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Physical and social environment and the risk of multiple sclerosis
Conclusions Our study did not reveal any additional factors beyond the previously published childbirths which could explain the extent of the MS incidence increase in women.
Source: Multiple Sclerosis and Related Disorders - November 3, 2014 Category: Neurology Source Type: research

Relationship between muscle strength parameters and functional capacity in persons with mild to moderate degree multiple sclerosis
Conclusions Maximal muscle strength of the weaker leg is the better predictor of walking performance in persons with mild to moderate multiple sclerosis. RFD, although also important for functional capacity, is a less strong predictor. Maximal strength of the knee extensors, rather than the knee flexors, predicted performance in the stairclimb and 5STS tests.
Source: Multiple Sclerosis and Related Disorders - January 29, 2015 Category: Neurology Source Type: research

Functional connectivity changes and their relationship with clinical disability and white matter integrity in patients with relapsing-remitting multiple sclerosis
Conclusions: Despite the within-network functional connectivity decrease and the widespread microstructural damage, the inter-network functional connectivity changes suggest a global brain functional rearrangement in multiple sclerosis. The correlation between functional connectivity alterations and callosal damage uncovers a link between functional and structural connectivity. Finally, functional connectivity abnormalities affect information processing speed rather than motor abilities.
Source: Multiple Sclerosis - October 29, 2015 Category: Neurology Authors: Sbardella, E., Tona, F., Petsas, N., Upadhyay, N., Piattella, M., Filippini, N., Prosperini, L., Pozzilli, C., Pantano, P. Tags: Original Research Papers Source Type: research

Should a psychotic or manic episode be considered an early manifestation of multiple sclerosis? a multiple case study
Conclusion Based on this multiple case study, we question whether past psychotic or manic episode should be considered equivalent to a first manifestation of MS.
Source: Multiple Sclerosis and Related Disorders - February 12, 2016 Category: Neurology Source Type: research

Brain intra- and extracellular sodium concentration in multiple sclerosis: a 7 T MRI study
Intra-axonal accumulation of sodium ions is one of the key mechanisms of delayed neuro-axonal degeneration that contributes to disability accrual in multiple sclerosis. In vivo sodium magnetic resonance imaging studies have demonstrated an increase of brain total sodium concentration in patients with multiple sclerosis, especially in patients with greater disability. However, total sodium concentration is a weighted average of intra- and extra-cellular sodium concentration whose changes reflect different tissue pathophysiological processes. The in vivo, non-invasive measurement of intracellular sodium concentration is quit...
Source: Brain - February 25, 2016 Category: Neurology Authors: Petracca, M., Vancea, R. O., Fleysher, L., Jonkman, L. E., Oesingmann, N., Inglese, M. Tags: Multiple Sclerosis/Neuroinflammation Original Articles Source Type: research

Comparing epidemiology and baseline characteristic of multiple sclerosis and neuromyelitis optica: A case-control study
Conclusion The results of this study reveal that the risk of MS is significantly higher in female and younger people in comparison to NMO. Having positive family history of MS can increase the risk of MS substantially. The findings of the study indicated that factors that predict susceptibility to MS, including a positive history of MS in relatives, do not appear to have any association with NMO.
Source: Multiple Sclerosis and Related Disorders - January 5, 2017 Category: Neurology Source Type: research

Multiple sclerosis showing elevation of adenosine deaminase levels in the cerebrospinal fluid
Publication date: Available online 6 February 2017 Source:Multiple Sclerosis and Related Disorders Author(s): Miharu Samuraki, Kenji Sakai, Yasuko Odake, Mitsuhiro Yoshita, Kouichi Misaki, Mitsutoshi Nakata, Masahito Yamada An 80-year-old man developed dysarthria, quadriplegia, sensory disturbance and ataxia in all limbs. Brain and spinal magnetic resonance imaging (MRI) revealed multiple enhanced lesions. Cerebrospinal fluid (CSF) levels of adenosine deaminase (ADA) remarkably elevated. Tuberculosis DNA was not detected, and tuberculosis was not cultured either in the CSF. Brain biopsy revealed the inflammatory demyelina...
Source: Multiple Sclerosis and Related Disorders - February 6, 2017 Category: Neurology Source Type: research

