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Procedure: Gastroschisis Repair
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Total 54334 results found since Jan 2013.
Cisplatin-induced DNA crosslinks trigger neurotoxicity in C. elegans
Biochim Biophys Acta Mol Cell Res. 2023 Sep 18:119591. doi: 10.1016/j.bbamcr.2023.119591. Online ahead of print.ABSTRACTThe anticancer drug cisplatin (CisPt) injures post-mitotic neuronal cells, leading to neuropathy. Furthermore, CisPt triggers cell death in replicating cells. Here, we aim to unravel the relevance of different types of CisPt-induced DNA lesions for evoking neurotoxicity. To this end, we comparatively analyzed wild-type and loss of function mutants of C. elegans lacking key players of specific DNA repair pathways. Deficiency in ercc-1, which is essential for nucleotide excision repair (NER) and interstrand...
Source: Biochimica et Biophysica Acta - September 20, 2023 Category: Biochemistry Authors: Fabian Wynen Johannes Krautstrunk Lisa Marie M üller Viktoria Graf Vanessa Brinkmann Gerhard Fritz Source Type: research
Patient Experiences With Hand Surgery in the Office Versus Ambulatory Surgery Center
Conclusions Though costs and time off of work differed between the two groups due to the different procedures in either setting, patient satisfaction metrics were comparable. While patient satisfaction depends on the operating physician, these results demonstrate that patients treated in-office and in an ASC have similar levels of approval with their hand surgery care.PMID:37727164 | PMC:PMC10506845 | DOI:10.7759/cureus.43763
Source: Pain Physician - September 20, 2023 Category: Anesthesiology Authors: Brandon W Knopp Jared Kushner Emma Eng Jake Goguen Ehsan Esmaeili Source Type: research
The assessment of thoracal approaches in the treatment of aortic coarctation
CONCLUSION: Thoracotomy provided feasible surgical access that led to satisfactory results with a low complication rate, negligible residual gradient, low incidence of hypertension and excellent rate for freedom from re-intervention in the treatment of CoA.PMID:37728294 | DOI:10.5830/CVJA-2023-039
Source: Cardiovascular Journal of Africa - September 20, 2023 Category: Cardiology Authors: Onur I şık G ökmen Akkaya Fatih Durak Defne Eng ür Meltem Çakmak Ali Rahmi Bakiler Muhammet Aky üz Source Type: research
Implications of ubiquitination and the maintenance of replication fork stability in cancer therapy
Biosci Rep. 2023 Sep 20:BSR20222591. doi: 10.1042/BSR20222591. Online ahead of print.ABSTRACTDNA replication forks are subject to intricate surveillance and strict regulation by sophisticated cellular machinery. Such close regulation is necessary to ensure the accurate duplication of genetic information and to tackle the diverse endogenous and exogenous stresses that impede this process. Stalled replication forks are vulnerable to collapse, which is a major cause of genomic instability and carcinogenesis. Replication stress responses, which are organized via a series of coordinated molecular events, stabilize stalled repli...
Source: Bioscience Reports - September 20, 2023 Category: Biomedical Science Authors: Donghui Xia Xuefei Zhu Ying Wang Peng Gong Hong-Shu Su Xingzhi Xu Source Type: research
Experimental evaluation of the use of starch and carboxymethylcellulose in the prevention of intraperitoneal adhesions in hernia surgery with coated meshes
CONCLUSIONS: The use of SC decreased the intensity of adhesions and the surface area of the mesh affected by adhesions. There was no negative interference of the product in the incorporation of the mesh into the abdominal wall.PMID:37729350 | DOI:10.1590/acb383323
Source: Acta Cirurgica Brasileira - September 20, 2023 Category: Surgery Authors: Paulo Vicente Dos Santos Filho Elcio Shiyoiti Hirano Source Type: research
Can Open Distal Repair Be Safely Used in All Patients with Type A Acute Aortic Dissection?
