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Procedure: Transplants
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Total 90018 results found since Jan 2013.
CDC42-mediated Wnt signaling facilitates odontogenic differentiation of DPCs during tooth root elongation
CONCLUSIONS: We innovatively revealed that CDC42 was responsible for guiding root elongation in a mesenchyme-specific manner. Furthermore, CDC42-mediated canonical Wnt signaling regulated odontogenic differentiation of DPCs during root formation.PMID:37726858 | PMC:PMC10510226 | DOI:10.1186/s13287-023-03486-2
Source: Cell Research - September 19, 2023 Category: Cytology Authors: Tao Zhou Guoqing Chen Yuchan Xu Shuning Zhang Huilin Tang Tao Qiu Weihua Guo Source Type: research
Heterogeneity in RAG 1/2 Deficiency: 35 Cases From A Single Center
This study aimed to define the clinical/laboratory spectrum of RAG1/2 deficiency. We retrospectively reviewed the clinical/laboratory data of 35 patients, grouped them as severe combined immunodeficiency (SCID), Omenn Syndrome (OS), and delayed-onset combined immunodeficiency (CID) and reported nine novel mutations. Male/female ratio was 23/12. Median age of clinical manifestations was 1 months (mo) (0.5-2), 2 mo (1.25-5), and 14 mo (3.63-27), age at diagnosis was 4 mo (3-6), 4.5 mo (2.5-9.75), and 27 mo (14.5-70) in SCID (n=25;71.4%), OS (n=5;14.3%), and CID (n=5;14.3%) patients, respectively. Common clinical manifestatio...
Source: Clinical and Developmental Immunology - September 19, 2023 Category: Allergy & Immunology Authors: Betul Karaatmaca Deniz Cagdas Saliha Esenboga Baran Erman Cagman Tan Tuba Turul Ozgur Kaan Boztug Mirjam Van Der Burg Ozden Sanal Ilhan Tezcan Source Type: research
The hemodynamic interplay between pulmonary ischemia-reperfusion injury and right ventricular function in lung transplantation: A translational porcine model
In conclusion, we demonstrate a delicate balance between development of pulmonary ischemia-reperfusion injury and right ventricular function during lung transplantation. Furthermore, we provide a physiological basis for potential benefit of extracorporeal life support technology.PMID:37724349 | DOI:10.1152/ajplung.00281.2022
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - September 19, 2023 Category: Cytology Authors: Michaela Orlitov á Tom Verbelen Anna E Frick Arno Vanstapel Dieter Van Beersel Sofie Ordies Jan Van Slambrouck Janne Kaes Jin Xin Walter Coudyzer Stijn E Verleden Geert M Verleden Bart M Vanaudenaerde Dirk E Van Raemdonck Robin Vos Laurens J Ceulemans Pi Source Type: research
Intraoperative partial pressure of arterial carbon dioxide levels and adverse outcomes in patients undergoing lung transplantation
CONCLUSION: These results demonstrate that intraoperative hypercapnia independently predicts postoperative adverse outcomes in patients undergoing LTx. Intraoperative hypocapnia shows predictive value for postoperative in-hospital mortality in LTx.PMID:37726182 | DOI:10.1016/j.asjsur.2023.09.016
Source: Asian Journal of Surgery - September 19, 2023 Category: Surgery Authors: Jing Yu Nan Zhang Zhiyuan Zhang Yu Fu Jiameng Gao Chang Chen Zongmei Wen Source Type: research
Establishing an Efficient Electroporation-Based Method to Manipulate Target Gene Expression in the Axolotl Brain
Cell Transplant. 2023 Jan-Dec;32:9636897231200059. doi: 10.1177/09636897231200059.ABSTRACTThe tetrapod salamander species axolotl (Ambystoma mexicanum) is capable of regenerating injured brain. For better understanding the mechanisms of brain regeneration, it is very necessary to establish a rapid and efficient gain-of-function and loss-of-function approaches to study gene function in the axolotl brain. Here, we establish and optimize an electroporation-based method to overexpress or knockout/knockdown target gene in ependymal glial cells (EGCs) in the axolotl telencephalon. By orientating the electrodes, we were able to a...
