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Total 2042466 results found since Jan 2013.

GSE234802 Amino acid intake strategies define pluripotent cell states
Contributors : Pavlina K Todorova ; Katrina I Paras ; Lydia W FinleySeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAmino acid intake strategies define pluripotent cell states
Source: GEO: Gene Expression Omnibus - September 22, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

GSE232052 Effect of methanol fixation on single cell RNA sequencing of the murine dentate gyrus.
Contributors : Marta S ánchez-Carbonell ; Patricia Jiménez Peinado ; Cathrin Bayer-Kaufmann ; Jean-Christopher Hennings ; Yvonne Hofmann ; Silvio Schmidt ; Otto W Witte ; Anja UrbachSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe evaluated the effect of methanol (MeOH) fixation on adult murine dentate gyrus (DG) single cell suspensions.
Source: GEO: Gene Expression Omnibus - September 22, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

GSE228062 Prostate tissue explant, epithelial cell, stromal cell, and extracellular vesicle microRNA characterization by NGS
Contributors : Larisa Nonn ; Morgan Zenner ; Trevor LeonardoSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Homo sapiensIntracellular and extracellular vesicle-contained microRNAs were profiled by next-generation sequencing from prostate cancer patient cells, tissues and serum.
Source: GEO: Gene Expression Omnibus - September 22, 2023 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by high throughput sequencing Homo sapiens Source Type: research

GSE228044 Differential usage of DNA modifications in neurons, astrocytes and microglia WGoxBS
Contributors : Kyla B Tooley ; Ana J Chucair-Elliott ; Sarah R Ocanas ; Kevin D Pham ; David R Stanford ; Willard M FreemanSeries Type : Methylation profiling by high throughput sequencingOrganism : Mus musculusCellular identity is determined, in part, by cell type-specific epigenomic profiles that govern gene expression. Isolation and epigenomic characterization of specific cell types is greatly needed in neuroscience. While single cell DNA modification studies offer promise to answer this question, these approaches suffer from limited genomic coverage and cannot differentiate between methylation and hydroxymethylation. T...
Source: GEO: Gene Expression Omnibus - September 22, 2023 Category: Genetics & Stem Cells Tags: Methylation profiling by high throughput sequencing Mus musculus Source Type: research

GSE228043 Differential usage of DNA modifications in neurons, astrocytes and microglia RNA-seq
Contributors : Kyla B Tooley ; Ana J Chucair-Elliott ; Sarah R Ocanas ; Kevin D Pham ; David R Stanford ; Willard M FreemanSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusCellular identity is determined, in part, by cell type-specific epigenomic profiles that govern gene expression. Isolation and epigenomic characterization of specific cell types is greatly needed in neuroscience. While single cell DNA modification studies offer promise to answer this question, these approaches suffer from limited genomic coverage and cannot differentiate between methylation and hydroxymethylation. Th...
Source: GEO: Gene Expression Omnibus - September 22, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

GSE218383 Nanostring gene expression data, comparison of response to subcutaneously implanted porcine-derived decellularized myocardial matrix hydrogels in mast cell deficient mice compared to deficient mice with mast cell engraftment and wild-type C57BL6/J mice
Contributors : Raymond M Wang ; Karen L ChristmanSeries Type : Expression profiling by arrayOrganism : Mus musculusNanostring gene expression count data from the Nanostring Mouse Immunology Panel consisting of 546 genes with 15 internal controls from excised subcutaneous injections of porcine derived decellularized myocardial matrix hydrogels that were lysed and extracted for total RNA. Data was then exported through the manufacturer nSolverTM Analysis Software 4.0 and analyzed through custom R scripts under R versions 4.04 with normalized counts determined by the NanostringDiff package and thresholding outside of one stan...
Source: GEO: Gene Expression Omnibus - September 22, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by array Mus musculus Source Type: research

GSE214003 Single cell sequecing analysis of exhausted CD8 T cell subsets in LCMV-clone13 infected mice
Contributors : Martin Vaeth ; Wolfgang Kastenm üller ; Konrad KnöpperSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo identify the subsets of exhausted T cells and to analyze the transcriptional-metabolic programs alongside their developmental trajectories at single-cell resolution, we isolated CD44+ PD-1hi CD8+ T cells from chronically infected wild-type (WT) mice 21 days after infection with the ‘clone 13’ strain of lymphocytic choriomeningitis virus (LCMV) by FACs sorting aand performed scRNA-sequencing.
Source: GEO: Gene Expression Omnibus - September 22, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

GSE213981 Endogenous B cell TACI-Short-APRIL signaling
Contributors : Miguel Fribourg ; Yolanda CarmonaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHere we show that TACI-S increases its expression with maturation and colocalizes in the intracellular compartment with the ligand APRIL. APRIL downregulation in human B cells, eliminated class switch. These studies suggest the importance of intracellular APRIL together with TACI-S in maintaining humoral immunity.
Source: GEO: Gene Expression Omnibus - September 22, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

