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Endometrial tumors with yolk sac tumor-like morphologic patterns or immunophenotypes: an expanded appraisal
Modern Pathology, Published online: 02 August 2019; doi:10.1038/s41379-019-0341-6Endometrial tumors with yolk sac tumor-like morphologic patterns or immunophenotypes: an expanded appraisal
Source: Modern Pathology - August 1, 2019 Category: Pathology Authors: Oluwole Fadare Nada Shaker Abrar Alghamdi Raji Ganesan Krisztina Z. Hanley Lien N. Hoang Jonathan L. Hecht Philip P. Ip Nuha Shaker Andres A. Roma Vinita Parkash Hussain Abubakr Source Type: research
Tools for the assessment of neuropsychomotor profile in the rehabilitation of children with central nervous system tumor: a systematic review.
CONCLUSION: The results highlight the need to develop and validate a global multidimensional AT for children with CNS tumor, overcoming the fragmentation of the assessment procedures and promoting standardized rehabilitation protocols.
PMID: 31452454 [PubMed - as supplied by publisher]
Source: Tumori - August 28, 2019 Category: Cancer & Oncology Tags: Tumori Source Type: research
Fluorescent In Situ Hybridization Analysis for 12p Alterations in Sarcomatoid Yolk Sac Tumors
“Sarcomas” in patients with testicular germ cell tumors (GCTs) are a common form of “somatic-type malignancy.” There is support, based on morphology and immunohistochemistry, that many such sarcomatous tumors represent an unusual form of yolk sac tumor (YST). A virtually universal chromosomal anomaly in GCTs is increase in 12p copy number, often in the form of isochromosome 12p [i(12p)], but this aspect of sarcomatoid YSTs has not hitherto been studied. We performed interphase fluorescent in situ hybridization assay for detection of increased 12p copy number in sarcomatoid YSTs using a bacterial artificial chromoso...
Source: The American Journal of Surgical Pathology - October 12, 2019 Category: Pathology Tags: Original Articles Source Type: research
"Endolymphatic sac tumour": A case report with review of literature.
Abstract
Endolymphatic sac tumour (ELST) is a non-metastasizing low grade adenocarcinoma of endolymphatic sac origin. It is also known as Heffner tumour, low grade adenocarcinoma of endolymphatic sac origin and aggressive papillary middle ear tumour. These tumours are closely associated with Von Hippel Lindau (VHL) disease. Here we report a case of Endolymphatic sac tumour in a 63 yr old lady who presented with left sided facial palsy. Since the tumour was highly vascular and required preoperative embolization, initial clinicoradiological diagnosis was Jugulotymphanic paraganglioma. Histopathology showed features ...
Source: Indian Journal of Pathology and Microbiology - September 30, 2019 Category: Pathology Authors: Rajeshwari B, Shanmugam S, Sadiya N, Mitra G, Chendilnathan B Tags: Indian J Pathol Microbiol Source Type: research
Yolk Sac Tumors of the Head and Neck in Aicardi Syndrome.
CONCLUSIONS: Rare germ cell tumors of the H&N, such as YSTs, have now been documented in several patients with Aicardi syndrome, indicating a possible association given the rarity of these tumors in the population. YSTs should be considered in the differential diagnosis of H&N masses in these patients, with emphasis on early tissue diagnosis and treatment.
PMID: 31640397 [PubMed - as supplied by publisher]
Source: The Annals of Otology, Rhinology, and Laryngology - October 21, 2019 Category: ENT & OMF Authors: Epperson MV, Born HL, Wang D, Myer CM Tags: Ann Otol Rhinol Laryngol Source Type: research
Successful treatment of a primary thoracic dumb-bell yolk sac tumor presenting with severe spinal cord compression: Case report
The objective of this study is to report a primary thoracic dumb-bell YST presenting with severe spinal cord compression successfully treated with posterior-only approach operation, followed by chemotherapy. The management of these unique cases has not been fully documented.
Patient concerns:
A 26-mounth-old, previously healthy girl presented with progressive numbness and weakness of the lower extremities. Neurological examination revealed paralysis of both lower extremities, sensory disturbance below T-8 and bladder-bowel dysfunction.
Diagnosis:
CT and MRI of spine showed a dumb-bell mass lesion with both epidural a...
Source: Medicine - October 1, 2019 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
Acute abdominal pain in an adolescent girl with an ovarian yolk sac tumor.
We report the case of a 12-year-old girl who came to our observation for an acute abdominal pain. Clinical examination evidenced a vague mass in the suprapubic region and a lower abdomen tenderness, the US imaging revealed a complex lesion of the left ovary (19 x 13 cm) and the alpha-fetoprotein (AFP) resulted high (5858 ng/mL). Computed tomography (CT) revealed a large pelvic mass. The treatment consisted of debulking surgery of yolk sac tumor followed by 4 cycles of BEP protocol (Bleomycin, Etoposide, Cisplatin). After 3 years of follow-up there was no evidence of disease recurrence. (www.actabiomedica.it).
