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Cancers, Vol. 15, Pages 4689: Estrogen Receptor Signaling in Breast Cancer
rzej Stepulak Estrogen receptor (ER) signaling is a critical regulator of cell proliferation, differentiation, and survival in breast cancer (BC) and other hormone-sensitive cancers. In this review, we explore the mechanism of ER-dependent downstream signaling in BC and the role of estrogens as growth factors necessary for cancer invasion and dissemination. The significance of the clinical implications of ER signaling in BC, including the potential of endocrine therapies that target estrogens&rsquo; synthesis and ER-dependent signal transmission, such as aromatase inhibitors or selective estrogen receptor modul...
Source: Cancers - September 23, 2023 Category: Cancer & Oncology Authors: Paulina Miziak Marzena Baran Ewa B łaszczak Alicja Przybyszewska-Podstawka Joanna Ka łafut Jolanta Smok-Kalwat Magdalena Dmoszy ńska-Graniczka Micha ł Kiełbus Andrzej Stepulak Tags: Review Source Type: research

Viruses, Vol. 15, Pages 1982: Molecular Imaging of ACE2 Expression in Infectious Disease and Cancer
J. Thorek Angiotensin-converting enzyme 2 (ACE2) is a cell-surface receptor that plays a critical role in the pathogenesis of SARS-CoV-2 infection. Through the use of ligands engineered for the receptor, ACE2 imaging has emerged as a valuable tool for preclinical and clinical research. These can be used to visualize the expression and distribution of ACE2 in tissues and cells. A variety of techniques including optical, magnetic resonance, and nuclear medicine contrast agents have been developed and employed in the preclinical setting. Positron-emitting radiotracers for highly sensitive and quantitative tomography have ...
Source: Viruses - September 23, 2023 Category: Virology Authors: Zhiyao Li Abbie Hasson Lasya Daggumati Hanwen Zhang Daniel L. J. Thorek Tags: Review Source Type: research

Viruses, Vol. 15, Pages 1983: Exploring the Comprehensive Kozak Sequence Landscape for AAV Production in Sf9 System
hin The widespread successful use of recombinant Adeno-associated virus (rAAV) in gene therapy has driven the demand for scale-up manufacturing methods of vectors with optimized yield and transduction efficiency. The Baculovirus/Sf9 system is a promising platform for high yield production; however, a major drawback to using an invertebrate cell line compared to a mammalian system is a generally altered AAV capsid stoichiometry resulting in lower biological potency. Here, we introduce a term of the structural and biological &ldquo;fitness&rdquo; of an AAV capsid as a function of two interdependent parame...
Source: Viruses - September 23, 2023 Category: Virology Authors: Oleksandr Kondratov Sergei Zolotukhin Tags: Article Source Type: research

Good Oral Health Linked to Improved Survival in Head & Neck Cancer
FRIDAY, Sept. 22, 2023 -- For patients with head and neck squamous cell carcinoma, good oral health is associated with improved survival, according to a study published online Sept. 19 in the Journal of the National Cancer Institute. Jason Tasoulas,...
Source: Drugs.com - Pharma News - September 22, 2023 Category: Pharmaceuticals Source Type: news

Mesenchymal Stem Cell –Originated Exosomal Lnc A2M-AS1 Alleviates Hypoxia/Reperfusion-Induced Apoptosis and Oxidative Stress in Cardiomyocytes
ConclusionLnc A2M-AS1 delivery via MSC-derived exosomes ameliorated H/R-induced cardiomyocyte apoptosis and oxidative stress via regulating miR-556-5p/XIAP, opening a new window into the pathogenesis of myocardial I/R injury.
Source: Cardiovascular Drugs and Therapy - September 22, 2023 Category: Cardiology Source Type: research

A Call for Matching Donors for the LEV Foundation " Robust Mouse Rejuvenation 2 " Fundraiser
The Longevity Escape Velocity (LEV) Foundation was founded by Aubrey de Grey to address an important missing aspect of the ongoing work to produce treatments that target the underlying mechanisms of aging. While the research and development community has made sizable strides in the past decade, and the first rejuvenation therapies now exist in at least prototype form, it remains the case that next to no-one is conducting combination studies that use two or more of these interventions. When considering therapies that can repair forms of the cell and tissue damage that cause aging, it seems plausible that two different thera...
Source: Fight Aging! - September 22, 2023 Category: Research Authors: Reason Tags: Activism, Advocacy and Education Source Type: blogs

Efficacy and Safety of Patidegib Gel 2% for Preventing Basal Cell Carcinomas on the Face of Adults With Gorlin Syndrome
Condition: Gorlin Syndrome Interventions: Drug: Patidegib Topical Gel; Drug: Vehicle Gel Sponsors: Sol-Gel Technologies, Ltd.; Premier Research Group plc Not yet recruiting
Source: ClinicalTrials.gov - September 22, 2023 Category: Research Source Type: clinical trials

Atezolizumab in Large Cell Neuroendocrine Carcinoma
Condition: Large Cell Neuroendocrine Carcinoma of the Lung Interventions: Drug: Atezolizumab; Drug: Carboplatin; Drug: Etoposide Sponsor: Oncology Center of Biochemical Education And Research Completed
Source: ClinicalTrials.gov - September 22, 2023 Category: Research Source Type: clinical trials

Nivolumab and Ipilimumab With and Without Camu Camu for the Treatment of Patients With Metastatic Renal Cell Carcinoma
Conditions: Clear Cell Renal Cell Carcinoma; Sarcomatoid Renal Cell Carcinoma; Stage III Renal Cell Cancer AJCC v8; Stage IV Renal Cell Cancer AJCC v8 Interventions: Procedure: Biospecimen Collection; Procedure: Bone Scan; Procedure: Computed Tomography; Biological: Ipilimumab; Procedure: Magnetic Resonance Imaging; Drug: Myrciaria dubia Prebiotic Supplement; Biological: Nivolumab Sponsors: City of Hope Medical Center; National Cancer Institute (NCI) Recruiting
Source: ClinicalTrials.gov - September 22, 2023 Category: Research Source Type: clinical trials

Prospective Evaluation of Single Cell Mutations in a Panel of Known Oncogenes in NSCLC Surgical Specimens
Condition: NSCLC Intervention: Other: Tapestry technology Sponsor: University of Milano Bicocca Recruiting
Source: ClinicalTrials.gov - September 22, 2023 Category: Research Source Type: clinical trials

Patient Perspectives in Mantle Cell Lymphoma Clinical Research
Condition: Mantle Cell Lymphoma Intervention: Sponsor: Power Life Sciences Inc. Not yet recruiting
Source: ClinicalTrials.gov - September 22, 2023 Category: Research Source Type: clinical trials

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