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Procedure: Gastroschisis Repair
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Total 54334 results found since Jan 2013.
ATM mutations associate with distinct co-mutational patterns and therapeutic vulnerabilities in NSCLC
CONCLUSIONS: ATM mutations define a distinct subset of NSCLC associated with KRAS mutations, increased TMB, decreased TP53 and EGFR co-occurrence, and potential increased sensitivity to ICIs in the context of DNA-damaging chemotherapy.PMID:37733794 | DOI:10.1158/1078-0432.CCR-23-1122
Source: Clinical Lung Cancer - September 21, 2023 Category: Cancer & Oncology Authors: Natalie I Vokes Ana Galan Cobo Margarita Fernandez-Chas David Molkentine Santiago Trevi ño Vitaly Druker Yu Qian Sonia Patel Stephanie Schmidt Lingzhi Hong Jeff Lewis Waree Rinsurongkawong Vadeerat Rinsurongkawong J Jack Lee Marcelo V Negrao Don L Gibbon Source Type: research
To Be Aggressive or Not in Type A Aortic Dissection Repair: That Is the Question
Ann Thorac Surg. 2023 Sep 19:S0003-4975(23)00968-2. doi: 10.1016/j.athoracsur.2023.09.017. Online ahead of print.NO ABSTRACTPMID:37734640 | DOI:10.1016/j.athoracsur.2023.09.017
Source: The Annals of Thoracic Surgery - September 21, 2023 Category: Cardiovascular & Thoracic Surgery Authors: Koray Ak Ece Çalışan Source Type: research
Prevalence of atrial septal defects and patent foramen ovale in a cohort of sudden cardiac death patients undergoing autopsy
CONCLUSIONS: The combined rate of PFO and ASD in a cohort of 517 patients undergoing autopsy was 7.9 %. None of these patients had experienced a cerebrovascular accident. This rate of PFOs appears lower than earlier reports and raises the possibility that the relative risk of an associated stroke could be higher than previously estimated.PMID:37734655 | DOI:10.1016/j.jjcc.2023.09.006
Source: Journal of Cardiology - September 21, 2023 Category: Cardiology Authors: Louise Fahy Stephanie Rowe Ziad Nehme Dion Stub Dominica Zentner Paul James Andreas Pflaumer Vanessa Connell Christopher Semsarian Jodie Ingles Andre La Gerche Elizabeth D Paratz Source Type: research
Administration of Milrinone Following Tetralogy of Fallot Repair Increases Postoperative Volume Administration Without Improving Cardiac Output
CONCLUSIONS: The use of milrinone within the first 72 hours following TOF repair is associated with more frequent administration of volume, a positive association between a higher total dose of postoperative milrinone and the amount of postoperative volume administered, a higher heart rate, and a lower blood pressure, but is not associated with improved cardiac output.PMID:37733944 | DOI:10.1213/ANE.0000000000006662
Source: Anesthesia and Analgesia - September 21, 2023 Category: Anesthesiology Authors: Kwannapas Saengsin Francesca Sperotto Minmin Lu Julia Garcia Mancebo Elizabeth Sacco Manasee Godsay James A DiNardo John N Kheir Source Type: research
Access to healthcare: waiting time until the surgical procedure
Background: Global surgery prioritizes the improvement of health and the search for equity in the population. However, population access is uneven, resulted a long waiting time and quality of life impact. Therefore, this study aimed to evaluate the time between health diagnosis and elective surgery of cholecystectomy, varicose veins and hernia repair in adult patients and analyze the quality of life after surgery.
Source: Clinical Nutrition ESPEN - September 21, 2023 Category: Nutrition Authors: Cassiane S. Lemos, Nancy Reynolds, Ana Maria M. Magalh ães, Fabiana Z. Martins, Vanessa B. Poveda Source Type: research
Can Open Distal Repair Be Safely Used in All Patients with Type A Acute Aortic Dissection?
