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Total 969764 results found since Jan 2013.
Evidence review finds that computer-based cognitive training can significantly improve memory in patients with multiple sclerosis (MS)
CONCLUSIONS: The present meta-analysis revealed a significant effect for computer-based cognitive training on the performance of the memory domain of patients with MS. This finding may have significant implications in the current treatment practice when cognitive decline is detected in MS patients.
The Study in Context
Next: Brain scans to identify children at high risk of developing multiple sclerosis (MS) before symptoms appear
Study: Transcranial Direct Current Stimulation (tDCS) can reduce fatigue in patients with Multiple Sclerosis (MS)
Merck and HAPPYneuron partner to include cognitive remediation program in M...
Source: SharpBrains - April 6, 2018 Category: Neuroscience Authors: SharpBrains Tags: Cognitive Neuroscience Health & Wellness Technology Cognitive-Training Computer-based cognitive rehabilitation meta-analysis multiple-sclerosis neuropsychological neuropsychological assessment Neuropsychological performance Systematic Source Type: blogs
Methods to Assess Ocular Motor Dysfunction in Multiple Sclerosis
Conclusions:
This overview should inform clinicians working with patients with MS of how ocular motor deficits can best be assessed and monitored in this population. It also provides a rationale for interest in this field with insights regarding which techniques should be used for studying which classes of eye movements and related dysfunction in the disease.
Source: Journal of Neuro-Ophthalmology - November 13, 2018 Category: Opthalmology Tags: Disease of the Year: Multiple Sclerosis Source Type: research
Association between suicide and multiple sclerosis: an updated meta-analysis
ConclusionOur meta-analysis shows a significant association between suicide and multiple sclerosis, although ethnic and geographical differences were not considered. These findings should be confirmed and extended in future large studies.
Source: Multiple Sclerosis and Related Disorders - June 20, 2019 Category: Neurology Source Type: research
The window of opportunity for treatment of progressive multiple sclerosis
Purpose of review
Based on the knowledge of disease mechanisms in the progressive course of multiple sclerosis and the experience from randomized clinical trials, we assessed the timing of disease-modifying therapy in patients with progressive multiple sclerosis to define the optimal window of opportunity for treatment of progressive multiple sclerosis.
Recent findings
In progressive multiple sclerosis both small molecules that cross the blood--brain barrier (siponimod) and monoclonal antibodies (ocrelizumab) have shown therapeutic efficacy and have been approved for treatment of progressive multiple sclerosis. Howeve...
Source: Current Opinion in Neurology - May 6, 2020 Category: Neurology Tags: MULTIPLE SCLEROSIS: Edited by Giancarlo Comi Source Type: research
Exploring in vivo multiple sclerosis brain microstructural damage through T1w/T2w ratio: a multicentre study
Conclusions
T1w/T2w ratio may represent a clinically relevant marker sensitive to demyelination, neurodegeneration and iron accumulation occurring at the different multiple sclerosis phases.
Source: Journal of Neurology, Neurosurgery and Psychiatry - July 13, 2022 Category: Neurosurgery Authors: Margoni, M., Pagani, E., Meani, A., Storelli, L., Mesaros, S., Drulovic, J., Barkhof, F., Vrenken, H., Strijbis, E., Gallo, A., Bisecco, A., Pareto, D., Sastre-Garriga, J., Ciccarelli, O., Yiannakas, M., Palace, J., Preziosa, P., Rocca, M. A., Filippi, M. Tags: Multiple sclerosis Source Type: research
John Dystel Prize for Multiple Sclerosis Research
Sponsored by the AAN and National Multiple Sclerosis Society and made possible through a special contribution from the John Dystel Multiple Sclerosis Research Fund at the National Multiple Sclerosis Society. The John Dystel Prize recognizes outstanding contributions to research in the understanding, treatment, or prevention of multiple sclerosis. The prize is intended to recognize significant and exciting work which has influenced the way we think about multiple sclerosis, but it is not to be a lifetime achievement award. Presentation Recipient is expected to present a 20-minute lecture during a scientific session...
Source: ScanGrants feed - July 31, 2013 Category: Research Authors: American Academy of Neurology/National Multiple Sclerosis Society Source Type: funding
Cortical atrophy patterns in multiple sclerosis are non-random and clinically relevant
See Chard and Miller (doi:10.1093/brain/awv354) for a scientific commentary on this article.
Grey matter atrophy is common in multiple sclerosis. However, in contrast with other neurodegenerative diseases, it is unclear whether grey matter atrophy in multiple sclerosis is a diffuse ‘global’ process or develops, instead, according to distinct anatomical patterns. Using source-based morphometry we searched for anatomical patterns of co-varying cortical thickness and assessed their relationships with white matter pathology, physical disability and cognitive functioning. Magnetic resonance imaging was performed at ...
