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Procedure: Transplants
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Human CD34 < sup > + < /sup > -derived complete plasmacytoid and conventional dendritic cell vaccine effectively induces antigen-specific CD8 < sup > + < /sup > T cell and NK cell responses in vitro and in vivo
In this study, we aimed to dissect the phenotypic identity of these non-DCs and their potential immune modulatory functions on the potency of cDCs and pDCs in stimulating tumor-reactive CD8+ T and NK cell responses, in order to obtain rationale for clinical translation of our DC-complete vaccine. The non-DC compartment was heterogeneous and comprised of myeloid progenitors and (immature) granulocyte- and monocyte-like cells. Importantly, non-DCs potentiated toll-like receptor-induced DC maturation, as reflected by increased expression of co-stimulatory molecules and enhanced cDC-derived IL-12 and pDC-derived IFN-α product...
Source: Cellular and Molecular Life Sciences : CMLS - September 20, 2023 Category: Cytology Authors: Jesper van Eck van der Sluijs Diede van Ens Jolanda Brummelman Daan Heister Aastha Sareen Lisa Truijen Dorette S van Ingen Schenau Mirjam H M Heemskerk Marieke Griffioen Michel G D Kester Nicolaas P M Schaap Joop H Jansen Anniek B van der Waart Harry Dols Source Type: research
Early T-Cell Precursor Leukemia: A High-Risk Subtype of Acute Lymphoblastic Leukemia, Single Center Experience in Jordan
CONCLUSION: ETP-ALL/LBL represents a high-risk disease subtype of adult ALL. Novel treatment strategies are needed to improve treatment outcomes in this patient's population.PMID:37730482 | DOI:10.1016/j.clml.2023.08.007
Source: Clinical Lymphoma and Myeloma - September 20, 2023 Category: Cancer & Oncology Authors: Khalid Halahleh Isra Muradi Mohammad Zakaria Khalil Lina Halahleh Maher Sughayer Nazmi Kamal Iyad Sultan Kamal Alrabi Source Type: research
Pain management for liver transplant recipients
We present current evidence-based literature that reviews optimal pain management strategies for this challenging patient demographic.RECENT FINDINGS: Multiple studies have shown that thoracic epidurals provide superior pain control in open hepatic resections. Recent data suggests thoracic epidurals may be safely considered in select liver transplant recipients with normal preoperative coagulation status; however, this evidence is limited, and further studies are needed. When the risks of coagulopathy prohibit epidural placement, truncal blocks such as transversus abdominis plane blocks or quadratus lumborum blocks and abd...
Source: Current Opinion in Organ Transplantation - September 20, 2023 Category: Transplant Surgery Authors: Simrat Kaur Patrick Henthorn Adrian Hendrickse Source Type: research
Coagulation management during liver transplantation: monitoring and decision making for hemostatic interventions
Curr Opin Organ Transplant. 2023 Sep 19. doi: 10.1097/MOT.0000000000001101. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: Rebalanced hemostasis describes the precarious balance of procoagulant and antithrombotic proteins in patients with severe liver failure. This review is aimed to discuss currently available coagulation monitoring tests and pertinent decision-making process for plasma coagulation factor replacements during liver transplantation (LT).RECENT FINDINGS: Contemporary viscoelastic coagulation monitoring systems have demonstrated advantages over conventional coagulation tests in assessing the patient's coagu...