PMID: 31...
Source: Acta Bio-Medica : Atenei Parmensis - December 22, 2019 Category: General Medicine Authors: Stefanelli E, Talarico V, Scavone M, Carboni E, Stranieri G, Galati MC, Salerno D, Raiola G Tags: Acta Biomed Source Type: research
SALL4 is a useful marker for pediatric yolk sac tumors
ConclusionsSALL4 is a sensitive marker for pediatric YSTs and it can be used to distinguish them from mature teratomas. SALL4 is likely to become a new and valuable biomarker for the diagnosis of pediatric YST.
Source: Pediatric Surgery International - March 27, 2020 Category: Surgery Source Type: research
Primary Pancreatic Yolk Sac Tumor Presenting as Diffusely Enlarged Pancreas in Initial 18F-FDG PET/CT
We report a case of yolk sac tumor primarily in the pancreas in a 32-year-old man. He presented with pancreatitis at presentation with significantly increased serum alpha-fetoprotein (AFP). 18F-FDG PET/CT revealed diffuse enlargement of the pancreas in the neck, body, and tail portion with homogeneously increased FDG uptake, similar to the change of pancreatitis. The lesion progressively developed to a huge pancreatic mass in the follow-up images, and endoscopic ultrasonography-guided aspiration biopsy of the pancreatic mass confirmed the diagnosis of yolk sac tumor.
Source: Clinical Nuclear Medicine - May 8, 2020 Category: Nuclear Medicine Tags: Interesting Images Source Type: research
HNF1β is a sensitive and specific novel marker for yolk sac tumor: a tissue microarray analysis of 601 testicular germ cell tumors
Modern Pathology, Published online: 19 June 2020; doi:10.1038/s41379-020-0597-xHNF1β is a sensitive and specific novel marker for yolk sac tumor: a tissue microarray analysis of 601 testicular germ cell tumors
Source: Modern Pathology - June 18, 2020 Category: Pathology Authors: Alessandra Gallo Christian Fankhauser Thomas Hermanns J örg Beyer Ailsa Christiansen Holger Moch Peter Karl Bode Source Type: research
Primary yolk sac tumor of orbit: Report of a rare case
Sandhya V Poflee, Prajkta S Pawar, Nilesh S Gaddewar, Waman K RautIndian Journal of Cancer 2020 57(3):337-339Extragonadal germ cell tumors (GCTs) of head and neck region account for 5% of all benign and malignant GCTs. Orbit is an uncommon site for occurrence of extragonadal GCTs. Pure yolk sac tumor (YST) of orbit is a rare neoplasm and only a few cases are reported in the literature. An 18-month-old boy presented with right eye proptosis of 2 months duration. Because of rapid clinical course and magnetic resonance imaging (MRI) findings, neoplastic lesion was suspected. Histopathological examination of the biopsy ...
Source: Indian Journal of Cancer - August 9, 2020 Category: Cancer & Oncology Authors: Sandhya V Poflee Prajkta S Pawar Nilesh S Gaddewar Waman K Raut Source Type: research
Multidisciplinary treatment of primary intracranial yolk sac tumor: A case report and literature review
Rationale:
Intracranial yolk sac tumors (YSTs) are rare malignancies with limited treatment options and a dismal prognosis. They are usually managed with surgical resection and chemoradiotherapy.
Patient concerns:
Here, we report a patient with primary YST in the pineal region who achieved long term survival. Despite undergoing treatment, he experienced several recurrences over a 15-year period.
Diagnosis:
Brain magnetic resonance imaging (MRI) demonstrated the presence of space-occupying lesions in the pineal region and the medial tail of the left lateral ventricle. The tumors were excised, and the histo...
Source: Medicine - May 14, 2021 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
Establishment and characterization of an ovarian yolk sac tumor patient-derived xenograft model
ConclusionWe have successfully established an OYST PDX model. This OYST model preserves the basic molecular features of the primary human tumor, thereby providing a valuable method to preclinically evaluate new treatments and explore disease pathogenesis.
Source: Pediatric Surgery International - May 24, 2021 Category: Surgery Source Type: research
SMARCB1 (INI1)–Deficient Sinonasal Carcinoma With Yolk Sac Tumor Differentiation: Case Report and Review of the Literature
SMARCB1 (INI1)–deficient sinonasal carcinoma is a recently described primary neoplasm of the sinonasal tract that occurs infrequently and displays aggressive clinical behavior. Classic histopathologic findings of INI1-deficient sinonasal carcinoma include sheets and nests of basaloid tumors cells with a monomorphic appearance. Variable amounts of rhabdoid and glandular differentiation have been reported. Diagnosis of this lesion can be challenging because of significant morphologic and immunohistochemical overlap between other primary lesions of the sinonasal tract, including basaloid and other nonkeratinizing squamous c...
Source: Pathology Case Reviews - July 1, 2021 Category: Pathology Tags: Case Reviews Source Type: research
