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Condition: Obesity
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Improvements in dietary intake, behaviors, and psychosocial measures in a community-randomized cardiovascular disease risk reduction intervention: Strong Hearts, Healthy Communities 2.0
CONCLUSIONS: SHHC-2.0 has strong potential to improve diet patterns and diet-related psychosocial wellbeing consistent with improved cardiovascular health. Registered at www.CLINICALTRIALS: gov on 23 February 2017 (NCT03059472).PMID:37717638 | DOI:10.1016/j.ajcnut.2023.09.003
Source: Am J Clin Nutr - September 17, 2023 Category: Nutrition Authors: Alexandra L MacMillan Uribe Margaret Demment Meredith L Graham Jacob Szeszulski Chad D Rethorst Phrashiah Githinji Miriam E Nelson David Strogatz Sara C Folta Regan L Bailey Jaimie N Davis Rebecca A Seguin-Fowler Source Type: research
Signaling mechanism of growth hormone-releasing hormone receptor
Vitam Horm. 2023;123:1-26. doi: 10.1016/bs.vh.2023.06.004. Epub 2023 Jul 7.ABSTRACTThe hypothalamic peptide growth hormone-releasing hormone (GHRH) stimulates the secretion of growth hormone (GH) from the pituitary through binding and activation of the pituitary type of GHRH receptor (GHRH-R), which belongs to the family of G protein-coupled receptors with seven potential membrane-spanning domains. Splice variants of GHRH-Rs (SV) in human tumors and other extra pituitary tissues were identified and their cDNA was sequenced. Among the SVs, splice variant 1 (SV1) possesses the greatest similarity to the full-length GHRH-R an...
Source: Vitamins and Hormones - September 17, 2023 Category: Endocrinology Authors: Gabor Halmos Zsuzsanna Szabo Eva Juhasz Andrew V Schally Source Type: research
Impact of diet modification on body mass and kidney function in patients with diabetic nephropathy: a pilot study
CONCLUSIONS: The study shows that obesity is a common comorbid disease in patients with DN and that dietary intervention is associated with a significant reduction in body mass and stabilization of eGFR in these patients.PMID:37717272 | DOI:10.18388/abp.2020_6889
Source: Acta Biochim Pol - September 17, 2023 Category: Biochemistry Authors: Ma łgorzata Kaczkan Sylwia Czaja-Stolc Ma łgorzata Sikorska-Wiśniewska Micha ł Chmielewski Alicja D ębska-Ślizień Sylwia Ma łgorzewicz Source Type: research
Improvements in dietary intake, behaviors, and psychosocial measures in a community-randomized cardiovascular disease risk reduction intervention: Strong Hearts, Healthy Communities 2.0
CONCLUSIONS: SHHC-2.0 has strong potential to improve diet patterns and diet-related psychosocial wellbeing consistent with improved cardiovascular health. Registered at www.CLINICALTRIALS: gov on 23 February 2017 (NCT03059472).PMID:37717638 | DOI:10.1016/j.ajcnut.2023.09.003
Source: The American Journal of Clinical Nutrition - September 17, 2023 Category: Nutrition Authors: Alexandra L MacMillan Uribe Margaret Demment Meredith L Graham Jacob Szeszulski Chad D Rethorst Phrashiah Githinji Miriam E Nelson David Strogatz Sara C Folta Regan L Bailey Jaimie N Davis Rebecca A Seguin-Fowler Source Type: research
Signaling mechanism of growth hormone-releasing hormone receptor
Vitam Horm. 2023;123:1-26. doi: 10.1016/bs.vh.2023.06.004. Epub 2023 Jul 7.ABSTRACTThe hypothalamic peptide growth hormone-releasing hormone (GHRH) stimulates the secretion of growth hormone (GH) from the pituitary through binding and activation of the pituitary type of GHRH receptor (GHRH-R), which belongs to the family of G protein-coupled receptors with seven potential membrane-spanning domains. Splice variants of GHRH-Rs (SV) in human tumors and other extra pituitary tissues were identified and their cDNA was sequenced. Among the SVs, splice variant 1 (SV1) possesses the greatest similarity to the full-length GHRH-R an...
Source: Vitamins and Hormones - September 17, 2023 Category: Endocrinology Authors: Gabor Halmos Zsuzsanna Szabo Eva Juhasz Andrew V Schally Source Type: research
The discovery of the natural compound Boeravinone-C as a potential antiobesity drug candidate targeting pancreatic lipase using chemo-informatics-based approaches
Cell Mol Biol (Noisy-le-grand). 2023 Jul 31;69(7):57-65. doi: 10.14715/cmb/2023.69.7.10.ABSTRACTObesity is a metabolic disorder distinguished by excess fat deposition in fatty tissues. Pancreatic lipase is one of the promising drug targets for treating obesity due to its critical role in the hydrolysis of triglycerides into mono-glycerides and free fatty acids. Due to unsatisfactory results and severe side effects of the current drugs available for treating obesity, there is an urgent need to identify novel therapeutic options. Boerhaavia diffusa is one of the widely known species of flowering plant commonly known as Punam...
