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Haploidentical Natural Killer Cell Therapy as an Adjunct to Stem Cell Transplantation for Treatment of Refractory Acute Myeloid Leukemia
Cell Transplant. 2023 Jan-Dec;32:9636897231198178. doi: 10.1177/09636897231198178.ABSTRACTRefractory acute myeloid leukemia (AML), defined as failure of two cycles of induction therapy at diagnosis or of one cycle at relapse, represents a subgroup with poor outcomes. Haploidentical natural killer cell (NK) therapy is a strategy that is being explored in refractory malignancies. Historically, at our center, patients with refractory AML have been treated with cytoreductive therapy (fludarabine + cytosine + granulocyte colony-stimulating factor ± idarubicin or mitoxantrone + etoposide) followed by 1-week rest and then reduce...
Source: Cell Transplantation - September 14, 2023 Category: Cytology Authors: Uday Kulkarni Arun Kumar Arunachalam Hamenth Kumar Palani Reeshma Radhakrishnan Nair Nithya Balasundaram Arvind Venkatraman Anu Korula Sushil Selvarajan Sharon Lionel Poonkuzhali Balasubramanian Madhavi Maddali Aby Abraham Biju George Vikram Mathews Source Type: research
Role of Serum Inflammatory Cytokines in Sepsis Rats Following BMSCs Transplantation: Protein Microarray Analysis
In this study, we investigated the effects of BMSCs on serum inflammatory cytokines in a rat model of lipopolysaccharide (LPS)-induced sepsis. Sepsis was induced by intravenous injection of LPS, followed by transplantation of BMSCs. We monitored survival rates for 72 h and evaluated organ functions, histopathological changes, and cytokines expression. Sepsis rats showed decreased levels of white blood cells, platelets, lymphocyte ratio, and oxygen partial pressure, along with increased levels of neutrophil ratio, carbon dioxide partial pressure, lactic acid, alanine aminotransferase, and aspartate aminotransferase. Histolo...
Source: Cell Transplantation - September 14, 2023 Category: Cytology Authors: Guanghui Xiu Xiuling Li Juan Chen Jintao Li Kun Chen Ping Liu Bin Ling Ying Yang Source Type: research
Improving liver transplant outcomes with transplant-omics and network biology
Curr Opin Organ Transplant. 2023 Sep 13. doi: 10.1097/MOT.0000000000001100. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: Molecular omics data is increasingly ubiquitous throughout medicine. In organ transplantation, recent large-scale research efforts are generating the 'transplant-ome' - the entire set of molecular omics data, including the genome, transcriptome, proteome, and metabolome. Importantly, early studies in anesthesiology have demonstrated how perioperative interventions alter molecular profiles in various patient populations. The next step for anesthesiologists and intensivists will be to tailor perioperat...
Source: Current Opinion in Organ Transplantation - September 14, 2023 Category: Transplant Surgery Authors: Joseph Scarpa Source Type: research
The Dosing of Mobile-Based Just-in-Time Adaptive Self-Management Prompts for Caregivers: Preliminary Findings From a Pilot Microrandomized Study
CONCLUSIONS: This study provides preliminary evidence to support the effectiveness of the self-management JITAI and offers practical guidance for designing future personalized JITAI strategies for diverse caregiver groups.TRIAL REGISTRATION: ClinicalTrials.gov NCT04556591; https://clinicaltrials.gov/ct2/show/NCT04556591.PMID:37707948 | DOI:10.2196/43099
Source: Cell Research - September 14, 2023 Category: Cytology Authors: Jitao Wang Zhenke Wu Sung Won Choi Srijan Sen Xinghui Yan Jennifer A Miner Angelle M Sander Angela K Lyden Jonathan P Troost Noelle E Carlozzi Source Type: research
Isoxanthohumol improves obesity and glucose metabolism via inhibiting intestinal lipid absorption with a bloom of Akkermansia muciniphila in mice
CONCLUSIONS: Our study demonstrated that IX prevents obesity and enhances glucose metabolism by inhibiting dietary fat absorption. This mechanism is linked to suppressing pancreatic lipase activity and shifts in microbial composition, notably an increase in A. muciniphila. These highlight new treatment strategies for preventing metabolic syndrome by boosting the gut microbiota with food components.PMID:37709134 | DOI:10.1016/j.molmet.2023.101797
