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Multiple Sclerosis Foundation Brighter Tomorrow Grant
Each year the Multiple Sclerosis Foundation makes dreams come true for individuals with multiple sclerosis across the country through the Brighter Tomorrow grant. The goal of the grant is to provide individuals with MS with goods or services (valued at up to $1000.00 per recipient) to improve their quality of life by enhancing safety, self-sufficiency, comfort, or well-being. Recipients of the Multiple Sclerosis Foundation's Brighter Tomorrow grant have received appliances, televisions, furniture, hobby supplies, retreats, and various home modifications. To qualify, a person must be 18 years of age or older an...
Source: ScanGrants feed - November 18, 2014 Category: Research Authors: Multiple Sclerosis Foundation Source Type: funding

P006 Association between trigeminal neuralgia and multiple sclerosis: A population-based study
Conclusions Our results showed a significant association between these two disorders supporting previous hypothesis based on the role of MS in etiology of TN.
Source: Multiple Sclerosis and Related Disorders - December 7, 2014 Category: Neurology Source Type: research

P009 Inflammatory cytokines in relapsing-remitting multiple sclerosis (RRMS) patients
Conclusions Our findings revealed the increased IL-27 and IL-33 levels in patients' group. In conclusion, the inhibition of IL-27 and IL-33 might be a novel and promising therapeutic strategy, especially in the therapy of autoimmune inflammatory diseases. IL-27 and IL-33 play pivotal roles in development of MS and might be a specific marker and therapeutic target for MS inhibition. As important of cytokines in pathogenesis of neurodegenerative diseases, future therapeutic approach for molecular inhibitors should be designed for regulation of disorders progression.
Source: Multiple Sclerosis and Related Disorders - December 7, 2014 Category: Neurology Source Type: research

Fabry disease mimicking multiple sclerosis: Lessons from two case reports
We present two cases of heterozygous adult women where clinical and radiological features initially suggested a diagnosis of multiple sclerosis. This led us to review the early clinical course and neurological features of Fabry disease and highlight the importance of assessing non-neurologic (systemic) symptoms when considering a diagnosis of multiple sclerosis and the need for specialist interpretation of neuroradiological findings.
Source: Multiple Sclerosis and Related Disorders - January 29, 2015 Category: Neurology Source Type: research

Multiple Sclerosis – Why a hug might be the last thing you need
Sourced from The Hysterectomy Association: Hysterectomy Association - Hysterectomy Association - hysterectomy, menopause and hormone replacement therapy (hrt) information and support for women. Multiple Sclerosis is an autoimmune disease, and another prime example of an invisible illness. Physically, an MS patient may look well for most of the time, and might be able to go about normal daily activities like work and family life. However, what’s happening below the surface tells a very different story. The immune system attacks the myelin sheathing which protects the body’s nervous system, leaving the nerve exposed. To ...
Source: The Hysterectomy Association - January 27, 2015 Category: OBGYN Authors: Linda Parkinson-Hardman Tags: Health Conditions covance invisible illness multiple sclerosis Source Type: news

Fingolimod first-dose effects in patients with relapsing multiple sclerosis concomitantly receiving selective serotonin-reuptake inhibitors
Publication date: Available online 13 April 2015 Source:Multiple Sclerosis and Related Disorders Author(s): R. Bermel , R. Hashmonay , X. Meng , S. Randhawa , P. von Rosenstiel , N. Sfikas , D. Kantor Selective serotonin-reuptake inhibitors (SSRIs), commonly administered for depression and anxiety in patients with multiple sclerosis, are associated with QT interval prolongation. Fingolimod (FTY720; Gilenya®, Novartis Pharma AG) is a first-in-class sphingosine 1-phosphate receptor modulator approved for relapsing forms of multiple sclerosis. Fingolimod first-dose administration is associated with a transient, generally a...
Source: Multiple Sclerosis and Related Disorders - April 17, 2015 Category: Neurology Source Type: research

A preliminary validation of the brief international cognitive Assessment for multiple sclerosis (BICAMS) tool in an Irish population with multiple sclerosis (MS)
Conclusions This study demonstrates that BICAMS is an easy test to administer and should be used as a basic tool to identify patients with cognitive impairment who may benefit from further neuropsychological assessment. Cognitive impairment can put patients at risk of poor self-management of disease including poor mediation adherence, and negatively impact on employment. Once identified appropriate support and monitoring can be put in place. BICAMS may also be used to help guide treatment decisions and rehabilitation. Further studies will be needed to assess its reliability over time and ability to detect meaningful changes.
Source: Multiple Sclerosis and Related Disorders - August 8, 2015 Category: Neurology Source Type: research

The high cost of spasticity in multiple sclerosis to individuals and society
Conclusions: Based on the survey results, it can be assumed that managing spasticity early and effectively could result in substantial cost savings, in addition to the improvements in health-related quality of life.
Source: Multiple Sclerosis - October 6, 2015 Category: Neurology Authors: Stevenson, V., Gras, A., Bardos, J., Broughton, J. Tags: Original Research Papers Source Type: research

