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Characterization of putative haematopoietic cells from bovine yolk sac
This study is crucial for the understanding of the development of the haematopoietic system and the embryonic function of this organ. Copyright © 2015 John Wiley & Sons, Ltd.
Source: Journal of Tissue Engineering and Regenerative Medicine - February 25, 2015 Category: Molecular Biology Authors: Vanessa C. Oliveira, Celina A. F. Mançanares, Lilian J. Oliveira, Natalia J. N. Gonçalves, Maria A. Miglino, Felipe Perecin, Flávio V. Meirelles, Jorge Piedrahita, Carlos E. Ambrósio Tags: Research Article Source Type: research
Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors
mp; Hans-Reimer Rodewald
Most haematopoietic cells renew from adult haematopoietic stem cells (HSCs), however, macrophages in adult tissues can self-maintain independently of HSCs. Progenitors with macrophage potential in vitro have been described in the yolk sac before emergence of HSCs, and fetal macrophages can develop independently of Myb, a transcription factor required for HSC, and can persist in adult tissues. Nevertheless, the origin of adult macrophages and the qualitative and quantitative contributions of HSC and putative non-HSC-derived progenitors are still unclear. Here we show in mice that the vast major...
Source: Nature - December 3, 2014 Category: Research Authors: Elisa Gomez PerdigueroKay KlapprothChristian SchulzKatrin BuschEmanuele AzzoniLucile CrozetHannah GarnerCeline TrouilletMarella F. de BruijnFrederic GeissmannHans-Reimer Rodewald Tags: Letter Source Type: research
Direct Effects of Microalgae and Protists on Herring (Clupea harengus) Yolk Sac Larvae
This study investigated effects of microalgae (Rhodomonas baltica) and heterotrophic protists (Oxyrrhis marina) on the daily growth, activity, condition and feeding success of Atlantic herring (Clupea harengus) larvae from hatch, through the end of the endogenous (yolk sac) period. Yolk sac larvae were reared in the presence and absence of microplankton and, each day, groups of larvae were provided access to copepods. Larvae reared with microalgae and protists exhibited precocious (2 days earlier) and ≥ 60% increased feeding incidence on copepods compared to larvae reared in only seawater (SW). In the absence and presenc...
Source: PLoS One - June 2, 2015 Category: Biomedical Science Authors: Björn Illing et al. Source Type: research
Sinonasal yolk sac (Endodermal sinus) tumor in an adult female – A case report and review of the literature
We present a case of sinonasal YST admixed with transitional cell carcinoma in a 58‐year‐old female. Magnetic resonance imaging revealed a mass in the right ethmoid fissure infiltrating into the posterior and anterior ethmoid sinuses and nasopharynx. Positron emission tomography examination showed a maximum standardized uptake value of 6.8. Histological examination of the biopsy specimen revealed two distinct features, YST and transitional cell carcinoma, with evidence of mutual transition that indicated the composite nature of the tumor. Immunohistochemical analysis revealed positive immunoreactivity for Sal‐like p...
Source: APMIS - June 1, 2015 Category: Research Authors: Xianglin Mei, Yang Xia, Hironobu Sasano, Hongwen Gao Tags: Case Report Source Type: research
Accuracy of first‐trimester ultrasound in diagnosis of intrauterine pregnancy prior to visualization of the yolk sac: a systematic review and meta‐analysis
ConclusionVisualization of a gestational sac, double decidual sac sign, intradecidual sign or chorionic rim sign increases the probability of an intrauterine pregnancy but is not as accurate for diagnosis as the detection of the yolk sac. However, the findings were limited by the small number and poor quality of the studies included and heterogeneity in the index test and reference standard. Copyright © 2014 ISUOG. Published by John Wiley & Sons Ltd.
