This page shows you your search results in order of date. This is page number 11.
Order by Relevance | Date
Total 2042466 results found since Jan 2013.
M2 macrophage inhibits the antitumor effects of Lenvatinib on intrahepatic cholangiocarcinoma
ConclusionCompared with M1, M2 macrophages can inhibit the anti-tumor effect of Lenvatinib on cholangiocarcinoma through immune regulation, which may be related to the tumor angiogenesis factor effect of M2 macrophage.
Source: Frontiers in Immunology - September 22, 2023 Category: Allergy & Immunology Source Type: research
Flow cytometric analysis of innate lymphoid cells: challenges and solutions
DiscussionThe ILC population is heterogeneous and the strategies to identify ILCs have to be designed for each ILC population and tissue. Excluding T cells in all cases is crucial, and a combination of transcription factors GATA3, RORγt, T-bet, and Eomes should be used to identify ILCs. Using CD3ϵ/TCRs in a different fluorochrome not in Lin cocktail minimizes contamination of T cells specifically identify individual ILC populations in various tissues.
Source: Frontiers in Immunology - September 22, 2023 Category: Allergy & Immunology Source Type: research
Impact of BRAFV600E mutation on aggressiveness and outcomes in adult clonal histiocytosis
Histiocytoses encompass a wide spectrum of diseases, all characterized by tissue infiltration by CD68+ histiocytes. Most adult histiocytoses are considered clonal diseases because they highlight recurrent somatic mutations in the MAP-kinase pathway gene, primarily BRAF. The presence of BRAF mutation is associated with widespread disease in children with Langerhans cell histiocytosis (LCH) or cardiovascular/neurological involvement in Erdheim–Chester disease (ECD). Nevertheless, few data are available on adult clonal histiocytosis. This is why we have conducted a retrospective study of all patients with clonal histiocytos...
Source: Frontiers in Immunology - September 22, 2023 Category: Allergy & Immunology Source Type: research
Homologs of bacterial heat-labile enterotoxin subunit A contribute to development, stress response, and virulence in filamentous entomopathogenic fungus Beauveria bassiana
This study expands our understanding of the enterotoxin_A domain proteins in fungal physiology and deepens mechanisms involved in the lifestyle of fungal insect pathogens.
Source: Frontiers in Immunology - September 22, 2023 Category: Allergy & Immunology Source Type: research
Antigen-driven T cell-macrophage interactions mediate the interface between innate and adaptive immunity in histidyl-tRNA synthetase-induced myositis
DiscussionOverall, HRS-induced myositis reflects the complex interplay between multiple cell types that collectively drive a TH1-predominant, pro-inflammatory tissue phenotype requiring antigen-mediated activation of both MyD88- and TCR-dependent T cell signaling pathways.
Source: Frontiers in Immunology - September 22, 2023 Category: Allergy & Immunology Source Type: research
Attenuated IL-2 muteins leverage the TCR signal to enhance regulatory T cell homeostasis and response in vivo
Interleukin-2 (IL-2), along with T-cell receptor (TCR) signaling, are required to control regulatory T cell (Treg) homeostasis and function in vivo. Due to the heightened sensitivity to IL-2, Tregs retain the ability to respond to low-dose or attenuated forms of IL-2, as currently being developed for clinical use to treat inflammatory diseases. While attenuated IL-2 increases Treg selectivity, the question remains as to whether a weakened IL-2 signal sufficiently enhances Treg suppressive function(s) toward disease modification. To understand this question, we characterized the in vivo activity and transcriptomic profiles ...
Source: Frontiers in Immunology - September 22, 2023 Category: Allergy & Immunology Source Type: research
Clinical features and mutational analysis of X-linked agammaglobulinemia patients in Malaysia
ConclusionThis report provides the first overview of demographic, clinical, immunological and genetic data of XLA in Malaysia. The combination of flow cytometric assessment and BTK genetic analysis provides a definitive diagnosis for XLA patients, especially with atypical clinical presentation. In addition, it may also allow carrier detection and assist in genetic counselling and prenatal diagnosis.
