Filtered By:
Procedure: Gastroschisis Repair
This page shows you your search results in order of date. This is page number 9.
Order by Relevance | Date
Total 54334 results found since Jan 2013.
NAT10 regulates the repair of UVB-induced DNA damage and tumorigenicity
Toxicol Appl Pharmacol. 2023 Sep 14:116688. doi: 10.1016/j.taap.2023.116688. Online ahead of print.ABSTRACTChemical modifications in messenger RNA (mRNA) regulate gene expression and play critical roles in stress responses and diseases. Recently we have shown that N6-methyladenosine (m6A), the most abundant mRNA modification, promotes the repair of UVB-induced DNA damage by regulating global genome nucleotide excision repair (GG-NER). However, the roles of other mRNA modifications in the UVB-induced damage response remain understudied. N4-acetylcytidine (ac4C) is deposited in mRNA by the RNA-binding acetyltransferase NAT10...
Source: Toxicology and Applied Pharmacology - September 16, 2023 Category: Toxicology Authors: Zizhao Yang Emma Wilkinson Yan-Hong Cui Haixia Li Yu-Ying He Source Type: research
Three-dimensional Anatomy of the Velopharyngeal Muscles in the Cleft Palate
CONCLUSIONS: With the help of Micro-CT technology, detailed anatomical features and the relationship between muscles could be visualized. In the specimen with cleft palate, muscles in the soft palate were associated with the pharyngeal muscles, which formed the 3D "velopharyngeal muscles complex." These findings provide anatomical evidence for muscle reconstruction in cleft palate repair.PMID:37715628 | DOI:10.1177/10556656231176867
Source: The Cleft Palate-Craniofacial Journal - September 16, 2023 Category: ENT & OMF Authors: Jiuli Zhao Hengyuan Ma Yongqian Wang Tao Song Di Wu Ningbei Yin Source Type: research
Live cell transcription-coupled nucleotide excision repair dynamics revisited
In this study, we employ knock-in cell lines designed to target the endogenous CSB gene locus with mClover, a GFP variant. Through live cell imaging, we uncover the intricate molecular dynamics of CSB in response to physiologically relevant UV doses. We showed that the DNA damage-induced association of CSB with chromatin is tightly regulated by the CSA-containing ubiquitin-ligase CRL complex (CRL4CSA). Combining the CSB-mClover knock-in cell line with SILAC-based GFP-mediated complex isolation and mass-spectrometry-based proteomics, revealed novel putative CSB interactors as well as discernible variations in complex compos...
Source: DNA Repair - September 16, 2023 Category: Genetics & Stem Cells Authors: Diana A Llerena Schiffmacher Katarzyna W Kliza Arjan F Theil Gert-Jan Kremers Jeroen A A Demmers Tomoo Ogi Michiel Vermeulen Wim Vermeulen Alex Pines Source Type: research
Three-dimensional Anatomy of the Velopharyngeal Muscles in the Cleft Palate
CONCLUSIONS: With the help of Micro-CT technology, detailed anatomical features and the relationship between muscles could be visualized. In the specimen with cleft palate, muscles in the soft palate were associated with the pharyngeal muscles, which formed the 3D "velopharyngeal muscles complex." These findings provide anatomical evidence for muscle reconstruction in cleft palate repair.PMID:37715628 | DOI:10.1177/10556656231176867
Source: The Cleft Palate-Craniofacial Journal - September 16, 2023 Category: ENT & OMF Authors: Jiuli Zhao Hengyuan Ma Yongqian Wang Tao Song Di Wu Ningbei Yin Source Type: research
NAT10 regulates the repair of UVB-induced DNA damage and tumorigenicity
Toxicol Appl Pharmacol. 2023 Sep 14;477:116688. doi: 10.1016/j.taap.2023.116688. Online ahead of print.ABSTRACTChemical modifications in messenger RNA (mRNA) regulate gene expression and play critical roles in stress responses and diseases. Recently we have shown that N6-methyladenosine (m6A), the most abundant mRNA modification, promotes the repair of UVB-induced DNA damage by regulating global genome nucleotide excision repair (GG-NER). However, the roles of other mRNA modifications in the UVB-induced damage response remain understudied. N4-acetylcytidine (ac4C) is deposited in mRNA by the RNA-binding acetyltransferase N...
