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Tumor-derived biomarkers predict efficacy of B7H3 antibody-drug conjugate treatment in metastatic prostate cancer models
We present a comprehensive therapeutic and biomarker analysis of a B7H3-ADC with pyrrolobenzodiazepine(PBD) payload in 26 treatment-resistant, metastatic prostate cancer(mPC) models. B7H3 is a tumor-specific surface protein widely expressed in mPC, and PBD is a DNA cross-linking agent. B7H3 expression was necessary but not sufficient for B7H3-PBD-ADC responsiveness. RB1 deficiency and/or replication stress, characteristics of poor prognosis, conferred sensitivity and were associated with complete tumor regression in both neuroendocrine (NEPC) and androgen receptor positive(ARPC) prostate cancer models, even with low B7H3 l...
Source: Clinical Prostate Cancer - September 19, 2023 Category: Cancer & Oncology Authors: Supreet Agarwal Lei Fang Kerry McGowen JuanJuan Yin Joel Bowman Anson T Ku Aian Neil Alilin Eva Corey Martine P Roudier Lawrence D True Ruth F Dumpit Ilsa Coleman John K Lee Peter S Nelson Brian J Capaldo Aida Mariani Clare E Hoover Ilya S Senatorov Micha Source Type: research
The Warburg effect on radioresistance: Survival beyond growth
Biochim Biophys Acta Rev Cancer. 2023 Sep 17:188988. doi: 10.1016/j.bbcan.2023.188988. Online ahead of print.ABSTRACTThe Warburg effect is a phenomenon in which cancer cells rely primarily on glycolysis rather than oxidative phosphorylation, even in the presence of oxygen. Although evidence of its involvement in cell proliferation has been discovered, the advantages of the Warburg effect in cancer cell survival under treatment have not been fully elucidated. In recent years, the metabolic characteristics of radioresistant cancer cells have been evaluated, enabling an extension of the original concept of the Warburg effect....
Source: Biochimica et Biophysica Acta - September 19, 2023 Category: Biochemistry Authors: Hyunkoo Kang Byeongsoo Kim Junhyeong Park HyeSook Youn BuHyun Youn Source Type: research
Endometrial adenocarcinoma recurring in the lung: impact of molecular profile and role of local therapies on prognosis
CONCLUSION: Although few patients will benefit from local treatment (stereotactic body radiation therapy or resection) after a recurrence involving the lung, local therapies might be considered as an option in oligometastatic lung recurrences as they achieve high local control rates and better oncological outcomes than systemic treatment alone.PMID:37726197 | DOI:10.1136/ijgc-2023-004534
Source: Cancer Control - September 19, 2023 Category: Cancer & Oncology Authors: Ana Luzarraga Aznar Vicente Bebia Carlos L ópez-Gil Alexandra Giraldo M P Montoya Ramona Verges Alberto Jauregui Josep Castellvi Assumpci ó Pérez-Benavente Eva Col ás Antonio Gil-Moreno Silvia Cabrera Source Type: research
Entinostat enhances the efficacy of chemotherapy in small cell lung cancer through S-phase arrest and decreased base excision repair
CONCLUSIONS: In this study, we decipher the molecular processes behind synergistic interactions between chemotherapy and HDAC inhibition. Moreover, we report novel mechanisms to overcome drug resistance in SCLC, which may be relevant to increase the therapeutic success.PMID:37725585 | DOI:10.1158/1078-0432.CCR-23-1795
Source: Clinical Lung Cancer - September 19, 2023 Category: Cancer & Oncology Authors: Anna Solta Kristiina Boettiger Ildik ó Kovács Christian Lang Zsolt Megyesfalvi Franziska Ferk Miroslav Mi šík Konrad Hoetzenecker Clemens Aigner Christian R Kowol Siegfried Knasmueller Michael Grusch Be áta Szeitz Melinda Rezeli Balazs Dome Karin Sch Source Type: research
The Role of Mesenchymal Stem/Stromal Cells Secretome in Macrophage Polarization: Perspectives on Treating Inflammatory Diseases
Curr Stem Cell Res Ther. 2023 Sep 4. doi: 10.2174/1574888X18666230811093101. Online ahead of print.ABSTRACTMesenchymal stem/stromal cells (MSCs) have exhibited potential for treating multiple inflammation- related diseases (IRDs) due to their easy acquisition, unique immunomodulatory and tissue repair properties, and immune-privileged characteristics. It is worth mentioning that MSCs release a wide array of soluble bioactive components in the secretome that modulate host innate and adaptive immune responses and promote the resolution of inflammation. As the first line of defense, macrophages exist throughout the entire inf...
