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Comparative efficacy of endogenous stem cells recruiting hydrogels and stem cell-loaded hydrogels in knee cartilage regeneration: a meta-analysis
Conclusion The current study indicates that both endogenous stem cell recruiting hydrogels and stem cell loaded hydrogels can effectively promote knee joint cartilage regeneration in animal trials.PMID:37711133 | DOI:10.2174/1574888X19666230914123443
Source: Current Stem Cell Research and Therapy - September 15, 2023 Category: Stem Cells Authors: Wanyun Feng Chaohua Zhu Ruoxiang Miao Danni Li Xi Xiong Ruyu Wang Guobing Liu Jun Ma Source Type: research
Effects of combined strength and endurance training on exercise capacity in kidney transplant cyclists and runners
CONCLUSIONS: These findings indicate that the combined strength and endurance training is well tolerated and may improve exercise performance in this selected population of KTRs.PMID:37712239 | DOI:10.4415/ANN_23_03_07
Source: Ann Ist Super Sanita - September 15, 2023 Category: Biomedical Science Authors: Valentina Totti Rocco Di Michele Giulio Sergio Roi Sandro Bartolomei Giovanni Mosconi Gianluigi Sella Alessandro Nanni Costa Gabriela Sangiorgi Manuela Trerotola Lia Bellis Franco Merni Massimo Cardillo Source Type: research
Exosomes and their miRNA/protein profile in keratoconus-derived corneal stromal cells
Exp Eye Res. 2023 Sep 13:109642. doi: 10.1016/j.exer.2023.109642. Online ahead of print.ABSTRACTKeratoconus (KC) is a corneal thinning disorder and a leading cause of corneal transplantation worldwide. Exosomes are small, secreted extracellular vesicles (30-150 nm) that mediate cellular communication via their proteins, lipids, and nucleic acid content. We aimed to characterize the exosomes secreted by primary corneal fibroblasts from subjects with or without KC. Using human keratoconus stromal fibroblast cells (HKC, n = 4) and healthy stromal fibroblasts (HCF, n = 4), we collected and isolated exosomes using serial ultrac...
Source: Experimental Eye Research - September 15, 2023 Category: Opthalmology Authors: Rachel Hadvina Mariam Lotfy Khaled Theresa Akoto Wenbo Zhi Dimitrios Karamichos Yutao Liu Source Type: research
Acute Myeloid Leukemia Causes T Cell Exhaustion and Depletion in a Humanized Graft-versus-Leukemia Model
J Immunol. 2023 Sep 15:ji2300111. doi: 10.4049/jimmunol.2300111. Online ahead of print.ABSTRACTAllogeneic hematopoietic stem cell transplantation (alloSCT) is, in many clinical settings, the only curative treatment for acute myeloid leukemia (AML). The clinical benefit of alloSCT greatly relies on the graft-versus-leukemia (GVL) effect. However, AML relapse remains the top cause of posttransplant death; this highlights the urgent need to enhance GVL. Studies of human GVL have been hindered by the lack of optimal clinically relevant models. In this article, we report, the successful establishment of a novel (to our knowledg...
Source: Journal of Immunology - September 15, 2023 Category: Allergy & Immunology Authors: Bei Jia Chenchen Zhao Kentaro Minagawa Hiroko Shike David F Claxton W Christopher Ehmann Witold B Rybka Shin Mineishi Ming Wang Todd D Schell K Sandeep Prabhu Robert F Paulson Yi Zhang Leonard D Shultz Hong Zheng Source Type: research
Periodontal Tissue Regeneration by Transplantation of Autologous Adipose Tissue-Derived Multi-Lineage Progenitor Cells With Carbonate Apatite
In this study, we selected carbonate apatite as a candidate scaffold material for ADMPCs and conducted an in vitro examination of its effect on the cellular function of ADMPCs. We further performed autologous ADMPC transplantation with carbonate apatite as the scaffold material in a model of one-wall bone defects in beagles and then analyzed the effect on periodontal tissue regeneration. The findings showed that carbonate apatite did not affect the cell morphology of ADMPCs and that it promoted proliferation. Moreover, no effect on secretor factor transcription was found. The results of the in vivo analysis confirmed the s...