CONCLUSION: We conclude that the open repair can be used in most if not all cases of surgical repair of type A acute aortic dissection.PMID:37730310 | DOI:10.5761/atcs.oa.23-00086
Source: Annals of Thoracic and Cardiovascular Surgery - September 20, 2023 Category: Cardiovascular & Thoracic Surgery Authors: Georgi Manchev Vassil Gegouskov Vladimir Kornovski Georgi Yankov Valya Goranovska Vicktoria Ilieva Vicktoria Petrova Source Type: research
Transcriptome analysis reveals molecular regulation mechanism of Tibet sheep tolerance to high altitude oxygen environment
This study will lay a certain foundation for Tibet sheep research.PMID:37729444 | DOI:10.1080/10495398.2023.2258953
Source: Animal Biotechnology - September 20, 2023 Category: Biotechnology Authors: Li An Yanyan Li Lin Yaq Yong Wang Qilin Dai Shizhang Du Yi Ru Qi Zhoucuo Jinling Wang Source Type: research
Aerobic exercise attenuates abnormal myelination and oligodendrocyte differentiation in 3xTg-AD mice
In this study we tested the hypotheses that 1) myelin structural alterations in 3xTg-AD mice would be related to abnormalities in oligodendrocyte lineage cells, resulting in impaired learning and memory, and 2) a 6-month aerobic exercise intervention would have beneficial effects on such alterations. Two-month-old male 3xTg-AD mice were randomly assigned to a control (AC) or an exercise (AE) group, and age-matched male C57BL/6;129 mice were also randomly assigned to a normal control (NC) or an exercise (NE) group, with n = 12 in each group. Mice in the exercise groups were trained on a motor-drive treadmill, 60 min per day...
Source: Experimental Gerontology - September 20, 2023 Category: Geriatrics Authors: Dan Qiu Shi Zhou James Donnelly Dongdong Xia Li Zhao Source Type: research
Discovery of BbX transcription factor in the patagonian blennie: Exploring expression changes following combined bacterial and thermal stress exposure
Dev Comp Immunol. 2023 Sep 18:105056. doi: 10.1016/j.dci.2023.105056. Online ahead of print.ABSTRACTHigh-Mobility Group (HMG) proteins are involved in different processes such as transcription, replication, DNA repair, and immune response. The role of HMG proteins in the immune response of fish has been studied mainly for HMGB1, where its expression can be induced by the stimulation of viral/bacterial PAMPs and can act as a proinflammatory mediator and as a global regulator of transcription in response to temperature. However, for BbX this role remains to be discovered. In this work, we identified the BbX of E. maclovinus ...
Source: Developmental and Comparative Immunology - September 20, 2023 Category: Allergy & Immunology Authors: Danixa Mart ínez Daniela Nualart Carlos Loncoman Juan C Opazo Kattina Zabala Francisco J Morera Gonzalo A Mardones Luis Vargas-Chacoff Source Type: research
< em > NOTCH2 < /em > gene mutation and gamma-secretase inhibitor in mediating the malignancy of ovarian cancer
Aging (Albany NY). 2023 Sep 19;15. doi: 10.18632/aging.205045. Online ahead of print.ABSTRACTThe carcinogenic mechanisms by which serous ovarian cancer (OC) occurs remain to be explored. Currently, we have conducted whole-exome sequencing (WES) and targeted deep sequencing to validate new molecular markers, including NOTCH2, that impede the progression of cell malignancy in ovarian cancer (OC). Following NOTCH2 P2113S mutation and NOTCH signaling pathway inhibitor N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester (DAPT) treatment, the cell proliferation, migration, and invasion of A2780 and SKOV3 OC cel...
Source: Aging - September 20, 2023 Category: Biomedical Science Authors: Wenjing Wang Ruiqian Liu Wei Liao Landie Ji Jie Mei Dan Su Source Type: research
History of peripheral nerve injuries
This article reviews the history of peripheral nerve (PN) injuries and successive advances in their management by notable pioneers, an interesting topic that I chose for my Doctoral Thesis in 1990 in Madrid. Mentioning all their names and contributions is an obligatory tribute, and I offer my sincere apologies for inevitably leaving a few out. For half a century I have witnessed microsurgery advances, and also experienced frequent failures in my practice with the use of new techniques; a testimony that we are very far from achieving the 'Holy Grail' of complete PN recovery for these injuries. Our experience is often like a...
