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Applications of Gold and Silver Nanoparticles in the Treatment of Acne Vulgaris: A Systematic Review
CONCLUSION: This review found gold and silver nanoparticles to be a promising treatment for acne vulgaris. Further randomized controlled studies are needed to determine clinical efficacy and the role of gold and silver nanoparticles in the treatment algorithm for acne. J Drugs Dermatol. 2021;20(6):666-670. doi:10.36849/JDD.5762.PMID:34076399 | DOI:10.36849/JDD.2021.5762
Source: Journal of Drugs in Dermatology - June 2, 2021 Category: Dermatology Authors: Kimberly Artounian Nour Bundogji Elika Hoss Monica Boen Source Type: research

Broad-spectrum bioactivities of silver nanoparticles: the emerging trends and future prospects.
Abstract There are alarming reports of growing microbial resistance to all classes of antimicrobial agents used against different infections. Also the existing classes of anticancer drugs used against different tumours warrant the urgent search for more effective alternative agents for treatment. Broad-spectrum bioactivities of silver nanoparticles indicate their potential to solve many microbial resistance problems up to a certain extent. The antibacterial, antifungal, antiviral, antiprotozoal, acaricidal, larvicidal, lousicidal and anticancer activities of silver nanoparticles have recently attracted the attenti...
Source: Applied Microbiology and Biotechnology - January 10, 2014 Category: Microbiology Authors: Rai M, Kon K, Ingle A, Duran N, Galdiero S, Galdiero M Tags: Appl Microbiol Biotechnol Source Type: research

Combination Ointment Containing Solid Tranilast Nanoparticles and Dissolved Sericin Is Efficacious for Treating Skin Wound-Healing Deficits and Redness in Diabetic Rats.
In conclusion, we have adapted kinetic analyses to skin wound healing in rats, and found these analyses to be useful as an index of wound healing ability by a wound-healing drug. In addition, we show that treatment with the TS-combination ointment enhances the skin wound healing rate and reduces redness. These findings provide information significant to the search for new wound-healing therapies and for the design of wound-healing drugs. PMID: 28381799 [PubMed - in process]
Source: Biological and Pharmaceutical Bulletin - April 8, 2017 Category: Drugs & Pharmacology Authors: Nagai N, Ogata F, Deguchi S, Ueno A, Kawasaki N, Ito Y Tags: Biol Pharm Bull Source Type: research

Colletotrichum sp.- mediated synthesis of sulphur and aluminium oxide nanoparticles and its in  vitro activity against selected food-borne pathogens.
Publication date: August 2017 Source:LWT - Food Science and Technology, Volume 81 Author(s): Pooja Suryavanshi, Raksha Pandit, Aniket Gade, Marcos Derita, Susana Zachino, Mahendra Rai Food spoilage is a major issue globally and million of people suffer from food-borne infections. Hence, there is a need to search for novel and effective antimicrobial agents. Nanoparticles act as antimicrobial agent, which can tackle the problem of food-borne pathogens. The present study includes mycosynthesis of sulphur nanoparticles (SNPs) and aluminium oxide nanoparticles (AlNPs) from Colletotrichum sp. and their characterization by UV-V...
Source: LWT Food Science and Technology - April 11, 2017 Category: Food Science Source Type: research

Efficacy of biogenic silver nanoparticles against clinical isolates of fungi causing mycotic keratitis in humans
Mycotic keratitis is mainly responsible for vision loss caused by various fungi. Sometimes, proper treatment of such infection is not possible due to unavailability of effective antifungal agents and development of resistance of such fungi to antimycotic drugs. Hence, it is necessary to search for potential antifungal agents, which can effectively eradicate fungal infection of eyes. Nanoparticles-based antifungal drugs overcome this problem by increasing permeability and properties of drug molecules. In the present study, silver nanoparticles were synthesised by using Helminthosporium sp. and Chaetomium sp. following seque...
Source: IET Nanobiotechnology - September 19, 2017 Category: Nanotechnology Source Type: research

