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International Pediatric Multiple Sclerosis Study Group criteria for pediatric multiple sclerosis and immune-mediated central nervous system demyelinating disorders: revisions to the 2007 definitions
Lauren B Krupp, Marc Tardieu, Maria Pia Amato, Brenda Banwell, Tanuja Chitnis, Russell C Dale, Angelo Ghezzi, Rogier Hintzen, Andrew Kornberg, Daniela Pohl, Kevin Rostasy, Silvia Tenembaum, Evangeline Wassmer, for the International Pediatric Multiple Sclerosis Study GroupSep 1, 2013; 19:1261-1267Review
Source: Multiple Sclerosis - September 1, 2013 Category: Neurology Authors: Lauren B Krupp, Marc Tardieu, Maria Pia Amato, Brenda Banwell, Tanuja Chitnis, Russell C Dale, Angelo Ghezzi, Rogier Hintzen, Andrew Kornberg, Daniela Pohl, Kevin Rostasy, Silvia Tenembaum, Evangeline Wassmer, for the International Pediatric Multiple Sc Tags: Review Source Type: research

The Potential Role of T Helper Cell 22 and IL-22 in Immunopathogenesis of Multiple Sclerosis
Conclusion Recent evidence shows changes in frequency and function of Th22 and its cytokine IL-22 in patients with MS, which suggests a potential relationship between Th22 cells, IL-22 levels, and the development and disease course of MS and its response to treatment. How Th22 cells and IL-22 levels affect the disease course of MS requires further elucidation. Additional studies on the immunopathogenesis of MS, specifically the roles Th22 cells and IL-22 cytokines may play in disease progression, are warranted and may lead to the development of new therapeutic strategies for treating neuro-inflammatory diseases, such as MS...
Source: Innovations in Clinical Neuroscience - August 1, 2016 Category: Neuroscience Authors: ICN Online Editor Tags: Current Issue Demyelinating Disease Genetics Multiple Sclerosis Neurology Review interleukin-22 T helper 22 Source Type: research

Heart Rate Variability Analysis in Patients with Multiple Sclerosis
Conclusion These findings reveals that our study population with multiple sclerosis had decreased heart rate variability compared to healthy controls. This was reflected by dysfunction of both parasympathetic and sympathetic parameters of hearth rate variability analysis. However, there is no significant relationship between hearth rate variability analysis and the findings on cranial, cervical, thoracic spinal magnetic resonance imaging findings, number of attack, Expanded Disability Status Scale score or Multiple Sclerosis Functional Composite scores in patients with multiple sclerosis.
Source: Multiple Sclerosis and Related Disorders - June 19, 2018 Category: Neurology Source Type: research

Ketamine Therapy for Treatment-resistant Depression in a Patient with Multiple Sclerosis: A Case Report
Conclusion—Ketamine may be an alternative treatment for resistant depression and may have a special use in patients with multiple sclerosis. Introduction Depression is a frequent finding in patients with multiple sclerosis (MS), with the lifetime prevalence rates for major depressive disorder (MDD) ranging from 36 to 54 percent, more than twice of that in the general population.[1] Even with advances in pharmacological options for treating depression, an estimated 33 to 66 percent of patients with MDD in the general population do not respond to the first antidepressant, and a reported 15 to 33 percent of patients do not ...
Source: Innovations in Clinical Neuroscience - February 1, 2017 Category: Neuroscience Authors: ICN Online Editor Tags: Case Report Current Issue Depression Multiple Sclerosis Neurology Psychiatry Psychopharmacology Electroconvulsive therapy Ketamine major depressive disorder treatment-resistant depression Source Type: research

Redefining Acute Relapses in Multiple Sclerosis: Implications for Phase 3 Clinical Trials and Treatment Algorithms
Conclusion A better definition of what constitutes a relapse in MS is urgently needed. From a treatment perspective, the management of relapses, particularly in the emergency department (ED), is highly variable. In general, it is possible that patients are treated with steroids based on symptomatology and an ED physician’s evaluation. It is often difficult in the ED to ascertain baseline status or a deviation from it, and an MRI may or may not be performed in the ED owing to cost and availability. However, if objective MRI data are not the singular surrogate biomarker to validate BBB breach, false-positive cases are prob...
Source: Innovations in Clinical Neuroscience - April 1, 2017 Category: Neuroscience Authors: ICN Online Editor Tags: Commentary Current Issue Devices Evaluations Multiple Sclerosis Neurology Technology acute relapse big data blood brain barrier imaging magnetic resonance imaging MRI MS Source Type: research

It ’s Time for Combination Therapies in Multiple Sclerosis
Conclusion In summary, MS?therapies that combine BBB-crossing molecules with peripherally acting MAbs should be a strategy of MS drug development. MS therapies that effectively limit or halt disease progression and improve overall treatment outcomes will need to address the disease mechanisms both inside and outside the CNS. It must also be recognized that the presence of lymphoid-follicle like structures are associated clinically with irreversible disability and, from a pathological perspective, show pronounced demyelination, microglial activation, and loss of neurites in the cerebral cortex.[14] Without addressing such f...
Source: Innovations in Clinical Neuroscience - June 1, 2017 Category: Neuroscience Authors: ICNS Online Editor Tags: Commentary Current Issue Drug Development Multiple Sclerosis Neurodegenerative Disease Neurology Neuromuscular Disease Psychopharmacology Update on Blood Brain Barrier combination therapies cyclophosphamide disability status laquin Source Type: research