CONCLUSION: We conclude that the open repair can be used in most if not all cases of surgical repair of type A acute aortic dissection.PMID:37730310 | DOI:10.5761/atcs.oa.23-00086
Source: Annals of Thoracic and Cardiovascular Surgery - September 20, 2023 Category: Cardiovascular & Thoracic Surgery Authors: Georgi Manchev Vassil Gegouskov Vladimir Kornovski Georgi Yankov Valya Goranovska Vicktoria Ilieva Vicktoria Petrova Source Type: research
< em > NOTCH2 < /em > gene mutation and gamma-secretase inhibitor in mediating the malignancy of ovarian cancer
Aging (Albany NY). 2023 Sep 19;15. doi: 10.18632/aging.205045. Online ahead of print.ABSTRACTThe carcinogenic mechanisms by which serous ovarian cancer (OC) occurs remain to be explored. Currently, we have conducted whole-exome sequencing (WES) and targeted deep sequencing to validate new molecular markers, including NOTCH2, that impede the progression of cell malignancy in ovarian cancer (OC). Following NOTCH2 P2113S mutation and NOTCH signaling pathway inhibitor N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester (DAPT) treatment, the cell proliferation, migration, and invasion of A2780 and SKOV3 OC cel...
Source: Aging - September 20, 2023 Category: Biomedical Science Authors: Wenjing Wang Ruiqian Liu Wei Liao Landie Ji Jie Mei Dan Su Source Type: research
History of peripheral nerve injuries
This article reviews the history of peripheral nerve (PN) injuries and successive advances in their management by notable pioneers, an interesting topic that I chose for my Doctoral Thesis in 1990 in Madrid. Mentioning all their names and contributions is an obligatory tribute, and I offer my sincere apologies for inevitably leaving a few out. For half a century I have witnessed microsurgery advances, and also experienced frequent failures in my practice with the use of new techniques; a testimony that we are very far from achieving the 'Holy Grail' of complete PN recovery for these injuries. Our experience is often like a...
Source: Hand Surgery - September 20, 2023 Category: Surgery Authors: Carlos Irisarri Source Type: research
Implications of ubiquitination and the maintenance of replication fork stability in cancer therapy
Biosci Rep. 2023 Sep 20:BSR20222591. doi: 10.1042/BSR20222591. Online ahead of print.ABSTRACTDNA replication forks are subject to intricate surveillance and strict regulation by sophisticated cellular machinery. Such close regulation is necessary to ensure the accurate duplication of genetic information and to tackle the diverse endogenous and exogenous stresses that impede this process. Stalled replication forks are vulnerable to collapse, which is a major cause of genomic instability and carcinogenesis. Replication stress responses, which are organized via a series of coordinated molecular events, stabilize stalled repli...
Source: Bioscience Reports - September 20, 2023 Category: Biomedical Science Authors: Donghui Xia Xuefei Zhu Ying Wang Peng Gong Hong-Shu Su Xingzhi Xu Source Type: research
Discovery of BbX transcription factor in the patagonian blennie: Exploring expression changes following combined bacterial and thermal stress exposure
Dev Comp Immunol. 2023 Sep 18:105056. doi: 10.1016/j.dci.2023.105056. Online ahead of print.ABSTRACTHigh-Mobility Group (HMG) proteins are involved in different processes such as transcription, replication, DNA repair, and immune response. The role of HMG proteins in the immune response of fish has been studied mainly for HMGB1, where its expression can be induced by the stimulation of viral/bacterial PAMPs and can act as a proinflammatory mediator and as a global regulator of transcription in response to temperature. However, for BbX this role remains to be discovered. In this work, we identified the BbX of E. maclovinus ...
Source: Developmental and Comparative Immunology - September 20, 2023 Category: Allergy & Immunology Authors: Danixa Mart ínez Daniela Nualart Carlos Loncoman Juan C Opazo Kattina Zabala Francisco J Morera Gonzalo A Mardones Luis Vargas-Chacoff Source Type: research
Transcriptome analysis reveals molecular regulation mechanism of Tibet sheep tolerance to high altitude oxygen environment
This study will lay a certain foundation for Tibet sheep research.PMID:37729444 | DOI:10.1080/10495398.2023.2258953
Source: Animal Biotechnology - September 20, 2023 Category: Biotechnology Authors: Li An Yanyan Li Lin Yaq Yong Wang Qilin Dai Shizhang Du Yi Ru Qi Zhoucuo Jinling Wang Source Type: research
Single-nucleus transcriptomic mapping uncovers targets for traumatic brain injury
In this study, we meticulously mapped the transcriptome atlas of murine SVZ and its responses to mTBI at the single-cell level. We observed cell-specific gene expression changes following mTBI and unveiled diverse cell-to-cell interaction networks that influence a wide array of cellular processes. Moreover, we reported novel neurogenesis lineage trajectories and related key transcription factors, which we subsequently validated through loss-of-function experiments. Specifically, we validated the role of Tcf7l1, a cell cycle gene regulator, in promoting neural stem cell differentiation towards the neuronal lineage after mTB...