Source: Molecular Medicine - September 14, 2023 Category: Molecular Biology Authors: Yoshiyuki Watanabe Shiho Fujisaka Yoshitomo Morinaga Shiro Watanabe Allah Nawaz Hideki Hatta Tomonobu Kado Ayumi Nishimura Muhammad Bilal Muhammad Rahil Aslam Keiko Honda Yoshimi Nakagawa Samir Softic Kenichi Hirabayashi Takashi Nakagawa Yoshinori Nagai K Source Type: research
Treg-targeted IL-2/anti-IL-2 complex controls graft- < em > versus < /em > -host disease and supports anti-tumor effect in allogeneic hematopoietic stem cell transplantation
Haematologica. 2023 Sep 14. doi: 10.3324/haematol.2022.282653. Online ahead of print.ABSTRACTModulating an immune response in opposite directions represents the holy grail in allogeneic hematopoietic stem cell transplantation (allo-HSCT) to avoid insufficient reactivity of donor T cells and hematologic malignancy relapse while controlling the potential development of graft-versus-host disease (GVHD), in which donor T cells attack the recipient's tissues. IL-2/anti-IL-2 complexes (IL2-Cxs) represents a therapeutic option to selectively accentuate or dampen the immune response. In dedicated experimental models of allo-HSCT, ...
Source: Haematologica - September 14, 2023 Category: Hematology Authors: Allan Thiolat Caroline Pilon Pamela Caudana Audrey Moatti Nhu Hanh To Christine Sedlik Mathieu Leclerc S ébastien Maury Eliane Piaggio Jos é L Cohen Source Type: research
Daratumumab and brentuximab vedotin combination therapy in T-cell acute lymphoblastic leukemia refractory to conventional chemotherapy and allogeneic stem cell transplant
Haematologica. 2023 Sep 14. doi: 10.3324/haematol.2023.283740. Online ahead of print.ABSTRACTNot available.PMID:37706335 | DOI:10.3324/haematol.2023.283740
Source: Haematologica - September 14, 2023 Category: Hematology Authors: Kebede H Begna Nadine H Abdallah Michelle Janania-Martinez Abhishek A Mangaonkar Aruna Rangan Jennifer L Herrick Naseema Gangat Source Type: research
Letermovir and new horizons in prevention of post-transplant CMV
Expert Rev Clin Pharmacol. 2023 Sep 14. doi: 10.1080/17512433.2023.2259308. Online ahead of print.NO ABSTRACTPMID:37706302 | DOI:10.1080/17512433.2023.2259308
Source: Pharmacological Reviews - September 14, 2023 Category: Drugs & Pharmacology Authors: Emily A Siegrist Joseph Sassine Source Type: research
Single-Cell RNA Sequencing of Coronary Perivascular Adipose Tissue From End-Stage Heart Failure Patients Identifies < em > SPP1 < /em > < sup > + < /sup > Macrophage Subpopulation as a Target for Alleviating Fibrosis
CONCLUSIONS: SPP1+ macrophages accumulated in the PVAT surrounding atherosclerotic coronary arteries, and they promoted the migration and proliferation of fibroadipogenic progenitor cells via OPN-CD44/integrin interaction and thus aggravated the fibrosis of coronary PVAT, which was positively correlated to the coronary stenosis burden. Therefore, SPP1+ macrophages in coronary PVAT may participate in the progression of coronary atherosclerosis.PMID:37706320 | DOI:10.1161/ATVBAHA.123.319828
Source: Arteriosclerosis, Thrombosis and Vascular Biology - September 14, 2023 Category: Cardiology Authors: Mengxia Fu Songren Shu Zhiming Peng Xiaorui Liu Xiao Chen Zhiwei Zeng Yicheng Yang Hao Cui Ruojin Zhao Xiaohu Wang Leilei Du Min Wu Wei Feng Jiangping Song Source Type: research
Activated carbon derived from wood biochar for Amperometric sensing of Ammonia for early screening of chronic kidney disease
In this study, we have elucidated the functionality and usefulness of a wearable microelectronic research prototype integrated with an HTC-activated carbon @RTIL-based electrochemical sensing platform for detecting ammonia levels released from the skin as a marker for chronic kidney disease screening. By enabling early detection and monitoring, these platforms can facilitate timely interventions, such as lifestyle modifications, medication adjustments, or referral to nephrology specialists. This proactive approach can potentially slow down disease progression, minimize the need for dialysis or transplantation, and ultimate...