Gold Nanoparticles: Promising Agent To Improve The Diagnosis And Therapy Of Cancer.
CONCLUSION: Gold nanoparticles have greatly improved the traditional treatment due to their unique properties. However, their size-dependent toxicity, distribution and clearance need further studies to make them a clinical reality. PMID: 28952430 [PubMed - as supplied by publisher]
Source: Current Drug Metabolism - September 25, 2017 Category: Drugs & Pharmacology Authors: Ning L, Zhu B, Gao T Tags: Curr Drug Metab Source Type: research

Chitosan-acrylic polymeric nanoparticles with dynamic covalent bonds. Synthesis and stimuli behavior.
Abstract Drug delivery represents one of the most important research fields within the pharmaceutical industry. Different strategies are reported every day in a dynamic search for carriers with the ability to transport drugs across the body, avoiding or decreasing toxic issues and improving therapeutic activity. One of the most interesting strategies currently under research is the development of drug delivery systems sensitive to different stimuli, due to the high potential attributed to the selective delivery of the payload. In this work, a stimuli-sensitive nanocarrier was built with a bifunctional acrylic poly...
Source: Chemical and Pharmaceutical Bulletin - October 12, 2017 Category: Drugs & Pharmacology Authors: Palacio H, Otálvaro F, Giraldo LF, Ponchel G, Segura-Sánchez F Tags: Chem Pharm Bull (Tokyo) Source Type: research

Recent advances in the use of metallic nanoparticles with antitumoral action.
Abstract The term cancer represents a set of more than 100 diseases that are caused due to an uncontrolled growth of cells; and their subsequent spread to the other tissues and organs of the body by a phenomenon, called 'metastasis'. According to the estimates provided by the World Health Organization (WHO), cancer is expected to account for about 10 million deaths per year by 2020, and 21 million cancer cases, which may lead to 13 million deaths by 2030, making cancer as the cause of highest mortality in contrast to other diseases. The search for potential therapeutics against cancer, which can reduce the side-ef...
Source: Current Medicinal Chemistry - February 13, 2018 Category: Chemistry Authors: da Silva PB, Machado RTA, Pironi AM, Alves RC, de Araujo PR, Dragalzew AC, Dalberto I, Chorilli M Tags: Curr Med Chem Source Type: research

Recent advances of polysaccharide-based nanoparticles for oral insulin delivery.
Abstract Diabetes mellitus is a highly prevalent metabolic and chronic disease affecting millions of people in the world. The most common route of insulin therapy is the subcutaneous injection due to its low bioavailability and enzymatic degradation. The search for effective and high patient compliance insulin delivery systems has been a major challenge over many decades. The polysaccharide-based nanoparticles as delivery vehicles for insulin oral administration have recently attracted substantial interests. The present review highlights the recent advances on the development of nanoparticles prepared from polysac...
Source: International Journal of Biological Macromolecules - August 28, 2018 Category: Biochemistry Authors: Hu Q, Luo Y Tags: Int J Biol Macromol Source Type: research

The Effect of Silver Nanoparticles on Listeria monocytogenes PCM2191 Peptidoglycan Metabolism and Cell Permeability.
Authors: Markowska K, Grudniak AM, Milczarek B, Wolska KI Abstract Listeria monocytogenes is Gram-positive bacterial pathogen, a causative agent of food poisoning and systemic disease - listeriosis. This species is still susceptible to several conventionally used antibiotics but an increase in its resistance has been reported. For this reason the search for new, alternative therapies is an urgent task. Silver nanoparticles seem to be the promising antibacterial agent. Minimal inhibitory concentration of silver nanoparticles was determined. Sublethal concentrations were used in study of nanosilver effect on cells ly...
Source: Polish Journal of Microbiology - November 21, 2018 Category: Microbiology Tags: Pol J Microbiol Source Type: research

Antiproliferative activity of Camellia sinensis mediated silver nanoparticles on three different human cancer cell lines
Conclusion: The superior activity of the silver nanoparticles may be due to its spherical shape and smaller particle size 10–30 nm as confirmed from NTA and TEM analysis. The data obtained in the study reveal the potent therapeutic value of biogenic silver nanoparticles.
Source: Journal of Cancer Research and Therapeutics - November 28, 2018 Category: Cancer & Oncology Authors: Anu Yadav Vijay D Mendhulkar Source Type: research