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Cost effectiveness of a pragmatic exercise intervention (EXIMS) for people with multiple sclerosis: economic evaluation of a randomised controlled trial
Conclusion: The pragmatic exercise intervention is highly likely to be cost effective at current established thresholds, and there is scope for it to be tailored to particular sub-groups of patients or services to reduce its cost impact.
Source: Multiple Sclerosis - June 16, 2014 Category: Neurology Authors: Tosh, J., Dixon, S., Carter, A., Daley, A., Petty, J., Roalfe, A., Sharrack, B., Saxton, J. Tags: Research Papers Source Type: research

Multiple Sclerosis as a Character in the Movie of Your Life
Someone once told me “Everyone directs their own movie.  They see life through their own lens.”  This is true on so many levels, most of which I won’t attend to in this blog. Working on a project for the past two weeks I’ve begun to see MS as a character in the story of my life.  MS is not the star – it’s not even a supporting role – but a former headliner making a cameo appearance at the most annoying times. It is a part of my story. As the director of my own film, it’s my job to keep this big-headed ego of a character from stealing the scenes, upstaging the important players, and steppi...
Source: Life with MS - July 7, 2014 Category: Other Conditions Authors: Trevis Gleason Tags: multiple sclerosis awareness Living with MS ms community Multiple Sclerosis Thesaurus Source Type: blogs

Atlas of Multiple Sclerosis 2013: A growing global problem with widespread inequity
Multiple sclerosis (MS) is one of the world's most common neurologic disorders, and in many countries it is the leading cause of nontraumatic neurologic disability in young adults. Despite this, global information on the epidemiology of MS and the availability of resources and services for people with MS is scarce in many regions of the world. The first Atlas of MS, published in 2008 as a joint project of the Multiple Sclerosis International Federation (MSIF) and the World Health Organization (WHO),1 endeavored to fill this knowledge gap with information from 112 countries. Here, we outline important updates in the recentl...
Source: Neurology - September 8, 2014 Category: Neurology Authors: Browne, P., Chandraratna, D., Angood, C., Tremlett, H., Baker, C., Taylor, B. V., Thompson, A. J. Tags: Quality of life, Medical care, Multiple sclerosis, All epidemiology, Prevalence studies GLOBAL PERSPECTIVES Source Type: research

Exome sequencing in single cells from the cerebrospinal fluid in multiple sclerosis
Conclusion: More robust methods applied to larger numbers of cells will be needed to define the role of somatic mutations.
Source: Multiple Sclerosis - October 24, 2014 Category: Neurology Authors: Kemppinen, A., Baker, A., Liao, W., Fiddes, B., Jones, J., Compston, A., Ban, M., Sawcer, S. Tags: Research Papers Source Type: research

Do patient and proxy agree? Long-term changes in multiple sclerosis physical impact and walking ability on patient-reported outcome scales
Conclusion: In the majority of the patient-proxy couples there was agreement. Proxies can serve as a valuable source of information, but caution remains essential when using scores from proxies.
Source: Multiple Sclerosis - October 24, 2014 Category: Neurology Authors: Sonder, J. M., Balk, L. J., Bosma, L. V., Polman, C. H., Uitdehaag, B. M. Tags: Research Papers Source Type: research

Core outcome measures for exercise studies in people with multiple sclerosis: recommendations from a multidisciplinary consensus meeting
The objective of this review is to report the recommendations of an International Consensus Meeting for a core set of outcome measures for use in exercise studies in MS. From the 100 categories of the International Classification of Function Core Sets for MS, 57 categories were considered as likely/potentially likely to be affected by exercise and were clustered into seven core groups. Outcome measures to address each group were evaluated regarding, for example, psychometric properties. The following are recommended: Modified Fatigue Impact Scale (MFIS) or Fatigue Severity Scale (FSS) for energy and drive, 6-Minute Walk Te...
Source: Multiple Sclerosis - October 24, 2014 Category: Neurology Authors: Paul, L., Coote, S., Crosbie, J., Dixon, D., Hale, L., Holloway, E., McCrone, P., Miller, L., Saxton, J., Sincock, C., White, L. Tags: Meeting Review Source Type: research

