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Mutation Profile via Next-Generation Sequencing in Patients with Colorectal Adenocarcinoma and Its Clinicopathological Correlation
CONCLUSION: It is necessary to have a comprehensive database of genomic alterations of colorectal carcinomas to interpret mutations more accurately clinically. There are no studies on the frequency of mutations in colorectal carcinomas in the Turkish population; thus, follow-up and treatment protocols are organized following the European and American databases and guidelines. A comprehensive study of the colorectal carcinoma patients' mutation profile in the Turkish patient cohort by the next-generation sequencing method will help to provide significant therapeutic, prognostic, and predictive data and design more successfu...
Source: The Turkish Journal of Gastroenterology - September 22, 2023 Category: Gastroenterology Authors: Sibel Osman Nesibe Kahraman Çetin İbrahim Halil Erdoğdu İbrahim Meteoğlu Source Type: research
S100A6 is a potential diagnostic and prognostic biomarker for human glioma
Oncol Lett. 2023 Sep 6;26(4):458. doi: 10.3892/ol.2023.14045. eCollection 2023 Oct.ABSTRACTS100 calcium-binding protein A6 (S100A6) is a protein that belongs to the S100 family. The present study aimed to investigate the function of S100A6 in the diagnosis and survival prediction of glioma and elucidated the potential processes affecting glioma development. The Cancer Genome Atlas database was searched to identify the relationship among S100A6 expression, immune cell infiltration, clinicopathological parameters and glioma prognosis. Several clinical cases were used to verify these findings. S100A6 gene expression was high ...
Source: Oncology Letters - September 22, 2023 Category: Cancer & Oncology Authors: Bo Hong Hui Zhang Yufei Xiao Lingwei Shen Yun Qian Source Type: research
Identification and validation of a fatty acid metabolism gene signature for the promotion of metastasis in liver cancer
Oncol Lett. 2023 Sep 6;26(4):457. doi: 10.3892/ol.2023.14044. eCollection 2023 Oct.ABSTRACTMetastasis is a fatal status for liver cancer, and the identification of an effective prediction model and promising therapeutic target is essential. Given the known relationship between fatty acid (FA) metabolism and the liver, the present study aimed to investigate dysregulation of genes associated with FA metabolism in liver cancer. Bioinformatics analyses were performed on data from patients with hepatocellular carcinoma (HCC) obtained from The Cancer Genome Atlas database using R software packages. Online public tools such as th...
Source: Oncology Letters - September 22, 2023 Category: Cancer & Oncology Authors: Zhenshan Zhang Jun Sun Chao Jin Likun Zhang Leilei Wu Gendong Tian Source Type: research
Adipocyte glucocorticoid receptor inhibits immune regulatory genes to maintain immune cell homeostasis in adipose tissue
Endocrinology. 2023 Sep 20:bqad143. doi: 10.1210/endocr/bqad143. Online ahead of print.ABSTRACTGlucocorticoids acting via the glucocorticoid receptors (GR) are key regulators of metabolism and the stress response. However, uncontrolled or excessive GR signaling adversely affects adipose tissue, including endocrine, immune, and metabolic functions. Inflammation of the adipose tissue promotes systemic metabolic dysfunction; however, the molecular mechanisms underlying the role of adipocyte GR in regulating genes associated with adipose tissue inflammation are poorly understood. We performed in vivo studies using adipocyte sp...
Source: Endocrinology - September 22, 2023 Category: Endocrinology Authors: Shripa Amatya Dylan Tietje-Mckinney Schaefer Mueller Maria G Petrillo Matthew D Woolard Sushma Bharrhan A Wayne Orr Christopher G Kevil John A Cidlowski Diana Cruz-Topete Source Type: research
Research Progress of Metformin in the Treatment of Oral Squamous Cell Carcinoma
Endocrinology. 2023 Sep 20:bqad139. doi: 10.1210/endocr/bqad139. Online ahead of print.ABSTRACTOral squamous cell carcinoma (OSCC) is one of the most common malignancies with high mortality, posing a great threat to both human physical and mental health. With the advancement of scientific research, a variety of cancer therapies have been used for OSCC treatment. However, the prognosis of OSCC shows no significant improvement. Metformin has been recognized as the first-line drug for the treatment of diabetes, and recent studies have shown that metformin has a remarkable suppressive effect on tumor progression. Metformin can...
