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Endothelial cell activation mediated by cold ischemia-released mitochondria is partially inhibited by defibrotide and impacts on early allograft function following liver transplantation
This study aimed to assess whether DAMPs present in the organ preservation solution (OPS) after cold ischemic storage (CIS) contribute to exacerbating the endothelial response to an inflammatory challenge and whether defibrotide treatment could counteract this effect. The activation of cultured human umbilical vein endothelial cells (HUVECs) was analyzed after challenging with end-ischemic OPS (eiOPS) obtained after CIS. Additionally, transwell assays were performed to study the ability of eiOPS to attract lymphocytes across the endothelium. The study revealed that eiOPS upregulated the expression of MCP-1 and IL-6 in HUVE...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 20, 2023 Category: Drugs & Pharmacology Authors: Francisco Villalba-L ópez David Garc Ãa-Bernal Sandra V Mateo Daniel Vidal-Correoso Marta Jover-Aguilar Felipe Alconchel Laura Mart Ãnez-Alarcón V Ãctor López-López Antonio R Ãos-Zambudio Pedro Cascales Jos é A Pons Pablo Ram Ãrez Pablo Pelegr à Source Type: research
Bone marrow mesenchymal stem cell exosome-derived lncRNA TUC339 influences the progression of osteoarthritis by regulating synovial macrophage polarization and chondrocyte apoptosis
In this study, we found that TUC339 was lower in the research group than in the control group and it was negatively correlated with IL-6, IL-8 and TNF-α. Prognosis TUC339 was lower in patients with recurrent OA than in those without recurrence, and ROC analysis manifested that TUC339 had a better predictive value for recurrence of OA. Phenotypic identification revealed elevated expression of CD29 and CD44 in BMSCs and TSG101, CD63 and CD81 in BMSCs-exosome (BMSCs-exo), with a stem cell versus exosome phenotype. Finally, animal experiments improved significantly in joint injury in the BMSCs-exo and TUC339-overexpression ve...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 20, 2023 Category: Drugs & Pharmacology Authors: Xun Shen Jian Qin Zijian Wei Feng Liu Source Type: research
The hemodynamic interplay between pulmonary ischemia-reperfusion injury and right ventricular function in lung transplantation: A translational porcine model
In conclusion, we demonstrate a delicate balance between development of pulmonary ischemia-reperfusion injury and right ventricular function during lung transplantation. Furthermore, we provide a physiological basis for potential benefit of extracorporeal life support technology.PMID:37724349 | DOI:10.1152/ajplung.00281.2022
Source: Am J Physiol Lung Ce... - September 19, 2023 Category: Respiratory Medicine Authors: Michaela Orlitov á Tom Verbelen Anna E Frick Arno Vanstapel Dieter Van Beersel Sofie Ordies Jan Van Slambrouck Janne Kaes Jin Xin Walter Coudyzer Stijn E Verleden Geert M Verleden Bart M Vanaudenaerde Dirk E Van Raemdonck Robin Vos Laurens J Ceulemans Pi Source Type: research
Myocardial perfusion scintigraphy in the assessment of cardiovascular risk in adult liver transplantation
CONCLUSIONS: MPS is a safe and reliable technique for cardiovascular assessment of patients who are candidates for liver transplantation, given the low rate of false negatives during follow-up.PMID:37726078 | DOI:10.1016/j.remnie.2023.09.001
Source: Molecular Medicine - September 19, 2023 Category: Molecular Biology Authors: C Guti érrez-Villamil C Zuluaga-Arbelaez G Hern ández N Hern ández-Hidalgo V Mar Ãn-Oyaga Source Type: research
Establishing an Efficient Electroporation-Based Method to Manipulate Target Gene Expression in the Axolotl Brain
Cell Transplant. 2023 Jan-Dec;32:9636897231200059. doi: 10.1177/09636897231200059.ABSTRACTThe tetrapod salamander species axolotl (Ambystoma mexicanum) is capable of regenerating injured brain. For better understanding the mechanisms of brain regeneration, it is very necessary to establish a rapid and efficient gain-of-function and loss-of-function approaches to study gene function in the axolotl brain. Here, we establish and optimize an electroporation-based method to overexpress or knockout/knockdown target gene in ependymal glial cells (EGCs) in the axolotl telencephalon. By orientating the electrodes, we were able to a...
