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KPT330 promotes the sensitivity of glioblastoma to olaparib by retaining SQSTM1 in the nucleus and disrupting lysosomal function
Autophagy. 2023 Sep 15. doi: 10.1080/15548627.2023.2252301. Online ahead of print.ABSTRACTPARP (poly(ADP-ribose) polymerase) inhibitors have demonstrated promising clinical activity in multiple homologous recombination (HR) deficiency tumors. However, glioblastoma (GBM) patients have obtained little benefit from PARP inhibitors alone. PARP inhibition shows considerable promise when used together with other therapeutic agents. Thus, novel combination therapies may enhance PARP inhibitor efficacy and overcome resistance mechanisms in GBM. Herein, we report that concurrent treatment with the PARP inhibitor olaparib and XPO1 (...
Source: Autophagy - September 15, 2023 Category: Cytology Authors: Li-Hong Wang Sen Wei Ye Yuan Ming-Jun Zhong Jiao Wang Ze-Xuan Yan Kai Zhou Tao Luo Li Liang Xiu-Wu Bian Source Type: research
Allele-specific expression reveals genetic drivers of tissue regeneration in mice
Cell Stem Cell. 2023 Sep 13:S1934-5909(23)00293-X. doi: 10.1016/j.stem.2023.08.010. Online ahead of print.ABSTRACTIn adult mammals, skin wounds typically heal by scarring rather than through regeneration. In contrast, "super-healer" Murphy Roths Large (MRL) mice have the unusual ability to regenerate ear punch wounds; however, the molecular basis for this regeneration remains elusive. Here, in hybrid crosses between MRL and non-regenerating mice, we used allele-specific gene expression to identify cis-regulatory variation associated with ear regeneration. Analyzing three major cell populations (immune, fibroblast, and endo...
Source: Cell Stem Cell - September 15, 2023 Category: Stem Cells Authors: Katya L Mack Heather E Talbott Michelle F Griffin Jennifer B L Parker Nicholas J Guardino Amanda F Spielman Michael F Davitt Shamik Mascharak Mauricio Downer Annah Morgan Caleb Valencia Deena Akras Mark J Berger Derrick C Wan Hunter B Fraser Michael T Lon Source Type: research
The Effect of Distributional Restrictions in Speech Perception: A Case Study From Korean and Taiwanese Southern Min
Lang Speech. 2023 Sep 15:238309231195263. doi: 10.1177/00238309231195263. Online ahead of print.ABSTRACTIn Korean, voiced oral stops can occur intervocalically as allophones of their voiceless lenis counterparts; they can also occur initially as variants of nasal stops as a result of initial denasalization (e.g., /motu/→[bodu] "all"). However, neither [ŋ] nor [ɡ] (the denasalized variant of the velar nasal) is allowed in the initial position due to the phonotactic restriction against initial [ŋ] in Korean. Given the distribution of nasal and voiced stops in Korean, this study draws on the idea of cue informativeness, ...
Source: Language and Speech - September 15, 2023 Category: Speech-Language Pathology Authors: Jiwon Hwang Yu-An Lu Source Type: research
Ki67 and prostate specific antigen are prognostic in metastatic hormone na ïve prostate cancer
CONCLUSION: PSA and Ki67 immunoreactive scores are prognostic in the metastatic hormone-sensitive setting, with PSA being superior. The combination of Ki67 and PSA did not give additional prognostic value. The results suggest immunohistochemical scoring of PSA to have potential to improve identification of patients responding well to ADT alone.PMID:37713321 | DOI:10.1080/0284186X.2023.2254480
Source: Acta Oncologica - September 15, 2023 Category: Cancer & Oncology Authors: Vasiliki Spyratou Eva Freyhult Anders Bergh Camilla Thellenberg-Karlsson Pernilla Wikstr öm Karin Wel én Andreas Josefsson Source Type: research
The Effect of Distributional Restrictions in Speech Perception: A Case Study From Korean and Taiwanese Southern Min
Lang Speech. 2023 Sep 15:238309231195263. doi: 10.1177/00238309231195263. Online ahead of print.ABSTRACTIn Korean, voiced oral stops can occur intervocalically as allophones of their voiceless lenis counterparts; they can also occur initially as variants of nasal stops as a result of initial denasalization (e.g., /motu/→[bodu] "all"). However, neither [ŋ] nor [ɡ] (the denasalized variant of the velar nasal) is allowed in the initial position due to the phonotactic restriction against initial [ŋ] in Korean. Given the distribution of nasal and voiced stops in Korean, this study draws on the idea of cue informativeness, ...