Source: Ultrasound in Obstetrics and Gynecology - June 29, 2015 Category: Radiology Authors: A. Richardson, I. Gallos, S. Dobson, B. K. Campbell, A. Coomarasamy, N. Raine‐Fenning Tags: Systematic Review Source Type: research
Successful radiotherapy in postoperative recurrence of a primary mediastinal yolk sac tumor: A case report
Abstract
A woman in her 60s was evaluated for anterior chest pain. Computed tomography (CT) revealed a 50 mm mass with irregular contrast enhancement in the anterior mediastinum. α‐fetoprotein (AFP) level was elevated to 1188 ng/mL. A germ cell tumor was diagnosed, mostly comprising of a yolk sac tumor (YST). Two courses of chemotherapy with cisplatin (CDDP) and etoposide (VP16) were administered and surgical tumor resection was then performed. The final diagnosis was YST. CDDP and VP16 were continued postoperatively; however, because the AFP level increased about six months after surgery, the chemotherapy regimen was...
Source: Thoracic Cancer - August 20, 2015 Category: Cancer & Oncology Authors: Masakuni Sakaguchi, Toshiya Maebayashi, Takuya Aizawa, Naoya Ishibashi, Shoko Fukushima, Tsutomu Saito Tags: Case Report Source Type: research
Definitive Hematopoiesis In The Yolk Sac Emerges from Wnt‐responsive Hemogenic Endothelium Independently Of Circulation and Arterial Identity
This article is protected by copyright. All rights reserved.
Graphical Abstract
Definitive hematopoiesis initiates as a broad temporal wave of yolk sac‐derived erythro‐myeloid progenitor (EMP) colony‐forming potential (red arrow with shaded area). EMPs emerge from flattened hemogenic endothelium (HE; green dotted line) between embryonic day (E)8.5 through as late as E10.5‐11, which correlates with the known temporal requirement for Runx1 in mediating EMP formation (green trapezoid). EMPs emerge from both arterial and venous regions of the yolk sac and do not require blood flow, but are regulated by Wnt signaling. ...
Source: Stem Cells - September 30, 2015 Category: Stem Cells Authors: Jenna M. Frame, Katherine H. Fegan, Simon J. Conway, Kathleen E. McGrath, James Palis Tags: Tissue‐Specific Stem Cells Source Type: research
Primary orbital yolk sac tumor: report of a case and review of literature
Abstract
Germ cell tumor can affect extragonadal sites. Teratoma is a well-recognized extragonadal tumor in the orbit. Primary yolk sac tumor (YST) or endodermal sinus tumor of orbit is rare and only few cases have been reported in the literature. Its clinical presentation may mimic many common pediatric orbital conditions, and delay in diagnosis affects ocular morbidity and mortality. In the past orbital YST has been treated with multimodal therapy including surgery, systemic chemotherapy, and radiotherapy. Herein we describe a case of primary orbital YST and reviewed the literature for similar cases. The rev...
Source: International Ophthalmology - October 19, 2015 Category: Opthalmology Source Type: research
Prognostic value of programmed-death-1 receptor (PD-1) and its ligand 1 (PD-L1) in testicular germ cell tumors
Conclusions
In this translational study, we showed, for the first time, the prognostic value of PD-L1 expression in TGCTs and our data imply that the PD-1/PD-L1 pathway could be a novel therapeutic target in TGCTs.
Source: Annals of Oncology - January 22, 2016 Category: Cancer & Oncology Authors: Cierna, Z., Mego, M., Miskovska, V., Machalekova, K., Chovanec, M., Svetlovska, D., Hainova, K., Rejlekova, K., Macak, D., Spanik, S., Ondrus, D., Kajo, K., Mardiak, J., Babal, P. Tags: urogenital tumors Source Type: research
Transdifferentiation of mouse visceral yolk sac cells into parietal yolk sac cells in vitro.
