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Ciltacabtagene Autoleucel in Patients With Prior Allogeneic Stem Cell Transplant in the CARTITUDE-1 Study
CONCLUSION: Cilta-cel efficacy and safety were comparable between CARTITUDE-1 patients with and without prior alloSCT. Additional studies are needed to fully elucidate the suitability of CAR-T cell therapy in the post-alloSCT setting.PMID:37716872 | DOI:10.1016/j.clml.2023.08.012
Source: Clinical Lymphoma and Myeloma - September 16, 2023 Category: Cancer & Oncology Authors: Myo Htut Binod Dhakal Adam D Cohen Thomas Martin Jesus G Berdeja Saad Z Usmani Mounzer Agha Carolyn C Jackson Deepu Madduri William Deraedt Enrique Zudaire Tzu-Min Yeh Xiaoying Xu Lida Pacaud Muhammad Akram Sundar Jagannath Source Type: research
Impact of thrice-weekly cotrimoxazole prophylaxis on creatinine and potassium plasma levels in kidney transplant recipients
CONCLUSIONS: Our study pinpoints the impact of CTX 800/160 thrice-weekly on creatinine and potassium levels in kidney transplant recipients. This should be considered when interpreting the evolution of plasma creatinine over time, especially in patients with graft dysfunction. Thus, creatinine levels of cohorts with 6 months versus lifelong CTX require different interpretations.PMID:37715935 | DOI:10.1007/s40620-023-01773-y
Source: Journal of Nephrology - September 16, 2023 Category: Urology & Nephrology Authors: August Ardhe Arnaud Devresse Ralph Crott Martine De Meyer Michel Mourad Eric Goffin Nada Kanaan Michel Jadoul Source Type: research
Telocytes protect against lung tissue fibrosis through hexokinase 2-dependent pathway by secreting hepatocyte growth factor
In conclusion, TCs can protect against lung tissue fibrosis by releasing HGF, a process dependent on HK2.PMID:37715611 | DOI:10.1111/1440-1681.13823
Source: Clinical and Experimental Pharmacology and Physiology - September 16, 2023 Category: Drugs & Pharmacology Authors: Shaoyuan Zhang Linyi Sun Borong Chen Siyun Lin Jianmin Gu Lijie Tan Miao Lin Source Type: research
Impact of thrice-weekly cotrimoxazole prophylaxis on creatinine and potassium plasma levels in kidney transplant recipients
CONCLUSIONS: Our study pinpoints the impact of CTX 800/160 thrice-weekly on creatinine and potassium levels in kidney transplant recipients. This should be considered when interpreting the evolution of plasma creatinine over time, especially in patients with graft dysfunction. Thus, creatinine levels of cohorts with 6 months versus lifelong CTX require different interpretations.PMID:37715935 | DOI:10.1007/s40620-023-01773-y
Source: Journal of Nephrology - September 16, 2023 Category: Urology & Nephrology Authors: August Ardhe Arnaud Devresse Ralph Crott Martine De Meyer Michel Mourad Eric Goffin Nada Kanaan Michel Jadoul Source Type: research
Telocytes protect against lung tissue fibrosis through hexokinase 2-dependent pathway by secreting hepatocyte growth factor
In conclusion, TCs can protect against lung tissue fibrosis by releasing HGF, a process dependent on HK2.PMID:37715611 | DOI:10.1111/1440-1681.13823
Source: Clinical and Experimental Pharmacology and Physiology - September 16, 2023 Category: Drugs & Pharmacology Authors: Shaoyuan Zhang Linyi Sun Borong Chen Siyun Lin Jianmin Gu Lijie Tan Miao Lin Source Type: research
Impact of thrice-weekly cotrimoxazole prophylaxis on creatinine and potassium plasma levels in kidney transplant recipients
CONCLUSIONS: Our study pinpoints the impact of CTX 800/160 thrice-weekly on creatinine and potassium levels in kidney transplant recipients. This should be considered when interpreting the evolution of plasma creatinine over time, especially in patients with graft dysfunction. Thus, creatinine levels of cohorts with 6 months versus lifelong CTX require different interpretations.PMID:37715935 | DOI:10.1007/s40620-023-01773-y
Source: Journal of Nephrology - September 16, 2023 Category: Urology & Nephrology Authors: August Ardhe Arnaud Devresse Ralph Crott Martine De Meyer Michel Mourad Eric Goffin Nada Kanaan Michel Jadoul Source Type: research
Ciltacabtagene Autoleucel in Patients With Prior Allogeneic Stem Cell Transplant in the CARTITUDE-1 Study
CONCLUSION: Cilta-cel efficacy and safety were comparable between CARTITUDE-1 patients with and without prior alloSCT. Additional studies are needed to fully elucidate the suitability of CAR-T cell therapy in the post-alloSCT setting.PMID:37716872 | DOI:10.1016/j.clml.2023.08.012
