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Overview of inorganic nanoparticles: An expanding horizon in tumor therapeutics
CONCLUSION: This review paper concludes that inorganic nanoparticles may be better alternatives to conventional approaches for the treatment of cancer. However, their presence in global pharmaceutical markets will be governed by the development of novel scale-up techniques and clinical evaluation.PMID:36200151 | DOI:10.2174/1574892817666221005094423
Source: Recent Patents on Anti-Cancer Drug Discovery - October 6, 2022 Category: Cancer & Oncology Authors: Lalit Kumar Shivani Verma Puneet Utreja Dinesh Kumar Source Type: research

Molecules, Vol. 27, Pages 6860: Antimicrobial Activity of Silver and Gold Nanoparticles Prepared by Photoreduction Process with Leaves and Fruit Extracts of Plinia cauliflora and Punica granatum
Courrol The increased number of resistant microbes generates a search for new antibiotic methods. Metallic nanoparticles have emerged as a new platform against several microorganisms. The nanoparticles can damage the bacteria membrane and DNA by oxidative stress. The photoreduction process is a clean and low-cost method for obtaining silver and gold nanoparticles. This work describes two original insights: (1) the use of extracts of leaves and fruits from a Brazilian plant Plinia cauliflora, compared with a well know plant Punica granatum, and (2) the use of phytochemicals as stabilizing agents in the photoreduction pr...
Source: Molecules - October 13, 2022 Category: Chemistry Authors: Marcia Regina Franzolin Daniella dos Santos Courrol Flavia Rodrigues de Oliveira Silva Lilia Coronato Courrol Tags: Article Source Type: research

Antibacterial and antibiofilm activity of mannose-modified chitosan/PMLA nanoparticles against multidrug-resistant Helicobacter pylori
Int J Biol Macromol. 2022 Nov 7:S0141-8130(22)02520-X. doi: 10.1016/j.ijbiomac.2022.10.265. Online ahead of print.ABSTRACTBecause of the apparent stasis in antibiotic discoveries and the growth of multidrug resistance, Helicobacter pylori-associated gastric infections are difficult to eradicate. In the search for alternative therapy, the reductive amination of chitosan with mannose, followed by ionic gelation, produced mannose functionalized chitosan nanoparticles. Then, molecular docking and molecular dynamics (MD) simulations were conducted with H. pylori lectin (HPLectin) as a target protein involved in bacterium adhere...
Source: International Journal of Biological Macromolecules - November 10, 2022 Category: Biochemistry Authors: Muhammad Arif Rafiq Ahmad Mohamed Sharaf None Samreen Javed Muhammad Mohnad Abdalla Wafa Ali Eltayb Chen-Guang Liu Source Type: research

Lessons from the history of inorganic nanoparticles for inhalable diagnostics and therapeutics
Adv Colloid Interface Sci. 2023 Apr 12;315:102903. doi: 10.1016/j.cis.2023.102903. Online ahead of print.ABSTRACTThe respiratory tract is one of the most accessible ones to exogenous nanoparticles, yet drug delivery by their means to it is made extraordinarily challenging because of the plexus of aerodynamic, hemodynamic and biomolecular factors at cellular and extracellular levels that synergistically define the safety and efficacy of this process. Here, the use of inorganic nanoparticles (INPs) for inhalable diagnostics and therapies of the lung is viewed through the prism of the history of studies on the interaction of ...
Source: Advances in Colloid and Interface Science - April 21, 2023 Category: Chemistry Authors: Vuk Uskokovi ć Source Type: research

Selenite bioreduction with concomitant green synthesis of selenium nanoparticles by a selenite resistant EPS and siderophore producing terrestrial bacterium
Biometals. 2023 Apr 29. doi: 10.1007/s10534-023-00503-y. Online ahead of print.ABSTRACTEnvironmental bacterial isolates play a very important role in bioremediation of metals and toxic metalloids. A bacterial strain with high selenite (SeO32-) tolerance and reducing capability was isolated from electronic waste dump site in Banaras Hindu University, Varanasi, India. Based on 16 S rRNA sequencing and BLAST search, this bacterial isolate was identified as Bacillus paramycoides and designated as strain MF-14. It tolerated Sodium selenite up to 110 mM when grown aerobically in LB broth and reduced selenite into elemental selen...
Source: Biometals - April 29, 2023 Category: Biochemistry Authors: Pooja Yadav Shraddha Pandey Santosh Kumar Dubey Source Type: research