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An ImmunoChip study of multiple sclerosis risk in African Americans
The aims of this study were: (i) to determine to what degree multiple sclerosis-associated loci discovered in European populations also influence susceptibility in African Americans; (ii) to assess the extent to which the unique linkage disequilibrium patterns in African Americans can contribute to localizing the functionally relevant regions or genes; and (iii) to search for novel African American multiple sclerosis-associated loci. Using the ImmunoChip custom array we genotyped 803 African American cases with multiple sclerosis and 1516 African American control subjects at 130 135 autosomal single nucleotide polymorphism...
Source: Brain - May 26, 2015 Category: Neurology Authors: Isobe, N., Madireddy, L., Khankhanian, P., Matsushita, T., Caillier, S. J., More, J. M., Gourraud, P.-A., McCauley, J. L., Beecham, A. H., International Multiple Sclerosis Genetics Consortium, Piccio, L., Herbert, J., Khan, O., Cohen, J., Stone, L., Santa Tags: Original Articles Source Type: research

Regulatory T Cell Number in Multiple Sclerosis Patients: A Meta-Analysis
Publication date: Available online 10 November 2015 Source:Multiple Sclerosis and Related Disorders Author(s): Ali Noori-Zadeh, Seyed Alireza Mesbah-Namin, Sara Bistoon-beigloo, Salar Bakhtiyari, Hojjat-Allah Abbaszadeh, Shahram Darabi, Masoumeh Rajabibazl, Alireza Abdanipour Regulatory T cells (Treg cells), defined as CD4+ CD25+ FoxP3+ T cells by expression of CD4, high-affinity IL-2 receptor and the transcription factor, forkhead box P3 (FoxP3). They play a pivotal role in protecting individuals from autoimmunity and a growing body of evidence suggests their role in the prevention of multiple sclerosis developm...
Source: Multiple Sclerosis and Related Disorders - November 10, 2015 Category: Neurology Source Type: research

Prevalence of neuropathic pain in early multiple sclerosis
Conclusions: Neuropathic pain appears to be less frequent in early multiple sclerosis than expected and is significantly associated with disability, depression and fatigue. The assessment and therapy of pain in multiple sclerosis should thus take into account neuropsychiatric symptoms already at early disease stages.
Source: Multiple Sclerosis - July 25, 2016 Category: Neurology Authors: Heitmann, H., Biberacher, V., Tiemann, L., Buck, D., Loleit, V., Selter, R. C., Knier, B., Tölle, T. R., Mühlau, M., Berthele, A., Hemmer, B., Ploner, M. Tags: Original Research Papers Source Type: research

Defining secondary progressive multiple sclerosis
A number of studies have been conducted with the onset of secondary progressive multiple sclerosis as an inclusion criterion or an outcome of interest. However, a standardized objective definition of secondary progressive multiple sclerosis has been lacking. The aim of this work was to evaluate the accuracy and feasibility of an objective definition for secondary progressive multiple sclerosis, to enable comparability of future research studies. Using MSBase, a large, prospectively acquired, global cohort study, we analysed the accuracy of 576 data-derived onset definitions for secondary progressive multiple sclerosis and ...
Source: Brain - August 23, 2016 Category: Neurology Authors: Lorscheider, J., Buzzard, K., Jokubaitis, V., Spelman, T., Havrdova, E., Horakova, D., Trojano, M., Izquierdo, G., Girard, M., Duquette, P., Prat, A., Lugaresi, A., Grand'Maison, F., Grammond, P., Hupperts, R., Alroughani, R., Sola, P., Boz, C., Pucci, E. Tags: Multiple Sclerosis/Neuroinflammation Original Articles Source Type: research

Does vagotomy protect against multiple sclerosis?
Publication date: July 2017 Source:Multiple Sclerosis and Related Disorders, Volume 15 Author(s): Jens Sundbøll, Erzsébet Horváth-Puhó, Kasper Adelborg, Elisabeth Svensson Objectives To examine the association between vagotomy and multiple sclerosis. Methods We conducted a matched cohort study of all patients who underwent truncal or super-selective vagotomy and a comparison cohort, by linking Danish population-based medical registries (1977−1995). Hazard ratios (HRs) for multiple sclerosis, adjusting for potential confounders were computed by means of Cox regression analysis. Results Median age of multiple sclerosi...
Source: Multiple Sclerosis and Related Disorders - July 7, 2017 Category: Neurology Source Type: research

Impact of pre-cooling therapy on the physical performance and functional capacity of multiple sclerosis patients: A systematic review
Publication date: Available online 13 November 2018Source: Multiple Sclerosis and Related DisordersAuthor(s): Antonia Kaltsatou, Andreas D. FlourisAbstractPatients with multiple sclerosis experience many complications that gradually lead them to comorbidity and disability. Exercise could prevent and ameliorate the symptoms that comorbidity or inactivity generate. However, until recently it was suggested that multiple sclerosis patients should not participate in exercise training programs because multiple sclerosis patients are characterized by thermoregulatory failure and the heat stress due to physical work could exacerba...
Source: Multiple Sclerosis and Related Disorders - November 14, 2018 Category: Neurology Source Type: research

Subclinical cochlear dysfunction in newly diagnosed relapsing-remitting multiple sclerosis
ConclusionsThis study shows decreased otoacoustic emission amplitudes in untreated multiple sclerosis patients with clinically normal hearing and no brainstem demyelinating plaques, suggesting a subclinical cochlear impairment. This alteration may represent an early sign of peripheral hearing damage, suggesting a role for otoacoustic emissions in the early diagnosis of cochlear dysfunction in multiple sclerosis patients. However, given that otoacoustic emissions primarily reflects cochlear function, and that the wave I of the auditory brainstem responses was spared, the evidence supporting a peripheral involvement of acous...
Source: Multiple Sclerosis and Related Disorders - May 28, 2019 Category: Neurology Source Type: research