Source: Toxicology and Applied Pharmacology - September 16, 2023 Category: Toxicology Authors: Zizhao Yang Emma Wilkinson Yan-Hong Cui Haixia Li Yu-Ying He Source Type: research
Live cell transcription-coupled nucleotide excision repair dynamics revisited
In this study, we employ knock-in cell lines designed to target the endogenous CSB gene locus with mClover, a GFP variant. Through live cell imaging, we uncover the intricate molecular dynamics of CSB in response to physiologically relevant UV doses. We showed that the DNA damage-induced association of CSB with chromatin is tightly regulated by the CSA-containing ubiquitin-ligase CRL complex (CRL4CSA). Combining the CSB-mClover knock-in cell line with SILAC-based GFP-mediated complex isolation and mass-spectrometry-based proteomics, revealed novel putative CSB interactors as well as discernible variations in complex compos...
Source: DNA Repair - September 16, 2023 Category: Genetics & Stem Cells Authors: Diana A Llerena Schiffmacher Katarzyna W Kliza Arjan F Theil Gert-Jan Kremers Jeroen A A Demmers Tomoo Ogi Michiel Vermeulen Wim Vermeulen Alex Pines Source Type: research
The Open Genes Database of Associations with Aging and Longevity
The Open Genes database provides summaries of the information available on longevity-associated genes, from well-established and well-replicated effects such as that associated with klotho expression, to much less well supported data. Thousands of genes have at least a study or two suggesting an effect on longevity in studies of lower animals, and many of those may turn out to be experimental error. Yet since every fundamental cellular process can be influenced by dozens or hundreds of genes, even though there are comparatively few important processes of aging, one might well expect there be to be thousands of related gene...
Source: Fight Aging! - September 15, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Proliferation and migration of ML1 follicular thyroid cancer cells are inhibited by IU1 targeting USP14: role of proteasome and autophagy flux
Front Cell Dev Biol. 2023 Aug 30;11:1234204. doi: 10.3389/fcell.2023.1234204. eCollection 2023.ABSTRACTUSP14 is a deubiquitinating enzyme involved in protein degradation by interacting with the proteasome and removal of poly-ubiquitin chains on target proteins. USP14 can influence cellular processes such as cell survival, DNA repair, ER stress, endocytosis, and the inflammatory response. USP14 further plays a role in tumor growth, and the inhibition of USP14 by compounds such as IU1 may affect cancer cell migration and invasion. Here we have studied the mechanisms for the action of IU1 in ML1 follicular thyroid cancer cell...
Source: Cancer Control - September 15, 2023 Category: Cancer & Oncology Authors: Vignesh Srinivasan Muhammad Yasir Asghar Sadia Zafar Kid T örnquist Dan Lindholm Source Type: research
Comparative efficacy of endogenous stem cells recruiting hydrogels and stem cell-loaded hydrogels in knee cartilage regeneration: a meta-analysis
Conclusion The current study indicates that both endogenous stem cell recruiting hydrogels and stem cell loaded hydrogels can effectively promote knee joint cartilage regeneration in animal trials.PMID:37711133 | DOI:10.2174/1574888X19666230914123443
Source: Current Stem Cell Research and Therapy - September 15, 2023 Category: Stem Cells Authors: Wanyun Feng Chaohua Zhu Ruoxiang Miao Danni Li Xi Xiong Ruyu Wang Guobing Liu Jun Ma Source Type: research
KPT330 promotes the sensitivity of glioblastoma to olaparib by retaining SQSTM1 in the nucleus and disrupting lysosomal function
Autophagy. 2023 Sep 15. doi: 10.1080/15548627.2023.2252301. Online ahead of print.ABSTRACTPARP (poly(ADP-ribose) polymerase) inhibitors have demonstrated promising clinical activity in multiple homologous recombination (HR) deficiency tumors. However, glioblastoma (GBM) patients have obtained little benefit from PARP inhibitors alone. PARP inhibition shows considerable promise when used together with other therapeutic agents. Thus, novel combination therapies may enhance PARP inhibitor efficacy and overcome resistance mechanisms in GBM. Herein, we report that concurrent treatment with the PARP inhibitor olaparib and XPO1 (...