Source: Cell Transplantation - September 15, 2023 Category: Cytology Authors: Masahide Takedachi Kohsuke Kawasaki Keigo Sawada Kazuma Sakura Mari Murata Junpei Shimomura Kazuma Kawakami Chiaki Morimoto Koji Miki Noboru Takeshita Tomoaki Iwayama Hanayuki Okura Akifumi Matsuyama Masahiro Saito Masahiro Kitamura Shinya Murakami Source Type: research
Endothelial activation and fibrotic changes are impeded by laminar flow-induced CHK1-SENP2 activity through mechanisms distinct from endothelial-to-mesenchymal cell transition
In this study, we have revealed a novel mechanism underlying the suppressive effects of L-flow on EC inflammation, migration, proliferation, apoptosis, and fibrotic changes through promoting CHK1-induced SENP2 S344 phosphorylation. The phospho-site mutation SENP2 S344A responds to L-flow through a distinct mechanism, which involves the upregulation of both mesenchymal and EC marker genes.PMID:37711550 | PMC:PMC10499395 | DOI:10.3389/fcvm.2023.1187490
Source: Atherosclerosis - September 15, 2023 Category: Cardiology Authors: Minh T H Nguyen Masaki Imanishi Shengyu Li Khanh Chau Priyanka Banerjee Loka Reddy Velatooru Kyung Ae Ko Venkata S K Samanthapudi Young J Gi Ling-Ling Lee Rei J Abe Elena McBeath Anita Deswal Steven H Lin Nicolas L Palaskas Robert Dantzer Keigi Fujiwara M Source Type: research
PRPF31-retinitis pigmentosa: Challenges and opportunities for clinical translation
Vision Res. 2023 Sep 13;213:108315. doi: 10.1016/j.visres.2023.108315. Online ahead of print.ABSTRACTMutations in pre-mRNA processing factor 31 cause autosomal dominant retinitis pigmentosa (PRPF31-RP), for which there is currently no efficient treatment, making this disease a prime target for the development of novel therapeutic strategies. PRPF31-RP exhibits incomplete penetrance due to haploinsufficiency, in which reduced levels of gene expression from the mutated allele result in disease. A variety of model systems have been used in the investigation of disease etiology and therapy development. In this review, we discu...
Source: Vision Research - September 15, 2023 Category: Opthalmology Authors: Hamzah Aweidah Zhouhuan Xi Jos é-Alain Sahel Leah C Byrne Source Type: research
Effects of combined strength and endurance training on exercise capacity in kidney transplant cyclists and runners
CONCLUSIONS: These findings indicate that the combined strength and endurance training is well tolerated and may improve exercise performance in this selected population of KTRs.PMID:37712239 | DOI:10.4415/ANN_23_03_07
Source: Annali dell'Istituto Superiore di Sanita - September 15, 2023 Category: International Medicine & Public Health Authors: Valentina Totti Rocco Di Michele Giulio Sergio Roi Sandro Bartolomei Giovanni Mosconi Gianluigi Sella Alessandro Nanni Costa Gabriela Sangiorgi Manuela Trerotola Lia Bellis Franco Merni Massimo Cardillo Source Type: research
Acute Myeloid Leukemia Causes T Cell Exhaustion and Depletion in a Humanized Graft-versus-Leukemia Model
J Immunol. 2023 Sep 15:ji2300111. doi: 10.4049/jimmunol.2300111. Online ahead of print.ABSTRACTAllogeneic hematopoietic stem cell transplantation (alloSCT) is, in many clinical settings, the only curative treatment for acute myeloid leukemia (AML). The clinical benefit of alloSCT greatly relies on the graft-versus-leukemia (GVL) effect. However, AML relapse remains the top cause of posttransplant death; this highlights the urgent need to enhance GVL. Studies of human GVL have been hindered by the lack of optimal clinically relevant models. In this article, we report, the successful establishment of a novel (to our knowledg...
Source: Journal of Immunology - September 15, 2023 Category: Allergy & Immunology Authors: Bei Jia Chenchen Zhao Kentaro Minagawa Hiroko Shike David F Claxton W Christopher Ehmann Witold B Rybka Shin Mineishi Ming Wang Todd D Schell K Sandeep Prabhu Robert F Paulson Yi Zhang Leonard D Shultz Hong Zheng Source Type: research
Exosomes and their miRNA/protein profile in keratoconus-derived corneal stromal cells
Exp Eye Res. 2023 Sep 13:109642. doi: 10.1016/j.exer.2023.109642. Online ahead of print.ABSTRACTKeratoconus (KC) is a corneal thinning disorder and a leading cause of corneal transplantation worldwide. Exosomes are small, secreted extracellular vesicles (30-150 nm) that mediate cellular communication via their proteins, lipids, and nucleic acid content. We aimed to characterize the exosomes secreted by primary corneal fibroblasts from subjects with or without KC. Using human keratoconus stromal fibroblast cells (HKC, n = 4) and healthy stromal fibroblasts (HCF, n = 4), we collected and isolated exosomes using serial ultrac...