Source: Current Stem Cell Research and Therapy - September 19, 2023 Category: Stem Cells Authors: Dongdong Ti Jun Yi Huihua Chen Haojie Hao Chunmeng Shi Source Type: research
The Warburg effect on radioresistance: Survival beyond growth
Biochim Biophys Acta Rev Cancer. 2023 Sep 17:188988. doi: 10.1016/j.bbcan.2023.188988. Online ahead of print.ABSTRACTThe Warburg effect is a phenomenon in which cancer cells rely primarily on glycolysis rather than oxidative phosphorylation, even in the presence of oxygen. Although evidence of its involvement in cell proliferation has been discovered, the advantages of the Warburg effect in cancer cell survival under treatment have not been fully elucidated. In recent years, the metabolic characteristics of radioresistant cancer cells have been evaluated, enabling an extension of the original concept of the Warburg effect....
Source: Biochimica et Biophysica Acta - September 19, 2023 Category: Biochemistry Authors: Hyunkoo Kang Byeongsoo Kim Junhyeong Park HyeSook Youn BuHyun Youn Source Type: research
Entinostat enhances the efficacy of chemotherapy in small cell lung cancer through S-phase arrest and decreased base excision repair
CONCLUSIONS: In this study, we decipher the molecular processes behind synergistic interactions between chemotherapy and HDAC inhibition. Moreover, we report novel mechanisms to overcome drug resistance in SCLC, which may be relevant to increase the therapeutic success.PMID:37725585 | DOI:10.1158/1078-0432.CCR-23-1795
Source: Clinical Lung Cancer - September 19, 2023 Category: Cancer & Oncology Authors: Anna Solta Kristiina Boettiger Ildik ó Kovács Christian Lang Zsolt Megyesfalvi Franziska Ferk Miroslav Mi šík Konrad Hoetzenecker Clemens Aigner Christian R Kowol Siegfried Knasmueller Michael Grusch Be áta Szeitz Melinda Rezeli Balazs Dome Karin Sch Source Type: research
Hemodynamics and diastolic function after native aortic valve preserving vs replacing surgery
Conclusion Preservation of native tissue in AV surgery results in superior transvalvular hemodynamics compared to prosthetic AV replacement. This may induce faster LV reverse remodeling and may explain more pronounced improvement in LV diastolic function.PMID:37726023 | DOI:10.1055/a-2178-0395
Source: The Thoracic and Cardiovascular Surgeon - September 19, 2023 Category: Cardiovascular & Thoracic Surgery Authors: Theresa Holst Xiaoqin Hua Christoph Sinning Benjamin Waschki Hermann Reichenspurner Evaldas Girdauskas Johannes Petersen Source Type: research
Repair of Distal Fibula Fractures with Minimally Invasive Intramedullary Nailing in the Elderly
J Am Podiatr Med Assoc. 2023 Jul-Aug;113(4):22-121. doi: 10.7547/22-121.ABSTRACTAnkle fractures have been well documented and are common, especially in the elderly, behind hip and distal radius fractures. Open reduction and internal fixation (ORIF) is the standard of treatment for displaced and unstable ankle fractures. Traditionally, ankle fractures in the elderly population have been treated with nonoperative methods; however, nonoperative methods have been associated with increased mortality. Thus, there has been a shift toward operative management for the elderly and less healthy patients. However, these patients often...
