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Procedure: Gastroschisis Repair
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Total 54334 results found since Jan 2013.
KPT330 promotes the sensitivity of glioblastoma to olaparib by retaining SQSTM1 in the nucleus and disrupting lysosomal function
Autophagy. 2023 Sep 15. doi: 10.1080/15548627.2023.2252301. Online ahead of print.ABSTRACTPARP (poly(ADP-ribose) polymerase) inhibitors have demonstrated promising clinical activity in multiple homologous recombination (HR) deficiency tumors. However, glioblastoma (GBM) patients have obtained little benefit from PARP inhibitors alone. PARP inhibition shows considerable promise when used together with other therapeutic agents. Thus, novel combination therapies may enhance PARP inhibitor efficacy and overcome resistance mechanisms in GBM. Herein, we report that concurrent treatment with the PARP inhibitor olaparib and XPO1 (...
Source: Autophagy - September 15, 2023 Category: Cytology Authors: Li-Hong Wang Sen Wei Ye Yuan Ming-Jun Zhong Jiao Wang Ze-Xuan Yan Kai Zhou Tao Luo Li Liang Xiu-Wu Bian Source Type: research
Factors Influencing Parental Satisfaction in Children with Cleft Lip and Palate Repair Based on Comprehensive Plastic Surgery Procedures at the Senyum Bali Foundation
Cleft Palate Craniofac J. 2023 Sep 14:10556656231201835. doi: 10.1177/10556656231201835. Online ahead of print.ABSTRACTAnalyze contributing factors toward satisfaction after cleft lip and palate treatments in Senyum Bali Foundation. Qualitative case study, an interview with a semi-structured question from February to April 2023 by purposive sampling informants including parents, foundation staff, and plastic surgeon. Unsatisfying nose and teeth appearance due imperfect effects after surgery and requirement of more procedures. Mini model theory study that includes the appearance of the face and lips; speech and hearing; the...
Source: The Cleft Palate-Craniofacial Journal - September 15, 2023 Category: ENT & OMF Authors: Tiesya Padmasari Ardi Ardi Source Type: research
Emerging Role of Ferroptosis in Breast Cancer: Characteristics, Therapy, and Translational Implications for the Present and Future
We present a fundamental analysis of the actual understanding of molecular mechanisms along with regulatory networks associated with ferroptosis, expected physiological functions in growth concealment, ferroptosis-associated differentially expressed genes, treatment targeting potential, and recent advances in the development of therapeutic strategies in this review.PMID:37711099 | DOI:10.2174/1566524023666230913105735
Source: Molecular Medicine - September 15, 2023 Category: Molecular Biology Authors: Suman Kumar Ray Sukhes Mukherjee Source Type: research
Machine learning to predict outcomes following endovascular abdominal aortic aneurysm repair
CONCLUSIONS: In this data set, machine learning was able to predict 1-year mortality following EVAR using preoperative data and outperformed standard logistic regression models.PMID:37710397 | DOI:10.1093/bjs/znad287
Source: The British Journal of Surgery - September 15, 2023 Category: Surgery Authors: Ben Li Badr Aljabri Raj Verma Derek Beaton Naomi Eisenberg Douglas S Lee Duminda N Wijeysundera Thomas L Forbes Ori D Rotstein Charles de Mestral Muhammad Mamdani Graham Roche-Nagle Mohammed Al-Omran Source Type: research
The Effect of Distributional Restrictions in Speech Perception: A Case Study From Korean and Taiwanese Southern Min
Lang Speech. 2023 Sep 15:238309231195263. doi: 10.1177/00238309231195263. Online ahead of print.ABSTRACTIn Korean, voiced oral stops can occur intervocalically as allophones of their voiceless lenis counterparts; they can also occur initially as variants of nasal stops as a result of initial denasalization (e.g., /motu/→[bodu] "all"). However, neither [ŋ] nor [ɡ] (the denasalized variant of the velar nasal) is allowed in the initial position due to the phonotactic restriction against initial [ŋ] in Korean. Given the distribution of nasal and voiced stops in Korean, this study draws on the idea of cue informativeness, ...
