatigue. The Study in Context Transcranial Direct Current Stimulation (tDCS) as depression treatment: much promise, some DIY risks Occupational therapy study: Improving processing speed seen as key target to help patients with multiple sclerosis 10 Neurotechnologies About to Transform Brain Enhancement and Brain Health Join the 2017 SharpBrains Virtual Summit: Brain Enhancement in the Digital Age (December 5-7th, 2017)
Source: SharpBrains - October 6, 2017 Category: Neuroscience Authors: SharpBrains Tags: Cognitive Neuroscience Health & Wellness Technology brain-stimulation electrical brain stimulation fatigue multiple-sclerosis non-invasive over-the-counter rehabilitation tDCS telerehabilitation tES Transcranial-direct-current-st Source Type: blogs

Spanish validation of a specific measure to assess work-related problems in people with multiple sclerosis: the Multiple Sclerosis Work Difficulties Questionnaire (MSWDQ-23)
Conclusion The Spanish version of the MSWDQ-23 shows appropriate feasibility, reliability, and discriminative performance as a patient-reported outcome. MSWDQ-23 may be a valuable addition to measure the impact of a comprehensive spectrum of difficulties experienced by people with MS in the workplace.
Source: Multiple Sclerosis and Related Disorders - April 4, 2018 Category: Neurology Source Type: research

Biotinidase deficiency should be considered in individuals thought to have multiple sclerosis and related disorders
ConclusionTherefore, although biotinidase deficiency is rare relative to that of multiple sclerosis, the disorder should be included in the differential diagnosis of individuals thought to have multiple sclerosis or related disorders. Biotinidase deficiency should be considered in individuals thought to have multiple sclerosis or related disorders.
Source: Multiple Sclerosis and Related Disorders - December 12, 2018 Category: Neurology Source Type: research

Multiple sclerosis and cancer incidence: A Danish nationwide cohort study
ConclusionIn this nationwide study, multiple sclerosis patients did not have increased cancer incidence or increased cancer-specific mortality. We observed an increased risk of malignant melanoma mainly attributed to increased risk in the first part of our study period.
Source: Multiple Sclerosis and Related Disorders - December 15, 2018 Category: Neurology Source Type: research

Recurrent atrial fibrillation after pulse corticosteroid treatment for a relapse of multiple sclerosis
Publication date: Available online 23 April 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Tin Pavičić, Berislav Ruška, Ivan Adamec, Mario HabekAbstractStandard therapy for a relapse of multiple sclerosis is a high dose pulse corticosteroid therapy. Cardiovascular adverse events ranging from palpitations to serious arrhythmias like atrial fibrillation and ventricular tachycardia have been associated with this treatment. The underlying mechanism behind the development of atrial fibrillation and treatment of multiple sclerosis relapse with steroids is still unclear. In this case, a 27-year-old male with mu...
Source: Multiple Sclerosis and Related Disorders - April 23, 2019 Category: Neurology Source Type: research

Impairments of humour comprehension in multiple sclerosis
ConclusionThese preliminary results suggest that a high proportion of relapsing-remitting multiple sclerosis patients may be impaired in humour comprehension, some as a primary deficit and others as a secondary deficit to more general comprehension difficulties. On a theoretical level, the dissociations obtained between verbal and visual material do not support an amodal humour comprehension model.
Source: Multiple Sclerosis and Related Disorders - October 15, 2019 Category: Neurology Source Type: research

CSF-resident CD4+ T-cells display a distinct gene expression profile relevant to multiple sclerosis
Conclusion We report numerous gene expression differences between CSF and blood CD4+ T-cells. Identi- fied genes have relevance to multiple sclerosis pathogenesis and could contain novel treatment targets. james.hrastelj@gmail.com
Source: Journal of Neurology, Neurosurgery and Psychiatry - May 27, 2022 Category: Neurosurgery Authors: Hrastelj, J., Andrews, R., Loveless, S., Morgan, J., Bishop, M., Bray, N., Williams, N., Robertson, N. Tags: Multiple Sclerosis: 04 Source Type: research

