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Multiple Sclerosis – Why a hug might be the last thing you need
Sourced from The Hysterectomy Association: Hysterectomy Association - Hysterectomy Association - hysterectomy, menopause and hormone replacement therapy (hrt) information and support for women. Multiple Sclerosis is an autoimmune disease, and another prime example of an invisible illness. Physically, an MS patient may look well for most of the time, and might be able to go about normal daily activities like work and family life. However, what’s happening below the surface tells a very different story. The immune system attacks the myelin sheathing which protects the body’s nervous system, leaving the nerve exposed. To ...
Source: The Hysterectomy Association - January 27, 2015 Category: OBGYN Authors: Linda Parkinson-Hardman Tags: Health Conditions covance invisible illness multiple sclerosis Source Type: news

Fingolimod first-dose effects in patients with relapsing multiple sclerosis concomitantly receiving selective serotonin-reuptake inhibitors
Publication date: Available online 13 April 2015 Source:Multiple Sclerosis and Related Disorders Author(s): R. Bermel , R. Hashmonay , X. Meng , S. Randhawa , P. von Rosenstiel , N. Sfikas , D. Kantor Selective serotonin-reuptake inhibitors (SSRIs), commonly administered for depression and anxiety in patients with multiple sclerosis, are associated with QT interval prolongation. Fingolimod (FTY720; Gilenya®, Novartis Pharma AG) is a first-in-class sphingosine 1-phosphate receptor modulator approved for relapsing forms of multiple sclerosis. Fingolimod first-dose administration is associated with a transient, generally a...
Source: Multiple Sclerosis and Related Disorders - April 17, 2015 Category: Neurology Source Type: research

A preliminary validation of the brief international cognitive Assessment for multiple sclerosis (BICAMS) tool in an Irish population with multiple sclerosis (MS)
Conclusions This study demonstrates that BICAMS is an easy test to administer and should be used as a basic tool to identify patients with cognitive impairment who may benefit from further neuropsychological assessment. Cognitive impairment can put patients at risk of poor self-management of disease including poor mediation adherence, and negatively impact on employment. Once identified appropriate support and monitoring can be put in place. BICAMS may also be used to help guide treatment decisions and rehabilitation. Further studies will be needed to assess its reliability over time and ability to detect meaningful changes.
Source: Multiple Sclerosis and Related Disorders - August 8, 2015 Category: Neurology Source Type: research

Reduced gamma-aminobutyric acid concentration is associated with physical disability in progressive multiple sclerosis
This study suggests that reduced gamma-aminobutyric acid levels reflect pathological abnormalities that may play a role in determining physical disability. These abnormalities may include decreases in the pre- and postsynaptic components of gamma-aminobutyric acid neurotransmission and in the density of inhibitory neurons. Additionally, the reduced gamma-aminobutyric acid concentration may contribute to the neurodegenerative process, resulting in increased firing of axons, with consequent increased energy demands, which may lead to neuroaxonal degeneration and loss of the compensatory mechanisms that maintain motor functio...
Source: Brain - August 24, 2015 Category: Neurology Authors: Cawley, N., Solanky, B. S., Muhlert, N., Tur, C., Edden, R. A. E., Wheeler-Kingshott, C. A. M., Miller, D. H., Thompson, A. J., Ciccarelli, O. Tags: Multiple Sclerosis/Neuroinflammation Original Articles Source Type: research

The high cost of spasticity in multiple sclerosis to individuals and society
Conclusions: Based on the survey results, it can be assumed that managing spasticity early and effectively could result in substantial cost savings, in addition to the improvements in health-related quality of life.
Source: Multiple Sclerosis - October 6, 2015 Category: Neurology Authors: Stevenson, V., Gras, A., Bardos, J., Broughton, J. Tags: Original Research Papers Source Type: research

Trichuris suis ova therapy in relapsing multiple sclerosis is safe but without signals of beneficial effect
Conclusions: In a small group of relapsing multiple sclerosis patients, Trichuris suis oral therapy was well tolerated but without beneficial effect.
Source: Multiple Sclerosis - October 29, 2015 Category: Neurology Authors: Voldsgaard, A., Bager, P., Garde, E., Akeson, P., Leffers, A., Madsen, C., Kapel, C., Roepstorff, A., Thamsborg, S., Melbye, M., Siebner, H., Sondergaard, H., Sellebjerg, F., Sorensen, P. S. Tags: Original Research Papers Source Type: research

Spasticity in multiple sclerosis: Associations with impairments and overall quality of life
Conclusions There is a strong association between spasticity and fatigue, depression, anxiety, pain and bladder problems. The retention of a significant direct relationship with QOL in a multivariate model emphasises its influence upon the everyday lives of people with MS.
Source: Multiple Sclerosis and Related Disorders - October 31, 2015 Category: Neurology Source Type: research

Reconstruction of single cortical projection neurons reveals primary spine loss in multiple sclerosis
See Friese (doi:10.1093/brain/awv349) for a scientific commentary on this article. Grey matter pathology has emerged as an important contributor to long-term disability in multiple sclerosis. To better understand where and how neuronal damage in the grey matter is initiated, we used high resolution confocal microscopy of Golgi-Cox impregnated tissue sections and reconstructed single cortical projection neurons in autopsies from eight patients with long-standing relapsing-remitting or secondary progressive multiple sclerosis and eight control patients without neurological disease. Analysis of several hundred individual neur...
Source: Brain - January 8, 2016 Category: Neurology Authors: Jürgens, T., Jafari, M., Kreutzfeldt, M., Bahn, E., Brück, W., Kerschensteiner, M., Merkler, D. Tags: Multiple Sclerosis/Neuroinflammation Reports Source Type: research