Source: Cell Transplantation - September 19, 2023 Category: Cytology Authors: Sulei Fu Cheng Peng Yan-Yun Zeng Yuanhui Qiu Yanmei Liu Ji-Feng Fei Source Type: research
Research for Cytomegalovirus Mutations Associated With Resistance to Antivirals in Kidney Transplant Receptors
Cell Transplant. 2023 Jan-Dec;32:9636897231195245. doi: 10.1177/09636897231195245.ABSTRACTCytomegalovirus (CMV) mutations associated with antiviral resistance have become a major problem related to high mortality in kidney transplant patients. The aim of the study was to investigate mutations in the CMV genes UL97 and UL54 associated with antiviral resistance. A retrospective observational cohort study was carried out at Hospital Ophir Loyola (HOL), a reference in Kidney Transplantation. A total of 81 patients who underwent kidney transplantation were followed up between 2016 and 2018 were monitored for CMV viral load by p...
Source: Cell Transplantation - September 19, 2023 Category: Cytology Authors: Carla de Castro Sant' Anna Silvia Regina da Cruz Migone Carlos Alberto Machado da Rocha Fernando Augusto Rodrigues Mello J únior Aline Damasceno Seabra Tha Ãs Brilhante Pontes Jo ão Marildo Rodrigues Salom é Aparecida Soares Viviane de Paiva Rego Joan Source Type: research
Newborn screening for severe combined immunodeficiencies (SCID) in Germany
Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2023 Sep 19. doi: 10.1007/s00103-023-03773-6. Online ahead of print.ABSTRACTPatients with a severe combined immunodeficiency (SCID) harbor genetic mutations disrupting T cell immunity and hence suffer severe, life-threatening infections or manifestations of immune dysregulation within the first months of their life. The only cure is to correct their immune system, usually by means of hematopoietic stem cell transplantation (HSCT). Pilot studies and national programs in the United States and in European countries have shown that patients can be identified at an ...
Source: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz - September 19, 2023 Category: International Medicine & Public Health Authors: Sujal Ghosh Michael H Albert Fabian Hauck Manfred H önig Catharina Sch ütz Ansgar Schulz Carsten Speckmann Source Type: research
Establishing an Efficient Electroporation-Based Method to Manipulate Target Gene Expression in the Axolotl Brain
Cell Transplant. 2023 Jan-Dec;32:9636897231200059. doi: 10.1177/09636897231200059.ABSTRACTThe tetrapod salamander species axolotl (Ambystoma mexicanum) is capable of regenerating injured brain. For better understanding the mechanisms of brain regeneration, it is very necessary to establish a rapid and efficient gain-of-function and loss-of-function approaches to study gene function in the axolotl brain. Here, we establish and optimize an electroporation-based method to overexpress or knockout/knockdown target gene in ependymal glial cells (EGCs) in the axolotl telencephalon. By orientating the electrodes, we were able to a...
Source: Cell Transplantation - September 19, 2023 Category: Cytology Authors: Sulei Fu Cheng Peng Yan-Yun Zeng Yuanhui Qiu Yanmei Liu Ji-Feng Fei Source Type: research
Research for Cytomegalovirus Mutations Associated With Resistance to Antivirals in Kidney Transplant Receptors
Cell Transplant. 2023 Jan-Dec;32:9636897231195245. doi: 10.1177/09636897231195245.ABSTRACTCytomegalovirus (CMV) mutations associated with antiviral resistance have become a major problem related to high mortality in kidney transplant patients. The aim of the study was to investigate mutations in the CMV genes UL97 and UL54 associated with antiviral resistance. A retrospective observational cohort study was carried out at Hospital Ophir Loyola (HOL), a reference in Kidney Transplantation. A total of 81 patients who underwent kidney transplantation were followed up between 2016 and 2018 were monitored for CMV viral load by p...
