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Surgical management and outcomes for stage 1 malignant ovarian germ cell tumours: a UK multicentre retrospective cohort study
Malignant ovarian germ cell tumours (MOGCTs) are rare with a yearly-adjusted incidence of 3.7 per million [1]. These account for 1-2% of all ovarian malignancies in Europe [2 –4] and comprise the histological subtypes: dysgerminoma, yolk sac tumour, mixed germ cell tumour, immature teratoma (IT) and embryonal carcinoma [5,3]. Fertility sparing surgery is a safe and effective strategy with excellent five year survival of 95% for stage one tumours [2,6].
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - February 16, 2022 Category: OBGYN Authors: Radha Graham, Nicola D MacDonald, Michelle Lockley, Rowan Miller, John Butler, Krithika Murali, Shah-Jalal Sarker, Susana Banerjee, Sara Stoneham, Jonathan Shamash, Viola Liberale, Daniel M Berney, Claire Newton Source Type: research
Yolk Sac Tumor of the Ovary: A Report of 150 Cases and Review of the Literature
One hundred fifty yolk sac tumors (YSTs) of the ovary in patients from 1 to 61 (mean: 21.5) years of age are described; 75% of the patients were in the second and third decades and only 1 was above 50 years of age. The clinical manifestations were typically related to a fast-growing adnexal mass; endocrine manifestations (hirsutism) were present in only 2 cases. The tumors were all unilateral and 70% were ≥15 cm; an associated dermoid cyst was present in 20 cases. The tumors were solid and cystic in 57% of the cases, 25% were multicystic, and 18% uniformly solid. The solid tissue was typically tan to pink or yellow and...
Source: The American Journal of Surgical Pathology - February 17, 2022 Category: Pathology Tags: Original Articles Source Type: research
Dramatic response to local radiotherapy in a refractory metastatic mediastinal yolk sac tumor patient harboring a germline < em > BRCA2 < /em > frameshift mutation: a case report
Cancer Biol Ther. 2022 Dec 31;23(1):393-400. doi: 10.1080/15384047.2022.2072635.ABSTRACTMediastinal yolk sac tumors (YSTs) are highly aggressive germ cell tumors with an extremely poor prognosis. Radiotherapy plays an important role in the treatment of mediastinal YSTs. To maximize benefit from radiotherapy in patients with mediastinal YSTs, exploring functionally relevant biomarkers is essential. Previous studies have demonstrated that mutations in DNA-damage repair (DDR) genes, including BRCA1/2, potentially enhance sensitivity to radiotherapy in solid tumors. However, DDR-gene mutations, as possible predictive biomarker...
Source: Cancer Biology and Therapy - May 16, 2022 Category: Cancer & Oncology Authors: Xi Cheng Haiming Yu Jinying Li Xiaona Han Erhong Meng Houqing Zhou Dongliang Wang Beifang Niu Xiaotao Zhang Source Type: research
An Unusual Enteric Yolk Sac Tumor: First Report of an Ovarian Germ Cell Tumor Associated With a Germline Pathogenic Variant in DICER1
We report an unusual enteric variant of ovarian YST in a 28-yr-old woman associated with a germline PV c.901C>T (p.Gln301Ter) in exon 7 of DICER1, accompanied by a somatic (YST-only) hotspot mutation: c.5437G>A, p.E1813K. To our knowledge, this is the first report of an ovarian germ cell tumor associated with a germline DICER1 PV. We review other reported cases of ovarian germ cell tumor with DICER1 PVs and discuss the differential diagnosis of this unusual variant of YST which was originally diagnosed as a mucinous adenocarcinoma.
Source: International Journal of Gynecological Pathology - June 29, 2022 Category: Pathology Tags: Pathology of the Upper Tract: Case Reports Source Type: research