Source: Autophagy - September 15, 2023 Category: Cytology Authors: Li-Hong Wang Sen Wei Ye Yuan Ming-Jun Zhong Jiao Wang Ze-Xuan Yan Kai Zhou Tao Luo Li Liang Xiu-Wu Bian Source Type: research
Emerging Role of Ferroptosis in Breast Cancer: Characteristics, Therapy, and Translational Implications for the Present and Future
We present a fundamental analysis of the actual understanding of molecular mechanisms along with regulatory networks associated with ferroptosis, expected physiological functions in growth concealment, ferroptosis-associated differentially expressed genes, treatment targeting potential, and recent advances in the development of therapeutic strategies in this review.PMID:37711099 | DOI:10.2174/1566524023666230913105735
Source: Molecular Medicine - September 15, 2023 Category: Molecular Biology Authors: Suman Kumar Ray Sukhes Mukherjee Source Type: research
Cardiac Tamponade Secondary to Hemorrhagic Pericardial Effusion: A Complication of STEMI
Conclusion: The differential for hemodynamic compromise in a patient with STEMI is broad, but quickly distinguishing pump failure from other life-threatening causes of shock is imperative to dictate time-sensitive management decisions. The presence of a hemorrhagic pericardial effusion in the setting of STEMI is a surrogate marker for a severe infarct and can help the bedside physician determine whether a patient will be better served in the catheterization lab for revascularization or in the operating room for surgical repair.PMID:37711482 | PMC:PMC10498953 | DOI:10.31486/toj.23.0023
Source: Pain Physician - September 15, 2023 Category: Anesthesiology Authors: Marvin Kajy Amy Rechenberg Connor Kerndt Kevin Wolschleger Source Type: research
Integrated BATF transcriptional network regulates suppressive intratumoral regulatory T cells
Sci Immunol. 2023 Sep 15;8(87):eadf6717. doi: 10.1126/sciimmunol.adf6717. Epub 2023 Sep 15.ABSTRACTHuman regulatory T cells (Tregs) are crucial regulators of tissue repair, autoimmune diseases, and cancer. However, it is challenging to inhibit the suppressive function of Tregs for cancer therapy without affecting immune homeostasis. Identifying pathways that may distinguish tumor-restricted Tregs is important, yet the transcriptional programs that control intratumoral Treg gene expression, and that are distinct from Tregs in healthy tissues, remain largely unknown. We profiled single-cell transcriptomes of CD4+ T cells in ...
Source: Cancer Control - September 15, 2023 Category: Cancer & Oncology Authors: Feng Shan Anthony R Cillo Carly Cardello Daniel Y Yuan Sheryl R Kunning Jian Cui Caleb Lampenfeld Asia M Williams Alexandra P McDonough Arjun Pennathur James D Luketich John M Kirkwood Robert L Ferris Tullia C Bruno Creg J Workman Panayiotis V Benos Dario Source Type: research
The FAM104 proteins VCF1/2 promote the nuclear localization of p97/VCP
Elife. 2023 Sep 15;12:e92409. doi: 10.7554/eLife.92409. Online ahead of print.ABSTRACTThe ATPase p97 (also known as VCP, Cdc48) has crucial functions in a variety of important cellular processes such as protein quality control, organellar homeostasis and DNA damage repair, and its de-regulation is linked to neuro-muscular diseases and cancer. p97 is tightly controlled by numerous regulatory cofactors, but the full range and function of the p97-cofactor network is unknown. Here, we identify the hitherto uncharacterized FAM104 proteins as a conserved family of p97 interactors. The two human family members VCP nuclear cofacto...
Source: Cancer Control - September 15, 2023 Category: Cancer & Oncology Authors: Maria K örner Susanne R Meyer Gabriella Marincola Maximilian J Kern Clemens Grimm Christina Schuelein-Voelk Utz Fischer Kay Hofmann Alexander Buchberger Source Type: research