MANBA, CXCR5, SOX8, RPS6KB1 and ZBTB46 are genetic risk loci for multiple sclerosis
A recent genome-wide association study reported five loci for which there was strong, but sub-genome-wide significant evidence for association with multiple sclerosis risk. The aim of this study was to evaluate the role of these potential risk loci in a large and independent data set of ~20 000 subjects. We tested five single nucleotide polymorphisms rs228614 (MANBA), rs630923 (CXCR5), rs2744148 (SOX8), rs180515 (RPS6KB1), and rs6062314 (ZBTB46) for association with multiple sclerosis risk in a total of 8499 cases with multiple sclerosis, 8765 unrelated control subjects and 958 trios of European descent. In addition, we as...
Source: Brain - June 5, 2013 Category: Neurology Authors: International Multiple Sclerosis Genetics Consortium, Lill, Schjeide, Graetz, Ban, Alcina, Ortiz, Perez, Damotte, Booth, Lopez de Lapuente, Broer, Schilling, Akkad, Aktas, Alloza, Antiguedad, Arroyo, Blaschke, Buttmann, Chan, Compston, Cournu-Rebeix, Dorn Tags: Original Articles Source Type: research

Contribution of cortical and white matter lesions to cognitive impairment in multiple sclerosis
Conclusions: These findings suggest a role of WM lesions in the development of cognitive deficits, especially information-processing speed, which may be higher than previously assumed. Abbreviations: CES-D: Center for Epidemiologic Studies Depression scale (ADS-L: Allgemeine Depressions Skala-L, German version of CES-D), CIS: clinically isolated syndrome, CL: cortical lesion, DIR: double inversion recovery, EDSS: Expanded Disability Status Scale, FSMC: fatigue scale for motor and cognitive functions, GM: grey matter, MRI: magnetic resonance imaging, MS: multiple sclerosis, PASAT-3: paced auditory serial addition test 3s, ...
Source: Multiple Sclerosis - August 30, 2013 Category: Neurology Authors: Papadopoulou, A., Muller-Lenke, N., Naegelin, Y., Kalt, G., Bendfeldt, K., Kuster, P., Stoecklin, M., Gass, A., Sprenger, T., Radue, E. W., Kappos, L., Penner, I.-K. Tags: Research Papers Source Type: research

First-line urological evaluation in multiple sclerosis: validation of a specific decision-making algorithm
Conclusion: The FLUE-MS algorithm was designed for neurologists and general practitioners, enabling identification of ‘red flags’, timely patient referral to specialist neuro-urology units, and appropriate first-line therapy.
Source: Multiple Sclerosis - November 25, 2013 Category: Neurology Authors: Amarenco, G., Chartier-Kastler, E., Denys, P., Jean, J. L., de Seze, M., Lubetzski, C. Tags: Research Papers Source Type: research

Multiple Sclerosis and Stroke (P6.169)
Conclusion: There are consistent differences between the rates of ischemic stroke and TIA in patients with MS compared to those without MS, possibly indicating common inflammatory mechanisms.Disclosure: Dr. Sung has nothing to disclose. Dr. Amezcua has received personal compensation for activities with Biogen Idec, Questcor, Novartis and Acorda Therapeutics. Dr. Amezcua has received research support from Novartis and Acorda Therapeutics. Dr. Cen has nothing to disclose. Dr. Krug has nothing to disclose. Dr. Sanossian has received personal compensation for activities with Boehringer-Ingelheim Pharmaceutical Inc.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Sung, E., Amezcua, L., Cen, S., Krug, A., Sanossian, N. Tags: Multiple Sclerosis Symptoms and Comorbidities Source Type: research

P025 A study of general health status and depression in multiple sclerosis patients and its relation with some of their individual characteristics in the Urmia City, Islamic Republic of Iran
Publication date: November 2014 Source:Multiple Sclerosis and Related Disorders, Volume 3, Issue 6 Author(s): N. Mohammadzaie , S. Taghavifar , A. Mosarrezaii , N. Ghasemzadeh , A.Y. Azar Introduction Mental health is a branch of general health that mostly discusses about decreasing psychological disorders in community. Somatic illness is known as a prominent risk factor affecting psychological health. Multiple sclerosis is classified in central nervous system disorders that destroys different segments of brain and spinal cord, by immune system attacks. Depression is associated with most of multiple sclerosis patients an...
Source: Multiple Sclerosis and Related Disorders - December 7, 2014 Category: Neurology Source Type: research

Multimodal Neurophysiological Evaluation of Primary Progressive Multiple Sclerosis - An Increasingly Valid Biomarker, with Limits
Conclusions Multi-modal evoked potential batteries generally show moderate and useful correlation with clinical status as measured by the regulatory standard of EDSS (r=.65 vs. mEPS p<0.005) and MSFC (r=.39 vs. mEPS p<0.05). The graded qualitative mEPS scoring system displayed the strongest relationship although the influence of scoring system applied appeared reassuringly minimal. Non-association with cognitive impairment is an important limitation however.
Source: Multiple Sclerosis and Related Disorders - August 8, 2015 Category: Neurology Source Type: research