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Patient Perspectives in Mantle Cell Lymphoma Clinical Research
Condition: Mantle Cell Lymphoma Intervention: Sponsor: Power Life Sciences Inc. Not yet recruiting
Source: ClinicalTrials.gov - September 22, 2023 Category: Research Source Type: clinical trials
Patients With Rheumatism Have Premature Immune System Aging Patients With Rheumatism Have Premature Immune System Aging
Researchers have studied how the T-cell aging process translates into metabolic reprogramming of the T-cells in patients with rheumatoid arthritis.Medscape Medical News
Source: Medscape Allergy Headlines - September 22, 2023 Category: Allergy & Immunology Tags: Rheumatology News Source Type: news
OHSRP Education Series-Considerations for Informed Consent in Cell and Gene Therapy Trials
Our speaker for this presentation is Daniel Kavanagh, PhD, RAC (Regulatory Affairs Certification). He is Senior Scientific Advisor, Gene Therapy, Vaccines, and Biologics at WCG where he serves as a scientific and regulatory lead for gene transfer research. Prior to joining WCG, he was Assistant Professor of Medicine at Harvard Medical School, and Vice Chair of the MGH-Brigham Institutional Biosafety Committee.
During this session, Dr. Kavanagh will address the following questions:• When a clinical trial involves gene therapy / human gene transfer research, what aspects of the informed consent process require special att...
Source: Videocast - All Events - September 22, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
PET/MR Imaging in Head and Neck Cancer
Head and neck squamous cell carcinoma (HNSCC) can either be examined with hybrid PET/MR imaging systems or sequentially, using PET/CT and MR imaging. Regardless of the acquisition technique, the superiority of MR imaging compared to CT lies in its potential to interrogate tumor and surrounding tissues with different sequences, including perfusion and diffusion. For this reason, PET/MR imaging is preferable for the detection and assessment of locoregional residual/recurrent HNSCC after therapy. In addition, MR imaging interpretation is facilitated when combined with PET. Nevertheless, distant metastases and distant second p...
Source: Magnetic Resonance Imaging Clinics of North America - September 22, 2023 Category: Radiology Authors: Minerva Becker, Claudio de Vito, Nicolas Dulguerov, Habib Zaidi Source Type: research
WellSky Acquires Experience Care to Enhance Long-Term Care Providers ’ Ability to Operate Efficiently, Advance Resident Care
Together, the Healthcare Technology Companies will Continue to Innovate and Strengthen Solutions that Position Organizations to Succeed Against Industry Challenges and Thrive in Value-Based Care
WellSky, a leading health and community care technology company, announced today that it has acquired Experience Care, an innovative technology company offering a suite of software solutions for post-acute and long-term care providers. With the addition of Experience Care, WellSky expands its commitment and investment in the long-term care market.
Experience Care has a proven track record with its leading electronic health record ...
Source: EMR and HIPAA - September 22, 2023 Category: Information Technology Authors: Healthcare IT News Tags: Health IT Company Healthcare IT Bill Miller Experience Care Gina Barrett Health IT Acquisitions Healthcare Growth Partners Healthcare M&A WellSky Source Type: blogs
The role of miR-139-5p in radioiodine-resistant thyroid cancer
ConclusionsOur study provides evidence of miR-139-5p involvement in iodine uptake metabolism and suggests its possible role as a therapeutic target in restoring iodine uptake in RAI-refractory DTC.
Source: Journal of Endocrinological Investigation - September 22, 2023 Category: Endocrinology Source Type: research
Ceruloplasmin regulating fibrosis in orbital fibroblasts provides a novel therapeutic target for Graves ’ orbitopathy
ConclusionCP was downregulated in GO and suppressed the expression of fibrosis-associated proteins in both GO and normal OFs. CP might serve as a promising therapeutic agent in the treatment regimens for GO.
Source: Journal of Endocrinological Investigation - September 22, 2023 Category: Endocrinology Source Type: research
Skin and gut microbial associations with squamous cell carcinoma in solid organ transplant recipients
AbstractSolid organ transplant recipients (SOTRs) are burdened with a significantly higher risk of squamous cell carcinoma (SCC) compared to the general population. Accumulating evidence suggests the potential influence of microbial dysbiosis on transplant outcomes. Based on these observations, we sought to identify differences in the cutaneous and gut microbiomes of SOTRs with and without a history of SCC. This case –control study collected and analyzed non-lesional skin and fecal samples of 20 SOTRs > 18 years old with either ≥ 4 diagnoses of SCC since most recent transplant (n = 10) or 0 diagnoses o...
Source: Archives of Dermatological Research - September 22, 2023 Category: Dermatology Source Type: research
Posaconazole and risk of cutaneous squamous cell carcinoma after lung transplantation: a single institution, retrospective cohort study
Source: Archives of Dermatological Research - September 22, 2023 Category: Dermatology Source Type: research
The Adaptation-Maladaptation Framework of Aging
While a great deal is known about the ways in which old tissues differ from young tissues, there remains considerable room to theorize on how exactly aging is caused and progresses. Which manifestations are causative, and which downstream consequences, which mechanisms are important, which are side-effects or diversions. Theories of aging abound, alongside frameworks intended to steer thinking about aging. We stand in the opening years of a new era of medicine, in which the first rejuvenation therapies exist or are under development, senolytics that can clear senescent cells, alongside reprogramming strategies and potentia...