Source: Cell Research - September 20, 2023 Category: Cytology Authors: Qiuyun Yang Lingxuan Zhang Manrui Li Yang Xu Xiaogang Chen Ruixuan Yuan Xiaofeng Ou Min He Miao Liao Lin Zhang Hao Dai Meili Lv Xiaoqi Xie Weibo Liang Xiameng Chen Source Type: research
Time-course transcriptome analysis of a double challenge bleomycin-induced lung fibrosis rat model uncovers ECM homoeostasis-related translationally relevant genes
CONCLUSIONS: The model of lung fibrosis presented in this study lends itself as a valuable tool for preclinical efficacy evaluation of new potential drug candidates. The main finding was the identification of a group of persistently dysregulated genes, mostly related to ECM homoeostasis, which are shared with human IPF.PMID:37730279 | DOI:10.1136/bmjresp-2022-001476
Source: Cell Research - September 20, 2023 Category: Cytology Authors: Martina Bonatti Vanessa Pitozzi Paola Caruso Silvia Pontis Maria Gloria Pittelli Caterina Frati Chiara Mangiaracina Costanza Anna Maria Lagrasta Federico Quaini Simona Cantarella Simone Ottonello Gino Villetti Maurizio Civelli Barbara Montanini Marcello T Source Type: research
Cisplatin-induced DNA crosslinks trigger neurotoxicity in C. elegans
Biochim Biophys Acta Mol Cell Res. 2023 Sep 18:119591. doi: 10.1016/j.bbamcr.2023.119591. Online ahead of print.ABSTRACTThe anticancer drug cisplatin (CisPt) injures post-mitotic neuronal cells, leading to neuropathy. Furthermore, CisPt triggers cell death in replicating cells. Here, we aim to unravel the relevance of different types of CisPt-induced DNA lesions for evoking neurotoxicity. To this end, we comparatively analyzed wild-type and loss of function mutants of C. elegans lacking key players of specific DNA repair pathways. Deficiency in ercc-1, which is essential for nucleotide excision repair (NER) and interstrand...
Source: Cell Research - September 20, 2023 Category: Cytology Authors: Fabian Wynen Johannes Krautstrunk Lisa Marie M üller Viktoria Graf Vanessa Brinkmann Gerhard Fritz Source Type: research
Combinatorial treatment with PARP and MAPK inhibitors overcomes phenotype switch-driven drug resistance in advanced melanoma
Cancer Res. 2023 Sep 20. doi: 10.1158/0008-5472.CAN-23-0485. Online ahead of print.ABSTRACTMetastatic melanoma is either intrinsically resistant or rapidly acquires resistance to targeted therapy treatments, such as MAPK inhibitors. A leading cause of resistance to targeted therapy is a dynamic transition of melanoma cells from a proliferative to a highly invasive state, a phenomenon called phenotype switching. Mechanisms regulating phenotype switching represent potential targets for improving treatment of melanoma patients. Using a drug screen targeting chromatin regulators in patient-derived 3D MAPK inhibitor-resistant m...
Source: Cell Research - September 20, 2023 Category: Cytology Authors: Lorenza P Ferretti Flurina B öhi Deena M Leslie Pedrioli Phil F Cheng Elena Ferrari Petra Baumgaertner Abdiel Alvarado-Diaz Federica Sella Alessandra Cereghetti Patrick Turko Roni H Wright Katrien De Bock Daniel E Speiser Roberto Ferrari Mitchell P Leves Source Type: research