Healthcare Resource Utilization and Costs of Multiple Sclerosis in Canada by Disability (P3.405)
Conclusions:Healthcare resource utilization remains high in MS. The annualized utilization and costs for each resource type will be presented by disability level.Study Supported by: Alberta Health and Roche CanadaDisclosure: Dr. Metz has received research support from Roche. Dr. Greenfield has nothing to disclose. Dr. Marrie has received research support from Canadian Institutes of Health Research, Multiple Sclerosis Society of Canada, National Multiple Sclerosis Society, Rx & D Health Research Foundation, Research Manitoba, Crohn's and Colitis Canada and Sanofi-Aventis. Dr. Jette has nothing to disclose. Dr. Suchowers...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Metz, L., Greenfield, J., Marrie, R.-A., Jette, N., Suchowersky, O., Svenson, L., Alikhani, K., Khan, M., Gholizadeh, S., Xue, C. Tags: Economic Implications of Multiple Sclerosis Source Type: research

Predicting Falls Among Patients With Multiple Sclerosis: Comparison of Patient-Reported Outcomes and Performance-Based Measures of Lower Extremity Functions
Conclusions The results of this study can be used by clinicians to identify and monitor potential fallers in MS patients.
Source: Multiple Sclerosis and Related Disorders - July 7, 2017 Category: Neurology Source Type: research

Worldwide Prevalence of Familial Multiple Sclerosis: A Systematic Review and Meta-Analysis
Conclusion We detected significant heterogeneity from Hungary to Saskatchewan for FMS prevalence that was not latitude and ethnicity dependent. This highlighted the accumulation effects of genetic and environment on FMS prevalence. Pooled prevalence of FMS in MS population was calculated 12.6% by random effect in the world.
Source: Multiple Sclerosis and Related Disorders - December 24, 2017 Category: Neurology Source Type: research

Adult brain volume in multiple sclerosis: The impact of paediatric onset
Conclusion Our data support the previous findings that POMS patients have reduced brain and deep grey matter volume, particularly thalamic volume, compared with sex- and age-matched AOMS patients and healthy controls. These findings appear to be independent of disease duration and other clinical features.
Source: Multiple Sclerosis and Related Disorders - March 7, 2018 Category: Neurology Source Type: research

Hypothesis: Multiple Sclerosis is caused by three-hits, strictly in order, in genetically susceptible persons
Publication date: Available online 4 July 2018Source: Multiple Sclerosis and Related DisordersAuthor(s): Patrick K A Kearns, Helen A Casey, John Paul LeachAbstractMultiple Sclerosis is a chronic, progressive and debilitating neurological disease which, despite extensive study for over 100 years, remains of enigmatic aetiology. Drawn from the epidemiological evidence, there exists a consensus that there are environmental (possibly infectious) factors that contribute to disease pathogenesis that have not yet been fully elucidated. Here we propose a three-tiered hypothesis: 1) a clinic-epidemiological model of multiple sclero...
Source: Multiple Sclerosis and Related Disorders - July 5, 2018 Category: Neurology Source Type: research

A cross-sectional study on the relationship between cardiorespiratory fitness, disease severity and walking speed in persons with Multiple Sclerosis
Conclusion: The present study shows that 1) an increase of 1 EDSS point is associated with a decrease of 1.88 mL•Kg−1•min−1 when adjusted for time since diagnosis, gender, age and MS type, 2) cardiorespiratory fitness and walking speed was significantly related but only minimally affected by MS type, and 3) hypertension is associated with a lower cardiorespiratory fitness level.
Source: Multiple Sclerosis and Related Disorders - January 12, 2019 Category: Neurology Source Type: research

Effect of Vitamin D Replacement on Depression in Multiple Sclerosis Patients
ConclusionLower vitamin D levels are associated with higher depressive scores, and vitamin D replacement could improve depressive symptoms in patients with relapsing remitting multiple sclerosis.
Source: Multiple Sclerosis and Related Disorders - January 24, 2019 Category: Neurology Source Type: research