Source: International Journal of Biological Macromolecules - September 14, 2023 Category: Biochemistry Authors: Ivneet Banga Anirban Paul Vikram Narayanan Dhamu Annapoorna Hochihally Ramasubramanya Sriram Muthukumar Shalini Prasad Source Type: research
Suspected Legionella Transmission from a Single Donor to Two Lung Transplant Recipients - Pennsylvania, May 2022
MMWR Morb Mortal Wkly Rep. 2023 Sep 15;72(37):1001-1004. doi: 10.15585/mmwr.mm7237a1.ABSTRACTIn July 2022, the Pennsylvania Department of Health received two reports of laboratory-confirmed Legionnaires disease in patients who had recently received lung transplants from the same donor at a single Pennsylvania hospital. The donor's cause of death was freshwater drowning in a river, raising suspicion of potential donor-derived transmission, because Legionella bacteria naturally live in fresh water. Further investigation of patients receiving other organs from the same donor did not identify additional legionellosis cases. He...
Source: MMWR Morb Mortal Wkl... - September 14, 2023 Category: Epidemiology Authors: Shannon McGinnis Rebecca J Free Jacqueline Burnell Sridhar V Basavaraju Trevor Kanaskie Elizabeth J Hannapel Nottasorn Plipat Kimberly Warren Chris Edens Source Type: research
Hyperbaric oxygen mitigates KIM-1 and inflammatory cytokine levels in kidney transplantation
Undersea Hyperb Med. 2023 Third Quarter;50(3):289-300.ABSTRACTThe aim of this study was to investigate the effect of hyperbaric oxygen (HBO2) administration during cold ischemic time to organs removed from donors before kidney transplantation. A total of 24 rats were divided into three groups: Group 1 was the control group, Group 2 received 60 minutes of HBO2 at 2.5 atmospheres absolute, and Group 3 received 120 minutes of 2.5 ATA HBO2. The renal artery was entered with a polyethylene catheter and perfused with a standard organ preservation solution. Falcon tubes containing organs obtained from rats in Groups 2 and 3 were ...
Source: Undersea and Hyperbaric Medicine - September 14, 2023 Category: Sports Medicine Authors: Ba şak Bűyűk Özlem Öztopuz Source Type: research
Heart Retransplantation Under the 2018 Adult Heart Allocation Policy
CONCLUSIONS: Heart retransplantation candidates have experienced improved waitlist outcomes following the 2018 adult heart allocation policy without significant changes to post-transplant survival.PMID:37709159 | DOI:10.1016/j.athoracsur.2023.09.001
Source: The Annals of Thoracic Surgery - September 14, 2023 Category: Cardiovascular & Thoracic Surgery Authors: Samuel T Kim Amit Iyengar Mark R Helmers Noah Weingarten David Rekhtman Cindy Song Max Shin Marisa Cevasco Pavan Atluri Source Type: research
Single-Cell RNA Sequencing of Coronary Perivascular Adipose Tissue From End-Stage Heart Failure Patients Identifies < em > SPP1 < /em > < sup > + < /sup > Macrophage Subpopulation as a Target for Alleviating Fibrosis
CONCLUSIONS: SPP1+ macrophages accumulated in the PVAT surrounding atherosclerotic coronary arteries, and they promoted the migration and proliferation of fibroadipogenic progenitor cells via OPN-CD44/integrin interaction and thus aggravated the fibrosis of coronary PVAT, which was positively correlated to the coronary stenosis burden. Therefore, SPP1+ macrophages in coronary PVAT may participate in the progression of coronary atherosclerosis.PMID:37706320 | DOI:10.1161/ATVBAHA.123.319828
Source: Atherosclerosis - September 14, 2023 Category: Cardiology Authors: Mengxia Fu Songren Shu Zhiming Peng Xiaorui Liu Xiao Chen Zhiwei Zeng Yicheng Yang Hao Cui Ruojin Zhao Xiaohu Wang Leilei Du Min Wu Wei Feng Jiangping Song Source Type: research
