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Rhabdomyolysis following Interferon-beta Treatment in a Patient with Multiple Sclerosis - a Case Report
Conclusion Clinicians should be aware of the possibility of rhabdomyolysis occurring during Interferon-beta-1-alpha therapy. In cases where patients complain of severe myalgia, and in particular if weakness is reported, creatine kinase activity should be measured to prevent irreversible rhabdomyolysis during Interferon-beta-1-alpha therapy in patients with multiple sclerosis.
Source: Multiple Sclerosis and Related Disorders - May 16, 2016 Category: Neurology Source Type: research

Rhabdomyolysis following interferon-beta treatment in a patient with multiple sclerosis – A case report
Conclusion Clinicians should be aware of the possibility of rhabdomyolysis occurring during Interferon-beta-1-alpha therapy. In cases where patients complain of severe myalgia, and in particular if weakness is reported, creatine kinase activity should be measured to prevent irreversible rhabdomyolysis during Interferon-beta-1-alpha therapy in patients with multiple sclerosis.
Source: Multiple Sclerosis and Related Disorders - May 24, 2016 Category: Neurology Source Type: research

No evidence for an effect on brain atrophy rate of atorvastatin add-on to interferon {beta}1b therapy in relapsing-remitting multiple sclerosis (the ARIANNA study)
Conclusions: Our results suggest that the combination of atorvastatin and interferon β1b is not justified in early relapsing–remitting multiple sclerosis and adds to the body of evidence indicating an absence of significant radiological and clinical benefit of statins in relapsing–remitting multiple sclerosis.
Source: Multiple Sclerosis - July 25, 2016 Category: Neurology Authors: Lanzillo, R., Quarantelli, M., Pozzilli, C., Trojano, M., Amato, M. P., Marrosu, M. G., Francia, A., Florio, C., Orefice, G., Tedeschi, G., Bellantonio, P., Annunziata, P., Grimaldi, L. M., Comerci, M., Brunetti, A., Bonavita, V., Alfano, B., Marini, S., Tags: Original Research Papers Source Type: research

Serological prevalence of celiac disease in brazilian population of multiple sclerosis, neuromyelitis optica and myelitis
Conclusion Our study do not confirm the relationship between celiac serological antibodies with multiple sclerosis, neuromyelitis optica and inflammatory myelitis of an unknown etiology.
Source: Multiple Sclerosis and Related Disorders - July 28, 2016 Category: Neurology Source Type: research

Paleo Diet vs. Sw. Diet for Multiple Sclerosis: Can Either Help Fatigue?
When the National Multiple Sclerosis Society announced last week that it was funding a study on nutrition and MS fatigue, many in the multiple sclerosis world were excited. When those people found out the research was to be conducted by controversial MS figure Terry Wahls, MD, enthusiasm waned for some — but the Society is holding the researchers to very high standards. I look forward to the results in about four years’ time. The study proposes to compare subjects’ standard diet with either the Wahls Protocol (a modified Paleolithic diet) or the Sw. MS Diet (a low-saturated-fat diet) as it relates to MS fatigue. Pr...
Source: Life with MS - August 30, 2016 Category: Neurology Authors: Trevis Gleason Tags: multiple sclerosis MS fatigue MS symptoms multiple sclerosis clinical trials research Symptom management Source Type: blogs

Immunomodulatory therapies delay disease progression in multiple sclerosis
Conclusions: DMDs significantly reduce the risk of multiple sclerosis progression both in patients with initial high-risk and patients with initial low-risk. These findings reinforce the role of DMDs in modifying the natural course of the disease, suggesting that they have a positive effect not only on the inflammatory but also on the neurodegenerative process. The study also confirms the capability of the BREMS score to predict MS evolution.
Source: Multiple Sclerosis - November 3, 2016 Category: Neurology Authors: Bergamaschi, R., Quaglini, S., Tavazzi, E., Amato, M. P., Paolicelli, D., Zipoli, V., Romani, A., Tortorella, C., Portaccio, E., DOnghia, M., Garberi, F., Bargiggia, V., Trojano, M. Tags: Original Research Papers Source Type: research

Abnormal galactosylation of immunoglobulin G in cerebrospinal fluid of multiple sclerosis patients
Background: Glycosylation alterations have been associated with the development of several human diseases and their animal models, including multiple sclerosis. Objectives: We aimed to determine whether immunoglobulin G galactosylation might be changed in multiple sclerosis. Methods: Immunoglobulin G was isolated from serum and cerebrospinal fluid of patients with multiple sclerosis or viral meningitis and control patients without history of inflammatory or autoimmune disease. A lectin-based assay was used to investigate potential galactosylation modifications of immunoglobulin G. Results and conclusion: Galactosylation...
Source: Multiple Sclerosis - December 8, 2016 Category: Neurology Authors: Decker, Y., Schomburg, R., Nemeth, E., Vitkin, A., Fousse, M., Liu, Y., Fassbender, K. Tags: Original Research Papers Source Type: research

