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An overview of the current state of evidence for the role of specific diets in multiple sclerosis
ConclusionThere is insufficient evidence to recommend the routine use of any specific diet by people with MS. Some diets touted for MS may have potential negative health consequences. It is important that clinicians inquire regarding dietary manipulations, so they can educate patients on any known efficacy data and potential adverse effects of individual diets. Consultation with a registered dietician is recommended for patients undertaking restrictive diets.
Source: Multiple Sclerosis and Related Disorders - September 11, 2019 Category: Neurology Source Type: research

Reporting quality of randomized-controlled trials in multiple sclerosis from 2000 to 2015, based on CONSORT statement
Conclusion The search identified 102 eligible articles for analysis. 20 of the 38 items of the checklist (52.6%) were addressed in 75% or more of the studies. Reporting of more than 75% of CONSORT items (>75% CONSORT compliance) was increased during the three five-year time periods from 2000 to 2015 (p<0.05). Conclusions Quality of reporting in RCTs focusing on multiple sclerosis is showing improvement over time, but still remains unsatisfactory. Further improvement of reporting is necessary to assess the validity of clinical research.
Source: Multiple Sclerosis and Related Disorders - July 28, 2016 Category: Neurology Source Type: research

Pregnancy outcomes with interferons or glatiramer acetate exposure in Multiple Sclerosis (P1.360)
Conclusions:With low confidence in the evidence due to lack of precision, exposure to GA and interferons during pregnancy may not increase the risk of CAs. Studies with more subjects should be undertaken to improve the accuracy and precision of the risk.Disclosure: Dr. Dargah-zada has nothing to disclose. Dr. Harden has received royalty payments from Wiley and Up-to-date.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Dargah-zada, N., Harden, C. Tags: Pregnancy and Multiple Sclerosis Source Type: research

Fluid phase biomarkers in multiple sclerosis
We present a new approach to search for biomarkers involving extracellular RNA, particularly microRNA (miRNA), and small extracellular vesicles. MiRNA represents an important molecular mechanism influencing gene expression, including those involved in MS pathogenesis and extracellular vesicles transfer multiple cargo, including myelin molecules from parental cells of central nervous system to the long-distance targets. Summary MiRNAs which control gene expression in cells involved in autoimmune processes in MS as well as extracellular vesicles transferring myelin content might generate a new promising categories of biomarkers of MS.
Source: Current Opinion in Neurology - June 1, 2022 Category: Neurology Tags: MULTIPLE SCLEROSIS: Edited by Hans-Peter Hartung Source Type: research

Behavioural symptoms and impairments in multiple sclerosis: a systematic review and meta-analysis
In conclusion the objective behavioural impairments and especially subjective symptoms are present in patients with MS. These manifestations should be taken into account in the diagnostics and treatment of the disease.
Source: Multiple Sclerosis - January 9, 2013 Category: Neurology Authors: Rosti-Otajarvi, E., Hamalainen, P. Tags: Review Source Type: research

To look for a needle in a haystack: the search for autoantibodies in multiple sclerosis
The search for autoantibodies in multiple sclerosis (MS) has been challenging for the last 3 decades. With the development of new proteomic methods and advances in expression and assay technologies, progress in the identification of MS autoantibodies has been made. A number of MS-specific autoantibodies have been proposed, most of them targeting proteins expressed in oligodendrocytes and along the myelin sheath. In this review, we summarize the status of antibody research in MS and then discuss recent developments and future strategies in defining and characterizing the potential antigenic targets of autoantibodies in MS.
Source: Multiple Sclerosis - March 3, 2014 Category: Neurology Authors: Schirmer, L., Srivastava, R., Hemmer, B. Tags: Topical Review Source Type: research

