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Condition: Obesity
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Total 71740 results found since Jan 2013.
The discovery of the natural compound Boeravinone-C as a potential antiobesity drug candidate targeting pancreatic lipase using chemo-informatics-based approaches
Cell Mol Biol (Noisy-le-grand). 2023 Jul 31;69(7):57-65. doi: 10.14715/cmb/2023.69.7.10.ABSTRACTObesity is a metabolic disorder distinguished by excess fat deposition in fatty tissues. Pancreatic lipase is one of the promising drug targets for treating obesity due to its critical role in the hydrolysis of triglycerides into mono-glycerides and free fatty acids. Due to unsatisfactory results and severe side effects of the current drugs available for treating obesity, there is an urgent need to identify novel therapeutic options. Boerhaavia diffusa is one of the widely known species of flowering plant commonly known as Punam...
Source: Molecular Medicine - September 16, 2023 Category: Molecular Biology Authors: Aziz Unnisa Sirajuddin Anwar Chettupalli Ananda K Nasrin E Khalifa Weam M A Khojali Mhdia E Osman Kareem M Younes Amr S Abouzied Suresh B Jandrajupalli Swarnalatha Chandolu Source Type: research
Comparison of various prediction models in the effect of Roux-en-Y gastric bypass on type 2 diabetes in the Chinese population 5 years after surgery
CONCLUSIONS: T2D was relieved to varying degrees 5 years after RYGB in patients with obesity. The prediction models in ABCD and the Panuzi et al. [34] studies showed the best prediction effects. ABCD was recommended for clinical use because of excellent predictive performance, good statistical test results, and simple and practical design features.PMID:37716844 | DOI:10.1016/j.soard.2023.05.012
Source: Surgery for Obesity and Related Diseases : official journal of the American Society for Bariatric Surgery - September 16, 2023 Category: Surgery Authors: Chengyuan Yu Zheng Wang Qiqige Wuyun Weijian Chen Zhehong Li Mingyue Shang Nengwei Zhang Source Type: research
Pancreastatin inhibitor PSTi8 ameliorates insulin resistance by decreasing fat accumulation and oxidative stress in high-fat diet-fed mice
Amino Acids. 2023 Sep 16. doi: 10.1007/s00726-023-03332-y. Online ahead of print.ABSTRACTAbnormal fat accumulation, enhanced free fatty acids (FFA) release, and their metabolites cause insulin resistance (IR) in major glucose-lipid metabolic organs such as skeletal muscle and adipose tissue. However, excessive lipolysis and FFA release from adipose tissue elevate plasma FFA levels leading to oxidative stress and skeletal muscle IR. Indeed, in obese individuals, there is enhanced pro-inflammatory secretion from adipose tissue influencing insulin signaling in skeletal muscles. Here, we investigated the effect of PSTi8 on FFA...
Source: Amino Acids - September 16, 2023 Category: Biochemistry Authors: Richa Garg Arun Agarwal Roshan Katekar Umesh Kumar Goand Naveen Singh Shubhi Yadav Shivam Rathaur Saurabh Verma Debalina Maity Sachin Vishwakarma Jiaur R Gayen Source Type: research
The role of macrophages in polycystic ovarian syndrome and its typical pathological features: A narrative review
Biomed Pharmacother. 2023 Sep 14;167:115470. doi: 10.1016/j.biopha.2023.115470. Online ahead of print.ABSTRACTPolycystic ovarian syndrome (PCOS) is the most common endocrine and metabolic disorder in women of childbearing age, with ovulatory dysfunction, hyperandrogenism, and polycystic ovarian morphology (PCOM) as the clinical features. Androgen excess, insulin resistance, obesity, adipose tissue dysfunction, ovulatory dysfunction, and gut microbiota dysbiosis are the main pathological features and pathogenesis of PCOS and are related to systemic chronic low-grade inflammation and chronic ovarian tissue inflammation in PC...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 16, 2023 Category: Drugs & Pharmacology Authors: Yuanyuan Feng Zhijing Tang Wei Zhang Source Type: research
Food Addiction and Impulsivity in Clinical Populations by Gender: a Systematic Review
AbstractPurpose of ReviewFood addiction (FA) has been found to be associated with impulsivity, mainly urgency (negative and positive) and lack of perseverance. The present systematic review aimed to identify differences in impulsivity by gender and current implications of treatment regarding FA and impulsivity in clinical populations. The search was conducted in PubMed, Scopus, and Web of Science (WOS) databases, using the following search terms: “food addiction” and “impuls*.” Studies were included if they were written in English, had an observational design (e.g., cross-sectional, longitudinal, case-control), and...
Source: Current Addiction Reports - September 16, 2023 Category: Addiction Source Type: research
A narrative review of exercise participation among adults with prediabetes or type 2 diabetes: barriers and solutions
Front Clin Diabetes Healthc. 2023 Aug 30;4:1218692. doi: 10.3389/fcdhc.2023.1218692. eCollection 2023.ABSTRACTType 2 diabetes (T2D) has been rising in prevalence over the past few decades in the US and worldwide. T2D contributes to significant morbidity and premature mortality, primarily due to cardiovascular disease (CVD). Exercise is a major cornerstone of therapy for T2D as a result of its positive effects on glycemic control, blood pressure, weight loss and cardiovascular risk as well as other measures of health. However, studies show that a majority of people with T2D do not exercise regularly. The reasons given as to...