GSE213847 Single-cell sequecing of LCMV-specific WT and HIF-1a-deficient CD8 T cells isolated from LCMV-Clone13 infected host mice
Contributors : Martin Vaeth ; Hao WuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo determine the role of hypoxia-inducible factor 1 alpha (HIF-1a) in exhausted T cells, we crossed Hif1a-fl/fl Cd4-Cre mice to tdTomato+ P14 animals and adoptively co-transferred equal numbers of WT and HIF-1a-deficient P14 CD8+ T cells into chronically infected WT host mice. 21 days post infection, we retrieved GFP+ (WT) and tdTomato+ (HIF-1a-deficient) donor P14 T cells by FACS sorting and subjected CITE-seq antibody-barcoded WT and HIF-1a-deficient CD8+ P14 T cells to multiplexed scRNA sequencing analysis.
Source: GEO: Gene Expression Omnibus - September 22, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

GSE210888 Enhancer retargeting at the PAX5/ZCCHC7 locus
Contributors : Lijing Wu ; Wanwei Zhang ; Gerson Rothschild ; Junghyun Lim ; Rebecca Leeman-Neill ; Uttiya BasuSeries Type : OtherOrganism : Homo sapiens2 kinds of SU-DHL-10 cell clones (Pax5-TSS2mut/deletion) were generated to investigate enhancer relocation, we campared 4C-seq data between the Pax5-TSS2mut/deletion clones and wild type SU-DHL-10.
Source: GEO: Gene Expression Omnibus - September 22, 2023 Category: Genetics & Stem Cells Tags: Other Homo sapiens Source Type: research

GSE210497 SARS-CoV-2 pathogenesis mediated by E protein's PBM was prevented by modulators of CFTR function
Contributors : Jose M Honrubia ; Francisco J Guti érrez-Álvarez ; Alejandro Sanz ; Diego Muñoz ; Ezequiel González ; Carlos Castaño-Rodríguez ; Jorge Ripoll ; Ana Esteban ; Raúl Fernández-Delgado ; Juan C Oliveros ; Stanley Perlman ; Paul McCray ; Luis EnjuanesSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe three human deadly coronaviruses (CoVs) (SARS-CoV, MERS-CoV and SARS-CoV-2) have infected around eight thousand, two thousand six hundred and 262 million people so far (December 2021), causing the death of 10%, 37% and 2% of them, respectively, so their implication in h...
Source: GEO: Gene Expression Omnibus - September 22, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

GSE206868 Epithelial Gab1 calibrates RIPK3-dependent necroptosis to prevent intestinal inflammation
We report that epithelial-Gab1 deficiency in mice facilitates inflammatory cell infiltration and aggravates colonic inflammation in colitis microenvironment
Source: GEO: Gene Expression Omnibus - September 22, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

Unprecedented Multifunctionality in Novel Monophase Micro/Nanostructured Ti ‐Zn Alloy
This study highlights the remarkable multifunctionality of an unexplored monophase of structurally and thermally stable micro/nanostructured Ti0.5Zn0.5 alloy. The integrated glucose-sensing-triggered energy-storage-device, featuring high-quality Ti0.5Zn0.5 electrodes, exhibits outstanding biocompatibility, antiwear characteristics, anticorrosive behavior, mechanical robustness, and antibacterial activity. This alloy shows promise for applications in durable, wearable, and point-of-care diagnostic tools for human and animal healthcare, and tracking applications. AbstractIt is always challenging to integrate multiple functio...
Source: Small - September 22, 2023 Category: Nanotechnology Authors: Hajeesh Kumar Vikraman, Jeena George, Rence P. Reji, Guru Prasad Kuppuswamy, Sanjay. D. Sutar, Anita Swami, Sharmiladevi Ramamoorthy, Anandhakumar Sundaramurthy, Sumit Pramanik, Surya Velappa Jayaraman, Suresh Perumal, Yuvaraj Sivalingam, S. R Tags: Research Article Source Type: research

A new scaffold-free tumoroid model provides a robust preclinical tool to investigate invasion and drug response in Renal Cell Carcinoma
Cell Death & Disease, Published online: 22 September 2023; doi:10.1038/s41419-023-06133-zA new scaffold-free tumoroid model provides a robust preclinical tool to investigate invasion and drug response in Renal Cell Carcinoma
Source: Cell death and disease - September 22, 2023 Category: Internal Medicine Authors: Irinka S éraudie Catherine Pillet Beatrice Cesana Pauline Bazelle Florian Jeanneret Bertrand Evrard Fr édéric Chalmel Assilah Bouzit Christophe Battail Jean-Alexandre Long Jean Luc Descotes Claude Cochet Odile Filhol Source Type: research

FBXW2 suppresses breast tumorigenesis by targeting AKT-Moesin-SKP2 axis
Cell Death & Disease, Published online: 22 September 2023; doi:10.1038/s41419-023-06127-xFBXW2 suppresses breast tumorigenesis by targeting AKT-Moesin-SKP2 axis
Source: Cell death and disease - September 22, 2023 Category: Internal Medicine Authors: Ganesh Kumar Barik Osheen Sahay Anindya Mukhopadhyay Rajesh Kumar Manne Sehbanul Islam Anup Roy Somsubhra Nath Manas Kumar Santra Source Type: research