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Total 4543034 results found since Jan 2013.
Environmentally friendly antibiofilm strategy based on cationized phytoglycogen nanoparticles
In this study, we investigate the potential of polysaccharidic phytoglycogen nanoparticles extracted from corn, in treating cyanobacterial biofilms, which are the source of toxins and pollution in aquatic environments. Our results revealed that the surface of cyanobacterial cells was dominated by the negatively charged functional groups such as carboxylic and phosphoric groups. The native phytoglycogen (PhX) nanoparticles were dominated with non-charged groups, such as hydroxyl groups, and the cationized phytoglycogen (PhXC) nanoparticles showed positively charged surfaces due to the presence of quaternary ammonium cations...
Source: Colloids and Surfaces - August 9, 2021 Category: Biotechnology Authors: Maryam Tavafoghi Sanchit Garg Anton Korenevski Maria Dittrich Source Type: research
Evaluation of the in vivo acute toxicity of poly(thioether-ester) and superparamagnetic poly(thioether-ester) nanoparticles obtained by thiol-ene miniemulsion polymerization
J Biomed Mater Res B Appl Biomater. 2021 Oct 7. doi: 10.1002/jbm.b.34949. Online ahead of print.ABSTRACTPoly(thioether-ester) (PTEe) nanoparticles obtained by thiol-ene polymerization have received attention of many researchers due to several advantages, including, biocompatibility and biodegradability. The search for new nanomaterials requires toxicity studies to assess potential toxic effects of their administration. Therefore, the aim of this study was to evaluate the in vivo acute toxicity of PTEe and poly(thioether-ester)-coated magnetic nanoparticles prepared by thiol-ene polymerization in miniemulsion. These nanopar...
Source: Biomed Res - October 7, 2021 Category: Research Authors: Paulo Emilio Feuser Mariana de Melo Cardoso Nathalia Coral Galvani Rubya Pereira Zaccaron Ligia Milanez Venturini Flavia Karine Rigo Ricardo Andrez Machado-de- Ávila Paulo Cesar Lock Silveira Claudia Sayer Pedro Henrique Hermes de Ara újo Source Type: research
Synergism between metallic nanoparticles and antibiotics
Appl Microbiol Biotechnol. 2022 Jun 7. doi: 10.1007/s00253-022-12001-1. Online ahead of print.ABSTRACTThe discovery of antibiotics in the twentieth century made it possible to treat bacterial infections and revolutionized modern medicine. However, gradually, it is possible to perceive a decrease in the effectiveness of antimicrobial agents against pathogenic isolates, which, together with the low investment in the discovery and/or development of new antibiotics by large pharmaceutical companies since the 1960s, makes it increasingly difficult to treatment of infections caused by these microorganisms. The search for strateg...
Source: Applied Microbiology and Biotechnology - June 7, 2022 Category: Microbiology Authors: Maria Anndressa Alves Agreles Iago Dillion Lima Cavalcanti Isabella Mac ário Ferro Cavalcanti Source Type: research
Evaluation of the effect of guanabenz-loaded nanoparticles on chronic toxoplasmosis in mice
Exp Parasitol. 2023 Jan 12:108460. doi: 10.1016/j.exppara.2023.108460. Online ahead of print.ABSTRACTChronic toxoplasmosis which is positively correlated with many neuropsychiatric problems has no curative treatment till now; due to the resistant tissue cysts especially in the brain. In search of an effective treatment guanabenz-loaded polyethylene glycol poly lactic-co-glycolic acid (PEG-PLGA) nanoparticles was evaluated against chronic experimental toxoplasmosis. For this purpose, each mouse was infected with 10 cysts of Toxoplasma gondii (ME 49 strain). Treated mice received either guanabenz alone (5 mg/kg/day) in subgr...
Source: Experimental Parasitology - January 15, 2023 Category: Parasitology Authors: Wesam Moustafa Abdelhamid Elgendy Yusuf Ahmed Yusuf Haggag Kholoud Abd Allah El-Nouby Samy Ibrahim El-Kowrany Sirria Mostafa El Marhoumy Source Type: research
Nanoparticles to Target Atherosclerotic Plaques
This popular science article takes a look at efforts to develop nanoparticles capable of reducing the size of plaques in blood vessels produced by the processes of atherosclerosis. These plaques narrow and deform blood vessels, ultimately breaking apart to cause blockages and ruptures of blood vessels that are often fatal. Atherosclerosis is caused at root by damaged lipids that enter the circulation and lodge in blood vessel tissue. This is followed by an unfortunate set of self-reinforcing signals sent by cells in the blood vessel wall and then by immune cells that turn up to try to deal with the problem. When immune cel...
