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Procedure: Gastroschisis Repair
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Total 54334 results found since Jan 2013.
Ki67 and prostate specific antigen are prognostic in metastatic hormone na ïve prostate cancer
CONCLUSION: PSA and Ki67 immunoreactive scores are prognostic in the metastatic hormone-sensitive setting, with PSA being superior. The combination of Ki67 and PSA did not give additional prognostic value. The results suggest immunohistochemical scoring of PSA to have potential to improve identification of patients responding well to ADT alone.PMID:37713321 | DOI:10.1080/0284186X.2023.2254480
Source: Acta Oncologica - September 15, 2023 Category: Cancer & Oncology Authors: Vasiliki Spyratou Eva Freyhult Anders Bergh Camilla Thellenberg-Karlsson Pernilla Wikstr öm Karin Wel én Andreas Josefsson Source Type: research
Emerging Role of Ferroptosis in Breast Cancer: Characteristics, Therapy, and Translational Implications for the Present and Future
We present a fundamental analysis of the actual understanding of molecular mechanisms along with regulatory networks associated with ferroptosis, expected physiological functions in growth concealment, ferroptosis-associated differentially expressed genes, treatment targeting potential, and recent advances in the development of therapeutic strategies in this review.PMID:37711099 | DOI:10.2174/1566524023666230913105735
Source: Current Molecular Medicine - September 15, 2023 Category: Molecular Biology Authors: Suman Kumar Ray Sukhes Mukherjee Source Type: research
Machine learning to predict outcomes following endovascular abdominal aortic aneurysm repair
CONCLUSIONS: In this data set, machine learning was able to predict 1-year mortality following EVAR using preoperative data and outperformed standard logistic regression models.PMID:37710397 | DOI:10.1093/bjs/znad287
Source: The British Journal of Surgery - September 15, 2023 Category: Surgery Authors: Ben Li Badr Aljabri Raj Verma Derek Beaton Naomi Eisenberg Douglas S Lee Duminda N Wijeysundera Thomas L Forbes Ori D Rotstein Charles de Mestral Muhammad Mamdani Graham Roche-Nagle Mohammed Al-Omran Source Type: research
The Effect of Distributional Restrictions in Speech Perception: A Case Study From Korean and Taiwanese Southern Min
Lang Speech. 2023 Sep 15:238309231195263. doi: 10.1177/00238309231195263. Online ahead of print.ABSTRACTIn Korean, voiced oral stops can occur intervocalically as allophones of their voiceless lenis counterparts; they can also occur initially as variants of nasal stops as a result of initial denasalization (e.g., /motu/→[bodu] "all"). However, neither [ŋ] nor [ɡ] (the denasalized variant of the velar nasal) is allowed in the initial position due to the phonotactic restriction against initial [ŋ] in Korean. Given the distribution of nasal and voiced stops in Korean, this study draws on the idea of cue informativeness, ...
Source: Language and Speech - September 15, 2023 Category: Speech-Language Pathology Authors: Jiwon Hwang Yu-An Lu Source Type: research
A Nationwide Study on Mitral Valve Repair Versus Replacement for Active Endocarditis
CONCLUSIONS: Contemporary trends in mitral valve surgery for active infective endocarditis suggest growing patient complexity but slightly declining early mortality rates. A trend of decreasing mitral valve repair rates was seen. Our results suggest improved late outcomes of valve repair compared to replacement.PMID:37714504 | DOI:10.1016/j.athoracsur.2023.08.032
Source: The Annals of Thoracic Surgery - September 15, 2023 Category: Cardiovascular & Thoracic Surgery Authors: Anton Tom šič Arend de Weger Michelle van der Stoel Robert J M Klautz Meindert Palmen Cardiothoracic Surgery Registration Committee of the Netherlands Heart Registration Source Type: research
The C-terminal tail of Rad17, iVERGE, binds the 9 ‒1‒1 complex independently of AAA+ ATPase domains to provide another clamploader interface
DNA Repair (Amst). 2023 Sep 6;130:103567. doi: 10.1016/j.dnarep.2023.103567. Online ahead of print.ABSTRACTThe ATR pathway plays a crucial role in maintaining genome integrity as the major DNA damage checkpoint. It also attracts attention as a therapeutic target in cancer treatment. The Rad17-RFC2-5 complex loads the Rad9-Hus1-Rad1 (9-1-1) DNA clamp complex onto damaged chromatin to activate the ATR pathway. We previously reported that phosphorylation of a polyanionic C-terminal tail of human Rad17, iVERGE, is essential for the interaction between Rad17 and the 9-1-1 complex. However, the molecular mechanism has remained u...
