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Total 969764 results found since Jan 2013.

Systematic review and network meta-analysis comparing ocrelizumab with other treatments for relapsing multiple sclerosis
Conclusions: Results suggest that ocrelizumab has an efficacy superior to or comparable with all other currently approved DMTs across all endpoints analyzed, and a similar safety profile, indicating it offers a valuable package for the treatment of patients with RMS.
Source: Multiple Sclerosis and Related Disorders - January 3, 2019 Category: Neurology Source Type: research

Neuroplasticity of the sensorimotor neural network associated with walking aid training in people with multiple sclerosis
This study provides preliminary support for supraspinal sensorimotor neuroplasticity in response to rehabilitation interventions such as task-oriented walking aid training, suggests specific neural targets for future mobility interventions, and supports the need for full-scale randomized controlled trials in this area.
Source: Multiple Sclerosis and Related Disorders - March 9, 2019 Category: Neurology Source Type: research

Cognitive and physical fatigue are associated with distinct problems in daily functioning, role fulfilment, and quality of life in multiple sclerosis.
ConclusionCognitive and physical fatigue were associated with distinct problems in daily functioning, which impact differentially on role fulfilment and quality of life in multiple sclerosis. Therefore, these two types of fatigue should be considered distinct domains of the fatigue experience in MS.
Source: Multiple Sclerosis and Related Disorders - April 3, 2019 Category: Neurology Source Type: research

Capturing fatigue parameters: The impact of vagal processing in multiple sclerosis related cognitive fatigue
Conclusion: Cognitive fatigue in MS is related to parasympathetic activity and reduced responsiveness, supporting our model representing fatigue as inflammatory processes in the brain. Standardized subjective and objective autonomous dysfunction measures might be considered as additional assessments in MS.
Source: Multiple Sclerosis and Related Disorders - April 15, 2019 Category: Neurology Source Type: research

Profile of Polish patients with primary progressive multiple sclerosis
ConclusionsPPMS occurs in about 10% of Polish patients with multiple sclerosis, and the first symptoms appear at around 40 years of age with the same frequency in both sexes. PPMS diagnosis takes more than twice the time for RRMS.
Source: Multiple Sclerosis and Related Disorders - May 22, 2019 Category: Neurology Source Type: research

Multiple Sclerosis and Psychosis: A case report
We describe the process which led us to make the diagnosis of Psychotic Disorder due to Medical Condition (Multiple Sclerosis). Because her criminal charges brought significant attention to her case, we also address the difficulty in treating a neurological condition with psychiatric features within the forensic context. Moreover, one of the main concerns of the patient was that Lyme Disease was the correct diagnosis as opposed to MS. We also report the difficulty of treating and initiating successful follow-up for a patient whose paranoia is enabled by the opinions of certain health advocacy groups.
Source: Multiple Sclerosis and Related Disorders - June 4, 2019 Category: Neurology Source Type: research

Acute Myocardial Infarction Associated with Initial Alemtuzumab Infusion Cycle in Relapsing-Remitting Multiple Sclerosis
We report a 30-year-old woman with relapsing-remitting multiple sclerosis who developed a type 2 non-ST elevated myocardial infarction (NSTEMI) during her first alemtuzumab infusion cycle. While acute coronary syndrome has been described with alemtuzumab in the treatment of lymphoma, alemtuzumab-associated cardiac ischemia in multiple sclerosis is uncommon and can occur in patients without cardiovascular risk factors.
Source: Multiple Sclerosis and Related Disorders - June 19, 2019 Category: Neurology Source Type: research

Quality of life in patients with multiple sclerosis and its association with depressive symptoms and physical disability
ConclusionsQuality of life, in patients with multiple sclerosis is an issue that worries health personnel, it is essential to implement strategies for reducing the impact of the disease on patients' lives, mainly through the application of programs aimed to decrees depression and improve social support.
Source: Multiple Sclerosis and Related Disorders - September 9, 2019 Category: Neurology Source Type: research

