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Systematic Review of Depression in Patients With Multiple Sclerosis And Its Relationship to Interferon β treatment
Conclusion The reviewed studies conclude that there is not a clear relationship between IFNβ and depression. A history of depression is a risk factor for developing depression during the first 6 months of treatment, nevertheless, it is not sufficient to contraindicate it. The development of new strategies is crucial for early detection of depressive symptoms. An adequate treatment can both improve the mood and deal with the neurological disease by increasing treatment adherence and interfering with inflammation. Chronic destructive brain changes and serotonergic depletion due to inflammatory factors have been proposed as ...
Source: Multiple Sclerosis and Related Disorders - July 12, 2017 Category: Neurology Source Type: research

Smoking and Multiple Sclerosis: A Systematic Review and Meta-Analysis Using the Bradford Hill Criteria for Causation
Conclusion This first review to supplement systematic review and meta-analytic methods with Hill's criteria to analyze the smoking-MS association provides evidence supporting the causal involvement of smoking in the development and progression of MS. Smoking prevention and cessation programs and policies should consider MS as an additional health risk when aiming to reduce smoking prevalence in the population. Abbreviations
Source: Multiple Sclerosis and Related Disorders - July 22, 2017 Category: Neurology Source Type: research

Intensity ratio to improve black hole assessment in multiple sclerosis
Conclusions This method of determining the degree of hypointensity within multiple sclerosis lesions can add information to conventional imaging.
Source: Multiple Sclerosis and Related Disorders - December 16, 2017 Category: Neurology Source Type: research

Reliability and Validity of the DYMUS Questionnaire for the assessment of dysphagia in Multiple Sclerosis (Greek version) and proposed modification
Conclusions The Greek version of DYMUS was found to be a valid, reliable and practical for clinical use questionnaire for the detection of dysphagia in Multiple Sclerosis. The first reported normative data for DYMUS suggest a cut-off for the diagnosis of dysphagia at 2 and our findings support a modification of DYMUS eliminating the question about weight loss.
Source: Multiple Sclerosis and Related Disorders - May 15, 2018 Category: Neurology Source Type: research

Validating the Portal Population of the United Kingdom Multiple Sclerosis Register
Publication date: Available online 25 May 2018 Source:Multiple Sclerosis and Related Disorders Author(s): RM Middleton, WJ Rodgers, J Chataway, K Schmierer, D Rog, I Galea, A Akbari, K Tuite-Dalton, H Lockhart-Jones, D Griffiths, DG Noble, KH Jones, A Al-Din, M Craner, N Evangelou, P Harman, T Harrower, J Hobart, H Husseyin, M Kasti, C Kipps, G McDonnell, C Owen, O Pearson, W Rashid, H Wilson, DV Ford The UK Multiple Sclerosis Register (UKMSR) is a large cohort study designed to capture ‘real world’ information about living with multiple sclerosis (MS) in the UK from diverse sources. The primary source of data is dire...
Source: Multiple Sclerosis and Related Disorders - May 25, 2018 Category: Neurology Source Type: research

Validating the portal population of the United Kingdom Multiple Sclerosis Register
Publication date: August 2018Source: Multiple Sclerosis and Related Disorders, Volume 24Author(s): R.M. Middleton, W.J. Rodgers, J. Chataway, K. Schmierer, D. Rog, I. Galea, A. Akbari, K. Tuite-Dalton, H. Lockhart-Jones, D. Griffiths, D.G. Noble, K.H. Jones, A. Al-Din, M. Craner, N. Evangelou, P. Harman, T. Harrower, J. Hobart, H. Husseyin, M. KastiAbstractThe UK Multiple Sclerosis Register (UKMSR) is a large cohort study designed to capture ‘real world’ information about living with multiple sclerosis (MS) in the UK from diverse sources. The primary source of data is directly from people with Multiple Sclerosis (pwMS)...
Source: Multiple Sclerosis and Related Disorders - July 5, 2018 Category: Neurology Source Type: research

Reliability and validity of the DYMUS questionnaire for the assessment of dysphagia in multiple sclerosis (Greek version) and proposed modification
ConclusionsThe Greek version of DYMUS was found to be a valid, reliable and practical for clinical use questionnaire for the detection of dysphagia in Multiple Sclerosis. The first reported normative data for DYMUS suggest a cut-off for the diagnosis of dysphagia at 2 and our findings support a modification of DYMUS eliminating the question about weight loss.
Source: Multiple Sclerosis and Related Disorders - July 5, 2018 Category: Neurology Source Type: research

Validating the portal population of the United Kingdom Multiple Sclerosis Register
Publication date: August 2018Source: Multiple Sclerosis and Related Disorders, Volume 24Author(s): R.M. Middleton, W.J. Rodgers, J. Chataway, K. Schmierer, D. Rog, I. Galea, A. Akbari, K. Tuite-Dalton, H. Lockhart-Jones, D. Griffiths, D.G. Noble, K.H. Jones, A. Al-Din, M. Craner, N. Evangelou, P. Harman, T. Harrower, J. Hobart, H. Husseyin, M. KastiAbstractThe UK Multiple Sclerosis Register (UKMSR) is a large cohort study designed to capture ‘real world’ information about living with multiple sclerosis (MS) in the UK from diverse sources. The primary source of data is directly from people with Multiple Sclerosis (pwMS)...
Source: Multiple Sclerosis and Related Disorders - July 10, 2018 Category: Neurology Source Type: research