Trichuris suis ova therapy in relapsing multiple sclerosis is safe but without signals of beneficial effect
Conclusions: In a small group of relapsing multiple sclerosis patients, Trichuris suis oral therapy was well tolerated but without beneficial effect.
Source: Multiple Sclerosis - October 29, 2015 Category: Neurology Authors: Voldsgaard, A., Bager, P., Garde, E., Akeson, P., Leffers, A., Madsen, C., Kapel, C., Roepstorff, A., Thamsborg, S., Melbye, M., Siebner, H., Sondergaard, H., Sellebjerg, F., Sorensen, P. S. Tags: Original Research Papers Source Type: research

Spasticity in multiple sclerosis: Associations with impairments and overall quality of life
Conclusions There is a strong association between spasticity and fatigue, depression, anxiety, pain and bladder problems. The retention of a significant direct relationship with QOL in a multivariate model emphasises its influence upon the everyday lives of people with MS.
Source: Multiple Sclerosis and Related Disorders - October 31, 2015 Category: Neurology Source Type: research

Reconstruction of single cortical projection neurons reveals primary spine loss in multiple sclerosis
See Friese (doi:10.1093/brain/awv349) for a scientific commentary on this article. Grey matter pathology has emerged as an important contributor to long-term disability in multiple sclerosis. To better understand where and how neuronal damage in the grey matter is initiated, we used high resolution confocal microscopy of Golgi-Cox impregnated tissue sections and reconstructed single cortical projection neurons in autopsies from eight patients with long-standing relapsing-remitting or secondary progressive multiple sclerosis and eight control patients without neurological disease. Analysis of several hundred individual neur...
Source: Brain - January 8, 2016 Category: Neurology Authors: Jürgens, T., Jafari, M., Kreutzfeldt, M., Bahn, E., Brück, W., Kerschensteiner, M., Merkler, D. Tags: Multiple Sclerosis/Neuroinflammation Reports Source Type: research

Interferon-beta exposure during first trimester is safe in women with multiple sclerosis--A prospective cohort study from the German Multiple Sclerosis and Pregnancy Registry
Conclusions: Interferon-beta exposure during early pregnancy does not influence the mean birth weight, risk of preterm birth, or other adverse pregnancy outcomes. Our study provides further reassurance that interferon-beta treatment can be safely continued up until women become pregnant.
Source: Multiple Sclerosis - April 17, 2016 Category: Neurology Authors: Thiel, S., Langer-Gould, A., Rockhoff, M., Haghikia, A., Queisser-Wahrendorf, A., Gold, R., Hellwig, K. Tags: Original Research Papers Source Type: research

Increased cortical grey matter lesion detection in multiple sclerosis with 7 T MRI: a post-mortem verification study
The relevance of cortical grey matter pathology in multiple sclerosis has become increasingly recognized over the past decade. Unfortunately, a large part of cortical lesions remain undetected on magnetic resonance imaging using standard field strength. In vivo studies have shown improved detection by using higher magnetic field strengths up to 7 T. So far, a systematic histopathological verification of ultra-high field magnetic resonance imaging pulse sequences has been lacking. The aim of this study was to determine the sensitivity of 7 T versus 3 T magnetic resonance imaging pulse sequences for the detection of cortical...
Source: Brain - April 25, 2016 Category: Neurology Authors: Kilsdonk, I. D., Jonkman, L. E., Klaver, R., van Veluw, S. J., Zwanenburg, J. J. M., Kuijer, J. P. A., Pouwels, P. J. W., Twisk, J. W. R., Wattjes, M. P., Luijten, P. R., Barkhof, F., Geurts, J. J. G. Tags: Multiple Sclerosis/Neuroinflammation Original Articles Source Type: research

In Memory of Those Lost to the Battle With Multiple Sclerosis
It always bothers me a bit when I am thanked for my service in the U.S. Coast Guard on the occasion of Memorial Day. While I appreciate the sentiment, it’s Veterans Day when we celebrate and appreciate all who have served their country in the military services. Memorial Day, on the other hand, is the day we remember with solemn thanks those who answered the call in times of war and crisis but did not return home. Armed Forces Day is the day we thank active-duty military personnel. No Veterans of Multiple Sclerosis There are no “veterans” of multiple sclerosis (MS) because there is no cure. We are all “active-duty...
Source: Life with MS - May 31, 2016 Category: Neurology Authors: Trevis Gleason Tags: MS multiple sclerosis Living with MS trevis gleason Source Type: blogs

Reporting quality of randomized-controlled trials in multiple sclerosis from 2000 to 2015, based on CONSORT statement
Conclusion The search identified 102 eligible articles for analysis. 20 of the 38 items of the checklist (52.6%) were addressed in 75% or more of the studies. Reporting of more than 75% of CONSORT items (>75% CONSORT compliance) was increased during the three five-year time periods from 2000 to 2015 (p<0.05). Conclusions Quality of reporting in RCTs focusing on multiple sclerosis is showing improvement over time, but still remains unsatisfactory. Further improvement of reporting is necessary to assess the validity of clinical research.
Source: Multiple Sclerosis and Related Disorders - July 28, 2016 Category: Neurology Source Type: research