The need for a disease-specific prospective pregnancy registry for multiple sclerosis (MS)
Publication date: Available online 24 October 2014 Source:Multiple Sclerosis and Related Disorders Author(s): Sura Alwan , Christina D. Chambers , Vincent T. Armenti , A. Dessa Sadovnick Multiple Sclerosis (MS) is the most commonly acquired neurological disorder affecting young adults of reproductive age with an approximately 3:1 female to male ratio. Although pregnancy is not contraindicated in MS, data are limited regarding pregnancy outcome among MS patients, and the safety or risk to the fetus associated with most maternal MS treatments, such as disease modifying therapies (DMTs), during pregnancy is unknown. We revi...
Source: Multiple Sclerosis and Related Disorders - November 3, 2014 Category: Neurology Source Type: research

A web-based decision support tool for prognosis simulation in multiple sclerosis
The objective of the current work is to implement a web-based tool, conveying decision relevant prognostic scientific evidence, which will help clinicians discuss prognosis with individual patients. Data were extracted from a set of reference studies, especially those dealing with the natural history of multiple sclerosis. The web-based decision support tool for individualized prognosis simulation was implemented with NetLogo, a program environment suited for the development of complex adaptive systems. Its prototype has been launched online; it enables clinicians to predict both the likelihood of CIS to CDMS conversion, a...
Source: Multiple Sclerosis and Related Disorders - November 3, 2014 Category: Neurology Source Type: research

Associations between onset age and disability in multiple sclerosis patients studied using MSSS and a progression model
Conclusion We found a significant change in the relationship between disability and onset age after about 31 years supporting the idea that while onset age does not define a sharp cut-off, it can help define subgroups of patients with differing rates of accumulation of disability.
Source: Multiple Sclerosis and Related Disorders - November 3, 2014 Category: Neurology Source Type: research

Risk stratification and mitigation in multiple sclerosis
Publication date: September 2014 Source:Multiple Sclerosis and Related Disorders, Volume 3, Issue 5 Author(s): Daniel Ontaneda , Samuel Cohn , Robert J. Fox The increasing availability of new agents to treat multiple sclerosis poses new challenges for clinicians who seek therapies that are both safe and effective for their patients. The introduction of additional effective therapies has been accompanied by the recognition of serious side effects. The clinician now must weigh both the benefits and risks of therapies to help patients decide which treatment best fits each patient׳s risk/benefit profile. An optimal selectio...
Source: Multiple Sclerosis and Related Disorders - November 3, 2014 Category: Neurology Source Type: research

P wave duration and dispersion and QT interval in multiple sclerosis
Conclusion In this study, P wave duration and P wave dispersion was found to be higher in MS patients than healthy control subjects.
Source: Multiple Sclerosis and Related Disorders - November 3, 2014 Category: Neurology Source Type: research

Deep brain stimulation and multiple sclerosis: Therapeutic applications
Publication date: July 2014 Source:Multiple Sclerosis and Related Disorders, Volume 3, Issue 4 Author(s): Holly A. Roy , Tipu Z. Aziz Deep brain stimulation is a neurosurgical technique that can be used to alleviate symptoms in a growing number of neurological conditions through modulating activity within brain networks. Certain applications of deep brain stimulation are relevant for the management of symptoms in multiple sclerosis. In this paper we discuss existing treatment options for tremor, facial pain and urinary dysfunction in multiple sclerosis and discuss evidence to support the potential use of deep brain stimu...
Source: Multiple Sclerosis and Related Disorders - November 3, 2014 Category: Neurology Source Type: research

Impaired recognition of emotional facial expressions in patients with multiple sclerosis
Conclusion Impaired recognition of facial emotions by patients with MS seems to be associated with both cognitive and affective (depression) aspects of the disease.
Source: Multiple Sclerosis and Related Disorders - November 3, 2014 Category: Neurology Source Type: research

Fingolimod in relapsing multiple sclerosis: An integrated analysis of safety findings
Conclusion The safety profile of fingolimod has been well characterized in this large combined trial population. Although infrequent SAEs can occur, there is no increased risk of infections, malignancies or serious cardiovascular events versus placebo.
Source: Multiple Sclerosis and Related Disorders - November 3, 2014 Category: Neurology Source Type: research

Long-term management of natalizumab discontinuation in a large monocentric cohort of multiple sclerosis patients
Conclusions Our data suggest that disease reactivation peaked during a “high risk period” between the second and the eighth month since stopping the drug. During this period no alternative treatments seemed to provide an adequate protection from disease reactivation. Though transient, this phase could be potentially dangerous, therefore we need to develop more effective strategies to deal with this challenge.
Source: Multiple Sclerosis and Related Disorders - November 3, 2014 Category: Neurology Source Type: research