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Total 2042466 results found since Jan 2013.
Oncologic outcomes of segmentectomy versus lobectomy for clinical T1c radiological pure-solid non-small cell lung cancer
CONCLUSIONS: In T1c radiological pure-solid non-small cell lung cancer, segmentectomy was significantly associated with worse survival and insufficient loco-regional cancer control. Lobectomy remains the standard surgical treatment; meanwhile, segmentectomy should be applied with great caution.PMID:37738593 | DOI:10.1093/icvts/ivad152
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Aritoshi Hattori Kazuya Takamochi Takeshi Matsunaga Mariko Fukui Kenji Suzuki Source Type: research
Regulatory circuits of mitophagy restrict distinct modes of cell death during memory CD8 < sup > + < /sup > T cell formation
Sci Immunol. 2023 Sep 29;8(87):eadf7579. doi: 10.1126/sciimmunol.adf7579. Epub 2023 Sep 22.ABSTRACTMitophagy, a central process guarding mitochondrial quality, is commonly impaired in human diseases such as Parkinson's disease, but its impact in adaptive immunity remains unclear. The differentiation and survival of memory CD8+ T cells rely on oxidative metabolism, a process that requires robust mitochondrial quality control. Here, we found that Parkinson's disease patients have a reduced frequency of CD8+ memory T cells compared with healthy donors and failed to form memory T cells upon vaccination against COVID-19, highli...
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Fabien Franco Alessio Bevilacqua Ruey-Mei Wu Kung-Chi Kao Chun-Pu Lin Lor ène Rousseau Fu-Ti Peng Yu-Ming Chuang Jhan-Jie Peng Jaeoh Park Yingxi Xu Antonino Cassotta Yi-Ru Yu Daniel E Speiser Federica Sallusto Ping-Chih Ho Source Type: research
Peroxisomal ROS control cytosolic Mycobacterium tuberculosis replication in human macrophages
J Cell Biol. 2023 Dec 4;222(12):e202303066. doi: 10.1083/jcb.202303066. Epub 2023 Sep 22.ABSTRACTPeroxisomes are organelles involved in many metabolic processes including lipid metabolism, reactive oxygen species (ROS) turnover, and antimicrobial immune responses. However, the cellular mechanisms by which peroxisomes contribute to bacterial elimination in macrophages remain elusive. Here, we investigated peroxisome function in iPSC-derived human macrophages (iPSDM) during infection with Mycobacterium tuberculosis (Mtb). We discovered that Mtb-triggered peroxisome biogenesis requires the ESX-1 type 7 secretion system, criti...
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Enrica Pellegrino Beren Aylan Claudio Bussi Antony Fearns Elliott M Bernard Natalia Athanasiadi Pierre Santucci Laure Botella Maximiliano G Gutierrez Source Type: research
Harnessing Dendritic Cells: Next Frontier for Durable Immune Control in Myeloma
Clin Cancer Res. 2023 Sep 22:OF1-OF3. doi: 10.1158/1078-0432.CCR-23-2292. Online ahead of print.ABSTRACTImmune-based approaches including T-cell redirection have transformed the therapeutic landscape in myeloma. Injection of dendritic cells (DC) led to the induction of immune responses in vaccinated patients with myeloma. These studies pave the way for future combination strategies harnessing DCs to enhance tumor immunity and improve outcomes in myeloma. See related article by Freeman et al., p. 000.PMID:37737650 | DOI:10.1158/1078-0432.CCR-23-2292
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Madhav V Dhodapkar Source Type: research
Oncolytic virus oHSV2 combined with PD-1/PD-L1 inhibitors exert antitumor activity by mediating CD4 + T and CD8 + T cell infiltration in the lymphoma tumor microenvironment
Autoimmunity. 2023 Dec;56(1):2259126. doi: 10.1080/08916934.2023.2259126. Epub 2023 Sep 22.ABSTRACTA novel therapeutic regimen showed that the oncolytic type II herpes simplex virus (oHSV2) was able to prevent colorectal cancer growth, recurrence, and metastasis. However, no study has yet explored whether oHSV2 has an impact on the development of diffuse large B-cell lymphoma (DLBCL). We chose the clinical chemotherapeutic drug doxorubicin (DOX) as a positive control to evaluate the effect of oHSV2 infection on the apoptotic, invasive, and proliferative capacity of DLBCL cells. We next further explored the therapeutic effi...