Source: Clinical Lymphoma and Myeloma - September 16, 2023 Category: Cancer & Oncology Authors: Myo Htut Binod Dhakal Adam D Cohen Thomas Martin Jesus G Berdeja Saad Z Usmani Mounzer Agha Carolyn C Jackson Deepu Madduri William Deraedt Enrique Zudaire Tzu-Min Yeh Xiaoying Xu Lida Pacaud Muhammad Akram Sundar Jagannath Source Type: research
Telocytes protect against lung tissue fibrosis through hexokinase 2-dependent pathway by secreting hepatocyte growth factor
In conclusion, TCs can protect against lung tissue fibrosis by releasing HGF, a process dependent on HK2.PMID:37715611 | DOI:10.1111/1440-1681.13823
Source: Clinical Lung Cancer - September 16, 2023 Category: Cancer & Oncology Authors: Shaoyuan Zhang Linyi Sun Borong Chen Siyun Lin Jianmin Gu Lijie Tan Miao Lin Source Type: research
Ciltacabtagene Autoleucel in Patients With Prior Allogeneic Stem Cell Transplant in the CARTITUDE-1 Study
CONCLUSION: Cilta-cel efficacy and safety were comparable between CARTITUDE-1 patients with and without prior alloSCT. Additional studies are needed to fully elucidate the suitability of CAR-T cell therapy in the post-alloSCT setting.PMID:37716872 | DOI:10.1016/j.clml.2023.08.012
Source: Clinical Lung Cancer - September 16, 2023 Category: Cancer & Oncology Authors: Myo Htut Binod Dhakal Adam D Cohen Thomas Martin Jesus G Berdeja Saad Z Usmani Mounzer Agha Carolyn C Jackson Deepu Madduri William Deraedt Enrique Zudaire Tzu-Min Yeh Xiaoying Xu Lida Pacaud Muhammad Akram Sundar Jagannath Source Type: research
Telocytes protect against lung tissue fibrosis through hexokinase 2-dependent pathway by secreting hepatocyte growth factor
In conclusion, TCs can protect against lung tissue fibrosis by releasing HGF, a process dependent on HK2.PMID:37715611 | DOI:10.1111/1440-1681.13823
Source: Clinical Lung Cancer - September 16, 2023 Category: Cancer & Oncology Authors: Shaoyuan Zhang Linyi Sun Borong Chen Siyun Lin Jianmin Gu Lijie Tan Miao Lin Source Type: research
Periodontal Tissue Regeneration by Transplantation of Autologous Adipose Tissue-Derived Multi-Lineage Progenitor Cells With Carbonate Apatite
In this study, we selected carbonate apatite as a candidate scaffold material for ADMPCs and conducted an in vitro examination of its effect on the cellular function of ADMPCs. We further performed autologous ADMPC transplantation with carbonate apatite as the scaffold material in a model of one-wall bone defects in beagles and then analyzed the effect on periodontal tissue regeneration. The findings showed that carbonate apatite did not affect the cell morphology of ADMPCs and that it promoted proliferation. Moreover, no effect on secretor factor transcription was found. The results of the in vivo analysis confirmed the s...
Source: Cell Transplantation - September 15, 2023 Category: Cytology Authors: Masahide Takedachi Kohsuke Kawasaki Keigo Sawada Kazuma Sakura Mari Murata Junpei Shimomura Kazuma Kawakami Chiaki Morimoto Koji Miki Noboru Takeshita Tomoaki Iwayama Hanayuki Okura Akifumi Matsuyama Masahiro Saito Masahiro Kitamura Shinya Murakami Source Type: research
Intratumoral Bacteria as Mediators of Cancer Immunotherapy Response
Cancer Res. 2023 Sep 15;83(18):2985-2986. doi: 10.1158/0008-5472.CAN-23-1857.ABSTRACTMultiple lines of evidence spanning from animal models to human clinical trials indicate that the microbiome influences cancer immunotherapy response. Whereas initial studies focused exclusively on the gastrointestinal (gut) microbiota-tumor axis, more recent studies have examined the possibility that bacteria located within tumor cells or within the tumor microenvironment mediate cancer treatment response. Strikingly, this phenomenon has been demonstrated in cancers that arise in anatomic locations that are traditionally thought to be dev...
Source: Cell Research - September 15, 2023 Category: Cytology Authors: Karen S Sfanos Source Type: research
Comparative efficacy of endogenous stem cells recruiting hydrogels and stem cell-loaded hydrogels in knee cartilage regeneration: a meta-analysis
Conclusion The current study indicates that both endogenous stem cell recruiting hydrogels and stem cell loaded hydrogels can effectively promote knee joint cartilage regeneration in animal trials.PMID:37711133 | DOI:10.2174/1574888X19666230914123443
Source: Cell Research - September 15, 2023 Category: Cytology Authors: Wanyun Feng Chaohua Zhu Ruoxiang Miao Danni Li Xi Xiong Ruyu Wang Guobing Liu Jun Ma Source Type: research