Source: Cell Transplantation - September 19, 2023 Category: Cytology Authors: Carla de Castro Sant' Anna Silvia Regina da Cruz Migone Carlos Alberto Machado da Rocha Fernando Augusto Rodrigues Mello J únior Aline Damasceno Seabra Tha Ãs Brilhante Pontes Jo ão Marildo Rodrigues Salom é Aparecida Soares Viviane de Paiva Rego Joan Source Type: research
Donor bile duct evaluation with magnetic resonance cholangiography in living-donor liver transplantation: a novel anatomical classification for predicting surgical techniques
CONCLUSION: The proposed classification in this study includes all anatomical variations. This inclusive classification accurately predicts the surgical technique for LDLT.PMID:37724709 | DOI:10.4274/dir.2023.232321
Source: Diagnostic and Interventional Radiology - September 19, 2023 Category: Radiology Authors: Afak Durur Karakaya Cemal Ayd ın Gündoğmuş Turan Kanmaz Cihan Karata ş Samet Kapakin Source Type: research
Racial Disparities in End-Stage Kidney Disease Outcomes Among Asians and Native Hawaiians and Other Pacific Islanders Across Geographic Residence
CONCLUSION: In the Mainland, Asians and NHOPIs had lower mortality vs. White patients, whereas in Hawaii/PIs this survival benefit was diminished in Asians and mitigated in NHOPIs. NHOPIs and Asians in Hawaii/PIs had less transplantation vs. those in the Mainland. Further research is needed to uncover factors contributing to differential ESKD outcomes among Asians and NHOPIs across geographic residence.PMID:37725913 | DOI:10.1159/000534052
Source: American Journal of Nephrology - September 19, 2023 Category: Urology & Nephrology Authors: Amy S You Keith C Norris Merle Kataoka-Yahiro James Davis Victoria Page Glen Hayashida Yoko Narasaki Shiuh Feng Cheng Roland Ng Linda L Wong Felix Lee Kamyar Kalantar-Zadeh Connie M Rhee Source Type: research
The hemodynamic interplay between pulmonary ischemia-reperfusion injury and right ventricular function in lung transplantation: A translational porcine model
In conclusion, we demonstrate a delicate balance between development of pulmonary ischemia-reperfusion injury and right ventricular function during lung transplantation. Furthermore, we provide a physiological basis for potential benefit of extracorporeal life support technology.PMID:37724349 | DOI:10.1152/ajplung.00281.2022
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - September 19, 2023 Category: Cytology Authors: Michaela Orlitov á Tom Verbelen Anna E Frick Arno Vanstapel Dieter Van Beersel Sofie Ordies Jan Van Slambrouck Janne Kaes Jin Xin Walter Coudyzer Stijn E Verleden Geert M Verleden Bart M Vanaudenaerde Dirk E Van Raemdonck Robin Vos Laurens J Ceulemans Pi Source Type: research
Donor bile duct evaluation with magnetic resonance cholangiography in living-donor liver transplantation: a novel anatomical classification for predicting surgical techniques
CONCLUSION: The proposed classification in this study includes all anatomical variations. This inclusive classification accurately predicts the surgical technique for LDLT.PMID:37724709 | DOI:10.4274/dir.2023.232321
Source: Diagnostic and Interventional Radiology : The Turkish Society of Radiology - September 19, 2023 Category: Radiology Authors: Afak Durur Karakaya Cemal Ayd ın Gündoğmuş Turan Kanmaz Cihan Karata ş Samet Kapakin Source Type: research
Intraoperative partial pressure of arterial carbon dioxide levels and adverse outcomes in patients undergoing lung transplantation
CONCLUSION: These results demonstrate that intraoperative hypercapnia independently predicts postoperative adverse outcomes in patients undergoing LTx. Intraoperative hypocapnia shows predictive value for postoperative in-hospital mortality in LTx.PMID:37726182 | DOI:10.1016/j.asjsur.2023.09.016
Source: Asian Journal of Surgery - September 19, 2023 Category: Surgery Authors: Jing Yu Nan Zhang Zhiyuan Zhang Yu Fu Jiameng Gao Chang Chen Zongmei Wen Source Type: research
Heterogeneity in RAG 1/2 Deficiency: 35 Cases From A Single Center
This study aimed to define the clinical/laboratory spectrum of RAG1/2 deficiency. We retrospectively reviewed the clinical/laboratory data of 35 patients, grouped them as severe combined immunodeficiency (SCID), Omenn Syndrome (OS), and delayed-onset combined immunodeficiency (CID) and reported nine novel mutations. Male/female ratio was 23/12. Median age of clinical manifestations was 1 months (mo) (0.5-2), 2 mo (1.25-5), and 14 mo (3.63-27), age at diagnosis was 4 mo (3-6), 4.5 mo (2.5-9.75), and 27 mo (14.5-70) in SCID (n=25;71.4%), OS (n=5;14.3%), and CID (n=5;14.3%) patients, respectively. Common clinical manifestatio...
Source: Clinical and Developmental Immunology - September 19, 2023 Category: Allergy & Immunology Authors: Betul Karaatmaca Deniz Cagdas Saliha Esenboga Baran Erman Cagman Tan Tuba Turul Ozgur Kaan Boztug Mirjam Van Der Burg Ozden Sanal Ilhan Tezcan Source Type: research