Abstract
The mouse embryonic yolk sac is an extraembryonic membrane that consists of a visceral yolk sac (VYS) and parietal yolk sac (PYS), and functions in hematopoietic-circulation in the fetal stage. The present study was undertaken to examine the normal development of both murine VYS and PYS tissues using various molecular markers, and to establish a novel VYS cell culture system in vitro for analyzing differentiation potentials of VYS cells. RT-PCR and immunohistochemical analyses of gene expression in VYS and PYS tissues during development revealed several useful markers for their identification: HNF1β, HNF...
Source: Biochemical and Biophysical Research communications - January 25, 2016 Category: Biochemistry Authors: Yagi S, Tagawa YI, Shiojiri N Tags: Biochem Biophys Res Commun Source Type: research
Targeting peptidyl-prolyl isomerase pin1 to inhibit tumor cell aggressiveness.
CONCLUSIONS: Our results support that PIN1 may be a valuable target to hit in cancer cells characterized by increased aggressive potential, overexpression of erbB receptor family members, and defective p53.
PMID: 26917410 [PubMed - as supplied by publisher]
Source: Tumori - February 29, 2016 Category: Cancer & Oncology Tags: Tumori Source Type: research
Giant seminoma case with very small yolk sac and embryo carcinoma components, detected by intensive histopathological examination
Publication date: September 2016 Source:Human Pathology: Case Reports, Volume 5 Author(s): Takeo Nakaya, Shuichiro Kobayashi, Satoshi Kitahara, Akira Tanaka, Hiroshi Kamma, Akio Komatsu We experienced the giant seminoma with 18×10×10cm sized and about 2.6kg weight of 25year old patient. We intensively examined the histological tissue type distributions in this giant seminoma. Most of the tumor consisted of seminoma components. In addition, the tumor included the very small fragments of yolk sac tumor and embryonal carcinoma component at the root part of the seminoma mass. This shows that intensive histological ex...
Source: Human Pathology: Case Reports - March 12, 2016 Category: Pathology Source Type: research
Different mechanisms of Na+ uptake and ammonia excretion by the gill and yolk sac epithelium of early life stage rainbow trout RESEARCH ARTICLE
Alex M. Zimmer, Jonathan M. Wilson, Patricia A. Wright, Junya Hiroi, and Chris M. Wood In rainbow trout, the dominant site of Na+ uptake (JNain) and ammonia excretion (Jamm) shifts from the skin to the gills over development. Post-hatch (PH; 7 days post-hatch) larvae utilize the yolk sac skin for physiological exchange, whereas by complete yolk sac absorption (CYA; 30 days post-hatch), the gill is the dominant site. At the gills, JNain and Jamm occur via loose Na+/NH4+ exchange, but this exchange has not been examined in the skin of larval trout. Based on previous work, we hypothesized that, contrary to the gill model, JNa...
Source: Journal of Experimental Biology - December 12, 2016 Category: Biology Authors: Zimmer, A. M., Wilson, J. M., Wright, P. A., Hiroi, J., Wood, C. M. Tags: RESEARCH ARTICLE Source Type: research
Embryo yolk sac membrane kynurenine formamidase of l-tryptophan to NAD(+) pathway as a primary target for organophosphorus insecticides (OPI) in OPI-induced NAD-associated avian teratogenesis.
The objective of this study was to provide in ovo evidence for the proposed role of kynurenine formamidase of l-tryptophan to NAD(+) pathway in embryo yolk sac membranes as a primary target for organophosphorus insecticide (OPI) teratogens in OPI-induced NAD-associated avian teratogenesis. Slices prepared from yolk sac membranes or embryo livers of chicken eggs treated with the OPI dicrotophos and/or methyl parathion were incubated with l-tryptophan. Yolk sac membrane slices metabolized l-tryptophan in the pathway to NAD(+) before that function was established in livers. OPI interfered in ovo with the second step of l-tryp...
Source: Toxicology in Vitro - August 4, 2017 Category: Toxicology Authors: Seifert J Tags: Toxicol In Vitro Source Type: research