The effect of galanin gene polymorphism rs948854 on the severity of multiple sclerosis: a significant association with the age of onset.
Conclusion: Collectively, our data support the contribution of galanin gene polymorphism rs948854 to the mechanisms of adverse course of the disease in the late onset MS.
Source: Multiple Sclerosis and Related Disorders - October 11, 2019 Category: Neurology Source Type: research

Comparison of the effects of two different exergaming systems on balance, functionality, fatigue, and quality of life in people with multiple sclerosis: A randomized controlled trial
ConclusionIn comparison with no intervention, exergaming with Nintendo Wii Fit and Balance Trainer improves balance, increases functionality, reduces fatigue severity, and increases quality of life in PwMS.
Source: Multiple Sclerosis and Related Disorders - December 21, 2019 Category: Neurology Source Type: research

Do Secondary Progressive Multiple Sclerosis patients benefit from Computer- based cognitive neurorehabilitation? A randomized sham controlled trial
ConclusionThese data provide the first evidence supporting the efficacy of computer based restorative cognitive rehabilitation applied at home exclusively in SPMS patients, suggesting that adaptive neuroplasticity may occur after functional cognitive training in progressive MS. Improved cognitive functioning in combination with mood augmentation appear to have ameliorated fatigue, which impacted daily functioning activity and culminated in improved health related quality of life.
Source: Multiple Sclerosis and Related Disorders - January 7, 2020 Category: Neurology Source Type: research

Why Do Multiple Sclerosis and Migraine Coexist? Running Title: Multiple Sclerosis and Migraine
Conclusion: To the best of our knowledge, this is the first study on this topic to date. Based on the results, our study may shed light on the etiopathogenesis of the coexistence of MS and migraine and new treatments. However, more studies are needed to better understand the etiology of this relationship and its negative effects.
Source: Multiple Sclerosis and Related Disorders - January 16, 2020 Category: Neurology Source Type: research

E-health and multiple sclerosis
Purpose of review To outline recent applications of e-health data and digital tools for improving the care and management of healthcare for people with multiple sclerosis. Recent findings The digitization of most clinical data, along with developments in communication technologies, miniaturization of sensors and computational advances are enabling aggregation and clinically meaningful analyses of real-world data from patient registries, digital patient-reported outcomes and electronic health records (EHR). These data are allowing more confident descriptions of prognoses for multiple sclerosis patients and the long-ter...
Source: Current Opinion in Neurology - May 6, 2020 Category: Neurology Tags: MULTIPLE SCLEROSIS: Edited by Giancarlo Comi Source Type: research

Mechanisms underlying progression in multiple sclerosis
Purpose of review In multiple sclerosis, currently approved disease-modifying treatments are effective in modulating peripheral immunity, and coherently, in reducing clinical/radiological relapses, but still, they perform poorly in preventing disease progression and overall disability accrual. This review provides an up-to-date overview of the neuropathology of progressive multiple sclerosis, including a summary of the main mechanisms of disease progression. Recent findings Clinical progression in multiple sclerosis is likely related to the accumulation of neuro-axonal loss in a lifelong inflammatory CNS environment (...
Source: Current Opinion in Neurology - May 6, 2020 Category: Neurology Tags: MULTIPLE SCLEROSIS: Edited by Giancarlo Comi Source Type: research

Multiple sclerosis in the era of COVID-19: disease course, DMTs and SARS-CoV2 vaccinations
Purpose of review As of January 21st 2022, over 340 million are confirmed cases of coronavirus disease 2019 (COVID-19), including nearly 5.6 million deaths. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is neurotropic and affects the neural parenchyma through direct viral invasion from the nasal mucosa and postinfectious cytokine storm. Further challenges of SARS-CoV-2 infection are nowadays linked to variants of concern. Multiple sclerosis is an inflammatory and progressive degenerative disorder of the central nervous system commonly affecting young adults and potentially generating irreversible disabil...
Source: Current Opinion in Neurology - June 1, 2022 Category: Neurology Tags: MULTIPLE SCLEROSIS: Edited by Hans-Peter Hartung Source Type: research