Source: Language and Speech - September 15, 2023 Category: Speech-Language Pathology Authors: Jiwon Hwang Yu-An Lu Source Type: research
BzATP reverses ferroptosis-induced gut microbiota disorders in collagen-induced arthritis mice
In this study, we aimed to discover the particular mechanism of RA treatment by microbiota by investigating the effects of ferroptosis on gut microbiota and its metabolites in collagen-induced arthritis (CIA) mice. Mice were divided into five groups: control, CIA, erastin, BzATP, and BzATP + erastin group. We performed 16S rDNA sequencing and metabolomics analysis on mouse feces and found that erastin and BzATP altered the microbiota and metabolites. The findings demonstrated that the microbiota was significantly disturbed at the phylum (Proteobacteria, Firmicutes, and Bacteroidota) and genus level (Lachnospiraceae_NK4A136...
Source: International Immunopharmacology - September 15, 2023 Category: Allergy & Immunology Authors: Yeye Ma Wenjing Li Sijia Niu Xiaoying Zhu Maolin Chu Weiyan Wang Wentian Sun Xuemin Wei Juan Zhang Zhiyi Zhang Source Type: research
Emerging Role of Ferroptosis in Breast Cancer: Characteristics, Therapy, and Translational Implications for the Present and Future
We present a fundamental analysis of the actual understanding of molecular mechanisms along with regulatory networks associated with ferroptosis, expected physiological functions in growth concealment, ferroptosis-associated differentially expressed genes, treatment targeting potential, and recent advances in the development of therapeutic strategies in this review.PMID:37711099 | DOI:10.2174/1566524023666230913105735
Source: Current Molecular Medicine - September 15, 2023 Category: Molecular Biology Authors: Suman Kumar Ray Sukhes Mukherjee Source Type: research
The C-terminal tail of Rad17, iVERGE, binds the 9 ‒1‒1 complex independently of AAA+ ATPase domains to provide another clamploader interface
DNA Repair (Amst). 2023 Sep 6;130:103567. doi: 10.1016/j.dnarep.2023.103567. Online ahead of print.ABSTRACTThe ATR pathway plays a crucial role in maintaining genome integrity as the major DNA damage checkpoint. It also attracts attention as a therapeutic target in cancer treatment. The Rad17-RFC2-5 complex loads the Rad9-Hus1-Rad1 (9-1-1) DNA clamp complex onto damaged chromatin to activate the ATR pathway. We previously reported that phosphorylation of a polyanionic C-terminal tail of human Rad17, iVERGE, is essential for the interaction between Rad17 and the 9-1-1 complex. However, the molecular mechanism has remained u...
Source: DNA Repair - September 15, 2023 Category: Genetics & Stem Cells Authors: Yasunori Fukumoto Tyuji Hoshino Yuji Nakayama Yasumitsu Ogra Source Type: research
Allele-specific expression reveals genetic drivers of tissue regeneration in mice
Cell Stem Cell. 2023 Sep 13:S1934-5909(23)00293-X. doi: 10.1016/j.stem.2023.08.010. Online ahead of print.ABSTRACTIn adult mammals, skin wounds typically heal by scarring rather than through regeneration. In contrast, "super-healer" Murphy Roths Large (MRL) mice have the unusual ability to regenerate ear punch wounds; however, the molecular basis for this regeneration remains elusive. Here, in hybrid crosses between MRL and non-regenerating mice, we used allele-specific gene expression to identify cis-regulatory variation associated with ear regeneration. Analyzing three major cell populations (immune, fibroblast, and endo...
