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MG53 does not mark cardiovascular risk and all-cause mortality in subjects with type 2 diabetes: a prospective, observational study
Subjects with type 2 diabetes (T2D) are characterized by a high cardiovascular morbidity and mortality. MG53, a marker of peripheral insulin resistance, has been linked with impaired β-cell function and decreased β-cell survival, and its circulating levels are increased in T2D. Its relationship with the cardiovascular risk profile and mortality in T2D is currently unknown.
Source: Diabetes Research and Clinical Practice - September 22, 2023 Category: Endocrinology Authors: Cristina Bianchi, Olga Vaccaro, Mariarosaria Distaso, Laura Franzini, Francesco Raggi, Anna Solini Source Type: research
A novel CAR-T cell product targeting CD74 is an effective therapeutic approach in preclinical mantle cell lymphoma models
ConclusionsTargeting CD74 with 74bbz CAR-T cells represents a new cell therapy to provide a potent and durable and anti-MCL activity.
Source: Experimental Hematology and Oncology - September 22, 2023 Category: Cancer & Oncology Source Type: research
Spinal Cord Compression from Widespread Extramedullary Hematopoiesis in Polycythemia Vera
Extramedullary hematopoiesis describes the proliferation of blood cells outside the bone marrow in the presence of predisposing hematological disorders, such as thalassemia, sickle cell anemia, polycythemia vera, and myelofibrosis. It usually occurs in sites related to hematopoiesis during fetal development and has rarely been reported in other locations. Since the first published report in 1958 by Close et al. 1, there have been a few reports of spinal cord compression due to extramedullary hematopoiesis in the spinal epidural space.
Source: The American Journal of Medicine - September 22, 2023 Category: General Medicine Authors: Adelaide Valluzzi, Julian S. Rechberger, Francesca Palandri, Davide Nasi, Giacomo Pavesi, Giorgio Palandri Tags: Clinical Communication to the Editor Source Type: research
Cell Therapy of Severe Ischemia in People with Diabetic Foot Ulcers —Do We Have Enough Evidence?
AbstractThis current opinion article critically evaluates the efficacy of autologous cell therapy (ACT) for chronic limb-threatening ischemia (CLTI), especially in people with diabetes who are not candidates for standard revascularization. This treatment approach has been used in ‘no-option’ CLTI in the last two decades and more than 1700 patients have received ACT worldwide. Here we analyze the level of published evidence of ACT as well as our experience with this treatment method. Many studies have shown that ACT is safe and an effective method for patients with the mo st severe lower limb ischemia. However, some tri...
Source: Molecular Diagnosis and Therapy - September 22, 2023 Category: Molecular Biology Source Type: research
Oxidative Stress and Potential Antioxidant Therapies in Vitiligo: A Narrative Review
AbstractVitiligo is a chronic skin disorder characterised by the loss of melanocytes and subsequent skin depigmentation. Although many theories have been proposed in the literature, none alone explains the pathogenesis of vitiligo. Oxidative stress has been identified as a potential factor in the pathogenesis of vitiligo. A growing body of evidence suggests that antioxidant therapies may offer a promising approach to managing this condition. This review summarises the potential mechanisms of oxidative stress and the types of melanocyte death in vitiligo. We also provide a brief overview of the most commonly studied antioxi...
Source: Molecular Diagnosis and Therapy - September 22, 2023 Category: Molecular Biology Source Type: research
TRIP13 overexpression in hepatocellular carcinoma: implications for poor prognosis and immune cell infiltration
ConclusionThese findings suggest that TRIP13 could be a potential prognostic biomarker for HCC.
Source: Hormones and Cancer - September 22, 2023 Category: Cancer & Oncology Source Type: research
Girl, 8, gets kidney transplant without need for life-long drugs in UK-first
The stem cell transplant performed at London's Great Ormond Street (Gosh), means the eight-year-old's body accepted the organ as her own, sparing her a lifetime of medication.
Source: the Mail online | Health - September 21, 2023 Category: Consumer Health News Source Type: news
Self-buckling and self-writhing of semi-flexible microorganisms
Soft Matter, 2023, Advance Article DOI: 10.1039/D3SM00572K, PaperWilson Lough, Douglas B. Weibel, Saverio E. Spagnolie Motility of multiflagellated cells requires a delicate balance between flagellar activity, geometry, and mechanical properties of the cell body. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Soft Matter latest articles - September 21, 2023 Category: Chemistry Authors: Wilson Lough Source Type: research
Piet Borst Wins a Lasker Award for Scientific Excellence
This year's Lasker~Koshland Award for Special Achievement was awarded to Piet Borst for his stellar work on cell organelles, trypanosomes, and cancer drug resistance.
Source: The Scientist - September 21, 2023 Category: Science Tags: News News & Opinion Source Type: news
Results from Human Clinical Trials Do Not Support Metformin as a Longevity Drug
The SENS Research Foundation staff have carried out the public service of extensively discussing and dismantling the evidence commonly cited in support of metformin as a way to modestly slow aging, showing that said evidence is problematic, to say the least. Metformin might make life modestly better for diabetics, but it doesn't slow aging. This view of the human data matches the poor quality of the animal model data, in which metformin makes a poor showing in comparison to the robust data for a modest slowing of aging that is produced by the use of, say, mTOR inhibitors, or the practice of calorie restriction.
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Source: Fight Aging! - September 21, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Hsa_circ_0102899 promotes epithelial –mesenchymal transition in non-small cell lung cancer
Conclusioncirc_0102899 promotes EMT and metastasis in NSCLC by regulating the miR-885-5p/EIF4G2 axis.
Source: Clinical and Translational Oncology - September 21, 2023 Category: Cancer & Oncology Source Type: research
ALDH2 activation attenuates oxygen –glucose deprivation/reoxygenation-induced cell apoptosis, pyroptosis, ferroptosis and autophagy
ConclusionsCollectively, our results implied that ALDH2 attenuated OGD/R-induced cell apoptosis, pyroptosis, ferroptosis and autophagy to promote cell viability in HT22 cells and mouse cortical neurons.
Source: Clinical and Translational Oncology - September 21, 2023 Category: Cancer & Oncology Source Type: research
AKAP12 promotes cancer stem cell-like phenotypes and activates STAT3 in colorectal cancer
ConclusionThis study suggests Colorectal CSCs overexpress AKAP12 and maintain stem cell characteristics through the
AKAP12/PKC/STAT3 pathway. AKAP12 may be an important therapeutic target for blocking the development of colorectal
cancer in the field of cancer stem cells.
Source: Clinical and Translational Oncology - September 21, 2023 Category: Cancer & Oncology Source Type: research
MTF1 has the potential as a diagnostic and prognostic marker for gastric cancer and is associated with good prognosis
ConclusionMTF1 is relatively lowly expressed in gastric cancer. MTF1 is also an independent prognostic factor for gastric cancer patients and is associated with good prognosis. It has the potential to be a diagnostic and prognostic marker for gastric cancer.
Source: Clinical and Translational Oncology - September 21, 2023 Category: Cancer & Oncology Source Type: research
Induction of perineural invasion in salivary adenoid cystic carcinoma by circular RNA RNF111
ConclusionTaken together, circ-RNF111 stimulates PNI in SACC by miR-361-5p/HMGB2 axis and may serve as a potential therapeutic target for SACC.
Source: Clinical and Translational Oncology - September 21, 2023 Category: Cancer & Oncology Source Type: research
