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Non-chemical signalling between mitochondria
A wide variety of studies have reported some form of non-chemical or non-aqueous communication between physically isolated organisms, eliciting changes in cellular proliferation, morphology, and/or metabolism. The sources and mechanisms of such signalling pathways are still unknown, but have been postulated to involve vibration, volatile transmission, or light through the phenomenon of ultraweak photon emission. Here, we report non-chemical communication between isolated mitochondria from MCF7 (cancer) and MCF10A (non-cancer) cell lines. We found that mitochondria in one cuvette stressed by an electron transport chain inhi...
Source: Frontiers in Physiology - September 22, 2023 Category: Physiology Source Type: research

Increased vitamin B12 levels in patients with oral cancer
Conclusion: Our study found increased vitamin B12 levels in OC patients, and it was statistically significant.
Source: Indian Journal of Dental Research - September 22, 2023 Category: Dentistry Authors: Prashant Gupta Subhash Chandra Awanindra Kumar Jha Tanya Khaitan Anjani Kumar Shukla Shantala R Naik Source Type: research

Imaging findings of granular cell tumours of the head and neck
To review the imaging characteristics of granular cell tumours in the head and neck and assess their associations with pathological findings.
Source: Clinical Radiology - September 22, 2023 Category: Radiology Authors: H.H. Moon, K. Jin, Y.J. Choi, K.-J. Cho, Y.S. Lee, J.H. Lee Source Type: research

Human pelvis injury risk curves from underbody blast impact
Conclusions This is the first study to develop axial and resultant force-based HIPCs defining human tolerance to injuries to the pelvis from vertical impacts using parametric survival analysis. Data can be used to advance military safety under vertical loading to the seated pelvis.
Source: Journal of the Royal Army Medical Corps - September 22, 2023 Category: General Medicine Authors: Yoganandan, N., Moore, J., Humm, J. R., Baisden, J. L., Banerjee, A., Pintar, F. A., Barnes, D. R., Loftis, K. L. Tags: Original research Source Type: research

In vivo self-assembly and delivery of VEGFR2 siRNA-encapsulated small extracellular vesicles for lung metastatic osteosarcoma therapy
Cell Death & Disease, Published online: 22 September 2023; doi:10.1038/s41419-023-06159-3In vivo self-assembly and delivery of VEGFR2 siRNA-encapsulated small extracellular vesicles for lung metastatic osteosarcoma therapy
Source: Cell death and disease - September 22, 2023 Category: Internal Medicine Authors: Lingfeng Yu Gentao Fan Qingyan Wang Yan Zhu Hao Zhu Jiang Chang Zhen Wang Shoubin Zhan Xianming Hua Diankun She Jianhao Huang Yicun Wang Jianning Zhao Chen-Yu Zhang Xi Chen Guangxin Zhou Source Type: research

Mitochondrial IRG1 traps MCL-1 to induce hepatocyte apoptosis and promote carcinogenesis
Cell Death & Disease, Published online: 22 September 2023; doi:10.1038/s41419-023-06155-7Mitochondrial IRG1 traps MCL-1 to induce hepatocyte apoptosis and promote carcinogenesis
Source: Cell death and disease - September 22, 2023 Category: Internal Medicine Authors: Liyuan Zhang Yue Dong Luxin Zhang Minjun Wang Ye Zhou Kaiwei Jia Suyuan Wang Mu Wang Yunhui Li Shudan Luo Shan Lu Yiwen Fan Dingji Zhang Yingyun Yang Nan Li Yizhi Yu Xuetao Cao Jin Hou Source Type: research

Methylation of BRD4 by PRMT1 regulates BRD4 phosphorylation and promotes ovarian cancer invasion
Cell Death & Disease, Published online: 22 September 2023; doi:10.1038/s41419-023-06149-5Methylation of BRD4 by PRMT1 regulates BRD4 phosphorylation and promotes ovarian cancer invasion
Source: Cell death and disease - September 22, 2023 Category: Internal Medicine Authors: Yi Liu Hejing Liu Miaomiao Ye Mengying Jiang Xin Chen Gendi Song Huihui Ji Zhi-wei Wang Xueqiong Zhu Source Type: research

Genomic view of the origins of cell-mediated immunity
AbstractNKp30 is an activating natural killer cell receptor (NKR) with a single-exon variable (VJ) –type immunoglobulin superfamily (IgSF) domain. Such VJ-IgSF domains predate the emergence of the antigen receptors (immunoglobulin and T cell receptor), which possess the same domain but undergo gene rearrangement.NCR3, the gene encoding NKp30, is present in jawed vertebrates from sharks to mammals; thus, unlike most NKR that are highly divergent among vertebrate taxa, NKp30 is uniquely conserved. We previously hypothesized that an ancestralNCR3 gene was encoded in the proto-major histocompatibility complex (MHC), the reg...
Source: Immunogenetics - September 22, 2023 Category: Genetics & Stem Cells Source Type: research

Molecules, Vol. 28, Pages 6768: Massive Solubility Changes in Neuronal Proteins upon Simulated Traumatic Brain Injury Reveal the Role of Shockwaves in Irreversible Damage
This study shows a way of developing a proteome-based meter for measuring irreversible shockwave-induced cell damage and provides a resource for identifying protein biomarkers of TBIs and potential drug targets for the development of products aimed at primary prevention and intervention.
Source: Molecules - September 22, 2023 Category: Chemistry Authors: Amir Ata Saei Hassan Gharibi Hezheng Lyu Brady Nilsson Maryam Jafari Hans Von Von Holst Roman A. Zubarev Tags: Article Source Type: research