Genetic analysis of the isolated Faroe Islands reveals SORCS3 as a potential multiple sclerosis risk gene
Conclusion: This study revealed an oversharing in case-case-pairs of a segment spanning 63 SNPs and the entire SORCS3. While not previously associated with MS, SORCS3 appears to be important in neuronal plasticity through its binding of neurotrophin factors and involvement in glutamate homeostasis. Although additional work is needed to scrutinise the genetic effect of the SORCS3-covering haplotype, this study suggests that SORCS3 may also be important in MS pathogenesis.
Source: Multiple Sclerosis - April 17, 2016 Category: Neurology Authors: Binzer, S., Stenager, E., Binzer, M., Kyvik, K., Hillert, J., Imrell, K. Tags: Original Research Papers Source Type: research

Urinary tract infections in multiple sclerosis
Conclusion: This review provides an overview of the diagnosis, treatment and prevention of UTIs in the setting of multiple sclerosis (MS).
Source: Multiple Sclerosis - June 1, 2016 Category: Neurology Authors: Phe, V., Pakzad, M., Curtis, C., Porter, B., Haslam, C., Chataway, J., Panicker, J. N. Tags: Topical Review Source Type: research

Language disorders in multiple sclerosis: A systematic review
Conclusion Given the various cognitive deficits in MS, it is expected that higher language abilities would be affected. This aspect should be investigated in future studies.
Source: Multiple Sclerosis and Related Disorders - September 27, 2016 Category: Neurology Source Type: research

Development and validation of a multidimensional health literacy questionnaire for multiple sclerosis patients
Conclusion: The developed 22-item-questionnaire is valid and reliable for assessment of levels of health literacy in Iranian patients with MS.
Source: Multiple Sclerosis and Related Disorders - July 26, 2018 Category: Neurology Source Type: research

The role of Vestibular Evoked Myogenic Potentials in multiple sclerosis-related vertigo. A systematic review of the literature
ConclusionsOur results suggest that VEMPs may detect very small lesions in the vestibular pathways of MS patients; thus, they could have a role in the diagnosis of MS-related vertigo and in the monitoring of vertigo in MS patients as a tool additional to traditional MRI.Graphical Abstract
Source: Multiple Sclerosis and Related Disorders - December 25, 2018 Category: Neurology Source Type: research

Multiple sclerosis and Fabry disease - diagnostic “mixup”
Publication date: Available online 15 June 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Miljenka-Jelena Jurašić, Vanja Bašić Kes, Iris ZavoreoAbstractA common disease like multiple sclerosis (MS) usually dominates the arena of demyelinating disorders; however, when a red flag such as a first relative family history of neurologic disease other than MS is present, the diagnostics may be more challenging.Recently, we have come across an intriguing clinical and diagnostic dilemma requiring extensive literature search and finally, decision making. Namely, initial presentation in our patient was that of a f...
Source: Multiple Sclerosis and Related Disorders - June 16, 2019 Category: Neurology Source Type: research

The long-term effects of disease modifying therapies on disability in people living with multiple sclerosis: a systematic review and meta-analysis
ConclusionThere is some evidence that long-term treatment with interferon beta reduces the risk of EDSS 6.0 and SPMS compared to no treatment or placebo. More work is needed on the effect of second generation DMT and the relative effect of DMT on health outcomes.
Source: Multiple Sclerosis and Related Disorders - August 16, 2019 Category: Neurology Source Type: research

The effect of emerging nutraceutical interventions for clinical and biological outcomes in multiple sclerosis: a systematic review
Conclusion: The existing literature provides preliminary support for the use of a number of nutraceutical interventions in MS. However, sufficiently powered long-term trials are required to expand the currently limited literature and to investigate unexplored nutraceuticals that may target relevant pathways involved in MS such as the gut microbiome and mitochondrial dysfunction. Prospero ID: CRD42018111736.
Source: Multiple Sclerosis and Related Disorders - November 2, 2019 Category: Neurology Source Type: research

Risk factors for reactivation of clinical disease activity in multiple sclerosis after natalizumab cessation
ConclusionHigh disease activity and a high level of disability prior to NTZ treatment seem to predict disease reactivation after treatment cessation. When switching to subsequent DMDs, the washout time should not exceed 3 months. However, subsequent DMDs failed to prevent the reactivation of MS in this cohort.
Source: Multiple Sclerosis and Related Disorders - November 5, 2019 Category: Neurology Source Type: research