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The Effectiveness of Nanoparticles on Gene Therapy for Glioblastoma Cells Apoptosis: A Systematic Review
CONCLUSION: In conclusion, these studies validated that NPs could be a practical choices to enhance the efficiency and specific delivery in gene therapies for GBM cell apoptosis. However, the choice of NP type and gene therapy mechanism affect the GBM cell apoptotic efficiency.PMID:33655831 | DOI:10.2174/1566523221666210224110454
Source: Current Gene Therapy - March 3, 2021 Category: Genetics & Stem Cells Authors: Firoozeh Alavian Sorayya Ghasemi Source Type: research

Evaluation of the in vivo acute toxicity of poly(thioether ‐ester) and superparamagnetic poly(thioether‐ester) nanoparticles obtained by thiol‐ene miniemulsion polymerization
AbstractPoly(thioether-ester) (PTEe) nanoparticles obtained by thiol-ene polymerization have received attention of many researchers due to several advantages, including, biocompatibility and biodegradability. The search for new nanomaterials requires toxicity studies to assess potential toxic effects of their administration. Therefore, the aim of this study was to evaluate the in vivo acute toxicity of PTEe and poly(thioether-ester)-coated magnetic nanoparticles prepared by thiol-ene polymerization in miniemulsion. These nanoparticles presented a mean size of approximately 120  nm, spherical morphology, and negative surf...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - October 7, 2021 Category: Materials Science Authors: Paulo Emilio Feuser, Mariana de Melo Cardoso, Nathalia Coral Galvani, Rubya Pereira Zaccaron, Ligia Milanez Venturini, Flavia Karine Rigo, Ricardo Andrez Machado ‐de‐Ávila, Paulo Cesar Lock Silveira, Claudia Sayer, Pedro Henrique Hermes de A Tags: RESEARCH ARTICLE Source Type: research

In search of best automated model: Explaining nanoparticle TEM image segmentation
This study focuses on finding the best segmentation model, which achieves high metrics and is robust to microscopy parameters. For this purpose, eight different models have been compared. The training dataset consists of 150 BF-TEM Platinum nanoparticle images containing 3629 nanoparticles of all kinds. Further, we examine the generalizability of the models on E-TEM Gold nanoparticle images. We also describe essential considerations while choosing a network for segmenting nanoparticle images that generalize well across the Platinum BF-TEM and Gold E-TEM nanoparticles dataset. The layer gradients are visualized to further e...
Source: Ultramicroscopy - December 25, 2021 Category: Laboratory Medicine Authors: Kunwar Muhammed Saaim Saima Khan Afridi Maryam Nisar Saiful Islam Source Type: research

Glutathione-Triggered catalytic response of Copper-Iron mixed oxide Nanoparticles. Leveraging tumor microenvironment conditions for chemodynamic therapy
J Colloid Interface Sci. 2022 Mar 11;617:704-717. doi: 10.1016/j.jcis.2022.03.036. Online ahead of print.ABSTRACTHeterogeneous catalysis has emerged as a promising alternative for the development of new cancer therapies. In addition, regarding the tumor microenvironment as a reactor with very specific chemical features has provided a new perspective in the search for catalytic nanoarchitectures with specific action against chemical species playing a key role in tumor metabolism. One of these species is glutathione (GSH), whose depletion is the cornerstone of emerging strategies in oncology, since this metabolite plays a pi...
Source: Cell Research - March 22, 2022 Category: Cytology Authors: Javier Bonet-Aleta Maria Sancho-Albero Javier Calzada-Funes Silvia Irusta Pilar Martin-Duque Jose L Hueso Jesus Santamaria Source Type: research

Effect of Chemically Modified Carbon-Coated Iron Nanoparticles on the Structure of Human Atherosclerotic Plaques Ex Vivo and on Adipose Tissue in Chronic Experiment In Vivo
Int J Mol Sci. 2022 Jul 26;23(15):8241. doi: 10.3390/ijms23158241.ABSTRACTThe high mortality rate caused by atherosclerosis makes it necessary to constantly search for new and better treatments. In previous reports, chemically modified carbon-coated iron nanoparticles (Fe@C NPs) have been demonstrated a high biocompatibility and promising anti-plaque properties. To further investigate these effects, the interaction of these nanoparticles with the adipose tissue of Wistar rats (in vivo) and human atherosclerotic plaques (ex vivo) was studied. For the in vivo study, cobalt-chromium (CoCr) alloy tubes, which are used for coro...
Source: Atherosclerosis - July 28, 2022 Category: Cardiology Authors: Shamil Akhmedov Sergey Afanasyev Natalia Beshchasna Marina Trusova Ivan Stepanov Mariya Rebenkova Ekaterina Poletykina Yuri Vecherskiy Sergei Tverdokhlebov Evgeny Bolbasov Sascha Balakin Joerg Opitz Anatoly Yermakov Boris Kozlov Source Type: research

Overview of inorganic nanoparticles: An expanding horizon in tumor therapeutics
CONCLUSION: This review paper concludes that inorganic nanoparticles may be better alternatives to conventional approaches for the treatment of cancer. However, their presence in global pharmaceutical markets will be governed by the development of novel scale-up techniques and clinical evaluation.PMID:36200151 | DOI:10.2174/1574892817666221005094423
Source: Recent Patents on Anti-Cancer Drug Discovery - October 6, 2022 Category: Cancer & Oncology Authors: Lalit Kumar Shivani Verma Puneet Utreja Dinesh Kumar Source Type: research