Source: Cell Transplantation - September 19, 2023 Category: Cytology Authors: Sulei Fu Cheng Peng Yan-Yun Zeng Yuanhui Qiu Yanmei Liu Ji-Feng Fei Source Type: research
Research for Cytomegalovirus Mutations Associated With Resistance to Antivirals in Kidney Transplant Receptors
Cell Transplant. 2023 Jan-Dec;32:9636897231195245. doi: 10.1177/09636897231195245.ABSTRACTCytomegalovirus (CMV) mutations associated with antiviral resistance have become a major problem related to high mortality in kidney transplant patients. The aim of the study was to investigate mutations in the CMV genes UL97 and UL54 associated with antiviral resistance. A retrospective observational cohort study was carried out at Hospital Ophir Loyola (HOL), a reference in Kidney Transplantation. A total of 81 patients who underwent kidney transplantation were followed up between 2016 and 2018 were monitored for CMV viral load by p...
Source: Cell Transplantation - September 19, 2023 Category: Cytology Authors: Carla de Castro Sant' Anna Silvia Regina da Cruz Migone Carlos Alberto Machado da Rocha Fernando Augusto Rodrigues Mello J únior Aline Damasceno Seabra Tha ís Brilhante Pontes Jo ão Marildo Rodrigues Salom é Aparecida Soares Viviane de Paiva Rego Joan Source Type: research
Donor bile duct evaluation with magnetic resonance cholangiography in living-donor liver transplantation: a novel anatomical classification for predicting surgical techniques
CONCLUSION: The proposed classification in this study includes all anatomical variations. This inclusive classification accurately predicts the surgical technique for LDLT.PMID:37724709 | DOI:10.4274/dir.2023.232321
Source: Diagnostic and Interventional Radiology : The Turkish Society of Radiology - September 19, 2023 Category: Radiology Authors: Afak Durur Karakaya Cemal Ayd ın Gündoğmuş Turan Kanmaz Cihan Karata ş Samet Kapakin Source Type: research
Racial Disparities in End-Stage Kidney Disease Outcomes Among Asians and Native Hawaiians and Other Pacific Islanders Across Geographic Residence
CONCLUSION: In the Mainland, Asians and NHOPIs had lower mortality vs. White patients, whereas in Hawaii/PIs this survival benefit was diminished in Asians and mitigated in NHOPIs. NHOPIs and Asians in Hawaii/PIs had less transplantation vs. those in the Mainland. Further research is needed to uncover factors contributing to differential ESKD outcomes among Asians and NHOPIs across geographic residence.PMID:37725913 | DOI:10.1159/000534052
Source: American Journal of Nephrology - September 19, 2023 Category: Urology & Nephrology Authors: Amy S You Keith C Norris Merle Kataoka-Yahiro James Davis Victoria Page Glen Hayashida Yoko Narasaki Shiuh Feng Cheng Roland Ng Linda L Wong Felix Lee Kamyar Kalantar-Zadeh Connie M Rhee Source Type: research
Heterogeneity in RAG 1/2 Deficiency: 35 Cases From A Single Center
This study aimed to define the clinical/laboratory spectrum of RAG1/2 deficiency. We retrospectively reviewed the clinical/laboratory data of 35 patients, grouped them as severe combined immunodeficiency (SCID), Omenn Syndrome (OS), and delayed-onset combined immunodeficiency (CID) and reported nine novel mutations. Male/female ratio was 23/12. Median age of clinical manifestations was 1 months (mo) (0.5-2), 2 mo (1.25-5), and 14 mo (3.63-27), age at diagnosis was 4 mo (3-6), 4.5 mo (2.5-9.75), and 27 mo (14.5-70) in SCID (n=25;71.4%), OS (n=5;14.3%), and CID (n=5;14.3%) patients, respectively. Common clinical manifestatio...
Source: Clinical and Developmental Immunology - September 19, 2023 Category: Allergy & Immunology Authors: Betul Karaatmaca Deniz Cagdas Saliha Esenboga Baran Erman Cagman Tan Tuba Turul Ozgur Kaan Boztug Mirjam Van Der Burg Ozden Sanal Ilhan Tezcan Source Type: research
Donor bile duct evaluation with magnetic resonance cholangiography in living-donor liver transplantation: a novel anatomical classification for predicting surgical techniques
CONCLUSION: The proposed classification in this study includes all anatomical variations. This inclusive classification accurately predicts the surgical technique for LDLT.PMID:37724709 | DOI:10.4274/dir.2023.232321
Source: Diagnostic and Interventional Radiology - September 19, 2023 Category: Radiology Authors: Afak Durur Karakaya Cemal Ayd ın Gündoğmuş Turan Kanmaz Cihan Karata ş Samet Kapakin Source Type: research
Evaluation of safety and efficacy of allogeneic adipose tissue-derived mesenchymal stem cells in pediatric bronchiolitis obliterans syndrome (BoS) after allogeneic hematopoietic stem cell transplantation (allo-HSCT)
CONCLUSIONS: AT-MSCs could be safely administered to our pediatric cases with BoS post-allo-HSCT. Considering their advanced stage of disease, their sub-optimal functional capacity due to steroid-induced complications, and COVID-19 infection post-treatment, we believe that AT-MSC therapy can have possible efficacy in the management of pediatric BoS. The conduction of further studies with larger sample sizes and more frequent injections is prudent for further optimization of AT-MSC therapy against BoS. Trial registration Iranian Registry of Clinical Trials (IRCT), IRCT20201202049568N2. Registered 22 February 2021, https://e...
