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Distinguishing among multiple sclerosis fallers, near-fallers and non-fallers
Conclusion Near-falls occur commonly in individuals with MS; near-fallers and fallers reported similar circumstances surrounding fall events and demonstrated similar performance on standard timed walking tests. Clinicians monitoring individuals with MS should consider evaluation of the circumstances surrounding falls in combination with quantitative walking measures to improve determination of fall risk and appropriate rehabilitation interventions.
Source: Multiple Sclerosis and Related Disorders - December 16, 2017 Category: Neurology Source Type: research

Predicting Falls in Multiple Sclerosis: Do Electrophysiological measures have a better predictive accuracy compared to clinical measures? To be published in: Multiple Sclerosis and Related Disorders
Conclusion P13, N10 and P37 latencies were the most accurate in predicting a future fall when compared to clinical measures.
Source: Multiple Sclerosis and Related Disorders - February 2, 2018 Category: Neurology Source Type: research

Coping strategies and quality of life in Mexican Multiple Sclerosis patients: physical, psychological and social factors relationship
CONCLUSION The use of positive coping strategies in conjunction with a suitable psycho-social environment and good physical health result in a better perception of QoL in Mexican patients living with MS. Still, the negative factors are ineffectively diagnosed and hence generally under treated in medical MS monitoring. An interdisciplinary evaluation will provide the adequate tools to confront the diagnosis and the uncertainty of multiple sclerosis evolution, benefiting the QoL of Mexican patients with MS.
Source: Multiple Sclerosis and Related Disorders - June 26, 2018 Category: Neurology Source Type: research

Hypothesis: Multiple Sclerosis is caused by three-hits, strictly in order, in genetically susceptible persons
Publication date: Available online 4 July 2018 Source:Multiple Sclerosis and Related Disorders Author(s): Patrick K A Kearns, Helen A Casey, John Paul Leach Multiple Sclerosis is a chronic, progressive and debilitating neurological disease which, despite extensive study for over 100 years, remains of enigmatic aetiology. Drawn from the epidemiological evidence, there exists a consensus that there are environmental (possibly infectious) factors that contribute to disease pathogenesis that have not yet been fully elucidated. Here we propose a three-tiered hypothesis: 1) a clinic-epidemiological model of multiple sclerosis a...
Source: Multiple Sclerosis and Related Disorders - July 5, 2018 Category: Neurology Source Type: research

Coping strategies and quality of life in Mexican Multiple Sclerosis patients: physical, psychological and social factors relationship
CONCLUSIONThe use of positive coping strategies in conjunction with a suitable psycho-social environment and good physical health result in a better perception of QoL in Mexican patients living with MS. Still, the negative factors are ineffectively diagnosed and hence generally under treated in medical MS monitoring. An interdisciplinary evaluation will provide the adequate tools to confront the diagnosis and the uncertainty of multiple sclerosis evolution, benefiting the QoL of Mexican patients with MS.
Source: Multiple Sclerosis and Related Disorders - July 5, 2018 Category: Neurology Source Type: research

Epidemiology of Multiple Sclerosis in Northeast of Iran during 1985-2016; Conversion of a Rare Disease to a Middle-high Prevalence Disease
Publication date: Available online 7 July 2018Source: Multiple Sclerosis and Related DisordersAuthor(s): Vahid Kazemi Moghaddam, Mohammad Sarmadi, Maryam Tatari, Fereshteh Najafi, Amir Esmaeili, Mostafa HadeiAbstractMany researchers believed that the risk of multiple sclerosis (MS) is associated with latitude gradient. Due to the increasing prevalence of MS in some areas around the equator such as Iran, this theory has been criticized in recent years. Since the distribution of multiple sclerosis in Iran is not uniform, this study was designed to describe the prevalence and incidence of MS in Northeastern area of Iran.The p...
Source: Multiple Sclerosis and Related Disorders - July 8, 2018 Category: Neurology Source Type: research

