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Molecules, Vol. 21, Pages 1227: Molecular-Based Fluorescent Nanoparticles Built from Dedicated Dipolar Thienothiophene Dyes as Ultra-Bright Green to NIR Nanoemitters
Fluorescent Organic Nanoparticles (FONs), prepared by self-aggregation of dedicated dyes in water, represent a promising green alternative to the toxic quantum dots (QDs) for bioimaging purposes. In the present paper, we describe the synthesis and photophysical properties of new dipolar push-pull derivatives built from thieno[3,2-b]thiophene as a π-conjugated bridge that connects a triphenylamine moiety bearing various bulky substituents as electron-releasing moiety to acceptor end-groups of increasing strength (i.e., aldehyde, dicyanovinyl and diethylthiobarbiturate). All dyes display fluorescence properties in chlorofor...
Source: Molecules - September 13, 2016 Category: Chemistry Authors: Cristiano Mastrodonato Paolo Pagano Jonathan Daniel Michel Vaultier Mireille Blanchard-Desce Tags: Article Source Type: research

Structural parameters of nanoparticles affecting their toxicity for biomedical applications: a review
J Nanopart Res. 2023;25(3):43. doi: 10.1007/s11051-023-05690-w. Epub 2023 Feb 27.ABSTRACTRapidly growing interest in using nanoparticles (NPs) for biomedical applications has increased concerns about their safety and toxicity. In comparison with bulk materials, NPs are more chemically active and toxic due to the greater surface area and small size. Understanding the NPs' mechanism of toxicity, together with the factors influencing their behavior in biological environments, can help researchers to design NPs with reduced side effects and improved performance. After overviewing the classification and properties of NPs, this ...
Source: Cell Research - March 6, 2023 Category: Cytology Authors: Reza Abbasi Ghazal Shineh Mohammadmahdi Mobaraki Sarah Doughty Lobat Tayebi Source Type: research

Sustained release of alpha ‐methylacyl‐CoA racemase (AMACR) antibody‐conjugated and free doxorubicin from silica nanoparticles for prostate cancer cell growth inhibition
This article presents silica nanoparticles for the sustained release of AMACR antibody-conjugated and free doxorubicin (DOX) for the inhibition of prostate cancer cell growth. Inorganic MCM-41 silica nanoparticles were synthesized, functionalized with phenylboronic acid groups (MCM-B), and capped with dextran (MCM-B-D). The nanoparticles were then characterized using Fourier-transform infrared spectroscopy, scanning electron microscopy, transmission electron microscopy, zeta potential analysis, nitrogen sorption, X-ray diffraction, and thermogravimetric analysis, before exploring their potential for drug loading and contro...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - November 1, 2022 Category: Materials Science Authors: Toyin Aina, Ali A. Salifu, Sonu Kizhakkepura, Yiporo Danyuo, John D. Obayemi, Josephine C. Oparah, Theresa C. Ezenwafor, Killian C. Onwudiwe, Chukwuemeka J. Ani, Suchi S. Biswas, Chinyerem Onyekanne, Olushola S. Odusanya, Jonathan Madukwe, Wi Tags: RESEARCH ARTICLE Source Type: research

Strain Sensors: Highly Sensitive Strain Sensors Based on Molecules –Gold Nanoparticles Networks for High‐Resolution Human Pulse Analysis (Small 8/2021)
In article number2007593, Artur Ciesielski, Paolo Samor ì, and co‐workers report the fabrication of a highly sensitive and flexible strain sensor for human‐health and vibration monitoring. The strain sensor is based on gold nanoparticles network bridged by organic molecules where the highly flexible nature of the linkers connecting the gold nanopart icles makes it possible to achieve superior sensing performance.
Source: Small - February 24, 2021 Category: Nanotechnology Authors: Chang ‐Bo Huang, Yifan Yao, Verónica Montes‐García, Marc‐Antoine Stoeckel, Miriam Von Holst, Artur Ciesielski, Paolo Samorì Tags: Inside Front Cover Source Type: research

Nanoparticles as an effective drug delivery system in COVID-19
CONCLUSION: Our current studies reveal that nanoparticles may prove very helpful in the delivery of drugs for Covid-19 treatment. Many cases showed that patients, where drugs are delivered with the help of nanoparticles, produced very few side effects.PMID:34649334 | DOI:10.1016/j.biopha.2021.112162
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - October 15, 2021 Category: Drugs & Pharmacology Authors: Neehasri Kumar Chowdhury None Deepika Reshma Choudhury Gaurav Ambadas Sonawane Shankar Mavinamar Xiaoming Lyu Ramendra Pati Pandey Chung-Ming Chang Source Type: research

Las altas temperaturas transforman nanopart ículas en catalizadores monoatómicos
Condiciones que habitualmente destruyen catalizadores basados en nanopart ículas pueden usarse para formar otros más estables que consisten en átomos metálicos aislados
Source: NanoFocus - July 7, 2016 Category: Nanotechnology Authors: Mitch Jacoby Source Type: research

The Biogenetic Synthesis of Metallic Nanoparticles and the Role They Play in Anti-inflammatory Drug Treatment
CONCLUSION: The current research focuses on metallic nanoparticles employed as anti-inflammatory medication molecules, although nanoparticles have applications in various areas (medicine, chemical engineering, and agriculture). Nanoparticles have a large surface-to-volume ratio, which can help them to penetrate cell membranes, and because of their solid ligand-binding capabilities, nanoparticles have been used in the medical treatment of inflammatory pathologies.PMID:37464822 | DOI:10.2174/1570163820666230718123544
Source: Current Drug Discovery Technologies - July 19, 2023 Category: Drugs & Pharmacology Authors: Meena Kurup Mohan Kumar Sambathkumar Ramanathan Margnat Chandra Source Type: research

Potential toxicity of engineered nanoparticles in mammalian germ cells and developing embryos: treatment strategies and anticipated applications of nanoparticles in gene delivery
BACKGROUND Engineered nanoparticles (ENPs) offer technological advantages for a variety of industrial and consumer products as well as show promise for biomedical applications. Recent progress in the field of nanotechnology has led to increased exposure to nanoparticles by humans. To date, little is known about the adverse effects of these ENPs on reproductive health, although interest in nanotechnology area is growing. A few biocompatible ENPs have a high loading capacity for exogenous substances, including drugs, DNA or proteins, and can selectively deliver molecular cargo into cells; however, they represent a potential ...
Source: Human Reproduction Update - August 25, 2016 Category: OBGYN Authors: Das, J., Choi, Y.-J., Song, H., Kim, J.-H. Tags: Review Source Type: research

New Strategies in the Treatment of Plasmodium Berghei Based on Nanoparticles: A Systematic Review
In this study, English-language online literature was obtained from the databases Science Direct, PubMed, Scopus, Ovid, and Cochrane to conduct a systematic review. In the search, we used the keywords: (Plasmodium Berghei) AND (Malaria) AND (Parasitemia) AND (antimalarial activity) AND (nanoparticles) AND (Solid lipid NPS) AND (Nano lipid carriers) AND (Artemether) AND (Chloroquine) AND (intraperitoneal) AND (in vivo). Initially, a total of 160 studies were retrieved from the search. After removing duplicates, 80 studies remained. After reviewing the title and abstract of each study, 45 unrelated studies were eliminated. T...
Source: Current Pharmaceutical Biotechnology - January 4, 2023 Category: Biotechnology Authors: Pegah Shakib Abdolrazagh Marzban Omid Mardanshah Shirzad Fallahi Israr Ali Khan Mohammad Azarhazin Kourosh Cheraghipour Source Type: research