Source: Cell Research - September 19, 2023 Category: Cytology Authors: Rashin Mohseni Pouya Mahdavi Sharif Maryam Behfar Mohammad Reza Modaresi Rohola Shirzadi Mahta Mardani Leila Jafari Fahimeh Jafari Zeynab Nikfetrat Amir Ali Hamidieh Source Type: research
Clinical analysis of bacterial infection characteristics in lymphoma patients with high-dose chemotherapy combined with autologous hematopoietic stem cell transplantation-a single-centered retrospective study
CONCLUSION: High-dose chemotherapy combined with autologous hematopoietic stem cell transplantation (HDT/AHSCT) is used to treat lymphoma. Although AHSCT has made considerable strides and become safer, HDT-AHSCT infection continues to be a leading cause of morbidity and mortality associated with transplantation.PMID:37718527 | DOI:10.2174/1386207326666230915115056
Source: Combinatorial Chemistry and High Throughput Screening - September 18, 2023 Category: Chemistry Authors: Dan-Hui Sun Di Mei Xiao-Qin Yaoz Yi-Hui Rong Gui-Qiang Wang Source Type: research
The two-step approach to allogeneic hematopoietic stem cell transplantation
Front Immunol. 2023 Sep 1;14:1237782. doi: 10.3389/fimmu.2023.1237782. eCollection 2023.ABSTRACTAllogeneic hematopoietic stem cell transplantation (HSCT) provides the only potentially curative option for multiple hematological conditions. However, allogeneic HSCT outcomes rely on an optimal balance of effective immune recovery, minimal graft-versus-host disease (GVHD), and lasting control of disease. The quest to attain this balance has proven challenging over the past few decades. The two-step approach to HSCT was conceptualized and pioneered at Thomas Jefferson University in 2005 and remains the main platform for allogra...
Source: Cancer Control - September 18, 2023 Category: Cancer & Oncology Authors: Sikemi Ibikunle Dolores Grosso Usama Gergis Source Type: research
Impact of bronchoalveolar lavage on the management of immunocompromised hosts
Eur J Intern Med. 2023 Sep 16:S0953-6205(23)00327-8. doi: 10.1016/j.ejim.2023.09.007. Online ahead of print.ABSTRACTBACKGROUND: Respiratory infections are an important cause of morbidity and mortality in immunocompromised individuals. Fiberoptic bronchoscopy with bronchoalveolar lavage (BAL) is an important tool to detect infectious agents in immunocompromised patients with low respiratory tract infections (LRTI).RESEARCH QUESTION: BAL changes the management of immunocompromised patients with suspected LRTI.STUDY DESIGN AND METHODS: Immunocompromised patients with a suspicion of LRTI underwent diagnostic BAL. The primary c...
Source: European Journal of Internal Medicine - September 18, 2023 Category: Internal Medicine Authors: Kathleen Jahn Meropi Karakioulaki Desiree M Schumann Hans H Hirsch Karoline Leuzinger Leticia Grize Stefano Aliberti Giovanni Sotgiu Michael Tamm Daiana Stolz Source Type: research
Using a Modified Delphi Panel to Estimate Health Service Utilization for Patients with Advanced and Non-Advanced Systemic Light Chain Amyloidosis
CONCLUSION: Experts estimated advanced patients, who would not be good candidates for HSCT, would have high rates of hospitalization (traditionally the most expensive type of healthcare utilization) and other health service use. The development of new treatment options that can facilitate organ recovery and improve function may lead to decreased utilization.PMID:37719133 | PMC:PMC10503521 | DOI:10.2147/CEOR.S412079
Source: Cell Research - September 18, 2023 Category: Cytology Authors: Morie Gertz Rafat Abonour Sarah N Gibbs Muriel Finkel Heather Landau Suzanne Lentzsch Grace Lin Anuj Mahindra Tiffany Quock Cara Rosenbaum Michael Rosenzweig Surbhi Sidana Sascha A Tuchman Ronald Witteles Irina Yermilov Michael S Broder Source Type: research