Source: Cell Stem Cell - September 15, 2023 Category: Stem Cells Authors: Katya L Mack Heather E Talbott Michelle F Griffin Jennifer B L Parker Nicholas J Guardino Amanda F Spielman Michael F Davitt Shamik Mascharak Mauricio Downer Annah Morgan Caleb Valencia Deena Akras Mark J Berger Derrick C Wan Hunter B Fraser Michael T Lon Source Type: research
Ki67 and prostate specific antigen are prognostic in metastatic hormone na ïve prostate cancer
CONCLUSION: PSA and Ki67 immunoreactive scores are prognostic in the metastatic hormone-sensitive setting, with PSA being superior. The combination of Ki67 and PSA did not give additional prognostic value. The results suggest immunohistochemical scoring of PSA to have potential to improve identification of patients responding well to ADT alone.PMID:37713321 | DOI:10.1080/0284186X.2023.2254480
Source: Acta Oncologica - September 15, 2023 Category: Cancer & Oncology Authors: Vasiliki Spyratou Eva Freyhult Anders Bergh Camilla Thellenberg-Karlsson Pernilla Wikstr öm Karin Wel én Andreas Josefsson Source Type: research
Plexiform neurofibroma (Hamartoma) of the median nerve: A two-case report
Hand Surg Rehabil. 2023 Sep 13:S2468-1229(23)00166-4. doi: 10.1016/j.hansur.2023.08.007. Online ahead of print.ABSTRACTPlexiform neurofibroma is a benign peripheral nerve-sheath tumor, rarely involving major nerves of the extremities. In the literature, there are no clear treatment strategies for plexiform neurofibroma of major peripheral nerves. Our experience encountered two patients with plexiform neurofibroma of the median nerve, presenting with a palmar mass and symptoms of carpal tunnel compression. Preoperatively, plexiform neurofibroma was diagnosed on MRI and clinical examination. Both patients also experienced si...
Source: Hand Surgery - September 15, 2023 Category: Surgery Authors: Ali Murat Ba şak Derya Özçelik Gupse Turan Source Type: research
Methods of Immobilization after Achilles Tendon Rupture Repair: A Comparative Study in Rat Model
CONCLUSION: K-wire has better stability, lower complication rate than other methods. Immobilization with K-wire may be a promising tool in future clinical Achilles tendon rupture applications.PMID:37712211 | DOI:10.1111/os.13860
Source: Hand Surgery - September 15, 2023 Category: Surgery Authors: Tianliang Wang Wenjie Wu Jiaxiang Gu Ruixing Hou Source Type: research
The continuous treatment of anterior segment open globe injury: an eye injury vitrectomy study
CONCLUSIONS: Initiating CST before fibrosis or scar formation might improve the prognosis of open AS injury, which was preferable to natural wound healing after wound repair.PMID:37711825 | PMC:PMC10498217 | DOI:10.21037/qims-23-645
Source: Hand Surgery - September 15, 2023 Category: Surgery Authors: Xijuan Wang Kang Feng Shikun He Xin Xie Zhizhong Ma Source Type: research
BACH1 loss exerts antitumor effects on mantle cell lymphoma cells via inducing a tumor-intrinsic innate immune response and cell cycle arrest
Mol Cancer Res. 2023 Sep 15. doi: 10.1158/1541-7786.MCR-23-0424. Online ahead of print.ABSTRACTBTB and CNC homology 1 (BACH1) is a transcription repressor that regulates multiple physiological processes including intracellular heme homeostasis and immune responses. Increasing lines of evidence indicate that BACH1 reshapes metastasis and metabolism of human solid tumors. However, its potential roles in mantle cell lymphoma (MCL) remain largely unknown. Here we found that silencing BACH1 in MCL cells induced markedly cell-cycle arrest and cell apoptosis, whereas overexpression of BACH1 exhibited the opposite patterns. Increa...
Source: Cell Research - September 15, 2023 Category: Cytology Authors: Guilan Li Min Feng Ziting Zhang Jiangyuan Liu Han Zhang Source Type: research
Comparative efficacy of endogenous stem cells recruiting hydrogels and stem cell-loaded hydrogels in knee cartilage regeneration: a meta-analysis
Conclusion The current study indicates that both endogenous stem cell recruiting hydrogels and stem cell loaded hydrogels can effectively promote knee joint cartilage regeneration in animal trials.PMID:37711133 | DOI:10.2174/1574888X19666230914123443
Source: Current Stem Cell Research and Therapy - September 15, 2023 Category: Stem Cells Authors: Wanyun Feng Chaohua Zhu Ruoxiang Miao Danni Li Xi Xiong Ruyu Wang Guobing Liu Jun Ma Source Type: research