Source: Brain - January 8, 2016 Category: Neurology Authors: Steenwijk, M. D., Geurts, J. J. G., Daams, M., Tijms, B. M., Wink, A. M., Balk, L. J., Tewarie, P. K., Uitdehaag, B. M. J., Barkhof, F., Vrenken, H., Pouwels, P. J. W. Tags: Multiple Sclerosis/Neuroinflammation Original Articles Source Type: research
The effects of fatigue, depression and the level of disability on the health-related quality of life of glatiramer acetate-treated relapsing-remitting patients with multiple sclerosis in Hungary
Conclusions Decreasing the disease activity in multiple sclerosis with immunomodulatory therapy, together with improvements of the diagnostics and treatment of the accompanying depression and fatigue are of high priority to improve the health-related quality of life of patients with multiple sclerosis.
Source: Multiple Sclerosis and Related Disorders - February 12, 2016 Category: Neurology Source Type: research
MicroRNAs targeting TGF{beta} signalling underlie the regulatory T cell defect in multiple sclerosis
Transforming growth factor beta (TGFβ) signalling is critical for regulatory T cell development and function, and regulatory T cell dysregulation is a common observation in autoimmune diseases, including multiple sclerosis. In a comprehensive miRNA profiling study of patients with multiple sclerosis naïve CD4 T cells, 19 differentially expressed miRNAs predicted to target the TGFβ signalling pathway were identified, leading to the hypothesis that miRNAs may be responsible for the regulatory T cell defect observed in patients with multiple sclerosis. Patients with multiple sclerosis had reduced levels of T...
Source: Brain - May 26, 2016 Category: Neurology Authors: Severin, M. E., Lee, P. W., Liu, Y., Selhorst, A. J., Gormley, M. G., Pei, W., Yang, Y., Guerau-de-Arellano, M., Racke, M. K., Lovett-Racke, A. E. Tags: Multiple Sclerosis/Neuroinflammation Original Articles Source Type: research
Headache Characteristics in Multiple Sclerosis
ConclusionIn our study, the prevalence of headache among all multiple sclerosis patients was 68%. The results of this study indicate a possible relationship may exist between headache and multiple sclerosis therapies since 80% of patients described headaches after the onset of treatments. The younger start and the shorter duration of interferon beta use caused the higher incidence of headache, but this correlation was not observed in other drugs. Interestingly, medication overuse headache was far more prevalent in multiple sclerosis patients than in previously reported community populations.
Source: Multiple Sclerosis and Related Disorders - October 5, 2018 Category: Neurology Source Type: research
Gene-environment interactions increase the risk of paediatric-onset multiple sclerosis associated with household chemical exposures
Conclusions
The presence of gene–environment interactions with household toxins supports their possible causal role in paediatric-onset multiple sclerosis.
Source: Journal of Neurology, Neurosurgery and Psychiatry - June 14, 2023 Category: Neurosurgery Authors: Nasr, Z., Schoeps, V. A., Ziaei, A., Virupakshaiah, A., Adams, C., Casper, T. C., Waltz, M., Rose, J., Rodriguez, M., Tillema, J.-M., Chitnis, T., Graves, J. S., Benson, L., Rensel, M., Krupp, L., Waldman, A. T., Weinstock-Guttman, B., Lotze, T., Greenber Tags: Multiple sclerosis Source Type: research
Periventricular venous density in multiple sclerosis is inversely associated with T2 lesion count: a 7 Tesla MRI study
Conclusion:
High spatially resolving anatomical T2*-weighted MRI revealed vascular alterations in early stages of multiple sclerosis, presumably as a part of widespread haemodynamic and metabolic alterations.
Source: Multiple Sclerosis - February 20, 2013 Category: Neurology Authors: Sinnecker, T., Bozin, I., Dorr, J., Pfueller, C. F., Harms, L., Niendorf, T., Brandt, A. U., Paul, F., Wuerfel, J. Tags: Research Papers Source Type: research
Multiple Sclerosis Détente
In the spring of 1983, I represented my school in our state’s model United Nations. After a long day of debate in the General Assembly, I was awarded first prize in the debate on denuclearize. That time in world history, the topic and experience inform today’s blog.
I’ve decided that I have entered into a cold war phase with my multiple sclerosis.
First I experienced symptoms of MS. Then I was diagnosed with the disease. I suffered from MS, I fought MS and I have learned to live with MS; I’ve just been looking for the right metaphor to describe how I’m living with multiple sclerosis.
Détente; that’s wh...
Source: Life with MS - July 10, 2013 Category: Other Conditions Authors: Trevis Gleason Tags: MS multiple sclerosis community Living with MS ms community Multiple Sclerosis Thesaurus Newly diagnosed Symptom management Source Type: blogs
Cardiovascular autonomic dysfunction in multiple sclerosis: A meta-analysis
Conclusions We found a wide variation in the proportion of patients with multiple sclerosis diagnosed with cardiovascular dysautonomia by using the two definitions. Consensus is needed to define autonomic dysfunction in patients with multiple sclerosis. In the meantime, we encourage investigators to report results using both thresholds.
Source: Multiple Sclerosis and Related Disorders - February 24, 2015 Category: Neurology Source Type: research