Reliability and validity of the DYMUS questionnaire for the assessment of dysphagia in multiple sclerosis (Greek version) and proposed modification
ConclusionsThe Greek version of DYMUS was found to be a valid, reliable and practical for clinical use questionnaire for the detection of dysphagia in Multiple Sclerosis. The first reported normative data for DYMUS suggest a cut-off for the diagnosis of dysphagia at 2 and our findings support a modification of DYMUS eliminating the question about weight loss.
Source: Multiple Sclerosis and Related Disorders - July 10, 2018 Category: Neurology Source Type: research

OCD and Multiple Sclerosis
Obsessive-compulsive disorder is a complicated illness, and the cause, or causes, remain unknown. Research has shown that OCD is seen more frequently than usual in those with various physical disorders, such as muscular dystrophy. An October 2018 study published in Frontiers in Immunology highlights a connection between OCD and another disease — multiple sclerosis. Multiple sclerosis (MS) is a debilitating autoimmune disorder, where the body’s immune system goes haywire and attacks healthy cells. It affects over two million people worldwide and has no known cure. Patients with multiple sclerosis and other autoimmun...
Source: World of Psychology - December 15, 2018 Category: Psychiatry & Psychology Authors: Janet Singer Tags: Health-related OCD Research Compulsions Multiple Sclerosis Obsessions Obsessive Compulsive Disorder Source Type: blogs

Effects of 4-aminopyridine on attention and executive functions of patients with multiple sclerosis: randomized, double-blind, placebo-controlled clinical trial. Preliminary report.
Conclusions4-aminopyridine proved to be an effective treatment on cognitive aspects in patients with relapsing-remitting multiple sclerosis. Drug doses were shown to be safe with mild to moderate adverse events. (ClinicalTrials.gov number, NCT02280096).
Source: Multiple Sclerosis and Related Disorders - December 19, 2018 Category: Neurology Source Type: research

Immunization and multiple sclerosis: Recommendations from the French Multiple Sclerosis Society
Conclusion: Physicians and patients should be aware of the updated recommendations for immunizations of patients with MS.
Source: Multiple Sclerosis and Related Disorders - April 11, 2019 Category: Neurology Source Type: research

Cells with Backpacks to Treat Multiple Sclerosis
Researchers at the Harvard Wyss Institute have developed a new type of cell therapy for multiple sclerosis patients. The technique involves taking a blood sample from the patient being treated, isolating a sample of myeloid white blood cells, and the...
Source: Medgadget - May 2, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Medicine MS multiple sclerosis wyssinstitute Source Type: blogs

Phenotypic and Functional Analysis of Immune Cell Subsets in Pediatric-onset Multiple Sclerosis (MS): Towards Definition of Earliest Disease Mechanisms (P2.236)
CONCLUSION: Our findings selectively implicate CD4+CCR2+CCR5+ and CD8+CD161high MAIT T cell subsests in early pediatric-onset MS pathophysiology, but not in pediatric monophasic CNS inflammatory conditions.Disclosure: Dr. Nyirenda has nothing to disclose. Dr. Li has nothing to disclose. Dr. Moore has nothing to disclose. Dr. Rozenberg has nothing to disclose. Dr. Rezk has nothing to disclose. Dr. Johnson has nothing to disclose. Dr. Sadovnick has received personal compensation for activities with Biogen Idec, Merck Serono, Teva Neuroscience, and Bayer Pharmaceuticals Corp. Dr. Arnold has received personal compensation for ...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Nyirenda, M., Li, R., Moore, C., Rozenberg, A., Rezk, A., Johnson, T., Sadovnick, D., Arnold, D., Marrie, R.-A., Banwell, B., Bar-Or, A. Tags: Pediatric Multiple Sclerosis and Other Demyelinating Diseases Source Type: research

Reduced gamma-aminobutyric acid concentration is associated with physical disability in progressive multiple sclerosis
This study suggests that reduced gamma-aminobutyric acid levels reflect pathological abnormalities that may play a role in determining physical disability. These abnormalities may include decreases in the pre- and postsynaptic components of gamma-aminobutyric acid neurotransmission and in the density of inhibitory neurons. Additionally, the reduced gamma-aminobutyric acid concentration may contribute to the neurodegenerative process, resulting in increased firing of axons, with consequent increased energy demands, which may lead to neuroaxonal degeneration and loss of the compensatory mechanisms that maintain motor functio...
Source: Brain - August 24, 2015 Category: Neurology Authors: Cawley, N., Solanky, B. S., Muhlert, N., Tur, C., Edden, R. A. E., Wheeler-Kingshott, C. A. M., Miller, D. H., Thompson, A. J., Ciccarelli, O. Tags: Multiple Sclerosis/Neuroinflammation Original Articles Source Type: research