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Condition: Obesity
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Total 71740 results found since Jan 2013.
Recent Secular Trends of Body Mass Index in Individuals With Bipolar Disorders and in the General Population
CONCLUSIONS: Adults with bipolar disorders had a higher BMI and a higher prevalence of obesity than the general population, indicating a higher cardiometabolic risk. Annually, BMI increased more in the group with bipolar disorders than in the general population, particularly among women and among those with high BMI.PMID:37727097 | DOI:10.1176/appi.ajp.20230012
Source: The American Journal of Psychiatry - September 20, 2023 Category: Psychiatry Authors: Hemen Najar Erik Joas Viktor Jonsson Erik P ålsson Mikael Land én Source Type: research
Cancer Prevention and Early Detection: A Changing Field With an Unchanging Goal
Clin J Oncol Nurs. 2023 Sep 15;27(5):457-458. doi: 10.1188/23.CJON.457-458.ABSTRACTModifiable risk factors such as tobacco and alcohol use, obesity, sun exposure, and infections account for 40%-50% of all new cancer diagnoses and all cancer deaths in the United States (American Cancer Society [ACS], 2023).PMID:37729455 | DOI:10.1188/23.CJON.457-458
Source: Clinical Journal of Oncology Nursing - September 20, 2023 Category: Nursing Authors: Joni Watson Source Type: research
Novel homozygous leptin receptor mutation in an infant with monogenic obesity
We report the case of a 12-month-old male infant born of a non-consanguineous marriage. He presented to us with rapid weight gain from 2 months of age along with hyperphagia. Biochemistry revealed a deranged lipid profile, elevated transaminases, and markedly raised serum leptin levels. On genetic analysis, a novel mutation was detected, which was a homozygous variation In exon 12 of the LEPR gene (chr1:g.65608901G>A) that resulted in the synonymous amino acid change of lysine at codon 584 proximal to donor splice site (p.Lys584). The in silico prediction of the variant was 'damaging' by MutationTaster2. The mutation wa...
Source: Pediatric Endocrinology, Diabetes, and Metabolism - September 20, 2023 Category: Endocrinology Authors: Hiya Boro Vikash Bundela Velmurugan Mannar Lakshmi Nagendra Vinita Jain Bimal Jain Senthil Kumar Sourabh Agstam Source Type: research
"The obesity pandemic" in the COVID-19 pandemic - new treatment for an old problem
This article provides a review of the literature on the recent worsening of obesity in the paediatric population, with particular emphasis on the importance of the COVID-19 pandemic. New methods of fighting obesity with the use of telemedicine and current methods of pharmacotherapy, including new drugs, are presented.PMID:37728462 | PMC:PMC10411083 | DOI:10.5114/pedm.2023.129342
Source: Pediatric Endocrinology, Diabetes, and Metabolism - September 20, 2023 Category: Endocrinology Authors: Kalina Fabin-Czepiel Karolina Pieczy ńska-Chapuła Gra żyna Deja Source Type: research
Lipid metabolism and renal function markers in obese adolescents
CONCLUSIONS: Renal function of the obese adolescents included in the study was normal and the associations with lipid metabolism were poorly expressed.PMID:37728460 | PMC:PMC10411080 | DOI:10.5114/pedm.2023.125612
Source: Pediatric Endocrinology, Diabetes, and Metabolism - September 20, 2023 Category: Endocrinology Authors: Aleksandra Radosz Anna Obuchowicz Source Type: research
The positive impact of lifestyle intervention on selected mio- and chemokines levels in prepubertal children with obesity
CONCLUSIONS: Personalized diet modification and regular, daily exercises may positively influence on the levels of irisin and chemerin.PMID:37728459 | PMC:PMC10411087 | DOI:10.5114/pedm.2023.127273
Source: Pediatric Endocrinology, Diabetes, and Metabolism - September 20, 2023 Category: Endocrinology Authors: Agnieszka Kozio ł-Kozakowska Ma łgorzata Wójcik Dominika Janu ś Jerzy Starzyk Source Type: research
Acetylation in pathogenesis: Revealing emerging mechanisms and therapeutic prospects