Source: Journal of the American Podiatric Medical Association - September 19, 2023 Category: Podiatry Authors: Rayven Bridges Angelica Saulabiu Source Type: research
Entinostat enhances the efficacy of chemotherapy in small cell lung cancer through S-phase arrest and decreased base excision repair
CONCLUSIONS: In this study, we decipher the molecular processes behind synergistic interactions between chemotherapy and HDAC inhibition. Moreover, we report novel mechanisms to overcome drug resistance in SCLC, which may be relevant to increase the therapeutic success.PMID:37725585 | DOI:10.1158/1078-0432.CCR-23-1795
Source: Clinical Cancer Research - September 19, 2023 Category: Cancer & Oncology Authors: Anna Solta Kristiina Boettiger Ildik ó Kovács Christian Lang Zsolt Megyesfalvi Franziska Ferk Miroslav Mi šík Konrad Hoetzenecker Clemens Aigner Christian R Kowol Siegfried Knasmueller Michael Grusch Be áta Szeitz Melinda Rezeli Balazs Dome Karin Sch Source Type: research
Gelatin Sponges with a Uniform Interoperable Pore Structure and Biodegradability for Liver Injury Hemostasis and Tissue Regeneration
Biomacromolecules. 2023 Sep 19. doi: 10.1021/acs.biomac.3c00803. Online ahead of print.ABSTRACTDeveloping a hemostatic sponge that can effectively control bleeding from visceral injuries while guiding in situ tissue regeneration in incompressible wounds remains a challenge. Most of the existing hemostatic sponges degrade slowly, are relatively single-functioning, and cannot cope with complex environments. Herein, a biodegradable rapidly hemostatic sponge (GPZ) was created by dual-dynamic-bond cross-linking among Zn2+, protocatechualdehyde (PA)-containing catechol and aldehyde groups, and gelatin. GPZ had a uniformly distri...
Source: Biomacromolecules - September 19, 2023 Category: Biochemistry Authors: Yangrui Du Yangjing Bai Shiying Lang Dandan Xing Li Ma Kaijun Li Jinyu Peng Xinyun Li Gongyan Liu Source Type: research
Hemodynamics and diastolic function after native aortic valve preserving vs replacing surgery
Conclusion Preservation of native tissue in AV surgery results in superior transvalvular hemodynamics compared to prosthetic AV replacement. This may induce faster LV reverse remodeling and may explain more pronounced improvement in LV diastolic function.PMID:37726023 | DOI:10.1055/a-2178-0395
Source: The Thoracic and Cardiovascular Surgeon - September 19, 2023 Category: Cardiovascular & Thoracic Surgery Authors: Theresa Holst Xiaoqin Hua Christoph Sinning Benjamin Waschki Hermann Reichenspurner Evaldas Girdauskas Johannes Petersen Source Type: research
Tumor-derived biomarkers predict efficacy of B7H3 antibody-drug conjugate treatment in metastatic prostate cancer models
We present a comprehensive therapeutic and biomarker analysis of a B7H3-ADC with pyrrolobenzodiazepine(PBD) payload in 26 treatment-resistant, metastatic prostate cancer(mPC) models. B7H3 is a tumor-specific surface protein widely expressed in mPC, and PBD is a DNA cross-linking agent. B7H3 expression was necessary but not sufficient for B7H3-PBD-ADC responsiveness. RB1 deficiency and/or replication stress, characteristics of poor prognosis, conferred sensitivity and were associated with complete tumor regression in both neuroendocrine (NEPC) and androgen receptor positive(ARPC) prostate cancer models, even with low B7H3 l...
Source: Clinical Prostate Cancer - September 19, 2023 Category: Cancer & Oncology Authors: Supreet Agarwal Lei Fang Kerry McGowen JuanJuan Yin Joel Bowman Anson T Ku Aian Neil Alilin Eva Corey Martine P Roudier Lawrence D True Ruth F Dumpit Ilsa Coleman John K Lee Peter S Nelson Brian J Capaldo Aida Mariani Clare E Hoover Ilya S Senatorov Micha Source Type: research