Source: Language and Speech - September 15, 2023 Category: Speech-Language Pathology Authors: Jiwon Hwang Yu-An Lu Source Type: research
Machine learning to predict outcomes following endovascular abdominal aortic aneurysm repair
CONCLUSIONS: In this data set, machine learning was able to predict 1-year mortality following EVAR using preoperative data and outperformed standard logistic regression models.PMID:37710397 | DOI:10.1093/bjs/znad287
Source: The British Journal of Surgery - September 15, 2023 Category: Surgery Authors: Ben Li Badr Aljabri Raj Verma Derek Beaton Naomi Eisenberg Douglas S Lee Duminda N Wijeysundera Thomas L Forbes Ori D Rotstein Charles de Mestral Muhammad Mamdani Graham Roche-Nagle Mohammed Al-Omran Source Type: research
Comparative efficacy of endogenous stem cells recruiting hydrogels and stem cell-loaded hydrogels in knee cartilage regeneration: a meta-analysis
Conclusion The current study indicates that both endogenous stem cell recruiting hydrogels and stem cell loaded hydrogels can effectively promote knee joint cartilage regeneration in animal trials.PMID:37711133 | DOI:10.2174/1574888X19666230914123443
Source: Current Stem Cell Research and Therapy - September 15, 2023 Category: Stem Cells Authors: Wanyun Feng Chaohua Zhu Ruoxiang Miao Danni Li Xi Xiong Ruyu Wang Guobing Liu Jun Ma Source Type: research
Allele-specific expression reveals genetic drivers of tissue regeneration in mice
Cell Stem Cell. 2023 Sep 13:S1934-5909(23)00293-X. doi: 10.1016/j.stem.2023.08.010. Online ahead of print.ABSTRACTIn adult mammals, skin wounds typically heal by scarring rather than through regeneration. In contrast, "super-healer" Murphy Roths Large (MRL) mice have the unusual ability to regenerate ear punch wounds; however, the molecular basis for this regeneration remains elusive. Here, in hybrid crosses between MRL and non-regenerating mice, we used allele-specific gene expression to identify cis-regulatory variation associated with ear regeneration. Analyzing three major cell populations (immune, fibroblast, and endo...
Source: Cell Stem Cell - September 15, 2023 Category: Stem Cells Authors: Katya L Mack Heather E Talbott Michelle F Griffin Jennifer B L Parker Nicholas J Guardino Amanda F Spielman Michael F Davitt Shamik Mascharak Mauricio Downer Annah Morgan Caleb Valencia Deena Akras Mark J Berger Derrick C Wan Hunter B Fraser Michael T Lon Source Type: research
Machine learning to predict outcomes following endovascular abdominal aortic aneurysm repair
CONCLUSIONS: In this data set, machine learning was able to predict 1-year mortality following EVAR using preoperative data and outperformed standard logistic regression models.PMID:37710397 | DOI:10.1093/bjs/znad287
Source: The British Journal of Surgery - September 15, 2023 Category: Surgery Authors: Ben Li Badr Aljabri Raj Verma Derek Beaton Naomi Eisenberg Douglas S Lee Duminda N Wijeysundera Thomas L Forbes Ori D Rotstein Charles de Mestral Muhammad Mamdani Graham Roche-Nagle Mohammed Al-Omran Source Type: research
Emerging Role of Ferroptosis in Breast Cancer: Characteristics, Therapy, and Translational Implications for the Present and Future
We present a fundamental analysis of the actual understanding of molecular mechanisms along with regulatory networks associated with ferroptosis, expected physiological functions in growth concealment, ferroptosis-associated differentially expressed genes, treatment targeting potential, and recent advances in the development of therapeutic strategies in this review.PMID:37711099 | DOI:10.2174/1566524023666230913105735