Source: Current Opinion in Organ Transplantation - September 20, 2023 Category: Transplant Surgery Authors: Kofi B Vandyck Walter Rusin Samhati Mondal Kenichi A Tanaka Source Type: research
Bone marrow mesenchymal stem cell exosome-derived lncRNA TUC339 influences the progression of osteoarthritis by regulating synovial macrophage polarization and chondrocyte apoptosis
In this study, we found that TUC339 was lower in the research group than in the control group and it was negatively correlated with IL-6, IL-8 and TNF-α. Prognosis TUC339 was lower in patients with recurrent OA than in those without recurrence, and ROC analysis manifested that TUC339 had a better predictive value for recurrence of OA. Phenotypic identification revealed elevated expression of CD29 and CD44 in BMSCs and TSG101, CD63 and CD81 in BMSCs-exosome (BMSCs-exo), with a stem cell versus exosome phenotype. Finally, animal experiments improved significantly in joint injury in the BMSCs-exo and TUC339-overexpression ve...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 20, 2023 Category: Drugs & Pharmacology Authors: Xun Shen Jian Qin Zijian Wei Feng Liu Source Type: research
Diagnosis and treatment of glomerular diseases with a membranoproliferative glomerulonephritis (MPGN) pattern of injury
Wien Klin Wochenschr. 2023 Aug;135(Suppl 5):688-695. doi: 10.1007/s00508-023-02264-7. Epub 2023 Sep 20.ABSTRACTMembranoproliferative glomerulonephritis (MPGN) represents a heterogeneous group of diseases. The common feature of a membranoproliferative lesion pattern in the kidney biopsy can either be idiopathic/primary or-much more frequently-have a secondary cause. The historical classification into MPGN types I to III has largely been abandoned and replaced in recent years by a pathogenesis-oriented classification. A MPGN with C1q, C3 and/or C4 deposits on light microscopy is referred to as immune complex GN (IC-GN), whil...
Source: Wiener Klinische Wochenschrift - September 20, 2023 Category: General Medicine Authors: Michael Rudnicki Martin Windpessl Kathrin Eller Balazs Odler Philipp Gauckler Irmgard Neumann Emanuel Zitt Heinz Regele Andreas Kronbichler Karl Lhotta Marcus D S äemann Source Type: research
Physician Preferences when Selecting Candidates for Lower-Quality Kidney Offers
CONCLUSIONS: Physicians appear to consider the recipient characteristics that inform expected post-transplant survival score when deciding whether to accept a marginal kidney for a given recipient.PMID:37729938 | DOI:10.2215/CJN.0000000000000302
Source: Clinical Journal of the American Society of Nephrology : CJASN - September 20, 2023 Category: Urology & Nephrology Authors: Juan M Gonzalez Sepulveda Sanjay Mehrotra Jui-Chen Yang Karolina J Schantz Yolanda Becker Richard Formica Daniela P Ladner Dixon Kaufman John Friedewald Source Type: research
Low-MFI (median fluorescence intensity) pre-transplant DSA (donor specific antibodies) leading to anamnestic antibody mediated rejection in live-related donor kidney transplantation
We present two cases of live-related donor kidney transplants (LDKTs) with low-MFI pre-transplant DSA values who experienced an early acute antibody-mediated rejection (ABMR) as a result of an anamnestic antibody response by DSA against HLA class II antibodies. These results were confirmed by retesting of both pre-transplant and post-transplant archived sera from patients as well as freshly obtained donor cells. Our examples indicate a possible ABMR in patients with low MFI pre-transplant DSA. Reclassification of low vs. high-risk may be appropriate for some patients with low-MFI DSA."PMID:37730185 | DOI:10.1016/j.trim.2023.101931
Source: Transplant Immunology - September 20, 2023 Category: Transplant Surgery Authors: Rajni Chauhan Aseem Kumar Tiwari Geet Aggarwal L Gowri Suresh Mohit Kumar Shyam Bihari Bansal Source Type: research
Bioequivalence evaluation and blood concentration estimation of generic and branded tacrolimus in healthy subjects under fasting: A randomized, four-periods, two-sequences, complete repeated, crossover study
CONCLUSION: Generic tacrolimus (Ruibeirong®) is bioequivalent to branded tacrolimus (Astagraf XL®) with tolerable safety, which AUC predictive equations work well and are interchangeable between the two products.PMID:37730184 | DOI:10.1016/j.trim.2023.101933