“Buprenorphine, It Works so Differently”: Adults with Sickle Cell Disease Describe Transitioning to Buprenorphine for Treatment of Chronic Pain
A growing body of literature describes the use of buprenorphine for the treatment of chronic pain in people with sickle cell disease. The experiences of people with sickle cell disease who have tried buprenorphine are not yet reported. This qualitative descriptive study was conducted to explore perspectives on buprenorphine for chronic pain in sickle cell disease. We interviewed 13 participants with sickle cell disease who had been prescribed buprenorphine and had a clinic visit between December 1, 2020 and April, 2022 in our Sickle Cell Center for Adults.
Source: The Journal of Pain - September 22, 2023 Category: Materials Science Authors: Elizabeth Prince, Paul Loeser, Macy Early, C. Patrick Carroll, Sophie Lanzkron, Lydia H. Pecker Source Type: research

Molecules, Vol. 28, Pages 6769: Revealing the Control Mechanisms of pH on the Solution Properties of Chitin via Single-Molecule Studies
Zheng Lu Qian Chitin is one of the most common polysaccharides and is abundant in the cell walls of fungi and the shells of insects and aquatic organisms as a skeleton. The mechanism of how chitin responds to pH is essential to the precise control of brewing and the design of smart chitin materials. However, this molecular mechanism remains a mystery. Results from single-molecule studies, including single-molecule force spectroscopy (SMFS), AFM imaging, and molecular dynamic (MD) simulations, have shown that the mechanical and conformational behaviors of chitin molecules show surprising pH responsiveness. This can be...
Source: Molecules - September 22, 2023 Category: Chemistry Authors: Song Zhang Miao Yu Guoqiang Zhang Guanmei He Yunxu Ji Juan Dong Huayan Zheng Lu Qian Tags: Article Source Type: research

Regenerative Surgery: Is This an Independent Field of Health Sciences or Only a Semantic Exercise?
AbstractPurpose of ReviewThis manuscript aims at contextualizing the termregenerative surgery, whose recent introduction in the medical jargon has generated some confusion on both its significance and interplay with its synonymousregenerative medicine.Recent FindingsThe manuscript will illustrate the worldwide experience relative to the development ofregenerative surgery–related technologies, as they may be applied and be of interest to transplant medicine. Only few centers have invested in these technologies, the most relevant of which is cell on scaffold seeding technologies whereby cells, ideally isolated from the pat...
Source: Current Transplantation Reports - September 22, 2023 Category: Transplant Surgery Source Type: research

Investigation of the effects of phthalates on in vitro thyroid models with RNA-Seq and ATAC-Seq
DiscussionWith this work, we showed that despite having only a few differentially expressed genes, diverse analysis methods could be applied to retrieve relevant information on phthalates, showing the potential of in vitro thyroid-relevant systems for the analysis of endocrine disruptors.
Source: Frontiers in Endocrinology - September 22, 2023 Category: Endocrinology Source Type: research

Genes, Vol. 14, Pages 1838: Whole-Exome Sequencing of 24 Spanish Families: Candidate Genes for Non-Syndromic Pediatric Keratoconus
Irene Rosa-Pérez Juan Carlos Acal Joana Blasco Marta Naranjo-Castresana Beatriz Ruz-Caracuel Victoria E. F. Montaño Cristina Ortega Patrón M. Esther Rubio-Martín Laura García-Fernández Emi Rikeros-Orozco María de Los Ángeles Gómez-Cano Luna Delgado-Mora Susana Noval Elena Vallespín Keratoconus is a corneal dystrophy that is one of the main causes of corneal transplantation and for which there is currently no effective treatment for all patients. The presentation of this disease in pediatric age is associated with rapid progression, a worse prognosis and, in 15–20% of ...
Source: Genes - September 22, 2023 Category: Genetics & Stem Cells Authors: Carmen Gonz ález-Atienza Elo ísa Sánchez-Cazorla Natalia Villoldo-Fern ández Almudena del Hierro Ana Boto Marta Guerrero-Carretero Mar ía Nieves-Moreno Natalia Arruti Patricia Rodr íguez-Solana Roc ío Mena Carmen Rodr íguez-Jiménez Irene Rosa-P Tags: Article Source Type: research

The Effects of Human Papillomavirus Status and Treatment on the Positive Predictive Value of Post-radiotherapy 18F-Fluorodeoxyglucose Positron Emission Tomography-Computed Tomography in Advanced Head and Neck Squamous Cell Carcinoma
The high negative predictive value of post-chemoradiation (CRT) positron emission tomography-computed tomography (PET-CT) is well established in head and neck squamous cell cancers (HNSCC). The positive predictive value (PPV) remains under scrutiny, with increasing evidence that it is affected by several factors. The aim of this study was to assess the PPV of post-treatment PET-CT for residual nodal disease when stratified by treatment modality and tumour human papillomavirus (HPV) status.
Source: Clinical Oncology - September 22, 2023 Category: Radiology Authors: S. Zhou, C. Chan, Y.C. Lau, R. Rulach, H. Dyab, F. Hendry, C. Wilson, S. Schipani, C. Lamb, D. Grose, A. James, C. Maxfield, M.-F. Dempsey, C. Paterson Tags: Original Article Source Type: research