Source: Current Molecular Medicine - September 15, 2023 Category: Molecular Biology Authors: Suman Kumar Ray Sukhes Mukherjee Source Type: research
A Nationwide Study on Mitral Valve Repair Versus Replacement for Active Endocarditis
CONCLUSIONS: Contemporary trends in mitral valve surgery for active infective endocarditis suggest growing patient complexity but slightly declining early mortality rates. A trend of decreasing mitral valve repair rates was seen. Our results suggest improved late outcomes of valve repair compared to replacement.PMID:37714504 | DOI:10.1016/j.athoracsur.2023.08.032
Source: The Annals of Thoracic Surgery - September 15, 2023 Category: Cardiovascular & Thoracic Surgery Authors: Anton Tom šič Arend de Weger Michelle van der Stoel Robert J M Klautz Meindert Palmen Cardiothoracic Surgery Registration Committee of the Netherlands Heart Registration Source Type: research
Allele-specific expression reveals genetic drivers of tissue regeneration in mice
Cell Stem Cell. 2023 Sep 13:S1934-5909(23)00293-X. doi: 10.1016/j.stem.2023.08.010. Online ahead of print.ABSTRACTIn adult mammals, skin wounds typically heal by scarring rather than through regeneration. In contrast, "super-healer" Murphy Roths Large (MRL) mice have the unusual ability to regenerate ear punch wounds; however, the molecular basis for this regeneration remains elusive. Here, in hybrid crosses between MRL and non-regenerating mice, we used allele-specific gene expression to identify cis-regulatory variation associated with ear regeneration. Analyzing three major cell populations (immune, fibroblast, and endo...
Source: Cell Stem Cell - September 15, 2023 Category: Stem Cells Authors: Katya L Mack Heather E Talbott Michelle F Griffin Jennifer B L Parker Nicholas J Guardino Amanda F Spielman Michael F Davitt Shamik Mascharak Mauricio Downer Annah Morgan Caleb Valencia Deena Akras Mark J Berger Derrick C Wan Hunter B Fraser Michael T Lon Source Type: research
Comparative efficacy of endogenous stem cells recruiting hydrogels and stem cell-loaded hydrogels in knee cartilage regeneration: a meta-analysis
Conclusion The current study indicates that both endogenous stem cell recruiting hydrogels and stem cell loaded hydrogels can effectively promote knee joint cartilage regeneration in animal trials.PMID:37711133 | DOI:10.2174/1574888X19666230914123443
Source: Current Stem Cell Research and Therapy - September 15, 2023 Category: Stem Cells Authors: Wanyun Feng Chaohua Zhu Ruoxiang Miao Danni Li Xi Xiong Ruyu Wang Guobing Liu Jun Ma Source Type: research
KPT330 promotes the sensitivity of glioblastoma to olaparib by retaining SQSTM1 in the nucleus and disrupting lysosomal function
Autophagy. 2023 Sep 15. doi: 10.1080/15548627.2023.2252301. Online ahead of print.ABSTRACTPARP (poly(ADP-ribose) polymerase) inhibitors have demonstrated promising clinical activity in multiple homologous recombination (HR) deficiency tumors. However, glioblastoma (GBM) patients have obtained little benefit from PARP inhibitors alone. PARP inhibition shows considerable promise when used together with other therapeutic agents. Thus, novel combination therapies may enhance PARP inhibitor efficacy and overcome resistance mechanisms in GBM. Herein, we report that concurrent treatment with the PARP inhibitor olaparib and XPO1 (...
Source: Autophagy - September 15, 2023 Category: Cytology Authors: Li-Hong Wang Sen Wei Ye Yuan Ming-Jun Zhong Jiao Wang Ze-Xuan Yan Kai Zhou Tao Luo Li Liang Xiu-Wu Bian Source Type: research