Interferon-beta exposure during first trimester is safe in women with multiple sclerosis--A prospective cohort study from the German Multiple Sclerosis and Pregnancy Registry
Conclusions: Interferon-beta exposure during early pregnancy does not influence the mean birth weight, risk of preterm birth, or other adverse pregnancy outcomes. Our study provides further reassurance that interferon-beta treatment can be safely continued up until women become pregnant.
Source: Multiple Sclerosis - April 17, 2016 Category: Neurology Authors: Thiel, S., Langer-Gould, A., Rockhoff, M., Haghikia, A., Queisser-Wahrendorf, A., Gold, R., Hellwig, K. Tags: Original Research Papers Source Type: research

Increased cortical grey matter lesion detection in multiple sclerosis with 7 T MRI: a post-mortem verification study
The relevance of cortical grey matter pathology in multiple sclerosis has become increasingly recognized over the past decade. Unfortunately, a large part of cortical lesions remain undetected on magnetic resonance imaging using standard field strength. In vivo studies have shown improved detection by using higher magnetic field strengths up to 7 T. So far, a systematic histopathological verification of ultra-high field magnetic resonance imaging pulse sequences has been lacking. The aim of this study was to determine the sensitivity of 7 T versus 3 T magnetic resonance imaging pulse sequences for the detection of cortical...
Source: Brain - April 25, 2016 Category: Neurology Authors: Kilsdonk, I. D., Jonkman, L. E., Klaver, R., van Veluw, S. J., Zwanenburg, J. J. M., Kuijer, J. P. A., Pouwels, P. J. W., Twisk, J. W. R., Wattjes, M. P., Luijten, P. R., Barkhof, F., Geurts, J. J. G. Tags: Multiple Sclerosis/Neuroinflammation Original Articles Source Type: research

In Memory of Those Lost to the Battle With Multiple Sclerosis
It always bothers me a bit when I am thanked for my service in the U.S. Coast Guard on the occasion of Memorial Day. While I appreciate the sentiment, it’s Veterans Day when we celebrate and appreciate all who have served their country in the military services. Memorial Day, on the other hand, is the day we remember with solemn thanks those who answered the call in times of war and crisis but did not return home. Armed Forces Day is the day we thank active-duty military personnel. No Veterans of Multiple Sclerosis There are no “veterans” of multiple sclerosis (MS) because there is no cure. We are all “active-duty...
Source: Life with MS - May 31, 2016 Category: Neurology Authors: Trevis Gleason Tags: MS multiple sclerosis Living with MS trevis gleason Source Type: blogs

Binocular Low-Contrast Letter Acuity and the Symbol Digit Modalities Test Improve the Ability of the Multiple Sclerosis Functional Composite to Predict Disease in Pediatric Multiple Sclerosis
Conclusions A modified MSFC (25FTW, 9HPT, SMDT, and binocular 1.25% LCLA) is more sensitive than the traditional MSFC or its components to capture the subtle impairments that characterize pediatric MS and should be validated in order to be considered for future pediatric MS trials.
Source: Multiple Sclerosis and Related Disorders - August 25, 2016 Category: Neurology Source Type: research

Clinical characteristics of patients with multiple sclerosis enrolled in a new registry in Egypt
Conclusions This is the first documented MS registry from Egypt. The clinical characteristics of MS in Egypt was similar to other Arab countries and western countries. MS is more common among females in Egypt, with RRMS being the most common presentation. Visual symptoms and motor symptoms were the most common presentations in RRMS and progressive MS, respectively. Our findings also highlight the value of establishing registries in Egypt in order to be able to study, prospectively, the clinical course of the disease, the response to various DMD's and the epidemiology of MS in Egypt.
Source: Multiple Sclerosis and Related Disorders - August 31, 2016 Category: Neurology Source Type: research

‘Clinic Speak’ Helps People With Multiple Sclerosis Take Control
The past couple of weeks have been exhausting for me, but at the same time, I’ve been rejuvenated with great information about living our lives with multiple sclerosis (MS). Two weekends ago I was at MS Life 2016, an event in London for people with MS and their families, and this past weekend I attended two days of presentations (one for healthcare providers and the other for people living with MS) as part of MS Ireland’s annual patient conference. The presenters at both of these events have given me mounds to digest regarding medical research, coping strategies, and advice on general well-being. I intend to share...
Source: Life with MS - September 27, 2016 Category: Neurology Authors: Trevis Gleason Tags: multiple sclerosis life with MS Living with MS multiple sclerosis clinical trials research Source Type: blogs

Multiple Sclerosis: association of gelatinase B/matrix metalloproteinase-9 with risk and clinical course the disease
Conclusion Although we did not find an association of this polymorphism with disease susceptibility or prognosis, MMP-9 appears to be a good therapeutic response marker for multiple sclerosis.
Source: Multiple Sclerosis and Related Disorders - December 12, 2016 Category: Neurology Source Type: research