This page shows you your search results in order of date. This is page number 12.
Order by Relevance | Date
Total 2042466 results found since Jan 2013.
Epigenetic targeting to enhance acute myeloid leukemia-directed immunotherapy
AML is a malignant disease of hematopoietic progenitor cells with unsatisfactory treatment outcome, especially in patients that are ineligible for intensive chemotherapy. Immunotherapy, comprising checkpoint inhibition, T-cell engaging antibody constructs, and cellular therapies, has dramatically improved the outcome of patients with solid tumors and lymphatic neoplasms. In AML, these approaches have been far less successful. Discussed reasons are the relatively low mutational burden of AML blasts and the difficulty in defining AML-specific antigens not expressed on hematopoietic progenitor cells. On the other hand, epigen...
Source: Frontiers in Immunology - September 22, 2023 Category: Allergy & Immunology Source Type: research
Type III interferon exerts thymic stromal lymphopoietin in mediating adaptive antiviral immune response
In conclusion, our review highlights the unique role of the IFN-III/TSLP axis in mediating host adaptive immunity, which is mechanically different from IFN-I. Therefore, the IFN-III/TSLP axis may provide novel insights for clinical immunotherapy.
Source: Frontiers in Immunology - September 22, 2023 Category: Allergy & Immunology Source Type: research
Extracellular vesicles as biomarkers for AIDS-associated non-Hodgkin lymphoma risk
In this study, we investigate the association of EVs bearing PD-L1 and molecules important in B-cell activation and differentiation with AIDS-NHL risk.MethodsEVs were isolated from archived serum collected prior to the diagnosis of AIDS-NHL in cases (N = 51) and matched HIV+ controls (N = 52) who were men enrolled in the Los Angeles site of the MACS/WIHS Combined Cohort Study (MWCCS). Serum specimens of AIDS-NHL cases were collected at a mean time of 1.25 years (range of 2 to 36 months) prior to an AIDS-NHL diagnosis. The expression of PD-L1 and other molecules on EVs (CD40, CD40L, TNF-RII, IL-6Rα, B7-H3, ICAM-1, and FasL...
Source: Frontiers in Immunology - September 22, 2023 Category: Allergy & Immunology Source Type: research
New insight into the role of fibroblasts in the epithelial immune microenvironment in the single-cell era
The skin is exposed to environmental challenges and contains heterogeneous cell populations such as epithelial cells, stromal cells, and skin-resident immune cells. As the most abundant type of stromal cells, fibroblasts have been historically considered silent observers in the immune responses of the cutaneous epithelial immune microenvironment (EIME), with little research conducted on their heterogeneity and immune-related functions. Single-cell RNA sequencing (scRNA-seq) and spatial transcriptomics (ST) have overcome the limitations of bulk RNA sequencing and help recognize the functional and spatial heterogeneity of fi...
Source: Frontiers in Immunology - September 22, 2023 Category: Allergy & Immunology Source Type: research
Identification of alternative splicing associated with clinical features: from pan-cancers to genitourinary tumors
ConclusionWe demonstrated the significant clinical relevance of ASEs in multiple cancer types. Furthermore, we identified and validated alternative splicing of TUBB3 and RNA binding proteins such as PCBP2 as critical regulators in the progression of urogenital cancers.
Source: Frontiers in Oncology - September 22, 2023 Category: Cancer & Oncology Source Type: research
Cordycepin, a bioactive compound from Cordyceps spp., moderates Alzheimer ’s disease-associated pathology via anti-oxidative stress and autophagy activation
.
Source: Journal of Asian Natural Products Research - September 22, 2023 Category: Complementary Medicine Authors: Natchadaporn SoraksaNudjanad HeebkaewWilasinee PromjantuekPhongsakorn KunhormPalakorn KaokeanNipha ChaicharoenaudomungParinya NoisaLaboratory of Cell-Based Assays and Innovations, School of Biotechnology, Institute of Agricultural Technology, Suranaree Un Source Type: research
Case Report: A rare case of non-small cell lung cancer with STRN-ALK fusion in a patient in very poor condition treated with first-line ensartinib
Several cases of STRN-ALK fusion have been reported, and some anaplastic lymphoma kinase (ALK) inhibitors have been shown to be effective for treatment. Nevertheless, no cases of COVID-19 leading to heart failure and respiratory failure have been reported in people older than 70 years treated with ALK inhibitors. The present case report describes a 70-year-old patient with usual chronic obstructive pulmonary disease, diabetes, depression, and carotid plaque disease. Next-generation sequencing of tissue obtained by puncture biopsy revealed a STRN-ALK mutation accompanied by a TP53 mutation. The patient was treated with ensa...
Source: Frontiers in Oncology - September 22, 2023 Category: Cancer & Oncology Source Type: research
Serum autoantibody profiling of oral squamous cell carcinoma patients reveals NUBP2 as a potential diagnostic marker
In conclusion, the differential serum autoantibodies identified in the current study, including those for NUBP2, could be used as potential biomarkers for early diagnosis or as screening biomarkers for OSCC pending investigation in a larger cohort.
