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High intensity interval training for people with Multiple Sclerosis: a systematic review.
Conclusion : HIIT appears to be safe and effective in increasing fitness in people with MS and low levels of disability. Further research is required to explore the effectiveness of HIIT in people with progressive MS and in those with higher levels of disability.
Source: Multiple Sclerosis and Related Disorders - June 13, 2018 Category: Neurology Source Type: research

High intensity interval training for people with multiple sclerosis: A systematic review
Conclusion HIIT appears to be safe and effective in increasing fitness in people with MS and low levels of disability. Further research is required to explore the effectiveness of HIIT in people with progressive MS and in those with higher levels of disability.
Source: Multiple Sclerosis and Related Disorders - June 21, 2018 Category: Neurology Source Type: research

Exploring the role of physical activity and exercise for managing vascular comorbidities in people with multiple sclerosis: A scoping review
ConclusionsEvidence points to a potential relationship between PA and exercise and risk factors related to vascular comorbidities in people with MS. PA and exercise training interventions may represent an effective therapeutic strategy for managing vascular comorbidities in people with MS, justifying further investigation.
Source: Multiple Sclerosis and Related Disorders - August 24, 2018 Category: Neurology Source Type: research

The role of gluten in multiple sclerosis: a systematic review
ConclusionsThere is still not sufficient evidence to state whether gluten plays a role in MS, but limitations of current evidence have been identified and directions of future research have been suggested.
Source: Multiple Sclerosis and Related Disorders - October 24, 2018 Category: Neurology Source Type: research

Coexistence of multiple sclerosis and alzheimer's disease: a review
ConclusionIn summary, we highlight a major knowledge gap in our understanding of two potentially common neurological conditions. With the ageing population, and an estimated 2.3 million people living with MS and 46 million with AD or other dementias worldwide, it will become increasingly important to recognize and understand how to manage individuals with these complex comorbid conditions.
Source: Multiple Sclerosis and Related Disorders - October 27, 2018 Category: Neurology Source Type: research

Safety outcomes of disease-modifying therapies for relapsing–remitting multiple sclerosis: a network meta-analysis
ConclusionSafety outcomes are poorly reported in primary studies of DMTs in RRMS, precluding the conduction of robust meta-analyses. Therefore, the current available data on safety of these drugs is not contributing to regulatory and clinical decision making, with adverse event reports underbalanced compared to efficacy outcomes.
Source: Multiple Sclerosis and Related Disorders - June 29, 2019 Category: Neurology Source Type: research

Homocysteine, vitamin B12, and folate levels in patients with multiple sclerosis in Chinese population: a case-control study and meta-analysis
ConclusionPatients with MS tend to have increased blood Hcy levels compared to controls. MS patients of Chinese origin and those in relapse may have decreased levels of VB12. Hcy and VB12 may contribute to pathogenesis of the disease, and VB12 may correlate with MS relapse.
Source: Multiple Sclerosis and Related Disorders - September 11, 2019 Category: Neurology Source Type: research

Independent Outdoor Mobility of Persons with Multiple Sclerosis – A systematic review
Conclusions: The reduced mobility may prevent pwMS participating in society. However, few studies investigating interventions or rehabilitation options to improve mobility were found in the existing literature, highlighting an until now under recognised unmet need.
Source: Multiple Sclerosis and Related Disorders - October 23, 2019 Category: Neurology Source Type: research

Evaluating Functional Electrical Stimulation (FES) Cycling on Cardiovascular, Musculoskeletal and Functional Outcomes in Adults with Multiple Sclerosis and Mobility Impairment: A systematic review
ConclusionFindings suggest FES cycle training may reduce CVD risk alongside trends for a reduction in spasticity post training, however the low quality of the literature precludes any definitive conclusions. FES cycle training appears to be well tolerated in PwMS with mobility impairment, with no serious adverse events.
Source: Multiple Sclerosis and Related Disorders - November 1, 2019 Category: Neurology Source Type: research

Effects of Mindfulness-based interventions on physical symptoms in people with multiple sclerosis – a systematic review and meta-analysis
ConclusionsMBIs appear to be an effective treatment for fatigue in PwMS. The optimal MBI in this context remains unclear. Further research into MBI optimisation, cost- and comparative-effectiveness is required.
Source: Multiple Sclerosis and Related Disorders - November 10, 2019 Category: Neurology Source Type: research

Do clinical trials for new disease modifying treatments include real world patients with multiple sclerosis?
Conclusion: We did not observe significant differences in most clinical and demographic aspects of included patients in RCT and RWS. Studies that include the full spectrum of MS patients followed in clinical practice are needed
Source: Multiple Sclerosis and Related Disorders - January 4, 2020 Category: Neurology Source Type: research

dCan a diagnosis of multiple sclerosis be made without ruling out neuromyelitis optica spectrum disorder ?
Conclusions: The results from our small study have significant implications – symptoms, clinical presentation or classic radiological findings perhaps cannot reliably separate MS from NMOSD. If our study findings can be replicated, guidelines to diagnose MS ought to recommend that NMOSD be excluded first despite typical clinical and radiological findings pointing to MS.
Source: Multiple Sclerosis and Related Disorders - January 16, 2020 Category: Neurology Source Type: research

Can a diagnosis of multiple sclerosis be made without ruling out neuromyelitis optica spectrum disorder ?
ConclusionsThe results from our small study have significant implications––symptoms, clinical presentation or classic radiological findings perhaps cannot reliably separate MS from NMOSD. If our study findings can be replicated, guidelines to diagnose MS ought to recommend that NMOSD be excluded first despite typical clinical and radiological findings pointing to MS.
Source: Multiple Sclerosis and Related Disorders - January 25, 2020 Category: Neurology Source Type: research