Source: Transplant Immunology - September 20, 2023 Category: Transplant Surgery Authors: Yulin Niu Gongbin Lan Jina Wang Tianzhong Yan Peng Jin Source Type: research
Association between blood transfusion after kidney transplantation and risk for the development of de novo HLA donor-specific antibodies and poor clinical outcomes: A single-center retrospective study
CONCLUSIONS: Our study showed that blood transfusion after transplantation is associated with the occurrence of de novo DSAs increasing an immunological risk for poor clinical outcomes for kidney transplantation recipients.PMID:37730183 | DOI:10.1016/j.trim.2023.101930
Source: Transplant Immunology - September 20, 2023 Category: Transplant Surgery Authors: Zhong-Yu Kang Chun Liu Wei Liu Daihong Li Source Type: research
Disseminated Nontuberculous Mycobacterial Infection in a Tertiary Referral Hospital in South Korea: A Retrospective Observational Study
CONCLUSION: D-NTM disease is rare in a tertiary referral center in South Korea. They occur primarily in immunocompromised patients at a relatively young age. Careful investigation of the underlying immune status is required when treating patients with D-NTM disease.PMID:37727920 | DOI:10.3349/ymj.2023.0046
Source: Yonsei Medical Journal - September 20, 2023 Category: Universities & Medical Training Authors: Hyejin Park Young Ae Kang Youngmok Park Source Type: research
Quality of life and financial toxicity of hematopoietic stem cell transplant recipients in COVID-19
CONCLUSION: the quality of life of the sample was low; there is a correlation between quality of life and financial toxicity, although not significant. The higher the financial toxicity, the lower the quality of life.PMID:37729248 | DOI:10.1590/1518-8345.6688.3995
Source: Revista Latino-Americana de Enfermagem - September 20, 2023 Category: Nursing Authors: Nat ália Naome Oshiro Luciana de Alcantara Nogueira Yasmin Hiorrana Dos Santos Paulo Ricardo Bittencourt Guimar ães Luciana Puchalski Kalinke Source Type: research
Impact of previous anthracycline therapy in patients with acute myeloid leukemia receiving venetoclax
In this study, prior chemotherapy/allo-SCT and cytogenetic risk were associated with VEN treatment outcomes.PMID:37728705 | DOI:10.1007/s12185-023-03664-1
Source: International Journal of Hematology - September 20, 2023 Category: Hematology Authors: Ryujiro Hara Shinichiro Machida Norisato Hashimoto Daisuke Ogiya Hidetsugu Kawai Shohei Kawakami Sawako Shiraiwa Makoto Onizuka Yoshiaki Ogawa Hiroshi Kawada Kiyoshi Ando Source Type: research
Updated guidelines for chronic active Epstein-Barr virus disease
Int J Hematol. 2023 Sep 20. doi: 10.1007/s12185-023-03660-5. Online ahead of print.ABSTRACTChronic active Epstein-Barr virus disease (CAEBV), formerly named chronic active Epstein-Barr virus infection, is characterized by systemic inflammation and clonal proliferation of Epstein-Barr virus (EBV)-infected T or NK cells. As CAEBV is a potentially life-threatening illness, appropriate diagnosis and therapeutic interventions are necessary for favorable clinical outcomes. Substantial evidence regarding the pathogenesis and treatment of CAEBV has been accumulated since previous guidelines for the diagnosis of CAEBV were proposed...
Source: International Journal of Hematology - September 20, 2023 Category: Hematology Authors: Jun-Ichi Kawada Yoshinori Ito Koichi Ohshima Masaki Yamada Shinsuke Kataoka Hideki Muramatsu Akihisa Sawada Taizo Wada Ken-Ichi Imadome Ayako Arai Keiji Iwatsuki Shouichi Ohga Hiroshi Kimura Committee for Guidelines for the Management of Chronic Active EB Source Type: research
Experiences of Indigenous Patients Receiving Dialysis: Systematic Review of Qualitative Studies
CONCLUSIONS: Indigenous patients receiving dialysis experience inequities in healthcare which compounds existing accessibility issues caused by colonization. Improving the accessibility and cultural responsiveness of dialysis and kidney transplant services in collaboration with Indigenous stakeholders holds promise to enhance the experience of Indigenous patients receiving dialysis.PMID:37730171 | DOI:10.1053/j.ajkd.2023.07.014
Source: Rural Remote Health - September 20, 2023 Category: Rural Health Authors: Marianne Kerr Allison Jaure Jacqueline H Stephens Siah Kim Richard Cutler Brydee Cashmore Michelle Dickson Nicole Evangelidis Jaquelyne T Hughes Ieyesha Roberts Nicole Scholes-Robertson Victoria Sinka GradDip Jonathan C Craig Source Type: research