Heart rate variability analysis in patients with multiple sclerosis
ConclusionThese findings reveals that our study population with multiple sclerosis had decreased heart rate variability compared to healthy controls. This was reflected by dysfunction of both parasympathetic and sympathetic parameters of hearth rate variability analysis. However, there is no significant relationship between hearth rate variability analysis and the findings on cranial, cervical, thoracic spinal magnetic resonance imaging findings, number of attack, Expanded Disability Status Scale score or Multiple Sclerosis Functional Composite scores in patients with multiple sclerosis.
Source: Multiple Sclerosis and Related Disorders - July 5, 2018 Category: Neurology Source Type: research

Human placenta-derived cells (PDA-001) for the treatment of adults with multiple sclerosis: A randomized, placebo-controlled, multiple-dose study
Conclusion PDA-001 infusions were safe and well tolerated in relapsing-remitting multiple sclerosis and secondary progressive multiple sclerosis patients. No paradoxical worsening of lesion counts was noted with either dose.
Source: Multiple Sclerosis and Related Disorders - November 3, 2014 Category: Neurology Source Type: research

P020 Comparative investigation of different sequences of Magnetic Resonance Imaging such as FLAIR, T2WI and PDWI in detection of Multiple Sclerosis patients referred to Magnetic Resonance Imaging Department of Imam Khomeini Hospital, Urmia, Iran
Conclusion Based on our study, PDWI Magnetic Resonance Imaging sequences is superior than FLAIR or T2WI sequences in detection of Multiple Sclerosis specific plaque in cerebellum.
Source: Multiple Sclerosis and Related Disorders - December 7, 2014 Category: Neurology Source Type: research

The Neuroscience Report—Vol. 16 (August 17, 2015): Multiple Sclerosis
The latest in neuroscience—sorted and summarized for you Welcome to the Neuroscience Report where each week we will highlight a specific topic in neuroscience and provide you with links to 5 journal articles, 5 news articles, and 5 wildcard picks. Brought to you by Innovations in Clinical Neuroscience—your source for peer-reviewed, evidence-based information. Volume 16 (August 17, 2015): Multiple Sclerosis Journal Articles Electroconvulsive Therapy in Multiple Sclerosis Sexual Dysfunction and Depression in Individuals with Multiple Sclerosis: Is There a link? Receptor Tyrosine Kinase and Tyrosine Kinase Inhibitor...
Source: Innovations in Clinical Neuroscience - August 17, 2015 Category: Neuroscience Authors: ICN Online Editor Tags: Drug Development General Multiple Sclerosis Neurology The Neuroscience Report drug pipeline Source Type: research

Vol. 48 (November 30, 2017): Multiple Sclerosis
The latest in neuroscience—sorted and summarized for you Welcome to The Neuroscience Report where each week we will highlight a specific topic in neuroscience and provide you with links to 5 journal articles, 5 news articles, and 5 wildcard picks. Brought to you by Innovations in Clinical Neuroscience—your source for peer-reviewed, evidence-based information. This week’s topic: Multiple Sclerosis Journal Articles Primary Progressive Multiple Sclerosis: Putting Together the Puzzle The State of Multiple Sclerosis: Current Insight Into the Patient/Health Care Provider Relationship, Treatment Challenges, and ...
Source: Innovations in Clinical Neuroscience - November 30, 2017 Category: Neuroscience Authors: ICNS Online Editor Tags: Neurodegenerative Disease The Neuroscience Report multiple sclerosis Source Type: research

Permeability of the blood-brain barrier predicts conversion from optic neuritis to multiple sclerosis
Optic neuritis is an acute inflammatory condition that is highly associated with multiple sclerosis. Currently, the best predictor of future development of multiple sclerosis is the number of T2 lesions visualized by magnetic resonance imaging. Previous research has found abnormalities in the permeability of the blood–brain barrier in normal-appearing white matter of patients with multiple sclerosis and here, for the first time, we present a study on the capability of blood–brain barrier permeability in predicting conversion from optic neuritis to multiple sclerosis and a direct comparison with cerebrospinal fl...
Source: Brain - August 24, 2015 Category: Neurology Authors: Cramer, S. P., Modvig, S., Simonsen, H. J., Frederiksen, J. L., Larsson, H. B. W. Tags: Multiple Sclerosis/Neuroinflammation Original Articles Source Type: research

Association between Helicobacter pylori infection and multiple sclerosis: A systematic review and meta-analysis
Conclusions: We demonstrate a significant lower prevalence of Helicobacter pylori infection in patients with multiple sclerosis. This pathogen might be a protective factor for developing multiple sclerosis.
Source: Multiple Sclerosis and Related Disorders - March 30, 2016 Category: Neurology Source Type: research