Adaptation to repeated gait-slip perturbations among individuals with multiple sclerosis
ConclusionWith practice, people with multiple sclerosis can adapt to large-scale, high-speed, gait-slips and acquire necessary skills against falls. Such skills primarily involve proactive strategy which is assisted by reactive strategy. The proactive strategy would shift the body's center of mass closer to the base of support, improving dynamic gait stability and reducing falls. Our findings could provide a theoretical foundation for deploying perturbation training to prevent falls in people with multiple sclerosis.
Source: Multiple Sclerosis and Related Disorders - July 24, 2019 Category: Neurology Source Type: research

Epilepsy in multiple sclerosis as a network disease
Publication date: Available online 17 September 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Mihaela Bustuchina VlaicuAbstractThis is a review paper, essentially a commentary with summary of literature that actualizes the problem of epilepsy in patients with multiple sclerosis. There is a bidirectional relation between multiple sclerosis and epilepsy. A possible associate pathophysiological pathway is considered. In multiple sclerosis, a combination of grey matter involvement and inflammation could influence epileptogenesis. Patients with multiple sclerosis have individual profiles and an inter-individual...
Source: Multiple Sclerosis and Related Disorders - September 19, 2019 Category: Neurology Source Type: research

Smoking as a risk factor for multiple sclerosis
Conclusions: This study confirms that smoking is a risk factor for multiple sclerosis. It has the advantage of using analyses of cotinine levels in samples that were collected several years before disease onset, thus excluding any risk for recall bias and minimising the risk for reversed causation. Our results also suggest that the smoking related immunological events that contribute to the development of multiple sclerosis occur early in life.
Source: Multiple Sclerosis - July 1, 2013 Category: Neurology Authors: Salzer, J., Hallmans, G., Nystrom, M., Stenlund, H., Wadell, G., Sundstrom, P. Tags: Research Papers Source Type: research

Multiple Sclerosis Nurses
I try not to gush too much here in the pages of the Life With Multiple Sclerosis Blog.  Today, however, I am going to drop said restraint and let fly with great admiration for the Multiple Sclerosis Nurses in our lives. So often, I have found, it is my relationship with the staff at my neurologist’s office or at the MS centers I have attended that have been a major factor in my comfort in my choice of one doc or another.  If I were to continue that train of thought, I cannot say enough about the men and woman who have turned their nursing degrees and experience into the passionate specialty of working with people livin...
Source: Life with MS - June 17, 2013 Category: Other Conditions Authors: Trevis Gleason Tags: MS multiple sclerosis community Living with MS MS and family ms community MS doctors MS treatment Newly diagnosed Source Type: blogs

Rate of Agreement for Manual and Automated Techniques for Determination of New T2 Lesions in Children with Multiple Sclerosis and Acute Demyelination (P2.242)
CONCLUSIONS: Agreement is high between manual and automated methods for new T2 lesion determination. Overall, the automated method is more sensitive than the manual readers and identifies a higher number of lesions.Study Supported by: Canadian Multiple Sclerosis Scientific Research FoundationDisclosure: Dr. Verhey has received research support from the Canadian Institutes of Health, and the Multiple Sclerosis Society of Canada. Dr. Elliott has nothing to disclose. Dr. Branson has nothing to disclose. Dr. Philpott has nothing to disclose. Dr. Shroff has nothing to disclose. Dr. Arbel has nothing to disclose. Dr. Banwell has...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Verhey, L., Elliott, C., Branson, H., Philpott, C., Shroff, M., Arbel, T., Banwell, B., Arnold, D. Tags: Pediatric Multiple Sclerosis and Other Demyelinating Diseases Source Type: research

Bibliometric profile of the global scientific research on multiple sclerosis (2003-2012)
Conclusions: We emphasise the progressive growth of publications worldwide, the publication of articles in a wide variety of journals covering numerous subject areas, and the research leadership of Western countries, most notably European countries, the US and Canada.
Source: Multiple Sclerosis - February 13, 2015 Category: Neurology Authors: Aleixandre-Benavent, R., Alonso-Arroyo, A., Gonzalez de Dios, J., Vidal-Infer, A., Gonzalez-Munoz, M., Sempere, A. P. Tags: Research Papers Source Type: research

Physician compensation for industry-sponsored clinical trials in multiple sclerosis influences patient trust
Conclusions Results of this study demonstrate that physician payment for study participation in multiple sclerosis clinical trials is a potential conflict that can adversely affect patient trust.
Source: Multiple Sclerosis and Related Disorders - May 16, 2016 Category: Neurology Source Type: research

No evidence for an effect on brain atrophy rate of atorvastatin add-on to interferon {beta}1b therapy in relapsing-remitting multiple sclerosis (the ARIANNA study)
Conclusions: Our results suggest that the combination of atorvastatin and interferon β1b is not justified in early relapsing–remitting multiple sclerosis and adds to the body of evidence indicating an absence of significant radiological and clinical benefit of statins in relapsing–remitting multiple sclerosis.
Source: Multiple Sclerosis - July 25, 2016 Category: Neurology Authors: Lanzillo, R., Quarantelli, M., Pozzilli, C., Trojano, M., Amato, M. P., Marrosu, M. G., Francia, A., Florio, C., Orefice, G., Tedeschi, G., Bellantonio, P., Annunziata, P., Grimaldi, L. M., Comerci, M., Brunetti, A., Bonavita, V., Alfano, B., Marini, S., Tags: Original Research Papers Source Type: research