Source: Fight Aging! - September 22, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
A Selection of Mechanisms Relevant to Atherosclerosis
Atherosclerosis is the growth of fatty lesions in blood vessel walls, leading eventually to a rupture and blockage to cause a heart attack or stroke, and along the way causing narrowing of blood vessels sufficient to lead to heart failure and dysfunction elsewhere in the body as the supply of blood to tissues is reduced. Today's paper on this topic is a little disorganized, something of a random assembly of thoughts on mechanisms relevant to the development of atherosclerosis. Atherosclerosis is the single largest cause of human mortality, and attempts to treat contributing mechanisms have so far not stopped it from being ...
Source: Fight Aging! - September 22, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Initial experience with an electron FLASH research extension (FLEX) for the Clinac system
CONCLUSION: Our studies characterized the non-clinical Clinac-FLEX system as a viable solution to conduct FLASH research that could substantially increase access to ultra-high-dose-rate capabilities for scientists.PMID:37735808 | DOI:10.1002/acm2.14159
Source: Journal of Applied Clinical Medical Physics - September 22, 2023 Category: Physics Authors: Kyuhak Oh Kyle J Gallagher Megan Hyun Diane Schott Sarah Wisnoskie Yu Lei Samuel Hendley Jeffrey Wong Shuo Wang Brendan Graff Christopher Jenkins Frank Rutar Md Ahmed Joshua McNeur Jeffrey Taylor Marty Schmidt Lasitha Senadheera Wendy Smith Donald Umstadt Source Type: research
Modeling unveils sex differences of signaling networks in mouse embryonic stem cells
Mol Syst Biol. 2023 Sep 21:e11510. doi: 10.15252/msb.202211510. Online ahead of print.ABSTRACTFor a short period during early development of mammalian embryos, both X chromosomes in females are active, before dosage compensation is ensured through X-chromosome inactivation. In female mouse embryonic stem cells (mESCs), which carry two active X chromosomes, increased X-dosage affects cell signaling and impairs differentiation. The underlying mechanisms, however, remain poorly understood. To dissect X-dosage effects on the signaling network in mESCs, we combine systematic perturbation experiments with mathematical modeling. ...
Source: Mol Biol Cell - September 22, 2023 Category: Molecular Biology Authors: Zeba Sultana Mathurin Dorel Bertram Klinger Anja Sieber Ilona Dunkel Nils Bl üthgen Edda G Schulz Source Type: research
Time-resolved cryo-EM (TR-EM) analysis of substrate polyubiquitination by the RING E3 anaphase-promoting complex/cyclosome (APC/C)
Nat Struct Mol Biol. 2023 Sep 21. doi: 10.1038/s41594-023-01105-5. Online ahead of print.ABSTRACTSubstrate polyubiquitination drives a myriad of cellular processes, including the cell cycle, apoptosis and immune responses. Polyubiquitination is highly dynamic, and obtaining mechanistic insight has thus far required artificially trapped structures to stabilize specific steps along the enzymatic process. So far, how any ubiquitin ligase builds a proteasomal degradation signal, which is canonically regarded as four or more ubiquitins, remains unclear. Here we present time-resolved cryogenic electron microscopy studies of the ...
Source: Mol Biol Cell - September 22, 2023 Category: Molecular Biology Authors: Tatyana Bodrug Kaeli A Welsh Derek L Bolhuis Ethan Paul аkonis Raquel C Martinez-Chacin Bei Liu Nicholas Pinkin Thomas Bonacci Liying Cui Pengning Xu Olivia Roscow Sascha Josef Amann Irina Grishkovskaya Michael J Emanuele Joseph S Harrison Joshua P Steim Source Type: research
PARylated PDHE1 α generates acetyl-CoA for local chromatin acetylation and DNA damage repair
Nat Struct Mol Biol. 2023 Sep 21. doi: 10.1038/s41594-023-01107-3. Online ahead of print.ABSTRACTChromatin relaxation is a prerequisite for the DNA repair machinery to access double-strand breaks (DSBs). Local histones around the DSBs then undergo prompt changes in acetylation status, but how the large demands of acetyl-CoA are met is unclear. Here, we report that pyruvate dehydrogenase 1α (PDHE1α) catalyzes pyruvate metabolism to rapidly provide acetyl-CoA in response to DNA damage. We show that PDHE1α is quickly recruited to chromatin in a polyADP-ribosylation-dependent manner, which drives acetyl-CoA generation to su...
Source: Mol Biol Cell - September 22, 2023 Category: Molecular Biology Authors: Jun Zhang Feng Chen Yuan Tian Wenchao Xu Qian Zhu Zhenhai Li Lingyu Qiu Xiaopeng Lu Bin Peng Xiangyu Liu Haiyun Gan Baohua Liu Xingzhi Xu Wei-Guo Zhu Source Type: research