Source: Cancer Control - September 15, 2023 Category: Cancer & Oncology Authors: Samantha C Thielen Jane E B Reusch Judith G Regensteiner Source Type: research
Curcumin Compensates GLP-1 Deficiency via the Microbiota-Bile Acids Axis and Modulation in Functional Crosstalk between TGR5 and FXR in ob/ob Mice
CONCLUSIONS: The findings suggest that Cur may act as a natural TGR5 agonist and FXR antagonist to improve obesity by enhancing GLP-1 release from L-cell expansion via the gut microbiota-BAs-TGR5/FXR axis, and it may serve as a promising therapeutic agent to compensate obesity-related metabolic disorders.PMID:37712101 | DOI:10.1002/mnfr.202300195
Source: Cell Research - September 15, 2023 Category: Cytology Authors: Fengyuan Tian Tianxi Chen Wangda Xu Yichang Fan Xiaohong Feng Qi Huang Jie Chen Source Type: research
Energy expenditure deficits drive obesity in a mouse model of Alstr öm syndrome
CONCLUSIONS: Either loss of ALMS1 causes a developmental delay in the mechanisms controlling early life EE or activation of compensatory mechanisms occurs after obesity is established in AS. Future studies will determine how ALMS1 modulates EE and how sex moderates this process.PMID:37712194 | DOI:10.1002/oby.23877
Source: Obesity - September 15, 2023 Category: Eating Disorders & Weight Management Authors: Erin J Stephenson Clint E Kinney Amanda S Stayton Joan C Han Source Type: research
Cumulative BMI and incident prediabetes over 30 years of follow-up: The CARDIA study
CONCLUSIONS: The cumulative burden of higher weight and longer duration was associated with incident prediabetes, but this association was statistically significant only after a higher threshold was reached. Strategies for prevention of prediabetes in middle age may focus on avoiding overweight in young adulthood to limit duration.PMID:37712179 | DOI:10.1002/oby.23866
Source: Obesity - September 15, 2023 Category: Eating Disorders & Weight Management Authors: Pamela J Schreiner Sejong Bae Norrina Allen Kiang Liu Jared P Reis Colin Wu Katherine H Ingram Donald Lloyd-Jones Cora E Lewis Jamal S Rana Source Type: research
The Association between Circulating Adipocytokine Omentin Levels and Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-analysis
CONCLUSION: Additional well-designed studies with more sample sizes are essential to clarify the potential role of Omentin as a risk marker of NAFLD.PMID:37711002 | DOI:10.2174/1566524023666230913105910
Source: Molecular Medicine - September 15, 2023 Category: Molecular Biology Authors: Rozita Khodashahi Mohsen Aliakbarian Gordon A Ferns Mohammad-Hassan Arjmand Source Type: research
The relationship of food addiction with binge eating disorder and obesity: A network analysis study
Appetite. 2023 Sep 13:107037. doi: 10.1016/j.appet.2023.107037. Online ahead of print.ABSTRACTFood addiction (FA) has been associated with binge eating disorder (BED) and obesity at varying levels of severity and treatment outcomes. Despite much debate and scientific interest in FA, the mechanisms that underlie its co-occurrence with both conditions are not yet well understood. In order to understand this relationship, this study explores FA in a clinical sample of individuals with BED and obesity using network analysis (NA). A total of 303 patients (151 with BED and 152 with obesity) completed a battery of tests that inve...
Source: Appetite - September 15, 2023 Category: Nutrition Authors: Elvira Anna Carbone Matteo Aloi Marianna Rania Renato de Filippis Daria Quirino Teresa Vanessa Fiorentino Cristina Segura-Garcia Source Type: research
Circulating miRNAs detect high versus low visceral adipose tissue inflammation in patients living with obesity
CONCLUSIONS: Circ-miRs that identify patients with low versus high VAT inflammation constitute a putative tool to improve personalized care of patients with obesity.PMID:37713174 | DOI:10.1210/clinem/dgad550
Source: The Journal of Clinical Endocrinology and Metabolism - September 15, 2023 Category: Endocrinology Authors: Nataly Makarenkov Yulia Haim Uri Yoel Yair Pincu Tanya Tarnovscki Idit F Liberty Ivan Kukeev Lior Baraf Oleg Dukhno Oleg Zilber Matthias Bl üher Assaf Rudich Isana Veksler-Lublinsky Source Type: research
Mentha pulegium: A Plant With Several Medicinal Properties
Endocr Metab Immune Disord Drug Targets. 2023 Sep 14. doi: 10.2174/1871530323666230914103731. Online ahead of print.ABSTRACTThe species Mentha pulegium L. (M. pulegium L.) belongs to the family Lamiaceae, native to Europe, North Africa, and the Middle East, and the genus Mentha. It has been traditionally used in food, cosmetics, and medicines. It is a perennial, fragrant, well-liked, herbaceous plant that can grow up to half a meter tall. It is extensively used as a food flavoring, particularly for Moroccan traditional drinks. Chewing mint and M. pulegium, a relaxing and refreshing plant, can be used to treat hiccups and a...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - September 15, 2023 Category: Endocrinology Authors: Smail Amtaghri Miloudia Slaoui Mohamed Eddouks Source Type: research