Source: Molecular Medicine - September 16, 2023 Category: Molecular Biology Authors: Aziz Unnisa Sirajuddin Anwar Chettupalli Ananda K Nasrin E Khalifa Weam M A Khojali Mhdia E Osman Kareem M Younes Amr S Abouzied Suresh B Jandrajupalli Swarnalatha Chandolu Source Type: research
Pancreastatin inhibitor PSTi8 ameliorates insulin resistance by decreasing fat accumulation and oxidative stress in high-fat diet-fed mice
Amino Acids. 2023 Sep 16. doi: 10.1007/s00726-023-03332-y. Online ahead of print.ABSTRACTAbnormal fat accumulation, enhanced free fatty acids (FFA) release, and their metabolites cause insulin resistance (IR) in major glucose-lipid metabolic organs such as skeletal muscle and adipose tissue. However, excessive lipolysis and FFA release from adipose tissue elevate plasma FFA levels leading to oxidative stress and skeletal muscle IR. Indeed, in obese individuals, there is enhanced pro-inflammatory secretion from adipose tissue influencing insulin signaling in skeletal muscles. Here, we investigated the effect of PSTi8 on FFA...
Source: Amino Acids - September 16, 2023 Category: Biochemistry Authors: Richa Garg Arun Agarwal Roshan Katekar Umesh Kumar Goand Naveen Singh Shubhi Yadav Shivam Rathaur Saurabh Verma Debalina Maity Sachin Vishwakarma Jiaur R Gayen Source Type: research
Comparison of various prediction models in the effect of Roux-en-Y gastric bypass on type 2 diabetes in the Chinese population 5 years after surgery
CONCLUSIONS: T2D was relieved to varying degrees 5 years after RYGB in patients with obesity. The prediction models in ABCD and the Panuzi et al. [34] studies showed the best prediction effects. ABCD was recommended for clinical use because of excellent predictive performance, good statistical test results, and simple and practical design features.PMID:37716844 | DOI:10.1016/j.soard.2023.05.012
Source: Surgery for Obesity and Related Diseases : official journal of the American Society for Bariatric Surgery - September 16, 2023 Category: Surgery Authors: Chengyuan Yu Zheng Wang Qiqige Wuyun Weijian Chen Zhehong Li Mingyue Shang Nengwei Zhang Source Type: research
Long-term incidence of haematological cancer after bariatric surgery or usual care in the Swedish Obese Subjects study: a prospective cohort study
This study is registered with ClinicalTrials.gov (NCT01479452) and is ongoing.FINDINGS: A total of 4047 individuals with obesity were enrolled between Sept 1, 1987, and Jan 31, 2001. Overall, 34 participants in the surgery group and 51 participants in the usual care control group were diagnosed with haematological cancer during follow-up (hazard ratio [HR] 0·60; 95% CI 0·39-0·92; p=0·020). Moreover, there were three deaths by haematological cancer in the surgery group and 13 deaths in the control group (0·22; 0·06-0·76; p=0·017). Surgery was also associated with a reduced incidence of lymphoma (0·45; 0·23-0·88; ...
Source: Cancer Control - September 16, 2023 Category: Cancer & Oncology Authors: Kajsa Sj öholm Johanna C Andersson-Assarsson Felipe M Kristensson Stephan Hjorth Hege Gravdahl Garelius Peter Jacobson Per-Arne Svensson Sofie Ahlin Bj örn Carlsson Markku Peltonen Lena M S Carlsson Magdalena Taube Source Type: research
The role of macrophages in polycystic ovarian syndrome and its typical pathological features: A narrative review
Biomed Pharmacother. 2023 Sep 14;167:115470. doi: 10.1016/j.biopha.2023.115470. Online ahead of print.ABSTRACTPolycystic ovarian syndrome (PCOS) is the most common endocrine and metabolic disorder in women of childbearing age, with ovulatory dysfunction, hyperandrogenism, and polycystic ovarian morphology (PCOM) as the clinical features. Androgen excess, insulin resistance, obesity, adipose tissue dysfunction, ovulatory dysfunction, and gut microbiota dysbiosis are the main pathological features and pathogenesis of PCOS and are related to systemic chronic low-grade inflammation and chronic ovarian tissue inflammation in PC...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 16, 2023 Category: Drugs & Pharmacology Authors: Yuanyuan Feng Zhijing Tang Wei Zhang Source Type: research
Trade liberalization and nutrition transition: Evidence from China
Econ Hum Biol. 2023 Sep 9;51:101304. doi: 10.1016/j.ehb.2023.101304. Online ahead of print.ABSTRACTWe examine the impact of trade liberalization on the nutrition transition between 1997 and 2011. Our findings demonstrate that the reduction in tariff rates has had a significant effect on the dietary patterns of both rural and urban residents in the country. With the decrease in tariffs, there has been a noticeable increase in the consumption of animal products (such as meat and aquatic products), vegetables, beans and nuts, as well as packaged and processed foods. Simultaneously, there has been a decrease in the demand for ...
Source: Economics and Human Biology - September 16, 2023 Category: Biology Authors: Xu Tian Faqin Lin Source Type: research
The discovery of the natural compound Boeravinone-C as a potential antiobesity drug candidate targeting pancreatic lipase using chemo-informatics-based approaches
Cell Mol Biol (Noisy-le-grand). 2023 Jul 31;69(7):57-65. doi: 10.14715/cmb/2023.69.7.10.ABSTRACTObesity is a metabolic disorder distinguished by excess fat deposition in fatty tissues. Pancreatic lipase is one of the promising drug targets for treating obesity due to its critical role in the hydrolysis of triglycerides into mono-glycerides and free fatty acids. Due to unsatisfactory results and severe side effects of the current drugs available for treating obesity, there is an urgent need to identify novel therapeutic options. Boerhaavia diffusa is one of the widely known species of flowering plant commonly known as Punam...
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Aziz Unnisa Sirajuddin Anwar Chettupalli Ananda K Nasrin E Khalifa Weam M A Khojali Mhdia E Osman Kareem M Younes Amr S Abouzied Suresh B Jandrajupalli Swarnalatha Chandolu Source Type: research
