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It ’s Time for Combination Therapies in Multiple Sclerosis
Conclusion In summary, MS?therapies that combine BBB-crossing molecules with peripherally acting MAbs should be a strategy of MS drug development. MS therapies that effectively limit or halt disease progression and improve overall treatment outcomes will need to address the disease mechanisms both inside and outside the CNS. It must also be recognized that the presence of lymphoid-follicle like structures are associated clinically with irreversible disability and, from a pathological perspective, show pronounced demyelination, microglial activation, and loss of neurites in the cerebral cortex.[14] Without addressing such f...
Source: Innovations in Clinical Neuroscience - June 1, 2017 Category: Neuroscience Authors: ICNS Online Editor Tags: Commentary Current Issue Drug Development Multiple Sclerosis Neurodegenerative Disease Neurology Neuromuscular Disease Psychopharmacology Update on Blood Brain Barrier combination therapies cyclophosphamide disability status laquin Source Type: research

Heart rate variability analysis in patients with multiple sclerosis
ConclusionThese findings reveals that our study population with multiple sclerosis had decreased heart rate variability compared to healthy controls. This was reflected by dysfunction of both parasympathetic and sympathetic parameters of hearth rate variability analysis. However, there is no significant relationship between hearth rate variability analysis and the findings on cranial, cervical, thoracic spinal magnetic resonance imaging findings, number of attack, Expanded Disability Status Scale score or Multiple Sclerosis Functional Composite scores in patients with multiple sclerosis.
Source: Multiple Sclerosis and Related Disorders - July 5, 2018 Category: Neurology Source Type: research

Permeability of the blood-brain barrier predicts conversion from optic neuritis to multiple sclerosis
Optic neuritis is an acute inflammatory condition that is highly associated with multiple sclerosis. Currently, the best predictor of future development of multiple sclerosis is the number of T2 lesions visualized by magnetic resonance imaging. Previous research has found abnormalities in the permeability of the blood–brain barrier in normal-appearing white matter of patients with multiple sclerosis and here, for the first time, we present a study on the capability of blood–brain barrier permeability in predicting conversion from optic neuritis to multiple sclerosis and a direct comparison with cerebrospinal fl...
Source: Brain - August 24, 2015 Category: Neurology Authors: Cramer, S. P., Modvig, S., Simonsen, H. J., Frederiksen, J. L., Larsson, H. B. W. Tags: Multiple Sclerosis/Neuroinflammation Original Articles Source Type: research

Vol. 48 (November 30, 2017): Multiple Sclerosis
The latest in neuroscience—sorted and summarized for you Welcome to The Neuroscience Report where each week we will highlight a specific topic in neuroscience and provide you with links to 5 journal articles, 5 news articles, and 5 wildcard picks. Brought to you by Innovations in Clinical Neuroscience—your source for peer-reviewed, evidence-based information. This week’s topic: Multiple Sclerosis Journal Articles Primary Progressive Multiple Sclerosis: Putting Together the Puzzle The State of Multiple Sclerosis: Current Insight Into the Patient/Health Care Provider Relationship, Treatment Challenges, and ...
Source: Innovations in Clinical Neuroscience - November 30, 2017 Category: Neuroscience Authors: ICNS Online Editor Tags: Neurodegenerative Disease The Neuroscience Report multiple sclerosis Source Type: research

Evidence review finds that computer-based cognitive training can significantly improve memory in patients with multiple sclerosis (MS)
CONCLUSIONS: The present meta-analysis revealed a significant effect for computer-based cognitive training on the performance of the memory domain of patients with MS. This finding may have significant implications in the current treatment practice when cognitive decline is detected in MS patients. The Study in Context Next: Brain scans to identify children at high risk of developing multiple sclerosis (MS) before symptoms appear Study: Transcranial Direct Current Stimulation (tDCS) can reduce fatigue in patients with Multiple Sclerosis (MS) Merck and HAPPYneuron partner to include cognitive remediation program in M...
Source: SharpBrains - April 6, 2018 Category: Neuroscience Authors: SharpBrains Tags: Cognitive Neuroscience Health & Wellness Technology Cognitive-Training Computer-based cognitive rehabilitation meta-analysis multiple-sclerosis neuropsychological neuropsychological assessment Neuropsychological performance Systematic Source Type: blogs

Methods to Assess Ocular Motor Dysfunction in Multiple Sclerosis
Conclusions: This overview should inform clinicians working with patients with MS of how ocular motor deficits can best be assessed and monitored in this population. It also provides a rationale for interest in this field with insights regarding which techniques should be used for studying which classes of eye movements and related dysfunction in the disease.
Source: Journal of Neuro-Ophthalmology - November 13, 2018 Category: Opthalmology Tags: Disease of the Year: Multiple Sclerosis Source Type: research