Source: Hand Surgery - September 20, 2023 Category: Surgery Authors: Carlos Irisarri Source Type: research
Entinostat enhances the efficacy of chemotherapy in small cell lung cancer through S-phase arrest and decreased base excision repair
CONCLUSIONS: In this study, we decipher the molecular processes behind synergistic interactions between chemotherapy and HDAC inhibition. Moreover, we report novel mechanisms to overcome drug resistance in SCLC, which may be relevant to increase the therapeutic success.PMID:37725585 | DOI:10.1158/1078-0432.CCR-23-1795
Source: Cell Research - September 19, 2023 Category: Cytology Authors: Anna Solta Kristiina Boettiger Ildik ó Kovács Christian Lang Zsolt Megyesfalvi Franziska Ferk Miroslav Mi šík Konrad Hoetzenecker Clemens Aigner Christian R Kowol Siegfried Knasmueller Michael Grusch Be áta Szeitz Melinda Rezeli Balazs Dome Karin Sch Source Type: research
The Role of Mesenchymal Stem/Stromal Cells Secretome in Macrophage Polarization: Perspectives on Treating Inflammatory Diseases
Curr Stem Cell Res Ther. 2023 Sep 4. doi: 10.2174/1574888X18666230811093101. Online ahead of print.ABSTRACTMesenchymal stem/stromal cells (MSCs) have exhibited potential for treating multiple inflammation- related diseases (IRDs) due to their easy acquisition, unique immunomodulatory and tissue repair properties, and immune-privileged characteristics. It is worth mentioning that MSCs release a wide array of soluble bioactive components in the secretome that modulate host innate and adaptive immune responses and promote the resolution of inflammation. As the first line of defense, macrophages exist throughout the entire inf...
Source: Cell Research - September 19, 2023 Category: Cytology Authors: Dongdong Ti Jun Yi Huihua Chen Haojie Hao Chunmeng Shi Source Type: research
Entinostat enhances the efficacy of chemotherapy in small cell lung cancer through S-phase arrest and decreased base excision repair
CONCLUSIONS: In this study, we decipher the molecular processes behind synergistic interactions between chemotherapy and HDAC inhibition. Moreover, we report novel mechanisms to overcome drug resistance in SCLC, which may be relevant to increase the therapeutic success.PMID:37725585 | DOI:10.1158/1078-0432.CCR-23-1795
Source: Clinical Cancer Research - September 19, 2023 Category: Cancer & Oncology Authors: Anna Solta Kristiina Boettiger Ildik ó Kovács Christian Lang Zsolt Megyesfalvi Franziska Ferk Miroslav Mi šík Konrad Hoetzenecker Clemens Aigner Christian R Kowol Siegfried Knasmueller Michael Grusch Be áta Szeitz Melinda Rezeli Balazs Dome Karin Sch Source Type: research
The Role of Mesenchymal Stem/Stromal Cells Secretome in Macrophage Polarization: Perspectives on Treating Inflammatory Diseases
Curr Stem Cell Res Ther. 2023 Sep 4. doi: 10.2174/1574888X18666230811093101. Online ahead of print.ABSTRACTMesenchymal stem/stromal cells (MSCs) have exhibited potential for treating multiple inflammation- related diseases (IRDs) due to their easy acquisition, unique immunomodulatory and tissue repair properties, and immune-privileged characteristics. It is worth mentioning that MSCs release a wide array of soluble bioactive components in the secretome that modulate host innate and adaptive immune responses and promote the resolution of inflammation. As the first line of defense, macrophages exist throughout the entire inf...
Source: Current Stem Cell Research and Therapy - September 19, 2023 Category: Stem Cells Authors: Dongdong Ti Jun Yi Huihua Chen Haojie Hao Chunmeng Shi Source Type: research