Biomed Pharmacother. 2023 Sep 18;167:115519. doi: 10.1016/j.biopha.2023.115519. Online ahead of print.ABSTRACTProtein acetylation modifications play a central and pivotal role in a myriad of biological processes, spanning cellular metabolism, proliferation, differentiation, apoptosis, and beyond, by effectively reshaping protein structure and function. The metabolic state of cells is intricately connected to epigenetic modifications, which in turn influence chromatin status and gene expression patterns. Notably, pathological alterations in protein acetylation modifications are frequently observed in diseases such as metabo...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 20, 2023 Category: Drugs & Pharmacology Authors: Nan Jiang Wenyong Li Shuanglin Jiang Ming Xie Ran Liu Source Type: research
Combination of an ACLY inhibitor with a GLP-1R agonist exerts additive benefits on nonalcoholic steatohepatitis and hepatic fibrosis in mice
Cell Rep Med. 2023 Sep 19;4(9):101193. doi: 10.1016/j.xcrm.2023.101193.ABSTRACTIncreased liver de novo lipogenesis (DNL) is a hallmark of nonalcoholic steatohepatitis (NASH). A key enzyme controlling DNL upregulated in NASH is ATP citrate lyase (ACLY). In mice, inhibition of ACLY reduces liver steatosis, ballooning, and fibrosis and inhibits activation of hepatic stellate cells. Glucagon-like peptide-1 receptor (GLP-1R) agonists lower body mass, insulin resistance, and steatosis without improving fibrosis. Here, we find that combining an inhibitor of liver ACLY, bempedoic acid, and the GLP-1R agonist liraglutide reduces li...
Source: Atherosclerosis - September 20, 2023 Category: Cardiology Authors: Eric M Desjardins Jianhan Wu Declan C T Lavoie Elham Ahmadi Logan K Townsend Marisa R Morrow Dongdong Wang Evangelia E Tsakiridis Battsetseg Batchuluun Russta Fayyazi Jacek M Kwiecien Theodoros Tsakiridis James S V Lally Guillaume Par é Stephen L Pinkosk Source Type: research
Robotic versus laparoscopic gastric bypass in bariatric surgery: a systematic review and meta-analysis on perioperative outcomes
CONCLUSION: This systematic review and meta-analysis showed that there was no significant difference in key outcome measures in robotic versus laparoscopic gastric bypass. RBS was associated with a slightly higher reoperation rate and there was no reduction in overall complication rate with the use of robotic platform.PMID:37730445 | DOI:10.1016/j.soard.2023.08.007
Source: Surgery for Obesity and Related Diseases : official journal of the American Society for Bariatric Surgery - September 20, 2023 Category: Surgery Authors: Yit J Leang Naveen Mayavel Wilson T W Yang Joseph C H Kong Chrys Hensman Paul R Burton Wendy A Brown Source Type: research
Role of the tripartite motif-containing (TRIM) family of proteins in insulin resistance and related disorders
Diabetes Obes Metab. 2023 Sep 19. doi: 10.1111/dom.15294. Online ahead of print.ABSTRACTEmerging evidence suggests that the ubiquitin-mediated degradation of insulin-signalling-related proteins may be involved in the development of insulin resistance and its related disorders. Tripartite motif-containing (TRIM) proteins, a superfamily belonging to the E3 ubiquitin ligases, are capable of controlling protein levels and function by ubiquitination, which is essential for the modulation of insulin sensitivity. Recent research has indicated that some of these TRIMs act as key regulatory factors of metabolic disorders such as ty...
Source: Atherosclerosis - September 20, 2023 Category: Cardiology Authors: Jianrong Chen Xianjie Feng Xu Zhou Yong Li Source Type: research
Polycystic Kidney Disease Diet: What Is Known and What Is Safe
Clin J Am Soc Nephrol. 2023 Sep 20. doi: 10.2215/CJN.0000000000000326. Online ahead of print.ABSTRACTAutosomal dominant polycystic kidney disease (ADPKD) is a genetic disorder characterized by kidney cyst formation and progressive kidney function loss. Dietary interventions such as caloric restriction, intermittent fasting, and the ketogenic diet have recently emerged as potential strategies to induce metabolic reprogramming and slow ADPKD progression. We review the available evidence supporting the efficacy and safety of these interventions in ADPKD. Dietary interventions show promise in managing ADPKD by improving metabo...
