This page shows you your search results in order of date. This is page number 15.
Order by Relevance | Date
Total 2042466 results found since Jan 2013.
Conformal 3D computed tomography planned endoluminal brachytherapy for the local control of esophageal cancer
To outline the toxicity, tolerability, and efficacy of a 3D conformal computed tomography planned endoluminal brachytherapy (ELBT) treatment for esophageal adenocarcinoma (OAC) or squamous cell carcinoma (OSCC).
Source: Brachytherapy - September 22, 2023 Category: Cancer & Oncology Authors: Christopher M. Jones, Annabel Lyles, Peter Bownes, Rebecca Goody, Mohan Hingorani, Eldho Joseph, Ganesh Radhakrishna Source Type: research
Depletion of G9A attenuates imiquimod-induced psoriatic dermatitis via targeting EDAR-NF-κB signaling in keratinocyte
Cell Death & Disease, Published online: 22 September 2023; doi:10.1038/s41419-023-06134-yDepletion of G9A attenuates imiquimod-induced psoriatic dermatitis via targeting EDAR-NF-κB signaling in keratinocyte
Source: Cell death and disease - September 22, 2023 Category: Internal Medicine Authors: Zhiqin Fang Yutong Wang Bo Huang Xiang Chen Rundong Jiang Mingzhu Yin Source Type: research
Emerging significance and therapeutic targets of ferroptosis: a potential avenue for human kidney diseases
Cell Death & Disease, Published online: 22 September 2023; doi:10.1038/s41419-023-06144-wEmerging significance and therapeutic targets of ferroptosis: a potential avenue for human kidney diseases
Source: Cell death and disease - September 22, 2023 Category: Internal Medicine Authors: Jinghan Li Sujuan Zheng Yumei Fan Ke Tan Source Type: research
Musclin Mitigates the Attachment of HUVECs to THP-1 Monocytes in Hyperlipidemic Conditions through PPAR α/HO-1-Mediated Attenuation of Inflammation
This study aimed to explore the impact of musclin on inflammatory responses and the interaction between endothelial cells and monocytes under hyperlipidemic conditions. The attachment levels of THP-1 monocytes on cultured HUVECs were examined. Inflammation and the expression of cell adhesion molecules were also evaluated. To explore the molecular mechanisms of musclin, PPAR α or heme oxygenase 1 (HO-1) siRNA transfection was performed in HUVECs. The results revealed that treatment with recombinant musclin effectively suppressed the attachment of palmitate-induced HUVECs to THP-1 cells and reduced the expression of cell ad...
Source: Inflammation - September 22, 2023 Category: Allergy & Immunology Source Type: research
Prospective identification of variables as outcomes for treatment (PIVOT): study protocol for a randomised, placebo-controlled trial of hydroxyurea for Ghanaian children and adults with haemoglobin SC disease
DiscussionFor children and adults with HbSC disease, PIVOT will determine the safety of hydroxyurea and identify measurable changes in laboratory and clinical parameters, suitable for future prospective testing in a definitive multi-centre phase III clinical trial.Trial registrationPACTR, PACTR202108893981080. Registered 24 August 2021,https://pactr.samrc.ac.za
Source: Trials - September 22, 2023 Category: Research Source Type: clinical trials
Adipose-derived stem cells significantly increases collagen level and fiber maturity in patient-specific biological engineered blood vessels
by Bryan T. Wonski, Bijal Patel, Donna G. Tepper, Aamir Siddiqui, Loay S. Kabbani, Mai T. Lam
Tissue engineering has driven significant research in the strive to create a supply of tissues for patient treatment. Cell integration into engineered tissues maximizes functional capabilities, however, issues of rejection remain. Autologous cell sources able to solve this issue are difficult to i dentify for tissue engineering purposes. Here, we present the efficacy of patient-sourced cells derived from adipose (adipose-derived stem cells, ASCs) and skin tissue (dermal fibroblasts, PtFibs) to build a combined engineered tunica m...
Source: PLoS One - September 22, 2023 Category: Biomedical Science Authors: Bryan T. Wonski Source Type: research
Reciprocal regulation of TWIST1 and OGT determines the decitabine efficacy in MDS/AML
Chemoresistance poses a significant impediment to effective treatment strategies for myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). Our previous study unveiled that oncogene TWIST1 interacte...
Source: Cell Communication and Signaling - September 22, 2023 Category: Molecular Biology Authors: Hongjiao Li, Yi Wang, Shuang Feng, Kaijing Chang, Xinwen Yu, Fenfang Yang, Haozhe Huang, Yuanbo Wang, Xiang Li and Feng Guan Tags: Research Source Type: research
Abnormal outer hair cell efferent innervation in < i > Hoxb1 < /i > -dependent sensorineural hearing loss
In this study, we assessed whether the abnormal auditory threshold and malformation of the sensory auditory cells, the outer hair cells, described inHoxb1null mutants depend on the absence of efferent motor innervation, or alternatively, is due to altered sensory auditory components. By using a whole series of conditional mutant mice, which inactivateHoxb1 in either rhombomere 4-derived sensory cochlear neurons or efferent motor neurons, we found that the hearing phenotype is mainly reproduced when efferent motor neurons are specifically affected. Our data strongly suggest that the interactions between olivocochlear motor ...