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Jingbo Zhang Yiwei Guo Huiying Fang Xiuchen Guo Lina Zhao Source Type: research
Argon-helium knife cryoablation plus programmed cell death protein 1 inhibitor in the treatment of advanced soft tissue sarcomas: there is no evidence of the synergistic effects of this combination therapy
CONCLUSION: Cryoablation combined with PD-1 inhibitors in the therapy of advanced STS is safe and can effectively shrink the cryoablation-target lesion. However, there is no evidence of the synergistic effects of this combination therapy.PMID:37736543 | PMC:PMC10509548 | DOI:10.3389/fonc.2023.1185291
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Jiaqiang Wang Dengwei Zong Shuping Dong Shilei Gao Yonghao Yang Peng Zhang Xin Wang Weitao Yao Zhichao Tian Source Type: research
Evaluation of enhanced permeability effect and different linear energy transfer of radionuclides in a prostate cancer xenograft model
In conclusion, we found that specific targeting might negatively influence normal organ uptake when targeting secreted antigens. Furthermore, different energy deposition i.e. linear energy transfer of a radionuclide might have diverse effects on receptor expression and cell proliferation in tumors.PMID:37736493 | PMC:PMC10509292
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Oskar Vilhelmsson Timmermand Marcella Safi Bo Holmqvist Joanna Strand Source Type: research
Chemo-immune cell therapy by intratumoral injection of adoptive NK cells with capecitabine in gastric cancer xenograft model
CONCLUSION: Although NK cell therapy could effectively decrease the mitotic count in vivo, the obtained findings indicated lesser potency than MC despite ex vivo activation. In order to enhance NK cell therapy effectiveness, suppressive features of the tumor microenvironment and inhibitory immune checkpoints blockade should be considered.PMID:37736341 | PMC:PMC10509737 | DOI:10.34172/bi.2022.26386
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Zeinab Ghazvinian Shahrokh Abdolahi Mohammad Ahmadvand Amir Hossein Emami Samad Muhammadnejad Hamid Asadzadeh Aghdaei Jafar Ai Mohammad Reza Zali Iman Seyhoun Javad Verdi Kaveh Baghaei Source Type: research
Activity of pazopanib in < em > EWSR1-NFATC2 < /em > translocation-associated bone sarcoma
Oncoscience. 2023 Sep 20;10:44-53. doi: 10.18632/oncoscience.587. eCollection 2023.ABSTRACTPazopanib is a multi-kinase inhibitor that is currently approved for treatment of advanced renal cell carcinoma and chemotherapy-refractory soft tissue sarcoma. In this case report, we discuss the case of a patient with a EWSR1-NFATC2 fusion positive bone sarcoma who had exceptional tumor control through using pazopanib and surgery for an overall duration exceeding 5 years. We also review the literature on EWSR1-NFATC2 translocation-associated sarcomas and use of pazopanib in bone sarcomas.PMID:37736255 | PMC:PMC10511123 | DOI:10.18632/oncoscience.587
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Mohamed A Gouda Maria A Zarzour Ara A Vaporciyan Kalevi Kairemo Hubert H Chuang Vivek Subbiah Source Type: research
METTL5-mediated 18S rRNA m < sup > 6 < /sup > A modification promotes oncogenic mRNA translation and intrahepatic cholangiocarcinoma progression
Mol Ther. 2023 Sep 20:S1525-0016(23)00501-4. doi: 10.1016/j.ymthe.2023.09.014. Online ahead of print.ABSTRACTIntrahepatic cholangiocarcinoma (ICC) is a deadly cancer with rapid tumor progression. While hyperactive mRNA translation caused by mis-regulated mRNA or tRNA modifications promotes ICC development, the role of rRNA modifications remains elusive. Here, we found that 18S rRNA m6A modification and its methyltransferase METTL5 were aberrantly upregulated in ICC and associated with poorer survival (Log rank test, p<0.05). We further revealed the critical role of METTL5-mediated 18S rRNA m6A modification in regulation...
