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Clinical analysis of bacterial infection characteristics in lymphoma patients with high-dose chemotherapy combined with autologous hematopoietic stem cell transplantation-a single-centered retrospective study
CONCLUSION: High-dose chemotherapy combined with autologous hematopoietic stem cell transplantation (HDT/AHSCT) is used to treat lymphoma. Although AHSCT has made considerable strides and become safer, HDT-AHSCT infection continues to be a leading cause of morbidity and mortality associated with transplantation.PMID:37718527 | DOI:10.2174/1386207326666230915115056
Source: Combinatorial Chemistry and High Throughput Screening - September 18, 2023 Category: Chemistry Authors: Dan-Hui Sun Di Mei Xiao-Qin Yaoz Yi-Hui Rong Gui-Qiang Wang Source Type: research

Impact of bronchoalveolar lavage on the management of immunocompromised hosts
Eur J Intern Med. 2023 Sep 16:S0953-6205(23)00327-8. doi: 10.1016/j.ejim.2023.09.007. Online ahead of print.ABSTRACTBACKGROUND: Respiratory infections are an important cause of morbidity and mortality in immunocompromised individuals. Fiberoptic bronchoscopy with bronchoalveolar lavage (BAL) is an important tool to detect infectious agents in immunocompromised patients with low respiratory tract infections (LRTI).RESEARCH QUESTION: BAL changes the management of immunocompromised patients with suspected LRTI.STUDY DESIGN AND METHODS: Immunocompromised patients with a suspicion of LRTI underwent diagnostic BAL. The primary c...
Source: European Journal of Internal Medicine - September 18, 2023 Category: Internal Medicine Authors: Kathleen Jahn Meropi Karakioulaki Desiree M Schumann Hans H Hirsch Karoline Leuzinger Leticia Grize Stefano Aliberti Giovanni Sotgiu Michael Tamm Daiana Stolz Source Type: research

Nitric oxide in kidney transplantation
Biomed Pharmacother. 2023 Sep 16;167:115530. doi: 10.1016/j.biopha.2023.115530. Online ahead of print.ABSTRACTKidney transplantation is the treatment of choice for patients with kidney failure. Compared to dialysis therapy, it provides better quality of life and confers significant survival advantage at a relatively lower cost. However, the long-term success of this life-saving intervention is severely hampered by an inexorable clinical problem referred to as ischemia-reperfusion injury (IRI), and increases the incidence of post-transplant complications including loss of renal graft function and death of transplant recipie...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 18, 2023 Category: Drugs & Pharmacology Authors: George J Dugbartey Source Type: research

In vitro spermatogenesis in artificial testis: current knowledge and clinical implications for male infertility
Cell Tissue Res. 2023 Sep 18. doi: 10.1007/s00441-023-03824-z. Online ahead of print.ABSTRACTMen's reproductive health exclusively depends on the appropriate maturation of certain germ cells known as sperm. Certain illnesses, such as Klinefelter syndrome, cryptorchidism, and syndrome of androgen insensitivity or absence of testis maturation in men, resulting in the loss of germ cells and the removal of essential genes on the Y chromosome, can cause non-obstructive azoospermia. According to laboratory research, preserving, proliferating, differentiating, and transplanting spermatogonial stem cells or testicular tissue could...
Source: Cell Research - September 18, 2023 Category: Cytology Authors: Zahra Bashiri Mazaher Gholipourmalekabadi Farnaz Khadivi Maryam Salem Azita Afzali Tat-Chuan Cham Morteza Koruji Source Type: research

Dysfunctional Cori and Krebs cycle and inhibition of lactate transporters constitute a mechanism of primary non-function of fatty liver allografts
Transl Res. 2023 Sep 16:S1931-5244(23)00146-9. doi: 10.1016/j.trsl.2023.09.006. Online ahead of print.ABSTRACTOrthotopic liver transplantation (OLT) is a lifesaving procedure. However, grafts may fail due to primary non-function (PNF). In the past, we demonstrated PNFs to be mainly associated with fatty allografts, and given its unpredictable nature, the development of a disease model is urgently needed. In an effort to investigate mechanism of fatty-allograft associated PNFs, we induced fatty liver disease in donor animals by feeding rats a diet deficient in methionine and choline (MCD). We performed OLT with allografts o...
Source: Translational Research : the journal of laboratory and clinical medicine - September 18, 2023 Category: Laboratory Medicine Authors: Ulf Kulik Caroline Moesta Reinhard Spanel J ürgen Borlak Source Type: research

Fight Aging! Newsletter, September 18th 2023
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - September 17, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Editorial introductions
Curr Opin Organ Transplant. 2022 Aug 1;27(4):v-vi. doi: 10.1097/MOT.0000000000001000.NO ABSTRACTPMID:37718277 | DOI:10.1097/MOT.0000000000001000
Source: Current Opinion in Organ Transplantation - September 17, 2023 Category: Transplant Surgery Source Type: research

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