Source: PLoS Genetics - September 22, 2023 Category: Genetics & Stem Cells Authors: Maria Di Bonito Source Type: research
Depletion of LONP2 unmasks differential requirements for peroxisomal function between cell types and in cholesterol metabolism
Peroxisomes play a central role in tuning metabolic and signaling programs in a tissue- and cell-type-specific manner. However, the mechanisms by which the status of peroxisomes is communicated and integrated ...
Source: Biology Direct - September 22, 2023 Category: Biology Authors: Akihiro Yamashita, Olesia Ignatenko, Mai Nguyen, Rapha ëlle Lambert, Kathleen Watt, Caroline Daneault, Isabelle Robillard-Frayne, Ivan Topisirovic, Christine Des Rosiers and Heidi M. McBride Tags: Research Source Type: research
Documentation of International Staging System (ISS) and Revised International Staging System (R-ISS) for Multiple Myeloma at a Tertiary Care Center: A Clinical Audit
In this study, we looked at the risk stratification done in our hospital setting among Newly diagnosed multiple myeloma patients (NDMM), and we noticed a time-based improvement in both ISS and R-ISS documentation, which reflects the evolution of better risk stratification of patients in clinical practice.
Source: Indian Journal of Clinical Biochemistry - September 22, 2023 Category: Biochemistry Source Type: research
SARS-CoV-2 egress from Vero cells: a morphological approach
This study aimed to shed light on the morphological features of SARS-CoV-2 egress by utilizing transmission and high-resolution scanning electron microscopy, along with serial electron tomography, to describe the route of nascent virions towards the extracellular medium. Electron microscopy revealed that the clusters of viruses in the paracellular space did not seem to result from collective virus release. Instead, virus accumulation was observed on incurved areas of the cell surface, with egress primarily occurring through individual vesicles. Additionally, our findings showed that the emission of long membrane projection...
Source: Histochemistry and Cell Biology - September 22, 2023 Category: Biomedical Science Source Type: research
A novel near-infrared EGFR targeting probe for metastatic lymph node imaging in preclinical mouse models
For the treatment of patients with oral squamous cell carcinoma (OSCC), the imaging of cervical lymph nodes and the evaluation of metastastic progression are of great significance. In recent years, the develop...
Source: Journal of Nanobiotechnology - September 22, 2023 Category: Nanotechnology Authors: Diya Xie, Yunlong Li, Jiahong Shi, Yao Ping Zhu, Yiqing Wang, Christopher J. Butch and Zhiyong Wang Tags: Research Source Type: research
BBB opening by low pulsed electric fields, depicted by delayed-contrast MRI, enables efficient delivery of therapeutic doxorubicin doses into mice brains
ConclusionsOur results demonstrate significant BBBo levels induced by extra-cranial L-PEFs, enabling efficient delivery of therapeutic Doxo doses into the brain and reducing tumor growth. As BBBo was undetectable by standard contrast-enhanced MRI, DCM was applied to generate maps depicting the BBBo levels throughout the brain. These findings suggest that BDF is a promising technology for efficient drug delivery into the brain with important implications for future treatment of brain cancer and additional CNS diseases.
Source: Fluids and Barriers of the CNS - September 22, 2023 Category: Neuroscience Source Type: research
A multicenter randomized, controlled clinical trial of adjuvant sintilimab for esophageal squamous cell carcinoma
Future Oncology, Ahead of Print.
Source: Future Oncology - September 22, 2023 Category: Cancer & Oncology Authors: Hai-Bo Sun Wen-Qun Xing Xian-Ben Liu Shu-Jun Yang Pei-Nan Chen Shi-Lei Liu Peng Li Ya-Xing Ma Duo Jiang Sen Yan Source Type: research
Circadian entrainment to red-light Zeitgebers and action spectrum for entrainment in the jewel wasp Nasonia vitripennis
In this study, we investigated the possibility ofNasonia circadian light entrainment under long-wavelength red LED light –dark cycles and characterized the strength of red light as a potentialZeitgeber. Additionally, we measured the possibility of entrainment under various light intensities (from 5 ·1012 to 4 ·1015 photons ·cm−2·s−1) and a broader range of wavelengths (455 —656 nm) to construct corresponding action spectra for characterizing all circadian photoreceptors involved in photic entrainment. We also conducted electroretinogram (ERG) recordings for each wavelength in the compound eyes. Our findings dem...
Source: Journal of Comparative Physiology A: Neuroethology, Sensory, Neural, and Behavioral Physiology - September 22, 2023 Category: Physiology Source Type: research