Association between suicide and multiple sclerosis: an updated meta-analysis
ConclusionOur meta-analysis shows a significant association between suicide and multiple sclerosis, although ethnic and geographical differences were not considered. These findings should be confirmed and extended in future large studies.
Source: Multiple Sclerosis and Related Disorders - June 20, 2019 Category: Neurology Source Type: research

The window of opportunity for treatment of progressive multiple sclerosis
Purpose of review Based on the knowledge of disease mechanisms in the progressive course of multiple sclerosis and the experience from randomized clinical trials, we assessed the timing of disease-modifying therapy in patients with progressive multiple sclerosis to define the optimal window of opportunity for treatment of progressive multiple sclerosis. Recent findings In progressive multiple sclerosis both small molecules that cross the blood--brain barrier (siponimod) and monoclonal antibodies (ocrelizumab) have shown therapeutic efficacy and have been approved for treatment of progressive multiple sclerosis. Howeve...
Source: Current Opinion in Neurology - May 6, 2020 Category: Neurology Tags: MULTIPLE SCLEROSIS: Edited by Giancarlo Comi Source Type: research

Exploring in vivo multiple sclerosis brain microstructural damage through T1w/T2w ratio: a multicentre study
Conclusions T1w/T2w ratio may represent a clinically relevant marker sensitive to demyelination, neurodegeneration and iron accumulation occurring at the different multiple sclerosis phases.
Source: Journal of Neurology, Neurosurgery and Psychiatry - July 13, 2022 Category: Neurosurgery Authors: Margoni, M., Pagani, E., Meani, A., Storelli, L., Mesaros, S., Drulovic, J., Barkhof, F., Vrenken, H., Strijbis, E., Gallo, A., Bisecco, A., Pareto, D., Sastre-Garriga, J., Ciccarelli, O., Yiannakas, M., Palace, J., Preziosa, P., Rocca, M. A., Filippi, M. Tags: Multiple sclerosis Source Type: research

Periventricular venous density in multiple sclerosis is inversely associated with T2 lesion count: a 7 Tesla MRI study
Conclusion: High spatially resolving anatomical T2*-weighted MRI revealed vascular alterations in early stages of multiple sclerosis, presumably as a part of widespread haemodynamic and metabolic alterations.
Source: Multiple Sclerosis - February 20, 2013 Category: Neurology Authors: Sinnecker, T., Bozin, I., Dorr, J., Pfueller, C. F., Harms, L., Niendorf, T., Brandt, A. U., Paul, F., Wuerfel, J. Tags: Research Papers Source Type: research

Multiple Sclerosis Détente
In the spring of 1983, I represented my school in our state’s model United Nations.  After a long day of debate in the General Assembly, I was awarded first prize in the debate on denuclearize.  That time in world history, the topic and experience inform today’s blog. I’ve decided that I have entered into a cold war phase with my multiple sclerosis. First I experienced symptoms of MS.  Then I was diagnosed with the disease.  I suffered from MS, I fought MS and I have learned to live with MS; I’ve just been looking for the right metaphor to describe how I’m living with multiple sclerosis. Détente; that’s wh...
Source: Life with MS - July 10, 2013 Category: Other Conditions Authors: Trevis Gleason Tags: MS multiple sclerosis community Living with MS ms community Multiple Sclerosis Thesaurus Newly diagnosed Symptom management Source Type: blogs

John Dystel Prize for Multiple Sclerosis Research
Sponsored by the AAN and National Multiple Sclerosis Society and made possible through a special contribution from the John Dystel Multiple Sclerosis Research Fund at the National Multiple Sclerosis Society. The John Dystel Prize recognizes outstanding contributions to research in the understanding, treatment, or prevention of multiple sclerosis. The prize is intended to recognize significant and exciting work which has influenced the way we think about multiple sclerosis, but it is not to be a lifetime achievement award. Presentation Recipient is expected to present a 20-minute lecture during a scientific session...
Source: ScanGrants feed - July 31, 2013 Category: Research Authors: American Academy of Neurology/National Multiple Sclerosis Society Source Type: funding

Cardiovascular autonomic dysfunction in multiple sclerosis: A meta-analysis
Conclusions We found a wide variation in the proportion of patients with multiple sclerosis diagnosed with cardiovascular dysautonomia by using the two definitions. Consensus is needed to define autonomic dysfunction in patients with multiple sclerosis. In the meantime, we encourage investigators to report results using both thresholds.
Source: Multiple Sclerosis and Related Disorders - February 24, 2015 Category: Neurology Source Type: research