Source: Frontiers in Immunology - September 22, 2023 Category: Allergy & Immunology Source Type: research
Genetic selection for reduced health treatment costs in Holstein cows: implications from a long-term study
The objective of this study was to estimate genetic parameters of health treatment cost of Holstein cows from producer-recorded health treatments in 8 herds over an 8-yr period of time. Genetic parameters of health treatment cost were estimated in first (n = 2,214), second (n = 1,487) and third (n = 800) parities of US Holstein cows. The health treatments were uniformly defined and consistently recorded by 8 high-performance dairy herds in Minnesota from 2008 to 2015. A fixed treatment cost was assigned to 14 types of health treatments, and the cost included the mean veterinary expense obtained from the veterinary clinics ...
Source: Frontiers in Genetics - September 22, 2023 Category: Genetics & Stem Cells Source Type: research
Genes, Vol. 14, Pages 1832: Radiogenomic Features of GIMAP Family Genes in Clear Cell Renal Cell Carcinoma: An Observational Study on CT Images
This study demonstrates CT imaging features of GIMAP expression in ccRCC. These results could allow the collection of data on GIMAP expression through a CT-approach and could be used for the development of a targeted therapy.
Source: Genes - September 22, 2023 Category: Genetics & Stem Cells Authors: Federico Greco Andrea Panunzio Alessandro Tafuri Caterina Bernetti Vincenzo Pagliarulo Bruno Beomonte Zobel Arnaldo Scardapane Carlo Augusto Mallio Tags: Article Source Type: research
Viruses, Vol. 15, Pages 1976: Extracellular Vesicles as a Translational Approach for the Treatment of COVID-19 Disease: An Updated Overview
a Di Domenico
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused a global pandemic in the years 2020–2022. With a high prevalence, an easy route of transmission, and a long incubation time, SARS-CoV-2 spread quickly and affected public health and socioeconomic conditions. Several points need to be elucidated about its mechanisms of infection, in particular, its capability to evade the immune system and escape from neutralizing antibodies. Extracellular vesicles (EVs) are phospholipid bilayer-delimited particles that are involved in cell-to-cell communication; they contain biological infor...
Source: Viruses - September 22, 2023 Category: Virology Authors: Enrica Serretiello Andrea Ballini Annafrancesca Smimmo Marina Acunzo Mariarosaria Raimo Stefania Cantore Marina Di Domenico Tags: Review Source Type: research
Viruses, Vol. 15, Pages 1975: Alterations in Patients & rsquo; Clinical Outcomes and Respiratory Viral Pathogen Activity following the COVID-19 Pandemic
Conclusions: We have demonstrated a reduction in the detection of several viruses, which might be due to the increase in public awareness toward infection protection measures after the COVID-19 pandemic.
Source: Viruses - September 22, 2023 Category: Virology Authors: Khaled Al Oweidat Ahmad A. Toubasi Ahmad Alghrabli Yasmeen Khater Noor Saleh Asma S. Albtoosh Rawan Shafeek Batarseh Tags: Article Source Type: research
Host microbiome in tuberculosis: disease, treatment, and immunity perspectives
Tuberculosis (TB), an airborne pulmonary disease caused by Mycobacterium tuberculosis (M. tb), poses an unprecedented health and economic burden to most of the developing countries. Treatment of TB requires prolonged use of a cocktail of antibiotics, which often manifest several side effects, including stomach upset, nausea, and loss of appetite spurring on treatment non-compliance and the emergence of antibiotic resistant M. tb. The anti-TB treatment regimen causes imbalances in the composition of autochthonous microbiota associated with the human body, which also contributes to major side effects. The microbiota residing...
Source: Frontiers in Microbiology - September 22, 2023 Category: Microbiology Source Type: research
Proteome level analysis of drug-resistant Prevotella melaninogenica for the identification of novel therapeutic candidates
In conclusion, our study reported novel drug and vaccine targets and designed a multi-epitope vaccine against the P. melaninogenica infection. Further experimental validation will help open new avenues in the treatment of this multi-drug-resistant pathogen.
Source: Frontiers in Microbiology - September 22, 2023 Category: Microbiology Source Type: research
A novel oncolytic virus-based biomarker participates in prognosis and tumor immune infiltration of glioma
ConclusionOur research uncovered a critical role of PTBP1 in outcomes and immune cell infiltration of glioma patients, particularly in those with LGG.
Source: Frontiers in Microbiology - September 22, 2023 Category: Microbiology Source Type: research
Editorial: Perspectives on the ultrastructure and cell biology of parasitic protists
Source: Frontiers in cellular and infection microbiology - September 22, 2023 Category: Microbiology Source Type: research