Source: Clinical Journal of the American Society of Nephrology : CJASN - September 20, 2023 Category: Urology & Nephrology Authors: Fouad T Chebib Kristen L Nowak Michel B Chonchol Kristen Bing Ahmad Ghanem Frederic F Rahbari-Oskoui Neera K Dahl Michal Mrug Source Type: research
Characterization, health benefits, and food applications of enzymatic digestion- resistant dextrin: A review
Int J Biol Macromol. 2023 Sep 18:126970. doi: 10.1016/j.ijbiomac.2023.126970. Online ahead of print.ABSTRACTResistant dextrin or resistant maltodextrin (RD), a short-chain glucose polymer that is highly resistant to hydrolysis by human digestive enzymes, has shown broad developmental prospects in the food industry and has gained substantial attention owing to its lack of undesirable effects on the sensory features of food or the digestive system. However, comprehensive fundamental and application information on RD and how RD improves anti-diabetes and obesity have not yet been received. Therefore, the characterization, hea...
Source: International Journal of Biological Macromolecules - September 20, 2023 Category: Biochemistry Authors: Fei Li Atif Muhmood Muhammad Akhter Xiang Gao Jie Sun Zubo Du Yuxi Wei Ting Zhang Yunlu Wei Source Type: research
The locus coeruleus contributes to the anorectic, nausea, and autonomic physiological effects of glucagon-like peptide-1
Sci Adv. 2023 Sep 22;9(38):eadh0980. doi: 10.1126/sciadv.adh0980. Epub 2023 Sep 20.ABSTRACTIncreasing the therapeutic potential and reducing the side effects of U.S. Food and Drug Administration-approved glucagon-like peptide-1 receptor (GLP-1R) agonists used to treat obesity require complete characterization of the central mechanisms that mediate both the food intake-suppressive and illness-like effects of GLP-1R signaling. Our studies, in the rat, demonstrate that GLP-1Rs in the locus coeruleus (LC) are pharmacologically and physiologically relevant for food intake control. Furthermore, agonism of LC GLP-1Rs induces illn...
Source: Adv Data - September 20, 2023 Category: Epidemiology Authors: Samantha M Fortin Jack C Chen Marisa C Petticord Forrest J Ragozzino James H Peters Matthew R Hayes Source Type: research
Prospective associations of neighborhood healthy food access and walkability with weight status in a regional pediatric health system
CONCLUSIONS: Findings provide evidence that residing in a neighborhood with healthy food access and walkability may support a healthy weight trajectory in children. Findings on changes in the neighborhood environment suggested that improved walkability in the neighborhood may support children's healthy weight. The greater and more consistent findings among movers may be due to movers experiencing greater changes in neighborhood features than the changes that typically occur within a neighborhood over a short period of time. Future research is needed to investigate more robust environmental changes to neighborhoods.PMID:377...
Source: Health Physics - September 20, 2023 Category: Physics Authors: Qianxia Jiang Bethany Forseth Lauren Fitzpatrick Helena H Laroche Sarah Hampl Ann M Davis Chelsea Steel Jordan Carlson Source Type: research
Both moderate- and high-intensity exercise training increase intramyocellular lipid droplet abundance and modify myocellular distribution in adults with obesity
This study compared high-intensity interval training (HIIT) with more conventional moderate-intensity continuous training (MICT) on intramyocellular lipid content, as well as LD characteristics (size and number) and abundance within the intramyofibrillar (IMF) and subsarcolemmal (SS) regions of type I and type II skeletal muscle fibers in adults with obesity. Thirty-six adults with obesity (BMI=33±3 kg/m2) completed 12 weeks (4d/week) of either HIIT (10x1 min, 90% HRmax + 1 min active recovery; n=19) or MICT (45 min steady-state exercise, 70% HRmax; n=17), while on a weight-maintaining diet throughout training. Skeletal m...
Source: Am J Physiol Endocri... - September 20, 2023 Category: Endocrinology Authors: Michael W Schleh Cheehoon Ahn Benjamin J Ryan Olivia K Chugh Austin T Luker Kathryn E Luker Jenna B Gillen Alison C Ludzki Douglas W Van Pelt Lisa M Pitchford Tao Zhang Thomas Rode Suzette M Howton Charles F Burant Jeffrey F Horowitz Source Type: research