Source: Endocrinology - September 22, 2023 Category: Endocrinology Authors: Jiayi Liu Jing Zhao Xue Qiao Source Type: research
STAT3-EphA7 axis contributes to the progression of esophageal squamous cell carcinoma
CONCLUSION: Our results showed that the transcriptional expression of EphA7 was increased by activated STAT3, and the STAT3 signaling may act through EphA7 to promote the development of ESCC.PMID:37738252 | DOI:10.1080/0284186X.2023.2259601
Source: Acta Oncologica - September 22, 2023 Category: Cancer & Oncology Authors: Li Wang Qiao-Feng Zhao Bing-Bing Yang Hui-Jie Liang Xian-E Zhang Xiao-Yan Zhang Wan-Jing Yang Zhi-Yu Guo Xin Xu Fang Tian Qing-Hua Wu Source Type: research
Fisetin, a potential skin rejuvenation drug that eliminates senescent cells in the dermis
Biogerontology. 2023 Sep 22. doi: 10.1007/s10522-023-10064-9. Online ahead of print.ABSTRACTAccumulation of senescent fibroblasts, chronic inflammation, and collagen remodeling due to aging-related secretory phenotypes have been hypothesized to cause age-related skin aging, which results in wrinkles and loss of skin elasticity, thus compromising appearance attractiveness. However, the rejuvenating effects of removing senescent cells from the human skin and the efficacy of related therapeutic agents remain unclear. Here, we investigated the effects of fisetin, a potential anti-aging component found in various edible fruits ...
Source: Biogerontology - September 22, 2023 Category: Geriatrics Authors: Kento Takaya Toru Asou Kazuo Kishi Source Type: research
Preparation of poly(acrylic acid)/tricalcium phosphate nanoparticles scaffold: Characterization and releasing UC-MSCs derived exosomes for bone differentiation
CONCLUSION: The current research is the first study fabricating a multiscale scaffold using triCaPNPs in the substrate of PPA polymer using a cross-linker and freeze-drying process. This scaffold could mimic the nanoscale structure and chemical combination of native bone minerals. In addition, our results suggest that the PAA/triCaPNPs scaffold could be beneficial to achieve controlled exosome release for exosome-based therapy in bone tissue engineering.PMID:37736343 | PMC:PMC10509736 | DOI:10.34172/bi.2022.24142
Source: BioImpacts - September 22, 2023 Category: Research Authors: Nahid Moradi Saeid Kaviani Mina Soufizomorrod Simzar Hosseinzadeh Masoud Soleimani Source Type: research
Chemo-immune cell therapy by intratumoral injection of adoptive NK cells with capecitabine in gastric cancer xenograft model
CONCLUSION: Although NK cell therapy could effectively decrease the mitotic count in vivo, the obtained findings indicated lesser potency than MC despite ex vivo activation. In order to enhance NK cell therapy effectiveness, suppressive features of the tumor microenvironment and inhibitory immune checkpoints blockade should be considered.PMID:37736341 | PMC:PMC10509737 | DOI:10.34172/bi.2022.26386
Source: BioImpacts - September 22, 2023 Category: Research Authors: Zeinab Ghazvinian Shahrokh Abdolahi Mohammad Ahmadvand Amir Hossein Emami Samad Muhammadnejad Hamid Asadzadeh Aghdaei Jafar Ai Mohammad Reza Zali Iman Seyhoun Javad Verdi Kaveh Baghaei Source Type: research
Vandetanib alters the tumoricidal capacity of human breast cancer stem cells via inhibiting vasculogenic capacity
CONCLUSION: Vandetanib suppressed vasculogenic mimicry (VM) networking through blunting stemness properties, coincided with suppression of VE-cadherin in CSCs.PMID:37736340 | PMC:PMC10509738 | DOI:10.34172/bi.2022.24208