Source: Experimental Eye Research - September 15, 2023 Category: Opthalmology Authors: Rachel Hadvina Mariam Lotfy Khaled Theresa Akoto Wenbo Zhi Dimitrios Karamichos Yutao Liu Source Type: research
Effects of combined strength and endurance training on exercise capacity in kidney transplant cyclists and runners
CONCLUSIONS: These findings indicate that the combined strength and endurance training is well tolerated and may improve exercise performance in this selected population of KTRs.PMID:37712239 | DOI:10.4415/ANN_23_03_07
Source: Annali dell'Istituto Superiore di Sanita - September 15, 2023 Category: International Medicine & Public Health Authors: Valentina Totti Rocco Di Michele Giulio Sergio Roi Sandro Bartolomei Giovanni Mosconi Gianluigi Sella Alessandro Nanni Costa Gabriela Sangiorgi Manuela Trerotola Lia Bellis Franco Merni Massimo Cardillo Source Type: research
PRPF31-retinitis pigmentosa: Challenges and opportunities for clinical translation
Vision Res. 2023 Sep 13;213:108315. doi: 10.1016/j.visres.2023.108315. Online ahead of print.ABSTRACTMutations in pre-mRNA processing factor 31 cause autosomal dominant retinitis pigmentosa (PRPF31-RP), for which there is currently no efficient treatment, making this disease a prime target for the development of novel therapeutic strategies. PRPF31-RP exhibits incomplete penetrance due to haploinsufficiency, in which reduced levels of gene expression from the mutated allele result in disease. A variety of model systems have been used in the investigation of disease etiology and therapy development. In this review, we discu...
Source: Cell Research - September 15, 2023 Category: Cytology Authors: Hamzah Aweidah Zhouhuan Xi Jos é-Alain Sahel Leah C Byrne Source Type: research
Endothelial activation and fibrotic changes are impeded by laminar flow-induced CHK1-SENP2 activity through mechanisms distinct from endothelial-to-mesenchymal cell transition
In this study, we have revealed a novel mechanism underlying the suppressive effects of L-flow on EC inflammation, migration, proliferation, apoptosis, and fibrotic changes through promoting CHK1-induced SENP2 S344 phosphorylation. The phospho-site mutation SENP2 S344A responds to L-flow through a distinct mechanism, which involves the upregulation of both mesenchymal and EC marker genes.PMID:37711550 | PMC:PMC10499395 | DOI:10.3389/fcvm.2023.1187490
Source: Atherosclerosis - September 15, 2023 Category: Cardiology Authors: Minh T H Nguyen Masaki Imanishi Shengyu Li Khanh Chau Priyanka Banerjee Loka Reddy Velatooru Kyung Ae Ko Venkata S K Samanthapudi Young J Gi Ling-Ling Lee Rei J Abe Elena McBeath Anita Deswal Steven H Lin Nicolas L Palaskas Robert Dantzer Keigi Fujiwara M Source Type: research
PRPF31-retinitis pigmentosa: Challenges and opportunities for clinical translation
Vision Res. 2023 Sep 13;213:108315. doi: 10.1016/j.visres.2023.108315. Online ahead of print.ABSTRACTMutations in pre-mRNA processing factor 31 cause autosomal dominant retinitis pigmentosa (PRPF31-RP), for which there is currently no efficient treatment, making this disease a prime target for the development of novel therapeutic strategies. PRPF31-RP exhibits incomplete penetrance due to haploinsufficiency, in which reduced levels of gene expression from the mutated allele result in disease. A variety of model systems have been used in the investigation of disease etiology and therapy development. In this review, we discu...
Source: Vision Research - September 15, 2023 Category: Opthalmology Authors: Hamzah Aweidah Zhouhuan Xi Jos é-Alain Sahel Leah C Byrne Source Type: research
Comparative efficacy of endogenous stem cells recruiting hydrogels and stem cell-loaded hydrogels in knee cartilage regeneration: a meta-analysis
Conclusion The current study indicates that both endogenous stem cell recruiting hydrogels and stem cell loaded hydrogels can effectively promote knee joint cartilage regeneration in animal trials.PMID:37711133 | DOI:10.2174/1574888X19666230914123443
Source: Current Stem Cell Research and Therapy - September 15, 2023 Category: Stem Cells Authors: Wanyun Feng Chaohua Zhu Ruoxiang Miao Danni Li Xi Xiong Ruyu Wang Guobing Liu Jun Ma Source Type: research