The Importance of Stretching With Multiple Sclerosis
I’ve said in more than one blog that I consider myself to be a healthy person who happens to live with multiple sclerosis (MS). “Healthy,” perhaps, but lately I’ve found myself significantly out of shape. With all that 2016 has brought upon me, I decided to ask my wife, Caryn, for help in getting onto a stretching program to help with the things that MS has thrown my way. How to Stretch With MS The National Multiple Sclerosis Society (NMSS) has set out the following guidelines for people with MS as we get into a stretching routine: Stretch on a daily basis, as much as is possible. Include muscle groups that are ti...
Source: Life with MS - December 15, 2016 Category: Neurology Authors: Trevis Gleason Tags: multiple sclerosis life with MS Living with MS MS doctors MS Fitness trevis gleason Source Type: blogs

Evidence Supporting the Use of MRI as a Surrogate for Clinical Endpoints in Randomized Controlled Trials for Pediatric Multiple Sclerosis (P1.342)
Conclusions:Using longitudinal analysis we found significant effects of treatment on risk of relapse and Gd lesion rate, and a statistically significant relationship between the two. These findings suggest that Gd count may serve as appropriate outcome measure in pedMS clinical trials-particularly in trials of therapeutic agents known to reduce both clinical attacks and Gd counts in adult MS.Disclosure: Dr. Brown has received personal compensation for activities with NeuroRx Research as a consultant. Dr. O'Mahony has nothing to disclose. Dr. Yeh has nothing to disclose. Dr. Marrie has received research support from Canadia...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Brown, R., OMahony, J., Yeh, E. A., Marrie, R.-A., Bar-Or, A., Banwell, B., Arnold, D., On behalf of the Canadian Pediatric Demyelinating Disease Network Tags: Pediatric Multiple Sclerosis Source Type: research

The RADIANCE and SUNBEAM phase 3 studies of ozanimod in relapsing multiple sclerosis: study design and baseline characteristics (P6.344)
Conclusions:Patient characteristics in RADIANCE Part B and SUNBEAM are consistent with the general RMS population. These phase 3 study results will characterize the efficacy/safety of ozanimod vs. IFNB-1a.Study Supported by: These studies were sponsored by Receptos, a wholly owned subsidiary of Celgene Corporation.Disclosure: Dr. Cree has received personal compensation for activities with AbbVie, Biogen, EMD Serono, Novartis and Shire as a consultant. Dr. Selmaj received personal compensation for activities with Biogen, Novartis, TEVA, Roche, Genzyme, Synthon, Receptos, and Bayer. Dr. Kopicko has received personal compensa...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Cree, B., Selmaj, K., Kopicko, J., Ziemssen, T., De Stefano, N., Bar-Or, A., Comi, G., Arnold, D., Steinman, L., Hartung, H.-P., Montalban, X., Havrdova, E., Kappos, L., Cohen, J. Tags: Disease Modifying Therapy for Multiple Sclerosis: Efficacy and Clinical Trial Outcomes I Source Type: research

Amyloid PET in pseudotumoral multiple sclerosis
Conclusion We report the findings of amyloid PET in a patient with pseudotumoral multiple sclerosis. This case provides further evidence on the role of amyloid PET in the assessment of white matter and demyelinating diseases.
Source: Multiple Sclerosis and Related Disorders - July 7, 2017 Category: Neurology Source Type: research

Smoking and Multiple Sclerosis: A Systematic Review and Meta-Analysis Using the Bradford Hill Criteria for Causation
Conclusion This first review to supplement systematic review and meta-analytic methods with Hill's criteria to analyze the smoking-MS association provides evidence supporting the causal involvement of smoking in the development and progression of MS. Smoking prevention and cessation programs and policies should consider MS as an additional health risk when aiming to reduce smoking prevalence in the population. Abbreviations
Source: Multiple Sclerosis and Related Disorders - July 22, 2017 Category: Neurology Source Type: research

Study: Transcranial Direct Current Stimulation (tDCS) can reduce fatigue in patients with Multiple Sclerosis (MS)
Conclusion:  tDCS is a potential treatment for MS-related fatigue. The Study in Context Transcranial Direct Current Stimulation (tDCS) as depression treatment: much promise, some DIY risks Occupational therapy study: Improving processing speed seen as key target to help patients with multiple sclerosis 10 Neurotechnologies About to Transform Brain Enhancement and Brain Health Join the 2017 SharpBrains Virtual Summit: Brain Enhancement in the Digital Age (December 5-7th, 2017)
Source: SharpBrains - October 6, 2017 Category: Neuroscience Authors: SharpBrains Tags: Cognitive Neuroscience Health & Wellness Technology brain-stimulation electrical brain stimulation fatigue multiple-sclerosis non-invasive over-the-counter rehabilitation tDCS telerehabilitation tES Transcranial-direct-current-st Source Type: blogs

Intensity ratio to improve black hole assessment in multiple sclerosis
Conclusions This method of determining the degree of hypointensity within multiple sclerosis lesions can add information to conventional imaging.
Source: Multiple Sclerosis and Related Disorders - December 16, 2017 Category: Neurology Source Type: research

Spanish validation of a specific measure to assess work-related problems in people with multiple sclerosis: the Multiple Sclerosis Work Difficulties Questionnaire (MSWDQ-23)
Conclusion The Spanish version of the MSWDQ-23 shows appropriate feasibility, reliability, and discriminative performance as a patient-reported outcome. MSWDQ-23 may be a valuable addition to measure the impact of a comprehensive spectrum of difficulties experienced by people with MS in the workplace.
Source: Multiple Sclerosis and Related Disorders - April 4, 2018 Category: Neurology Source Type: research