Source: BioImpacts - September 22, 2023 Category: Research Authors: Sanya Haiaty Mohammad-Reza Rashidi Maryam Akbarzadeh Ahad Bazmany Mostafa Mostafazadeh Saba Nikanfar Roya Shabkhizan Rostam Rezaeian Reza Rahbarghazi Mohammad Nouri Source Type: research
Autophagy-induced mesenchymal stem cell-derived extracellular vesicles ameliorated renal fibrosis in an < em > in vitro < /em > model
CONCLUSION: Our findings suggest that AEVs can be considered as a therapeutic modality for renal fibrosis in the future.PMID:37736337 | PMC:PMC10509741 | DOI:10.34172/bi.2022.24256
Source: BioImpacts - September 22, 2023 Category: Research Authors: Behnaz Ahrabi Hojjat Allah Abbaszadeh Abbas Piryaei Faezeh Shekari Navid Ahmady Roozbahany Mahya Rouhollahi Forough Azam Sayahpour Mahnaz Ahrabi Hadi Azimi Reza Moghadasali Source Type: research
Autophagy induced macrophages by α-alumina(α-AL2O3) conjugated cysteine peptidase, enhances the cytotoxic activity of CD8 < sup > + < /sup > T lymphocytes against < em > Leishmania major < /em >
CONCLUSION: α-AL2O3 nanoparticles enhance the cross-presentation of L. major antigens to CD8+ T cells by inducing autophagy. This finding supports the positive role of autophagy and encourages the use of α-AL2O3 in vaccine design.PMID:37736336 | PMC:PMC10509742 | DOI:10.34172/bi.2023.25282
Source: BioImpacts - September 22, 2023 Category: Research Authors: Fatemeh Beyzay Ahmad Zavaran Hosseini Ali Hazrati Mozhdeh Karimi Sara Soudi Source Type: research
NKG2A discriminates natural killer cells with a suppressed phenotype in pediatric acute leukemia
In conclusion, high expression of NKG2A dominates NK cell phenotypes from pediatric BCP-ALL patients, indicating that NKG2A could be targeted in therapies for this patient group.PMID:37738462 | DOI:10.1093/jleuko/qiad112
Source: Journal of Leukocyte Biology - September 22, 2023 Category: Hematology Authors: Aina Ulvmoen Victor Greiff Anne G Bechensteen Marit Inngjerdingen Source Type: research
A H3K27M-targeted vaccine in adults with diffuse midline glioma
Nat Med. 2023 Sep 21. doi: 10.1038/s41591-023-02555-6. Online ahead of print.ABSTRACTSubstitution of lysine 27 to methionine in histone H3 (H3K27M) defines an aggressive subtype of diffuse glioma. Previous studies have shown that a H3K27M-specific long peptide vaccine (H3K27M-vac) induces mutation-specific immune responses that control H3K27M+ tumors in major histocompatibility complex-humanized mice. Here we describe a first-in-human treatment with H3K27M-vac of eight adult patients with progressive H3K27M+ diffuse midline glioma on a compassionate use basis. Five patients received H3K27M-vac combined with anti-PD-1 treat...
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Niklas Grassl Isabel Poschke Katharina Lindner Lukas Bunse Iris Mildenberger Tamara Boschert Kristine J ähne Edward W Green Ingrid H ülsmeyer Simone J ünger Tobias Kessler Abigail K Suwala Philipp Eisele Michael O Breckwoldt Peter Vajkoczy Oliver M Gra Source Type: research
Circ_0068481 affects the human pulmonary artery smooth muscle cells' progression by miR-361-3p/KLF5 axis
CONCLUSION: Circ_0068481 knockdown ameliorated hypoxia-induced hPASMC proliferation, invasion and migration at least in part through the miR-361-3p/KLF5 axis.PMID:37738301 | DOI:10.1093/ajh/hpad028
Source: American Journal of Hypertension - September 22, 2023 Category: Cardiology Authors: Hai-Rong Li Guan-Liang Chen Xiao-Li Fang Xing-Jiu Cai Rong-Li Xu Dong-Dong Li Zhi-Wei Zhang Source Type: research