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Zihao Dai Wanjie Zhu Yingdong Hou Xinyue Zhang Xuxin Ren Kai Lei Junbin Liao Haining Liu Zhihang Chen Sui Peng Shaoqiang Li Shuibin Lin Ming Kuang Source Type: research
Survivin Dendritic Cell Vaccine Safely Induces Immune Responses and Is Associated with Durable Disease Control after Autologous Transplant in Patients with Myeloma
CONCLUSIONS: Two doses of DC:Ad-S, one given immediately before and another after ASCT, were feasible and safe. A high frequency of vaccine-specific immune responses was seen in combination with durable clinical outcomes, supporting ongoing investigation into the potential of this approach.PMID:37735756 | DOI:10.1158/1078-0432.CCR-22-3987
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Ciara L Freeman Reginald Atkins Indumathy Varadarajan Meghan Menges Jeffrey Edelman Rachid Baz Jason Brayer Omar Castaneda Puglianini Jose Leonel Ochoa-Bayona Taiga Nishihori Kenneth H Shain Bijal Shah Dung Tsa Chen Linda Kelley Domenico Coppola Melissa A Source Type: research
The long non-coding RNA BBOX1 antisense RNA 1 is upregulated in polycystic ovary syndrome (PCOS) and suppresses the role of microRNA-19b in the proliferation of ovarian granulose cells : Short title: BBOX1 antisense RNA 1 in cell proliferation
CONCLUSION: BBOX1-AS1 is highly upregulated in PCOS, and it may serve as an endogenous competing RNA for miR-19b to suppress its role in inhibiting granulosa cell proliferation. Our study suggested the role of BBOX1-AS1 as a potential target to treat PCOS.PMID:37735639 | DOI:10.1186/s12905-023-02632-5
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Zhi Zhou Yong Zhang Can Tan Juan Zhang Guohui Yi Bangbei Wang Yejuan Li Hui Lu Weiying Lu Xiaopo Zhang Source Type: research
Discrimination of cell-intrinsic and environment-dependent effects of natural genetic variation on Kupffer cell epigenomes and transcriptomes
Nat Immunol. 2023 Sep 21. doi: 10.1038/s41590-023-01631-w. Online ahead of print.ABSTRACTNoncoding genetic variation drives phenotypic diversity, but underlying mechanisms and affected cell types are incompletely understood. Here, investigation of effects of natural genetic variation on the epigenomes and transcriptomes of Kupffer cells derived from inbred mouse strains identified strain-specific environmental factors influencing Kupffer cell phenotypes, including leptin signaling in Kupffer cells from a steatohepatitis-resistant strain. Cell-autonomous and non-cell-autonomous effects of genetic variation were resolved by ...
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Hunter Bennett Ty D Troutman Enchen Zhou Nathanael J Spann Verena M Link Jason S Seidman Christian K Nickl Yohei Abe Mashito Sakai Martina P Pasillas Justin M Marlman Carlos Guzman Mojgan Hosseini Bernd Schnabl Christopher K Glass Source Type: research
ORM1 promotes tumor progression of kidney renal clear cell carcinoma (KIRC) through CALR-mediated apoptosis
This study provides us a new way to recognize the development and progression in KIRC.PMID:37735575 | DOI:10.1038/s41598-023-42962-w
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Gang Yu Juan Gao Weifeng Hu Dayong Hu Weibing Wang Shiquan Yang Jing Gao Source Type: research
Spatiotemporal, optogenetic control of gene expression in organoids
Nat Methods. 2023 Sep 21. doi: 10.1038/s41592-023-01986-w. Online ahead of print.ABSTRACTOrganoids derived from stem cells have become an increasingly important tool for studying human development and modeling disease. However, methods are still needed to control and study spatiotemporal patterns of gene expression in organoids. Here we combined optogenetics and gene perturbation technologies to activate or knock-down RNA of target genes in programmable spatiotemporal patterns. To illustrate the usefulness of our approach, we locally activated Sonic Hedgehog (SHH) signaling in an organoid model for human neurodevelopment. ...
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Ivano Legnini Lisa Emmenegger Alessandra Zappulo Agnieszka Rybak-Wolf Ricardo Wurmus Anna Oliveras Martinez Cledi Cerda Jara Anastasiya Boltengagen Tal é Hessler Guido Mastrobuoni Stefan Kempa Robert Zinzen Andrew Woehler Nikolaus Rajewsky Source Type: research