Source: DNA Repair - September 15, 2023 Category: Genetics & Stem Cells Authors: Yasunori Fukumoto Tyuji Hoshino Yuji Nakayama Yasumitsu Ogra Source Type: research
Nanotechnology in Coronary Heart Disease
Acta Biomater. 2023 Sep 13:S1742-7061(23)00545-7. doi: 10.1016/j.actbio.2023.09.011. Online ahead of print.ABSTRACTCoronary heart disease (CHD) is one of the major causes of death and disability worldwide, especially in low- and middle-income countries and among older populations. Conventional diagnostic and therapeutic approaches have limitations such as low sensitivity, high cost and side effects. Nanotechnology offers promising alternative strategies for the diagnosis and treatment of CHD by exploiting the unique properties of nanomaterials. In this review, we use bibliometric analysis to identify research hotspots in t...
Source: Atherosclerosis - September 15, 2023 Category: Cardiology Authors: Junsong Guo Hao Wang Ying Li Shuang Zhu Houxiang Hu Zhanjun Gu Source Type: research
Preclinical activity of selinexor in combination with eribulin in uterine leiomyosarcoma
In this study, we evaluated the effects of selinexor in combination with doxorubicin and eribulin in the LMS tumor model in vitro and in vivo. Treatment of selinexor combined with eribulin showed synergistic effects on tumor growth inhibition in SK-UT1 LMS-derived xenografts. Immunohistochemical assessment of the tumor tissues showed a significantly reduced expression of proliferation (Ki67) and XPO1 markers following combination therapy compared to the control group. Global transcriptome analyses on tumor tissue revealed that the combination therapy regulates genes from several key cancer-related pathways that are differe...
Source: Cancer Control - September 15, 2023 Category: Cancer & Oncology Authors: Sonam Mittal Ishaque Pulikkal Kadamberi Hua Chang Feng Wang Sudhir Kumar Shirng-Wern Tsaih Christopher J Walker Pradeep Chaluvally-Raghavan John Charlson Yosef Landesman Sunila Pradeep Source Type: research
Factors Influencing Parental Satisfaction in Children with Cleft Lip and Palate Repair Based on Comprehensive Plastic Surgery Procedures at the Senyum Bali Foundation
Cleft Palate Craniofac J. 2023 Sep 14:10556656231201835. doi: 10.1177/10556656231201835. Online ahead of print.ABSTRACTAnalyze contributing factors toward satisfaction after cleft lip and palate treatments in Senyum Bali Foundation. Qualitative case study, an interview with a semi-structured question from February to April 2023 by purposive sampling informants including parents, foundation staff, and plastic surgeon. Unsatisfying nose and teeth appearance due imperfect effects after surgery and requirement of more procedures. Mini model theory study that includes the appearance of the face and lips; speech and hearing; the...
Source: The Cleft Palate-Craniofacial Journal - September 15, 2023 Category: ENT & OMF Authors: Tiesya Padmasari Ardi Ardi Source Type: research
Preservation of circadian rhythm in hepatocellular cancer
J Biol Chem. 2023 Sep 13:105251. doi: 10.1016/j.jbc.2023.105251. Online ahead of print.ABSTRACTCircadian rhythms are controlled at the cellular level by a molecular clock consisting of several genes/proteins engaged in a transcription-translation-degradation feedback loop. These core clock proteins regulate thousands of tissue-specific genes. Regarding circadian control in neoplastic tissues, reports to date have demonstrated anomalous circadian function in tumor models and cultured tumor cells. We have extended these studies by analyzing circadian rhythmicity genome-wide in a mouse model of liver cancer, in which mice tre...