Source: Fight Aging! - May 31, 2016 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Bovine serum albumin nanoparticles containing amphotericin B were effective in treating murine cutaneous leishmaniasis and reduced the drug toxicity.
This study investigated the antileishmanial activity of bovine serum albumin (BSA) nanoparticles containing amphotericin B (AmB) against Leishmania amazonensis. The antiproliferative activity against promastigotes and amastigotes was assessed and the cytotoxicity was determined and compared to commercial AmB-deoxycholate (AmB-D). In vivo antileishmania activity was evaluated in murine cutaneous leishmaniasis model. BSA nanoparticles showed spherical shape, mean size about 180 nm, zeta potential of ≈ -45 mV and AmB encapsulation efficiency >95%. AmB-D was effective in promastigote and amastigote forms, while Am...
Source: Experimental Parasitology - July 16, 2018 Category: Parasitology Authors: Casa DM, Scariot DB, Khalil NM, Nakamura CV, Mainardes RM Tags: Exp Parasitol Source Type: research
Evaluation of biologically synthesized Au-CuO and CuO-ZnO nanoparticles against glioma cells and microorganisms
Publication date: Available online 17 December 2018Source: Saudi Pharmaceutical JournalAuthor(s): Renata Dobrucka, Mariusz Kaczmarek, Małgorzata Łagiedo, Agata Kielan, Jolanta DlugaszewskaAbstractDue to the search for new methods of producing bimetallic nanoparticles, in this work, we have conducted a biological synthesis of Au-CuO and CuO-ZnO nanoparticles using Cnici benedicti. The synthesized Au-CuO and CuO-ZnO nanoparticles were also analyzed in terms of their antibacterial activity, as well as their influence on cell viability, using two specific cell lines: C6 rat brain glioma (ATCC® CCL-107 ™) and T98G human gl...
Source: Saudi Pharmaceutical Journal - December 18, 2018 Category: Drugs & Pharmacology Source Type: research
Photoprotective activity of zirconia nanoparticles
Colloids Surf B Biointerfaces. 2021 Feb 18;202:111636. doi: 10.1016/j.colsurfb.2021.111636. Online ahead of print.ABSTRACTThe increasing incidence of diseases caused by the harmful effects of UV radiation in skin, predominantly skin cancer, induce the search for more efficient photoprotector agents. Nowadays, titanium dioxide (TiO2) and zinc oxide (ZnO) are the most widely used photoprotectors and therefore form the main components of commercially available sunscreens. Although the outstanding efficiency in absorbing and scattering UV radiation, mainly as nanoparticles, recent studies have raised concerns regarding the saf...
Source: Colloids and Surfaces - March 11, 2021 Category: Biotechnology Authors: Renata Guimar ães de Sá Tatiane Moraes Arantes Erenilda Ferreira de Macedo Lu ísa Molina Dona' Jeniffer C F Pereira Carolina Ramos Hurtado R Jose Varghese Oluwatobi Samuel Oluwafemi Dayane Batista Tada Source Type: research
Highlighting the use of micro and nanoparticles based-drug delivery systems for the treatment of < em > Helicobacter pylori < /em > infections
Crit Rev Microbiol. 2021 Mar 16:1-26. doi: 10.1080/1040841X.2021.1895721. Online ahead of print.ABSTRACTDue to the high adaptability of Helicobacter pylori and the low targeting specificity of the drugs normally used in pharmacological therapy, the strains are becoming increasingly resistant to these drugs, making it difficult to eradicate the infection. Thus, the search for new therapeutic approaches has been considered urgent. The incorporation of drugs in advanced drug delivery systems, such as nano and microparticles, would allow the improvement of the retention time in the stomach and the prolongation of drug release ...
Source: Critical Reviews in Microbiology - March 16, 2021 Category: Microbiology Authors: Maur ício Palmeira Chaves de Souza Bruna Almeida Furquim de Camargo Larissa Sp ósito Giovanna Capaldi Fortunato Gabriela Corr êa Carvalho Gabriel Davi Marena Andr éia Bagliotti Meneguin Ta ís Maria Bauab Marlus Chorilli Source Type: research