Coping strategies and quality of life in Mexican Multiple Sclerosis patients: physical, psychological and social factors relationship
CONCLUSIONThe use of positive coping strategies in conjunction with a suitable psycho-social environment and good physical health result in a better perception of QoL in Mexican patients living with MS. Still, the negative factors are ineffectively diagnosed and hence generally under treated in medical MS monitoring. An interdisciplinary evaluation will provide the adequate tools to confront the diagnosis and the uncertainty of multiple sclerosis evolution, benefiting the QoL of Mexican patients with MS.
Source: Multiple Sclerosis and Related Disorders - July 10, 2018 Category: Neurology Source Type: research

Treatment retention on fingolimod compared with injectable multiple sclerosis therapies in African–American patients: A subgroup analysis of a randomized phase 4 study
Conclusion: In PREFERMS, fingolimod was associated with better treatment retention than iDMTs in African–American patients. Optimal outcomes in the management of multiple sclerosis depend on good persistence with treatment, and this is particularly important in patient populations at increased risk of a rapidly progressing disease course.Trial Registration: NCT01623596.Funding: Novartis Pharmaceuticals Corporation.
Source: Multiple Sclerosis and Related Disorders - July 11, 2018 Category: Neurology Source Type: research

Treatment retention on fingolimod compared with injectable multiple sclerosis therapies in African-American patients: A subgroup analysis of a randomized phase 4 study
ConclusionIn PREFERMS, fingolimod was associated with better treatment retention than iDMTs in African-American patients. Optimal outcomes in the management of multiple sclerosis depend on good persistence with treatment, and this is particularly important in patient populations at increased risk of a rapidly progressing disease course.
Source: Multiple Sclerosis and Related Disorders - July 20, 2018 Category: Neurology Source Type: research

Oligoclonal bands in multiple sclerosis; functional significance and therapeutic implications. Does the specificity matter?
Publication date: Available online 20 July 2018Source: Multiple Sclerosis and Related DisordersAuthor(s): Gareth Pryce, David BakerAbstractSince their discovery, the existence of secreted oligoclonal immunoglobulin in the central nervous system in people with multiple sclerosis has been the subject of scientific investigation and debate over several decades. Although autoantibodies can be detected in some individuals, probably secondary to release of neo-antigens after damage, evidence for a major, primary involvement of damaging antibodies is still relatively lacking. However it is possible to construct a working hypothes...
Source: Multiple Sclerosis and Related Disorders - July 20, 2018 Category: Neurology Source Type: research

Metabolomic profile of insulin resistance in patients with multiple sclerosis is associated to the severity of the disease
ConclusionInsulin resistance is frequent in patients with multiple sclerosis and might contribute to metabolic complications and general disability. Early markers of dysglycemia should be sought for in these patients to avoid additional deterioration of their quality of life.
Source: Multiple Sclerosis and Related Disorders - August 26, 2018 Category: Neurology Source Type: research

Bacterial and CMV pneumonia in a patient treated with alemtuzumab for multiple sclerosis
We describe the case of a patient that developed both viral (CMV) and bacterial pneumonia one month after alemtuzumab infusion for multiple sclerosis. Physicians dealing with this drug should be aware of this serious but treatable complication.
Source: Multiple Sclerosis and Related Disorders - October 5, 2018 Category: Neurology Source Type: research

Erythema Nodosum in A Patient With Multiple Sclerosis on Dimethyl Fumarate
Publication date: Available online 25 December 2018Source: Multiple Sclerosis and Related DisordersAuthor(s): Hussein Algahtani, Bader Shirah, Siham Marghalani, Ayed AlgarniAbstractErythema nodosum is an uncommon cutaneous hypersensitivity reaction characterized by tender round slightly raised red nodules that become bruise-like and then resolve without scarring. It may be caused by infections, pregnancy, malignancy, systemic illnesses, or idiopathic. Several drugs have been reported in association with erythema nodosum including oral contraceptive pills, penicillin, and sulphonamides. Glatiramer acetate is the only medica...
Source: Multiple Sclerosis and Related Disorders - December 25, 2018 Category: Neurology Source Type: research

Systematic review and network meta-analysis comparing ocrelizumab with other treatments for relapsing multiple sclerosis
Conclusions: Results suggest that ocrelizumab has an efficacy superior to or comparable with all other currently approved DMTs across all endpoints analyzed, and a similar safety profile, indicating it offers a valuable package for the treatment of patients with RMS.
Source: Multiple Sclerosis and Related Disorders - January 3, 2019 Category: Neurology Source Type: research