Source: Cancer Control - September 15, 2023 Category: Cancer & Oncology Authors: Yanyan Yang Ashraf N Abdo Hiroaki Kawara Christopher P Selby Aziz Sancar Source Type: research
Olaparib plus abiraterone versus placebo plus abiraterone in metastatic castration-resistant prostate cancer (PROpel): final prespecified overall survival results of a randomised, double-blind, phase 3 trial
This study is registered with ClinicalTrials.gov, NCT03732820, and is completed and no longer recruiting.FINDINGS: Between Oct 31, 2018 and March 11, 2020, 1103 patients were screened, of whom 399 were randomly assigned to olaparib plus abiraterone and 397 to placebo plus abiraterone. Median follow-up for overall survival in patients with censored data was 36·6 months (IQR 34·1-40·3) for olaparib plus abiraterone and 36·5 months (33·8-40·3) for placebo plus abiraterone. Median overall survival was 42·1 months (95% CI 38·4-not reached) with olaparib plus abiraterone and 34·7 months (31·0-39·3) with placebo plus a...
Source: Cancer Control - September 15, 2023 Category: Cancer & Oncology Authors: Fred Saad Noel W Clarke Mototsugu Oya Neal Shore Giuseppe Procopio Jo ão Daniel Guedes Cagatay Arslan Niven Mehra Francis Parnis Emma Brown Friederike Schl ürmann Jae Young Joung Mikio Sugimoto Oliver Sartor Yu-Zhen Liu Christian Poehlein Laura Barker P Source Type: research
Plexiform neurofibroma (Hamartoma) of the median nerve: A two-case report
Hand Surg Rehabil. 2023 Sep 13:S2468-1229(23)00166-4. doi: 10.1016/j.hansur.2023.08.007. Online ahead of print.ABSTRACTPlexiform neurofibroma is a benign peripheral nerve-sheath tumor, rarely involving major nerves of the extremities. In the literature, there are no clear treatment strategies for plexiform neurofibroma of major peripheral nerves. Our experience encountered two patients with plexiform neurofibroma of the median nerve, presenting with a palmar mass and symptoms of carpal tunnel compression. Preoperatively, plexiform neurofibroma was diagnosed on MRI and clinical examination. Both patients also experienced si...
Source: Hand Surgery - September 15, 2023 Category: Surgery Authors: Ali Murat Ba şak Derya Özçelik Gupse Turan Source Type: research
Methods of Immobilization after Achilles Tendon Rupture Repair: A Comparative Study in Rat Model
CONCLUSION: K-wire has better stability, lower complication rate than other methods. Immobilization with K-wire may be a promising tool in future clinical Achilles tendon rupture applications.PMID:37712211 | DOI:10.1111/os.13860
Source: Hand Surgery - September 15, 2023 Category: Surgery Authors: Tianliang Wang Wenjie Wu Jiaxiang Gu Ruixing Hou Source Type: research
The continuous treatment of anterior segment open globe injury: an eye injury vitrectomy study
CONCLUSIONS: Initiating CST before fibrosis or scar formation might improve the prognosis of open AS injury, which was preferable to natural wound healing after wound repair.PMID:37711825 | PMC:PMC10498217 | DOI:10.21037/qims-23-645
Source: Hand Surgery - September 15, 2023 Category: Surgery Authors: Xijuan Wang Kang Feng Shikun He Xin Xie Zhizhong Ma Source Type: research
Cardiac Tamponade Secondary to Hemorrhagic Pericardial Effusion: A Complication of STEMI
Conclusion: The differential for hemodynamic compromise in a patient with STEMI is broad, but quickly distinguishing pump failure from other life-threatening causes of shock is imperative to dictate time-sensitive management decisions. The presence of a hemorrhagic pericardial effusion in the setting of STEMI is a surrogate marker for a severe infarct and can help the bedside physician determine whether a patient will be better served in the catheterization lab for revascularization or in the operating room for surgical repair.PMID:37711482 | PMC:PMC10498953 | DOI:10.31486/toj.23.0023
Source: Pain Physician - September 15, 2023 Category: Anesthesiology Authors: Marvin Kajy Amy Rechenberg Connor Kerndt Kevin Wolschleger Source Type: research