Source: Frontiers in Oncology - September 22, 2023 Category: Cancer & Oncology Source Type: research
Updates in pathobiological aspects of anaplastic large cell lymphoma
Anaplastic large cell lymphomas (ALCL) encompass several distinct subtypes of mature T-cell neoplasms that are unified by the expression of CD30 and anaplastic cytomorphology. Identification of the cytogenetic abnormality t(2;5)(p23;q35) led to the subclassification of ALCLs into ALK+ ALCL and ALK- ALCL. According to the most recent World Health Organization (WHO) Classification of Haematolymphoid Tumours as well as the International Consensus Classification (ICC) of Mature Lymphoid Neoplasms, ALCLs encompass ALK+ ALCL, ALK- ALCL, and breast implant-associated ALCL (BI-ALCL). Approximately 80% of systemic ALCLs harbor rear...
Source: Frontiers in Oncology - September 22, 2023 Category: Cancer & Oncology Source Type: research
Choice of radiotherapy modality for the combined treatment of non-small cell lung cancer with brain metastases: whole-brain radiation therapy with simultaneous integrated boost or stereotactic radiosurgery
ConclusionIn the context of systemic drug therapy, WBRT+SIB may have better intracranial local control than SRS in NSCLC-BM patients.
Source: Frontiers in Oncology - September 22, 2023 Category: Cancer & Oncology Source Type: research
A nomogram based on the preoperative neutrophil-to-lymphocyte ratio to distinguish sarcomatoid renal cell carcinoma from clear cell renal cell carcinoma
ConclusionNLR is a potential indicator for preoperative differentiation of SRCC and CCRCC, and the predictive model constructed based on NLR has a good predictive ability. The new model could provide suggestions for the early identification of SRCC.
Source: Frontiers in Oncology - September 22, 2023 Category: Cancer & Oncology Source Type: research
Postoperative serum squamous cell carcinoma antigen and carcinoembryonic antigen predict overall survival in surgical patients with esophageal squamous cell carcinoma
ConclusionPostoperative serum SCC and CEA levels predict the overall survival of ESCC surgical patients. More importance should be attached to the use of these markers in clinical applications.
Source: Frontiers in Oncology - September 22, 2023 Category: Cancer & Oncology Source Type: research
Survival benefit with checkpoint inhibitors versus chemotherapy is modified by brain metastases in patients with recurrent small cell lung cancer
ConclusionCPI was associated with a lower risk of 1-year mortality compared to chemotherapy. However, the effect on OS was significantly modified by intracranial disease and radiotherapy, suggesting the benefit was driven by patients without BM.
Source: Frontiers in Oncology - September 22, 2023 Category: Cancer & Oncology Source Type: research
Cancers, Vol. 15, Pages 4681: Decanoic Acid Exerts Its Anti-Tumor Effects via Targeting c-Met Signaling Cascades in Hepatocellular Carcinoma Model
Kwang Seok Ahn
DA, one of the medium-chain fatty acids found in coconut oil, is suggested to have diverse biochemical functions. However, its possible role as a chemoprevention agent in HCC has not been deciphered. Aberrant activation of c-Met can modulate tumor growth and progression in HCC. Here, we report that DA exhibited pro-found anti-tumor effects on human HCC through the suppression of HGF/c-Met signaling cascades in vitro and in vivo. It was noted that DA inhibited HGF-induced activation of c-Met and its downstream signals. DA induced apoptotic cell death and inhibited the expression of diverse tumorigenic pr...
Source: Cancers - September 22, 2023 Category: Cancer & Oncology Authors: Min Hee Yang Mina Lee Amudha Deivasigamani Duc Dat Le Chakrabhavi Dhananjaya Mohan Kam Man Hui Gautam Sethi Kwang Seok Ahn Tags: Article Source Type: research
Cancers, Vol. 15, Pages 4679: Glucocorticoid Receptor Activation in Lobular Breast Cancer Is Associated with Reduced Cell Proliferation and Promotion of Metastases
Suzanne D. Conzen
Estrogen receptor-positive (ER+) invasive lobular breast cancer (ILC) comprises about ~15% of breast cancer. ILC’s unique genotypic (loss of wild type E-cadherin expression) and phenotypic (small individual round cancer cells that grow in discontinuous nests) are thought to contribute to a distinctive pattern of metastases to serosal membranes. Unlike invasive ductal carcinoma (IDC), ILC metastases often intercalate into the mesothelial layer of the peritoneum and other serosal surfaces. While ER activity is a known driver of ILC proliferation, very little is known about how additiona...
Source: Cancers - September 22, 2023 Category: Cancer & Oncology Authors: Baylee A. Porter Candace Frerich Muriel Lain é Abigail B. Clark Ishrat Durdana Jeon Lee Manisha Taya Sunati Sahoo Geoffrey L. Greene Lynda Bennett Suzanne D. Conzen Tags: Article Source Type: research
